372 Matching Annotations
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    Local, but not circulating, complement C3 shapes immune checkpoint blockade efficacy by controlling myeloid cell infiltration
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    pmc.ncbi.nlm.nih.gov/articles/PMC13490386/
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    Engineered mechanosensitive MSCs enable synthetic radiotheranostic targeting across tumor types
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    sciencedirect.com/science/article/pii/S1934590926002754
  4. Aug 2026
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    OTUD5 Maintains STAT1/2 Stability and Promotes IFNγ-driven Intestinal Inflammation
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    sciencedirect.com/science/article/pii/S0021925826022921
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    Cblb Gene Editing in T Cells Sustains Expansion and Immunogenic CAR T Tumor Killing Under Chronic Antigenic Stimulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13464884/
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    Canonical and isomiR products of miR-142 enhance dendritic cell reprogramming
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    sciencedirect.com/science/article/pii/S2211124726009034
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti-PD-1 Immunotherapy
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    onlinelibrary.wiley.com/doi/10.1155/cjgh/5689742
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    PDL1-driven self-amplifying drug homing with immune homeostasis restoration
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    sciencedirect.com/science/article/pii/S2590006426007830
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    Improving Anti–CTLA-4 Therapies through Peptide Masking and Fragment Crystallizable Non-fucosylation: Preclinical Characterization of Three Novel Antibodies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13367003/
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    d-serine as a metabolic immune checkpoint in the tumour microenvironment
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    sciencedirect.com/science/article/pii/S2352396426002860
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    MCT4-mediated lactate efflux promotes STING-dependent dendritic cell antitumor immunity
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    sciencedirect.com/science/article/pii/S2211124726008569
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    Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death
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    pmc.ncbi.nlm.nih.gov/articles/PMC13401815/
  14. Jul 2026
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    Therapeutic Gfral silencing via antisense oligonucleotides ameliorates cancer-associated cachexia and extends survival in tumor-bearing mice
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    sciencedirect.com/science/article/pii/S2666379126003563
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    A poly(I:C)/QS-21-based in situ vaccine synergizes with anti-PD-1 therapy to overcome tumor immunoresistance
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    sciencedirect.com/science/article/pii/S2666379126003496
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    ACSS2 is required for colorectal cancer progression and a druggable target for colorectal cancer treatment
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    sciencedirect.com/science/article/pii/S2589004226022388
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    UFMylation Suppresses Hepatocellular Carcinoma Metastasis by Inhibiting β-catenin-Driven Hybrid EMT and NK Cell Evasion
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    aacrjournals.org/cancerres/article/86/13/3213/786139/UFMylation-Suppresses-Hepatocellular-Carcinoma
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  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Soluble Uric Acid Drives CD8+ T-cell Exhaustion by Inducing KSR1-Mediated MAPK Hyperactivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13370115/
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    SOCS5 suppresses antitumor immunity in colorectal cancer by promoting IFNAR1 ubiquitylation and type I interferon response
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    sciencedirect.com/science/article/pii/S0925443926002309
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    An Optimized Platform Overcomes Excessive Tumor Immune Rejection Induced by the CRISPR/Cas9 Lentiviral System
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    aacrjournals.org/cancerres/article/85/22/4315/767078/An-Optimized-Platform-Overcomes-Excessive-Tumor
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    ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes
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    Combining PD-L1 blockade with a second-generation HSP110 inhibitor enhances antitumor immunity in colorectal cancer
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    Gut Microbiota-Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    S100A14 promotes colorectal cancer progression and anti-PD-1 resistance via UPF1-mediated activation of the non-canonical NF-κB signaling
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    Genetically Programmed Engineered Nanodevices Trigger Cascade Reinforcement between AMPK and cGAS-STING Activation for Colon Cancer Sonoimmunotherapy
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  30. Jun 2026
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    Chlorogenic acid promotes macrophage phagocytosis through the METTL3–SIRPA axis in an m6A-dependent manner for colon cancer therapy
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    Integrin CD11b/CD18 reprograms macrophage polarization by suppressing ERK/STAT3 signaling to enhance antitumor immunity in colitis-associated colorectal cancer
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    Targeted TNF Potentiates the Activity of Bispecific T-cell Engagers in Solid Tumors by Turning Cold Tumors Hot
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    CD4 + cell depletion accelerates dendritic cell migration and enhances resident dendritic cell proliferation in tumor-draining lymph nodes
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    DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy
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    CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment
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    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid
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    Characterization of a transmembrane-activating STING agonist using genetically humanized mice
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  44. May 2026
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver
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  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial Multiomics Analyses Reveal That Diabetes Promotes Pancreatic Cancer Progression by Stimulating Cholesterol-Induced Neutrophil Extracellular Trap Formation
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    GBP2 enhances anti–PD-L1 response in colorectal cancer via GSDMD-mediated YAP nuclear translocation by non-pyroptotic
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    mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
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    IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma
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  54. Apr 2026
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    Removal of Interstitial Hyaluronan Facilitates Subcutaneous Administration and Lymphatic Delivery of Anti-CTLA4 and Improves Antitumor Efficacy
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    Neferine-enhanced Shenling Baizhu Tang potentiates anti-PD-1 therapy in colorectal cancer liver metastasis via CYP2E1–PPARα–mediated lipid reprogramming
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    Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy
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    Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages
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    FcRγ-dependent NK cell licensing through CD244 promotes antitumour immunity
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    Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer
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    Targeted Delivery of a Potent STING Agonist Payload via an Antibody–Drug Conjugate Drives Robust Antitumor Activity in Preclinical Models
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    A novel colchicine-binding site inhibitor suppresses triple-negative breast cancer growth and metastasis and synergizes with anti-PD-L1 immunotherapy in an immunogenic cancer model
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    Targeting PAR-2 with a negative allosteric modulator increases tumor antigen presentation and potentiates anti-PD-1 immunotherapy
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    Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment
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    Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP-Mediated Invasion Activates Ras Signaling and Destabilizes p53
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517245
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    SHR-2005, an FcγR-Dependent CD40 Agonistic Antibody with Potent Antitumor Activities and Favorable Safety Profile
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    aacrjournals.org/mct/article/24/11/1671/766867/SHR-2005-an-Fc-R-Dependent-CD40-Agonistic-Antibody
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    All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
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    Dual-Targeting mRNA Cancer Vaccines for Simultaneous Antigen Presentation in Dendritic and Tumor Cells
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    pubs.acs.org/doi/10.1021/acsnano.5c20535
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    EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522826
  73. Mar 2026
  74. www.sciencedirect.com www.sciencedirect.com
    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity
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    sciencedirect.com/science/article/pii/S153561082600111X
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    NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520055
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    Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra-Targeted Tumor α-Therapy
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    onlinelibrary.wiley.com/doi/full/10.1002/exp2.70144
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evexomostat (SDX-7320), a methionine aminopeptidase type 2 inhibitor, stimulates weight loss and inhibits obesity-accelerated tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12958372/
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    The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
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    TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer
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  84. Feb 2026
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulating the tumor immune phenotypes by radiotherapy: formulating and validating the combination therapy of radiation, PD-L1, and TIM-3 blockade in colorectal cancer
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    pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2452199X26001003
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  175. Jun 2025
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    Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells
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  179. www.sciencedirect.com www.sciencedirect.com
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  184. www.sciencedirect.com www.sciencedirect.com
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  186. May 2025
  187. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  189. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4+ and CD8+ tumor-infiltrating lymphocytes
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  193. Apr 2025
  194. www.sciencedirect.com www.sciencedirect.com
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  203. Mar 2025
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  207. aacrjournals.org aacrjournals.org
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  209. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  210. Feb 2025
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  213. aacrjournals.org aacrjournals.org
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  218. Dec 2024
  219. www.cell.com www.cell.com
    Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity
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