262 Matching Annotations
  1. Dec 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition
    1
    1. scibot 21 Dec 2024
      RRID:AB_2160739

      DOI: 10.1158/2767-9764.CRC-24-0408

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    pmc.ncbi.nlm.nih.gov/articles/PMC11586712/
  3. www.cell.com www.cell.com
    UBA1 inhibition sensitizes cancer cells to PARP inhibitors
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    1. scibot 05 Dec 2024
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      DOI: 10.1016/j.xcrm.2024.101834

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00605-0
  4. www.sciencedirect.com www.sciencedirect.com
    A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.immuni.2024.10.010

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    sciencedirect.com/science/article/pii/S1074761324004904
  5. Nov 2024
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
    1
    1. scibot 08 Nov 2024
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      DOI: 10.1158/0008-5472.CAN-23-3574

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
  7. Oct 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts
    1
    1. scibot 09 Oct 2024
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      DOI: 10.1016/j.molcel.2024.09.020

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    sciencedirect.com/science/article/pii/S1097276524007767
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
    1
    1. scibot 04 Oct 2024
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      DOI: 10.1158/1535-7163.MCT-23-0564

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis
    1
    1. scibot 04 Oct 2024
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      DOI: 10.1158/1078-0432.CCR-24-1317

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    ncbi.nlm.nih.gov/pmc/articles/PMC11443218/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion
    1
    1. scibot 04 Oct 2024
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      DOI: 10.1158/1541-7786.MCR-23-1003

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  12. Sep 2024
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma
    1
    1. scibot 25 Sep 2024
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      DOI: 10.1158/0008-5472.CAN-22-3784

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948029/
  14. www.mdpi.com www.mdpi.com
    Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells
    1
    1. scibot 25 Sep 2024
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      DOI: 10.3390/cancers12040875

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      Curator comments: Rabbit Anti-PARP Monoclonal Antibody, Unconjugated, Clone 46D11 Cell Signaling Technology Cat# 9532

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  15. www.sciencedirect.com www.sciencedirect.com
    Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome
    1
    1. scibot 25 Sep 2024
      RRID:AB_10616513

      DOI: 10.1016/j.molcel.2019.06.006

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    sciencedirect.com/science/article/pii/S1097276519304393
  16. www.sciencedirect.com www.sciencedirect.com
    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
    1
    1. scibot 17 Sep 2024
      AB_2160739

      DOI: 10.1016/j.celrep.2024.114751

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    sciencedirect.com/science/article/pii/S2211124724011021
  17. www.sciencedirect.com www.sciencedirect.com
    Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro.
    1
    1. scibot 11 Sep 2024
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      DOI: 10.1016/j.ajoms.2024.09.003

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    sciencedirect.com/science/article/pii/S2212555824001649
  18. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
    1
    1. scibot 04 Sep 2024
      AB_2160739

      DOI: 10.1016/j.xcrm.2024.101703

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    sciencedirect.com/science/article/pii/S2666379124004245
  19. Aug 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
    1
    1. scibot 18 Aug 2024
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      DOI: 10.1186/s12885-024-12691-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11292958/
  21. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
    1. scibot 13 Aug 2024
      Cell Signaling Cat# 9542

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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  22. www.mdpi.com www.mdpi.com
    A Bioinformatics Analysis Identifies the Telomerase Inhibitor MST-312 for Treating High-STMN1-Expressing Hepatocellular Carcinoma
    1
    1. scibot 02 Aug 2024
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      DOI: 10.3390/jpm11050332

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    mdpi.com/2075-4426/11/5/332/htm
  23. Jul 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Eupalinolide B suppresses pancreatic cancer by ROS generation and potential cuproptosis
    1
    1. scibot 26 Jul 2024
      AB_2160739

      DOI: 10.1016/j.isci.2024.110496

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    sciencedirect.com/science/article/pii/S2589004224017218
  25. www.sciencedirect.com www.sciencedirect.com
    Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1016/j.chembiol.2024.06.014

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    sciencedirect.com/science/article/pii/S2451945624002745
  26. www.cell.com www.cell.com
    Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
    1
    1. scibot 23 Jul 2024
      RRID:AB_2160739

      DOI: 10.1016/j.celrep.2024.114497

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    cell.com/cell-reports/fulltext/S2211-1247(24)00826-X
  27. www.sciencedirect.com www.sciencedirect.com
    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    1
    1. scibot 17 Jul 2024
      RRID:AB_2160739

      DOI: 10.1016/j.celrep.2024.114464

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    sciencedirect.com/science/article/pii/S2211124724007939
  28. www.sciencedirect.com www.sciencedirect.com
    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
    1
    1. scibot 11 Jul 2024
      RRID:AB_2160739

      DOI: 10.1016/j.chembiol.2024.06.004

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    sciencedirect.com/science/article/pii/S245194562400223X
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits
    1
    1. scibot 03 Jul 2024
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      DOI: 10.3389/fresc.2024.1375561

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    ncbi.nlm.nih.gov/pmc/articles/PMC11208732/
  30. Jun 2024
  31. www.sciencedirect.com www.sciencedirect.com
    The ribotoxic stress response drives UV-mediated cell death
    1
    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.018

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    sciencedirect.com/science/article/pii/S0092867424005270
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
    1. scibot 03 Jun 2024
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      DOI: 10.1016/j.isci.2024.109983

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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  33. May 2024
  34. www.sciencedirect.com www.sciencedirect.com
    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
    1
    1. scibot 21 May 2024
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      DOI: 10.1016/j.celrep.2024.114214

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    sciencedirect.com/science/article/pii/S2211124724005424
  35. 52.53.155.43 52.53.155.43
    ol_28_1_14449_PDF-html.html
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    1. scibot 17 May 2024
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      DOI: 10.3892/ol.2024.14449

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    52.53.155.43/917364cd3fceb398a38ff7cf2bbe2411971526ce/ol_28_1_14449_PDF-html.html
  36. www.biorxiv.org www.biorxiv.org
    Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
    1
    1. scibot 16 May 2024
      RRID:AB_2160739

      DOI: 10.1101/2024.02.22.581507

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    biorxiv.org/content/10.1101/2024.02.22.581507v1
  37. www.cell.com www.cell.com
    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
    1
    1. scibot 03 May 2024
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      DOI: 10.1016/j.xcrm.2024.101519

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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00188-5
  38. Apr 2024
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1093/narcan/zcae018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11025007/
  41. 52.53.155.43 52.53.155.43
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
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      Cell SignalingCat# 9542

      DOI: 10.1038/s44318-024-00043-2

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    52.53.155.43/96a93e3423f1799636791061d7a89146b9cf3fe1/andronikou-et-al-2024-parg-deficient-tumor-cells-have-an-increased-dependence-on-exo1-fen1-mediated-dna-repair (1)-html.html
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden
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      DOI: 10.1158/2767-9764.CRC-23-0430

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003453/
  43. www.sciencedirect.com www.sciencedirect.com
    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
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      9542

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    sciencedirect.com/science/article/pii/S0006295224001813
  44. Mar 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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      DOI: 10.1016/j.celrep.2024.113998

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    sciencedirect.com/science/article/pii/S2211124724003267
  46. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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      DOI: 10.1158/1535-7163.MCT-23-0025

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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
    1
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      DOI: 10.1038/s44319-023-00026-0

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  49. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
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  54. Jan 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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  56. Dec 2023
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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  58. Nov 2023
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    Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery
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    Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
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    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
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    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
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    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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  64. Oct 2023
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    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
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  67. Sep 2023
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    TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
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  69. Aug 2023
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    HIF-1α inhibition in macrophages preserves acute liver failure by reducing IL-1β production
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    Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
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  75. Jul 2023
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    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos
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    The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity
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  79. Jun 2023
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    MYO10 regulates genome stability and cancer inflammation through mediating mitosis
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  84. Apr 2023
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    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
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  91. Feb 2023
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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    Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma
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  97. Jan 2023
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer
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    Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways
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  106. Dec 2022
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    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
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    Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma
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  111. Nov 2022
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    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    Inhibition of Glycogen Metabolism Induces Reactive Oxygen Species-Dependent Cytotoxicity in Anaplastic Thyroid Cancer in Female Mice
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    Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury
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  120. Sep 2022
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune response
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  123. Aug 2022
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    The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth
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    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  127. Jul 2022
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    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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  132. May 2022
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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  137. Apr 2022
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    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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  142. Mar 2022
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    Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex
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    Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
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    Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
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    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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    EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
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    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape
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  149. Feb 2022
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    Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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    Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
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  153. Jan 2022
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    Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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  156. Dec 2021
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    ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
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    APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain
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    Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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    Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells
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    Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages
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  164. Nov 2021
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    Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis
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    A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
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  167. Oct 2021
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    Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival
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  169. Sep 2021
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    Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity
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    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
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  173. Aug 2021
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    Muscle-Derived Cytokines Reduce Growth, Viability and Migratory Activity of Pancreatic Cancer Cells
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    HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
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    The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors
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    Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor
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  182. Jul 2021
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    Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate
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    Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer
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      PARP rabbit antibody

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  185. rupress.org rupress.org
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    The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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    IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells
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    Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
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    Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  196. Jun 2021
  197. www.sciencedirect.com www.sciencedirect.com
    Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs
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    Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage
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    Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis
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  202. May 2021
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    Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
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  204. cancerres.aacrjournals.org cancerres.aacrjournals.org
    Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors
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    Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
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    Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains
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    A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
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    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
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    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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  217. Feb 2021
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-Negative Breast Cancer Anoikis Resistance
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis
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      DOI: 10.1113/JP279150

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  223. Jan 2021
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    BRD4-mediated repression of p53 is a target for combination therapy in AML
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    Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
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    Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon
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  227. Dec 2020
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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  229. Nov 2020
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    TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
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  231. Oct 2020
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    A uro-protective agent with restorative actions on urethral and striated muscle morphology
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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells
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    MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities
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    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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    BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer
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    Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30
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      DOI: 10.1016/j.celrep.2020.03.011

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      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2160739

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      RRIDCUR:Validated RRID:AB_2160739
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    sciencedirect.com/science/article/pii/S221112472030317X
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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    1. scibot 10 Sep 2020
      RRID:AB_2160739

      DOI: 10.1016/j.celrep.2019.12.032

      Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2160739

      What is this?
      RRID:AB_2160739 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719316821