203 Matching Annotations
  1. Aug 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
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    1. scibot 23 Aug 2024
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    sciencedirect.com/science/article/pii/S1097276524006609
  3. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
    1
    1. scibot 02 Aug 2024
      S6K phospho-Thr389

      DOI: 10.1016/j.molcel.2020.11.008

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  4. Jul 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial perturbations in low-protein-diet-fed mice are associated with altered neutrophil development and effector functions
    1
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      DOI: 10.1016/j.celrep.2024.114493

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    sciencedirect.com/science/article/pii/S2211124724008222
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles
    1
    1. scibot 17 Jul 2024
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      DOI: 10.14814/phy2.16145

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    ncbi.nlm.nih.gov/pmc/articles/PMC11245571/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.devcel.2020.07.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
  8. Jun 2024
  9. 52.53.155.43 52.53.155.43
    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
    2
    1. scibot 06 Jun 2024
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      DOI: 10.1101/2024.02.09.579580

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    52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
    1
    1. scibot 03 Jun 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
  11. May 2024
  12. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
    1
    1. scibot 25 May 2024
      AB_330944

      DOI: 10.1113/JP285339

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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285339
  13. 52.53.155.43 52.53.155.43
    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
    2
    1. scibot 24 May 2024
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      DOI: 10.1152/ajpcell.00669.2023

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      DOI: 10.1152/ajpcell.00669.2023

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    52.53.155.43/76598b44d554c4165a9f84a25bc34c671709ff41/lee-et-al-2024-everolimus-exerts-anticancer-effects-through-inhibiting-the-interaction-of-matrix-metalloproteinase-7-html.html
  14. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
    2
    1. scibot 10 May 2024
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      DOI: 10.1038/nature05972

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    52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
  15. 52.53.155.43 52.53.155.43
    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
    1
    1. scibot 03 May 2024
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      DOI: 10.1101/2024.01.12.575269

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  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
  18. www.sciencedirect.com www.sciencedirect.com
    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
    2
    1. scibot 18 Apr 2024
      RRID:AB_330944

      DOI: 10.1016/j.celrep.2024.114094

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    sciencedirect.com/science/article/pii/S2211124724004224
  19. www.sciencedirect.com www.sciencedirect.com
    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    sciencedirect.com/science/article/pii/S2211124724004479
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1038/s41598-024-58716-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  21. Feb 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
    1
    1. scibot 03 Feb 2024
      RRID:AB_330944

      DOI: 10.1016/j.isci.2024.108853

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830876/
  23. Jan 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
      RRID:AB_330944

      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  25. Dec 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
    1
    1. scibot 19 Dec 2023
      RRID:AB_330944

      DOI: 10.1016/j.devcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1534580723006214
  27. www.sciencedirect.com www.sciencedirect.com
    Sequestration of translation initiation factors in p62 condensates
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113583

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    sciencedirect.com/science/article/pii/S2211124723015954
  28. www.sciencedirect.com www.sciencedirect.com
    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.023

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    sciencedirect.com/science/article/pii/S1097276523009681
  29. Nov 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease
    1
    1. scibot 29 Nov 2023
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      DOI: 10.1016/j.isci.2023.108278

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    sciencedirect.com/science/article/pii/S2589004223023556
  31. www.sciencedirect.com www.sciencedirect.com
    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101285

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    sciencedirect.com/science/article/pii/S2666379123004792
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    1. scibot 03 Nov 2023
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  33. 52.53.155.43 52.53.155.43
    s11684-022-0959-5 (1)-html.html
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    1. scibot 03 Nov 2023
      RRID:AB_330944

      DOI: 10.3389/fncel.2020.552213

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      DOI: 10.3389/fncel.2020.552213

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  34. Oct 2023
  35. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    1. scibot 20 Oct 2023
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      DOI: 10.15252/embr.202356815

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    embopress.org/doi/10.15252/embr.202356815
  36. Sep 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Underpinning the food matrix regulation of post-exercise myofibrillar protein synthesis by comparing salmon ingestion versus the sum of its isolated nutrients in healthy young adults
    1
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      DOI: 10.1016/j.tjnut.2023.02.037

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    sciencedirect.com/science/article/pii/S0022316623352799
  38. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
    1
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      DOI: 10.1113/EP091284

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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  39. Aug 2023
  40. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
    1
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      DOI: 10.1016/j.celrep.2023.112986

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    sciencedirect.com/science/article/pii/S221112472300997X
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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      DOI: 10.1016/j.isci.2023.107368

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  42. www.sciencedirect.com www.sciencedirect.com
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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      DOI: 10.1016/j.molcel.2023.07.015

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    sciencedirect.com/science/article/pii/S1097276523005580
  43. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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      DOI: 10.1158/1535-7163.MCT-23-0110

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    aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
  44. Jul 2023
  45. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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      DOI: 10.1101/2023.05.18.541123

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  46. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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      DOI: 10.1158/1535-7163.MCT-22-0224

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  47. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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      DOI: 10.1158/1535-7163.mct-22-0224

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  48. Jun 2023
  49. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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      DOI: 10.1523/JNEUROSCI.0146-23.2023

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    jneurosci.org/content/43/15/2631
  50. May 2023
  51. 52.53.155.43 52.53.155.43
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    1. scibot 27 May 2023
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    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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  65. Jan 2023
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  68. Nov 2022
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    Liver autophagy-induced valine and leucine in plasma reflect the metabolic effect of sodium glucose co-transporter 2 inhibitor dapagliflozin
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  124. Jul 2021
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  131. May 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
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  144. Mar 2021
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  146. Feb 2021
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    In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition
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  149. Jan 2021
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    Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity
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  154. Dec 2020
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    Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth
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    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  157. Nov 2020
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system
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  161. Oct 2020
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    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
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    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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    Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
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    Vcp Overexpression and Leucine Supplementation Increase Protein Synthesis and Improve Fear Memory and Social Interaction of Nf1 Mutant Mice
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    Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1
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    The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
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    mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression
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    The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance
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    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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      DOI: 10.1016/j.stem.2019.12.006

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    Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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      Anti‐phospho‐S6K

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    β2‐adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
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    Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma
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  183. Jan 2020
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    Mechanistic target of rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions
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      DOI: 10.1016/j.ygcen.2019.113209

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    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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    Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
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    Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells
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    Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
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    A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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    Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
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    Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
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    Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan
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    Aldosterone Modulates the Mechanistic Target of Rapamycin Signaling in Male Mice
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    Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice
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    Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
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    Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster
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    L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
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