331 Matching Annotations
  1. Last 7 days
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    DYRK1A regulates cancer cell and cancer-associated fibroblast secretomes to foster an immunosuppressive microenvironment in pancreatic cancer
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    biorxiv.org/content/10.1101/2025.11.26.690756v1
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    RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer
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    nature.com/articles/s41556-025-01816-5
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Interactions between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12671567/
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    Sustained reductions in valine and isoleucine mediate anti-cancer pharmacological effects of inhibiting amino acid transporter LAT1 in cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12673697/
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    Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy
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    sciencedirect.com:5037/science/article/pii/S1550413125004759
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    IFN-γ-driven UBE2D3 upregulation impairs antigen presentation pathways and anti-tumor immunity in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12663187/
  9. Nov 2025
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    Dynasore as a dual modulator of lipid rafts and cell death in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1476558625001344
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    KLF5 enables dichotomous lineage programs in pancreatic cancer via the AAA+ ATPase coactivators RUVBL1 and RUVBL2
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    nature.com/articles/s41467-025-66007-0
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    A pentacyclic triterpene tormentic acid inhibits the proliferation and migration of pancreatic ductal adenocarcinoma cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12605405/
  13. 54.241.53.176 54.241.53.176
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  15. Oct 2025
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    Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas
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    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513552
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    Integrated spatial morpho-transcriptomics predicts functional traits in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12533583/
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    Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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    Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma
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    Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer
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    science.org/doi/10.1126/scisignal.adu7145
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    DUSP6 is upregulated in metastasis and influences migration and metabolism in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12484808/
  24. Sep 2025
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    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer
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    link.springer.com/article/10.1007/s00535-025-02291-3
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    Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma
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    BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies
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    c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
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    Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis
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    Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
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    Multi-parametric magnetic resonance imaging evaluation of a novel ex ovo chick chorioallantoic membrane model for cancer research
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    pmc.ncbi.nlm.nih.gov/articles/PMC12397616/
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    Stress and obesity signaling converge on CREB phosphorylation to promote pancreatic cancer
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HuR-regulated extracellular vesicles promote endothelial cell remodeling in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12405104/
  34. Aug 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202510071
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    Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance
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    ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584292/
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    NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers
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    nature.com/articles/s41586-025-09299-y
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    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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    Pathway metabolite ratios reveal distinctive glutamine metabolism in a subset of proliferating cells
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
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    degruyterbrill.com/document/doi/10.1515/oncologie-2025-0171/html
  48. Jul 2025
  49. www.sciencedirect.com www.sciencedirect.com
    Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
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    Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
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    science.org/doi/10.1126/science.adq8331
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    The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer
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    A STAT3/integrin axis accelerates pancreatic cancer initiation and progression
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    SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202508431
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    CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts
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    nature.com/articles/s41598-025-09411-2
  56. www.science.org www.science.org
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    science.org/doi/10.1126/sciadv.adu2339
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    Interferon-α and thymosin-α1 plus tislelizumab enhance CD8+ T cell cytotoxicity toward pancreatic ductal adenocarcinoma
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    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12189944/
  59. Jun 2025
  60. www.science.org www.science.org
    Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy
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    science.org/doi/10.1126/sciadv.adu9948
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    EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70066
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    pmc.ncbi.nlm.nih.gov/articles/PMC12151665/
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    Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
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    Efficacy of SOAT1 Inhibitors Against Pancreatic Cancer with TP53 Mutations
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    link.springer.com/article/10.1245/s10434-025-17482-8
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    Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer
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  67. May 2025
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    ILF3 mediates lipid metabolism to promote pancreatic cancer development by regulating CPT1A-activated PPARa signaling pathway
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    sciencedirect.com/science/article/pii/S0925443925002674
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    Pharmacologic ascorbate resistant pancreatic cancer demonstrates enhanced metastatic potential
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    Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079996/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glecirasib, a Potent and Selective Covalent KRAS G12C Inhibitor Exhibiting Synergism with Cetuximab or SHP2 Inhibitor JAB-3312
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  74. Apr 2025
  75. www.sciencedirect.com www.sciencedirect.com
    Cytosolic cytochrome c represses ferroptosis
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    CD44 Identified as a Diagnostic Biomarker for Highly Malignant CA19-9 Negative Pancreatic Cancer
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    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124725003122
  78. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  79. Mar 2025
  80. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
  81. Feb 2025
  82. aacrjournals.org aacrjournals.org
    MR1 gene and protein expression are enhanced by inhibition of the extracellular signal-regulated kinase ERK
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    aacrjournals.org/cancerimmunolres/article/12/10/1452/748716/MR1-Gene-and-Protein-Expression-Are-Enhanced-by
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    The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11795354/
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    pmc.ncbi.nlm.nih.gov/articles/PMC11904601/
  85. Jan 2025
  86. www.sciencedirect.com www.sciencedirect.com
    Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis
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    sciencedirect.com/science/article/pii/S2666379125000011
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    Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11742192/
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    Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11704331/
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    Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
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    sciencedirect.com/science/article/pii/S1074761324005685
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    Targeting macrophage circadian rhythms with microcurrent stimulation to activate cancer immunity through phagocytic defense
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    pmc.ncbi.nlm.nih.gov/articles/PMC11671381/
  91. Dec 2024
  92. www.cell.com www.cell.com
    Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00652-9
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    MIRO2 promotes cancer invasion and metastasis via MYO9B suppression of RhoA activity
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    cell.com/cell-reports/abstract/S2211-1247(24)01471-2
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    PEG-BCT-100 and Canavanine Synergistically Induce Apoptosis in Arginine Biosynthetic Enzyme-Deficient Pancreatic Cancer
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    aacrjournals.org/cancerrescommun/article/4/12/3180/750649/PEG-BCT-100-and-Canavanine-Synergistically-Induce
  95. Nov 2024
  96. www.sciencedirect.com www.sciencedirect.com
    Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
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  194. Jul 2023
  195. www.sciencedirect.com www.sciencedirect.com
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  196. Jun 2023
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  198. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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  199. aacrjournals.org aacrjournals.org
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    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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  201. May 2023
  202. www.nature.com www.nature.com
    Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer
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  203. onlinelibrary.wiley.com onlinelibrary.wiley.com
    KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity
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    Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors
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  206. Apr 2023
  207. link.springer.com link.springer.com
    Activation of Vitamin D/VDR Signaling Reverses Gemcitabine Resistance of Pancreatic Cancer Cells Through Inhibition of MUC1 Expression
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    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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    A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma
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  212. Mar 2023
  213. www.spandidos-publications.com www.spandidos-publications.com
    HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
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  214. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZL-1211 Exhibits Robust Antitumor Activity by Enhancing ADCC and Activating NK Cell–mediated Inflammation in CLDN18.2-High and -Low Expressing Gastric Cancer Models
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  215. www.nature.com www.nature.com
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  216. Feb 2023
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    Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
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  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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  219. Jan 2023
  220. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index
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    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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  223. Dec 2022
  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    JNK inhibitor IX restrains pancreatic cancer through p53 and p21
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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  226. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  227. Nov 2022
  228. www.sciencedirect.com www.sciencedirect.com
    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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  230. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  231. Oct 2022
  232. aacrjournals.org aacrjournals.org
    Selenium modulates cancer cell response to pharmacologic ascorbate
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  233. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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