304 Matching Annotations
  1. Dec 2024
  2. 52.53.155.43 52.53.155.43
    Article PDF-html.html
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    1. scibot 12 Dec 2024
      CST,  14793

      DOI: 10.1007/s40265-020-01461-2

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    52.53.155.43/25878c53e924c2e6be95e43c0a8a174e01834d73/Article PDF-html.html
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    1. scibot 12 Dec 2024
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      DOI: 10.1016/j.molcel.2024.11.024

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    sciencedirect.com/science/article/pii/S1097276524009493
  4. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224027652-main-html.html
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    1. scibot 10 Dec 2024
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    Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
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    1. scibot 10 Dec 2024
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      DOI: 10.1016/j.cels.2024.11.004

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    sciencedirect.com/science/article/pii/S2405471224003375
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    Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy
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    1. scibot 06 Dec 2024
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    sciencedirect.com/science/article/pii/S2666379124006098
  7. Nov 2024
  8. www.sciencedirect.com www.sciencedirect.com
    Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina
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    1. scibot 24 Nov 2024
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    sciencedirect.com/science/article/pii/S1534580724006312
  9. www.biorxiv.org www.biorxiv.org
    Structure of the TXNL1-bound proteasome
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    1. scibot 15 Nov 2024
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      DOI: 10.1101/2024.11.08.622741

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    biorxiv.org/content/10.1101/2024.11.08.622741v1
  10. www.embopress.org www.embopress.org
    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    embopress.org/doi/10.1038/s44318-024-00290-3
  11. 52.53.155.43 52.53.155.43
    wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html
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    1. scibot 14 Nov 2024
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    52.53.155.43/052dd78e8f9f0d46ee449e71fc9d1d608c537305/wang-et-al-2024-nuclear-receptor-e75-nr1d2-promotes-tumor-malignant-transformation-by-integrating-hippo-and-notch-html.html
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
    1
    1. scibot 14 Nov 2024
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    sciencedirect.com/science/article/pii/S2211124724012683
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    Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis
    1
    1. scibot 11 Nov 2024
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    sciencedirect.com/science/article/pii/S2211124724013172
  14. Sep 2024
  15. www.biorxiv.org www.biorxiv.org
    Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity
    1
    1. scibot 29 Sep 2024
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      DOI: 10.1101/2024.09.11.612521

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    biorxiv.org/content/10.1101/2024.09.11.612521v1
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    CircPOLA2 sensitizes non-small cell lung cancer cells to ferroptosis and suppresses tumorigenesis via the Merlin-YAP signaling pathway
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2589004224020571
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724011136
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    LHP1 and INO80 cooperate with ethylene signaling for warm ambient temperature response by activating specific bivalent genes
    1
    1. scibot 13 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724011094
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    CD14 is a decision-maker between Fas-mediated death and inflammation
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010362
  20. Aug 2024
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    1. scibot 22 Aug 2024
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      DOI: 10.1186/s13046-024-03124-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321020/
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006191
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
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    1. scibot 21 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    1. scibot 20 Aug 2024
      AB_2572291

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    sciencedirect.com/science/article/pii/S2211124724009586
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    Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies
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      DOI: 10.1016/j.chembiol.2024.07.005

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    sciencedirect.com/science/article/pii/S2451945624003076
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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    sciencedirect.com/science/article/pii/S2211124724009604
  27. academic.oup.com academic.oup.com
    First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1
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      DOI: 10.1210/clinem/dgac640

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac640/6806102
  28. 52.53.155.43 52.53.155.43
    Supplemental_Materials (1)-html.html
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      DOI: 10.2337/figshare.21183496

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  29. Jul 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
    2
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    ncbi.nlm.nih.gov/pmc/articles/PMC11285331/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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      DOI: 10.1016/j.celrep.2021.109363

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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
  32. www.cell.com www.cell.com
    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    cell.com/iscience/fulltext/S2589-0042(24)01642-0
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    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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    sciencedirect.com/science/article/pii/S2211124724008064
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    SWI/SNF chromatin remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cell migration
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    sciencedirect.com/science/article/pii/S2211124724007873
  35. www.cell.com www.cell.com
    Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00782-4
  36. Jun 2024
  37. elifesciences.org elifesciences.org
    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
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      DOI: 10.7554/eLife.88375

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    elifesciences.org/articles/88375
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol to test for the formation of ternary protein complexes in vivo or in vitro using a two-step immunoprecipitation approach
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141244/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
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      DOI: 10.1038/s41467-024-49016-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11143359/
  40. May 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11108982/
  42. www.sciencedirect.com www.sciencedirect.com
    Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor
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      DOI: 10.1016/j.cell.2024.04.023

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    sciencedirect.com/science/article/pii/S0092867424004483
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    Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer
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      DOI: 10.1016/j.celrep.2024.114174

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    sciencedirect.com/science/article/pii/S2211124724005023
  44. Apr 2024
  45. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning
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      DOI: 10.7554/eLife.91269

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    Triggering endogenous Z-RNA sensing for anti-tumor therapy through ZBP1-dependent necroptosis
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    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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  94. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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  95. Oct 2023
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    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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    MiniBAR/GARRE1 is a dual Rac and Rab effector required for ciliogenesis
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    Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits
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    Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
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  103. www.science.org www.science.org
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    Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8
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    TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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    Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
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    Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping
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    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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  115. Aug 2023
  116. www.cell.com www.cell.com
    Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
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    USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential
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    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  123. Jul 2023
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    Structural basis for membrane-proximal proteolysis of substrates by ADAM10
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    Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover
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    Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1
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    Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression
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