240 Matching Annotations
  1. Last 7 days
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    ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signaling
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    sciencedirect.com/science/article/pii/S2589004226013258
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining ferroptosis inducers with gemcitabine to enhance treatment efficacy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13185238/
  4. May 2026
  5. www.nature.com www.nature.com
    Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis
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    nature.com/articles/s42003-026-09538-6
  6. aacrjournals.org aacrjournals.org
    Constitutive STAT3 signaling, in comparison to STAT5, enhances CAR T cell efficacy and lowers systemic toxicity
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    aacrjournals.org/cancerimmunolres/article/14/5/845/784457/Constitutive-STAT3-Signaling-in-Comparison-with
  7. Apr 2026
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    GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S221112472600392X
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Vitamin D3 Analog Calcipotriol Attenuates Pancreatic Cancer Malignancy via Downregulating Thrombospondin 1 in Pancreatic Stellate Cells
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    onlinelibrary.wiley.com/doi/10.1155/mi/2632235
  10. www.biorxiv.org www.biorxiv.org
    Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.04.13.717530v1
  11. 54.241.53.176 54.241.53.176
    2026.03.16.711738.full-html.html
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  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13080325/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13039881/
  14. www.biorxiv.org www.biorxiv.org
    Reassessment of RNF43 Function Reveals No Impact on Endogenous EGFR or BRAF Protein Stability
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    biorxiv.org/content/10.64898/2026.03.18.712374v1
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    Adipogenic transdifferentiation reprograms EMT-high PDAC cells into a post-mitotic adipocyte-like state and limits metastasis
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    nature.com/articles/s41419-026-08613-4
  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Efficacy and immunogenic effects of Tumor Treating Fields (TTFields) in preclinical models of pancreatic ductal adenocarcinoma, with and without gemcitabine/nab-paclitaxel
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    onlinelibrary.wiley.com/doi/10.1002/ijc.70408
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Combination of a BCL-xL PROTAC and an mTOR Inhibitor Sensitizes Pancreatic Ductal Adenocarcinoma to KRASG12D Inhibitor Treatment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13025216/
  18. Mar 2026
  19. www.sciencedirect.com www.sciencedirect.com
    Targeting PI3Kδ suppresses pancreatic cancer by dual disruption of fibrosis and immune evasion
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    sciencedirect.com/science/article/pii/S2211124726002664
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    A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
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    sciencedirect.com/science/article/pii/S0092867426002692
  21. www.sciencedirect.com www.sciencedirect.com
    A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126001059
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12970238/
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    β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer
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    sciencedirect.com/science/article/pii/S0092867426001698
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sym024 interacts with a unique epitope on the CD73 homodimer, favoring effective bivalent binding to improve anti-PD1 therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12950896/
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    Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy
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    sciencedirect.com/science/article/pii/S2666379126000613
  26. Feb 2026
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12937152/
  28. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    An Insulin-Exosome-TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202515606
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    A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity
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    sciencedirect.com/science/article/pii/S266723752600007X
  30. www.biorxiv.org www.biorxiv.org
    ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma
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    biorxiv.org/content/10.64898/2026.02.11.705411v1
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Prolyl Isomerase PIN1 Impacts Fibroblast Differentiation States and Crosstalk in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12912258/
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    Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2666379126000303
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    Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
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    Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cyclic di-GMP suppresses cancer metastasis by targeting proteasome 26S subunit non-ATPase 3 independently of STING
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    pmc.ncbi.nlm.nih.gov/articles/PMC12868630/
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    Supplemental_Material.pdf
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Interruption of cross-communication pathways alters the immune cell signature of pancreatic cancer and decreases tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859874/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Lysine Demethylase KDM4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12856980/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316562/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12859075/
  41. Jan 2026
  42. www.sciencedirect.com www.sciencedirect.com
    Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML
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    sciencedirect.com/science/article/pii/S155041312600001X
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12847887/
  44. www.biorxiv.org www.biorxiv.org
    The combination of BCL-xL PROTAC and mTOR inhibitor sensitizes pancreatic ductal adenocarcinoma to KRASG12D inhibitor treatment by enhancing apoptosis induction
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    biorxiv.org/content/10.64898/2026.01.05.697773v1
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    In situ multi-modal characterization of pancreatic cancer reveals tumor cell identity as a defining factor of the surrounding microenvironment
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    sciencedirect.com/science/article/pii/S2211124725015992
  46. www.nature.com www.nature.com
    SLC6A14-mediated glutamine promotes SYTL4–CXCL8 axis activation to drive gemcitabine resistance and immune evasion in pancreatic cancer
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    nature.com/articles/s12276-025-01596-w
  47. Dec 2025
  48. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
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    RAS mutation–specific responses to paralog- and state-selective RAS inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Niclosamide nanoparticles enhance pancreatic cancer sensitivity to gemcitabine via HIF-1α inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12704315/
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    Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
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    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Olaparib and radiotherapy induce type I interferon and CD8+ T cell-dependent sensitization to immunotherapy in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12137021/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
  55. Nov 2025
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
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    UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
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    IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy
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    sciencedirect.com/science/article/pii/S1074761325004753
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12616096/
  60. www.nature.com www.nature.com
    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
  62. Oct 2025
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    sciencedirect.com/science/article/pii/S2211124725012586
  64. app.jove.com app.jove.com
    Mapping Dysfunctional Protein-Protein Interactions in Disease
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer
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  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S1368764625001153
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  71. Sep 2025
  72. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202511726
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    Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies
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    pmc.ncbi.nlm.nih.gov/articles/PMC12427560/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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  75. link.springer.com link.springer.com
    RACK1 attenuates pancreatic tumorigenesis by suppressing acinar-to-ductal metaplasia through inflammatory signaling modulation
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    link.springer.com/article/10.1007/s13402-025-01084-3
  76. Aug 2025
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    Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer
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    sciencedirect.com/science/article/pii/S266637912500374X
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
  79. pubs.acs.org pubs.acs.org
    Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers
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    pubs.acs.org/doi/10.1021/acs.molpharmaceut.5c00525
  80. www.biorxiv.org www.biorxiv.org
    Engineering a Juxtamembrane-Targeting CAR T-Cell Against Mesothelin: A Novel Binder Resilient to Shed Antigen in Ovarian and Pancreatic Cancer
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    biorxiv.org/content/10.1101/2025.08.02.668276v1
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    sciencedirect.com/science/article/pii/S1535610825003101
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322234/
  83. Jul 2025
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting FGFR4 abrogates HNF1A-driven metastasis in pancreatic ductal adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12306140/
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    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    sciencedirect.com/science/article/pii/S266637912500326X
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  87. www.science.org www.science.org
    Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
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    science.org/doi/10.1126/science.adq8331
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    The transcriptomic fingerprint of cancer response to Tumor Treating Fields (TTFields)
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    nature.com/articles/s41420-025-02615-5
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    Uncertainty-aware quantitative analysis of high-throughput live cell migration data
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    biorxiv.org/content/10.1101/2025.06.12.659342v1
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    nature.com/articles/s41598-025-09411-2
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    Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor
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  94. Jun 2025
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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  208. Nov 2022
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  212. Oct 2022
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  218. Jul 2022
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  224. May 2022
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  226. Apr 2022
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  229. Feb 2022
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  232. Jan 2022
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  236. Dec 2021
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