219 Matching Annotations
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    The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance
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    sciencedirect.com/science/article/pii/S1074761324005326
  3. Dec 2024
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    PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress
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    sciencedirect.com/science/article/pii/S2211124724014177
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    Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus
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    The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
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    Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain
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  8. Nov 2024
  9. 52.53.155.43 52.53.155.43
    glae258-html.html
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    Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females
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  11. Sep 2024
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    Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations
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    Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance
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  14. Aug 2024
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    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
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      DOI: 10.7554/eLife.76940

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    ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
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    Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in Drosophila melanogaster
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    nemeth-et-al-2024-adiponectin-suppresses-stiffness-dependent-pro-fibrotic-activation-of-lung-fibroblasts-html.html
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    The fork protection complex promotes parental histone recycling and epigenetic memory
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  20. Jul 2024
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    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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    CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection
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    cell.com/cell-reports/abstract/S2211-1247(24)00734-4
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    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
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    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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  25. Jun 2024
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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  27. May 2024
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    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
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    Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants
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    Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics
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    Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
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    Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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  34. Apr 2024
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    Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    Metabolic signature and response to glutamine deprivation are independent of p53 status in B cell malignancies
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    Chromatin context-dependent regulation and epigenetic manipulation of prime editing
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    A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
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  41. Mar 2024
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
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  43. Feb 2024
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    Alternative mRNA splicing events and regulators in epidermal differentiation
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    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10867425/
  46. Jan 2024
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    Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease
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      DOI: 10.1016/j.cmet.2023.12.024

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    sciencedirect.com/science/article/pii/S1550413123004758
  48. Dec 2023
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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      DOI: 10.1016/j.molcel.2023.11.016

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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  52. Nov 2023
  53. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Light activates Ube3a, an Angelman syndrome-associated gene, by mediating the chromatin structures during postnatal development of mouse retina
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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  55. Oct 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
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    Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin
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    Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
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  59. Sep 2023
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    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
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  61. Aug 2023
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    A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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  64. 52.53.155.43 52.53.155.43
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  65. Jul 2023
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    FOXA2 controls the anti-oxidant response in FH-deficient cells
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  69. Jun 2023
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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    52.53.155.43/7a1276d45430138c9432ff25359932d8ef5aed01/British J Pharmacology - 2023 - Mazzotta - BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic-html.html
  74. www.mdpi.com www.mdpi.com
    Inducible Knockout of 14-3-3β Attenuates Proliferation and Spheroid Formation in a Human Glioblastoma Cell Line U87MG
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  75. May 2023
  76. 52.53.155.43 52.53.155.43
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    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
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    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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    Nrl:CreERT2 mouse model to induce mosaic gene expression in rod photoreceptors
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    Sex-specific Phenotypes in the Aging Mouse Heart and Consequences for Chronic Fibrosis
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    Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis
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  82. Apr 2023
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    A tubule-sheet continuum model for the mechanism of nuclear envelope assembly
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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  85. Mar 2023
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium
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  88. Feb 2023
  89. www.nature.com www.nature.com
    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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    Recycling of modified H2A-H2B provides short-term memory of chromatin states
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  92. Jan 2023
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis
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    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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  97. Dec 2022
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  99. Nov 2022
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    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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  102. Oct 2022
  103. aacrjournals.org aacrjournals.org
    Selenium modulates cancer cell response to pharmacologic ascorbate
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      DOI: 10.1158/0008-5472.CAN-22-0408

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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of OX40 agonists for canine cancer immunotherapy
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    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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  107. Sep 2022
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    Confined migration induces heterochromatin formation and alters chromatin accessibility
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    Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment
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  110. Aug 2022
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    Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
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    Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice
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  113. Jun 2022
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  117. May 2022
  118. journals.biologists.com journals.biologists.com
    Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
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  120. Apr 2022
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    miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence
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    A presynaptic phosphosignaling hub for lasting homeostatic plasticity
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    Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis
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  124. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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    Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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  130. Feb 2022
  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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      DOI: 10.15252/emmm.202114876

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    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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    Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis
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  135. Jan 2022
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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    miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence
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    Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
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    Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral Chronic Graft-Versus-Host Disease
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  140. Dec 2021
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    Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  145. Nov 2021
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    The hepatic compensatory response to elevated systemic sulfide promotes diabetes
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  147. Oct 2021
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    Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease
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    Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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  151. Sep 2021
  152. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing
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      DOI: 10.1111/jnc.15491

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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Oncogene-dependent sloppiness in mRNA translation
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    STING nuclear partners contribute to innate immune signaling responses
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells
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  157. Aug 2021
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    Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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    HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization
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    FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner
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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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    Chemo-proteomics exploration of HDAC degradability by small molecule degraders
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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  165. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  166. Jul 2021
  167. www.frontiersin.org www.frontiersin.org
    The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons
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  168. www.cell.com www.cell.com
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  169. academic.oup.com academic.oup.com
    Menin Associates with the Mitotic Spindle and is Important for Cell Division
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    Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
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      DOI: 10.1523/JNEUROSCI.1873-18.2018

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  171. www.nature.com www.nature.com
    A chemical toolbox for the study of bromodomains and epigenetic signaling
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      donkey anti-mouse

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  172. www.sciencedirect.com www.sciencedirect.com
    RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway
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      IRDye 680RD Donkey anti-mouse

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    Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
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  175. Jun 2021
  176. www.sciencedirect.com www.sciencedirect.com
    Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity
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    Pumilio2 and Staufen2 selectively balance the synaptic proteome
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      RRID:AB_10953628

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    Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
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    Generation and validation of APOE knockout human iPSC-derived cerebral organoids
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  180. May 2021
  181. www.sciencedirect.com www.sciencedirect.com
    RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
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  182. journals.physiology.org journals.physiology.org
    MARCKS-Like Protein-1(MLP-1) regulates ENaC Activity in Renal Distal Convoluted Tubule Cells
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      DOI: 10.1152/ajpcell.00218.2020

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    Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue
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      DOI: 10.1016/j.stem.2021.01.002

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    Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  187. Apr 2021
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    The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure
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    HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
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    A Quantitative Proteome Map of the Human Body
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    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
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  192. Mar 2021
  193. journals.sagepub.com journals.sagepub.com
    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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      IRDye 680RD donkey anti-mouse

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  194. www.sciencedirect.com www.sciencedirect.com
    Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  196. Feb 2021
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    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
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    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
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    Rucaparib Treatment Alters p53 Oscillations in Single Cells to Enhance DNA-Double-Strand-Break-Induced Cell Cycle Arrest
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
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    PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation
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    High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down
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    Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
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    A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity
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    The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells | American Journal of Physiology-Endocrinology and Metabolism
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    Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification
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      DOI: 10.1016/j.chembiol.2019.06.006

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    sciencedirect.com/science/article/pii/S2451945619302077
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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      DOI: 10.1016/j.celrep.2019.08.105

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    sciencedirect.com/science/article/pii/S2211124719311672
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    Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy
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      DOI: 10.1016/j.cmet.2019.08.005

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    sciencedirect.com/science/article/pii/S1550413119304346
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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      DOI: 10.1016/j.stem.2019.08.017

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    sciencedirect.com/science/article/pii/S1934590919303844
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    Marine bacterial extracts as a new rich source of drugs against Alzheimer's disease
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      DOI: 10.1111/jnc.14847

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    Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
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      DOI: 10.1016/j.chembiol.2019.06.005

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    Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
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      DOI: 10.1016/j.str.2019.05.008

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    sciencedirect.com/science/article/pii/S0969212619301704
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    Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
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      DOI: 10.1016/j.celrep.2019.03.057

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