273 Matching Annotations
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    Selective targeting of mu opioid receptors to primary cilia
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    An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II
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    Macrophages preserve endothelial cell specialization in the adrenal gland to modulate aldosterone secretion and blood pressure
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    cell.com/cell-reports/abstract/S2211-1247(24)00723-X
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    Reproductive regulation of the mitochondrial stress response in Caenorhabditis elegans
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    cell.com/cell-reports/abstract/S2211-1247(24)00664-8
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    CCAR1 promotes DNA repair via alternative splicing
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    Evolution of ion transporter Na+/K+-ATPase expression in the osmoregulatory maxillary glands of an invasive copepod
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    An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
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  9. Jul 2024
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    The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation
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  11. Jun 2024
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    Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells
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  13. Apr 2024
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    Expansion of human centromeric arrays in cells undergoing break-induced replication
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
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  18. Mar 2024
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    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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  22. Feb 2024
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    Identification of an H-Ras nanocluster disrupting peptide
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    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning
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    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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    Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
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    Hydroxypyridone anti-fungals selectively induce myofibroblast apoptosis in an in vitro model of hypertrophic scars
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  31. Jan 2024
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    Live-cell imaging defines a threshold in CDK activity at the G2/M transition
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    Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model
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    Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
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  35. Dec 2023
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    Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
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    Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures
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    Subcytoplasmic location of translation controls protein output
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes
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    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
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  42. Nov 2023
  43. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
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      DOI: 10.1101/2023.11.01.564830

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    biorxiv.org/content/10.1101/2023.11.01.564830v1
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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    sciencedirect.com/science/article/pii/S2589004223022460
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    APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
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    sciencedirect.com/science/article/pii/S2211124723012640
  46. Oct 2023
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    Universal features of Nsp1-mediated translational shutdown by coronaviruses
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    The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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    52.53.155.43/7a1276d45430138c9432ff25359932d8ef5aed01/British J Pharmacology - 2023 - Mazzotta - BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic-html.html
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    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
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    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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    APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
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    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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    The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
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    MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes
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  81. Mar 2023
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    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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    Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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    Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line
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    N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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    Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    Vitamin B12 deficiency induces glucose intolerance, delays peak insulin levels and promotes ketogenesis in female rats
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis
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    Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization
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    Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT
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    The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation
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  102. Nov 2022
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    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars
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    Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein
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  108. Sep 2022
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    Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding
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    Dopamine drives neuronal excitability via KCNQ channel phosphorylation for reward behavior
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    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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    From guide to guard—activation mechanism of the stress-sensing chaperone Get3
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    A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
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    Context-dependent regulation of ferroptosis sensitivity
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  118. Jun 2022
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    Modelling the structure of Short Gastrulation and generation of a toolkit for studying its function in Drosophila
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021–22 Northern Hemisphere influenza season
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  123. May 2022
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    Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemiaNovel non-canonical function of AGO2 in T-PLL
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    Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3
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    A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer
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    Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing
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    Mapping the invisible chromatin transactions of prophase chromosome remodeling
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    Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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    Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling
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    Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  146. Nov 2021
  147. mct.aacrjournals.org mct.aacrjournals.org
    SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
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  150. Oct 2021
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    Deiodinase-3 is a thyrostat to regulate podocyte homeostasis
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    Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
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    c-FOS drives reversible basal to squamous cell carcinoma transition
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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  155. Sep 2021
  156. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing
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    Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
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  159. Aug 2021
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    Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
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  161. elifesciences.org elifesciences.org
    Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics
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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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  168. Jul 2021
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    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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      IRDye 800CW Donkey anti-Mouse IgG

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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    PI3K inhibitors protect against glucocorticoid-induced skin atrophy
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    Menin Associates with the Mitotic Spindle and is Important for Cell Division
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    Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signaling
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  177. www.nature.com www.nature.com
    Quantification of phosphoinositides reveals strong enrichment of PIP 2 in HIV-1 compared to producer cell membranes
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  178. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aspirin upregulates Suppressor of Cytokine Signaling 3 in glial cells via PPARα
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    Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
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  180. Jun 2021
  181. www.sciencedirect.com www.sciencedirect.com
    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  184. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  185. May 2021
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  187. www.sciencedirect.com www.sciencedirect.com
    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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    RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
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    A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy
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    Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease
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  193. Apr 2021
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    The Scaffold Protein Axin Promotes Signaling Specificity within the Wnt Pathway by Suppressing Competing Kinase Reactions
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    β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors
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    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
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    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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  208. Feb 2021
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    Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis
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    Deficiency of Meis1, a transcriptional regulator, in mice and worms: neurochemical and behavioral characterizations with implications in the restless legs syndrome
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    TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47
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    Neuronal non-CG methylation is an essential target for MeCP2 function
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  214. Jan 2021
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    Purified Bighead protein efficiently promotes head development in the South African clawed frog, Xenopus laevis
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  216. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
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  218. Nov 2020
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    Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
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    Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior
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    An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model
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    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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  223. Oct 2020
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  225. Sep 2020
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    Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant
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    Involvement of progesterone and estrogen receptors in the ram sperm acrosome reaction
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    PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Does Melatonin Exert Its Effect on Ram Sperm Capacitation Through Nitric Oxide Synthase Regulation?
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      RRIDCUR:Validated RRID:AB_621847
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    mdpi.com/1422-0067/21/6/2093
  237. www.sciencedirect.com www.sciencedirect.com
    CenH3-Independent Kinetochore Assembly in Lepidoptera Requires CCAN, Including CENP-T
    1
    1. scibot 16 Sep 2020
      RRID:AB_621847

      DOI: 10.1016/j.cub.2019.12.014

      Resource: (LI-COR Biosciences Cat# 926-32212, RRID:AB_621847)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_621847

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      RRIDCUR:Validated RRID:AB_621847
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    sciencedirect.com/science/article/pii/S0960982219316094
  238. www.sciencedirect.com www.sciencedirect.com
    Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
    1
    1. scibot 15 Sep 2020
      RRID:AB_621847

      DOI: 10.1016/j.celrep.2019.12.028

      Resource: (LI-COR Biosciences Cat# 926-32212, RRID:AB_621847)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_621847

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      RRID:AB_621847 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S221112471931678X
  239. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
    1
    1. scibot 15 Sep 2020
      RRID:AB_621847

      DOI: 10.1016/j.celrep.2020.107863

      Resource: (LI-COR Biosciences Cat# 926-32212, RRID:AB_621847)

      Curator: @evieth

      SciCrunch record: RRID:AB_621847

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      RRID:AB_621847 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC7303637/