464 Matching Annotations
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    Selective targeting of mu opioid receptors to primary cilia
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    The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice.
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  4. Jul 2024
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    Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication
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    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
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    cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
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    SigmaR1 shapes rough endoplasmic reticulum membrane sheets
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  8. Jun 2024
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    EYA protein complex is required for Wntless retrograde trafficking from endosomes to Golgi
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  10. May 2024
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
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  12. Apr 2024
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    Mycobacterial SapM hampers host autophagy initiation for intracellular bacillary survival via dephosphorylating Raptor
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    The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells
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  15. Mar 2024
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    FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
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    Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes
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    The circular RNA circATP8B(2) regulates ROS production and antiviral immunity in Drosophila
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    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3(25b+) pathway
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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    Rim aperture of yeast autophagic membranes balances cargo inclusion with vesicle maturation
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    Jasmonate signaling pathway confers salt tolerance through a NUCLEAR FACTOR-Y trimeric transcription factor complex in Arabidopsis
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development
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  29. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    Mycobacterial Rv1804c binds to the PEST domain of IκBα and activates macrophage-mediated proinflammatory responses
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    EHBP1 is critically involved in dendritic arbor formation and is coupled to factors promoting actin filament formation
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    SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
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    Characterization of ATG8-family protein phosphorylation by Phos-tag gel for autophagy study
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  35. Jan 2024
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    Mechanistic and structural studies reveal NRAP-1-dependent coincident activation of NMDARs
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    PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis
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    JNEUROSCI.0236-23.2023.full-html.html
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    Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency
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    Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B
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    Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
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  42. Dec 2023
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    High-throughput PRIME-editing screens identify functional DNA variants in the human genome
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    Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction
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    A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease
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    PP2A-B55SUR-6 promotes nuclear envelope breakdown in C. elegans embryos
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    TET2 is recruited by CREB to promote Cebpb, Cebpa and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation
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    Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1
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    Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer
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    The structural mechanism of dimeric DONSON in replicative helicase activation
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    OLIG2 translocates to chromosomes during mitosis via a temperature downshift: a novel neural cold response of mitotic bookmarking
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    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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    Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity
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    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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    O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species
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    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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    Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
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    The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice
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    A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy
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    TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
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    ATF3 stimulates FSHβ expression in vitro, but is dispensable for FSH production in murine gonadotropes in vivo
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  90. May 2023
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    A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma
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    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
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    Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation
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    Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases
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    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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    Fluorescence-resonance-energy-transfer-based assay to estimate modulation of TDP1 activity through arginine methylation
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    Lysine long-chain fatty acylation regulates the TEAD transcription factor
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications
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    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
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    A pair of readers of bivalent chromatin mediate formation of Polycomb-based “memory of cold” in plants
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    The lysine methyltransferase SMYD5 amplifies HIV-1 transcription and is post-transcriptionally upregulated by Tat and USP11
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    DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
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    NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
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    DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
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    Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome
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    GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
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    Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma
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    The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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    Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Membrane Estrogen Receptor Beta is Sufficient to Mitigate Cardiac Cell Pathology
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    Nitrate availability controls translocation of the transcription factor NAC075 for cell-type-specific reprogramming of root growth
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    Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin
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    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
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    Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
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    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation
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    CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors
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  143. Oct 2022
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    Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress
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  146. Sep 2022
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    Human sensory neurons modulate melanocytes through secretion of RGMB
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    Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase
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    PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis
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    L2Δ13, a splicing isoform of lysyl oxidase-like 2, causes adipose tissue loss via the gut microbiota and lipid metabolism
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    In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification
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    Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance
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    Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway
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    Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism
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    PEX5 translocation into and out of peroxisomes drives matrix protein import
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    A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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    Chl1 coordinates with H3K9 methyltransferase Clr4 to reduce the accumulation of RNA-DNA hybrids and maintain genome stability
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    Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets
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    Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors
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    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
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    Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma
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    Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling
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    Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcaemia
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    MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
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    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion
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    Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis
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    The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
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    PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery
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    The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth
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    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing
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    Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants
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    Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  193. Jan 2022
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
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    Structure and transport mechanism of the human cholesterol transporter ABCG1
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    Acetylation-dependent regulation of BRAF oncogenic function
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
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  199. elifesciences.org elifesciences.org
    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
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    Protocol for identification and validation of 2′3′-cGAMP-binding proteins by photoaffinity probes
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular self-avoidance in synaptic neurexin complexes
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  203. Dec 2021
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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    Molecular self-avoidance in synaptic neurexin complexes
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    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
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    A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
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    The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
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  209. Nov 2021
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    MAR1 links membrane adhesion to membrane merger during cell-cell fusion in Chlamydomonas
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    A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
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    Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle
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    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
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    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
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    The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
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  216. Oct 2021
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Aberrant RNA methylation triggers recruitment of an alkylation repair complex
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    Biosensors based on peptide exposure show single molecule conformations in live cells
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    Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis
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    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
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  222. Sep 2021
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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    Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress
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