354 Matching Annotations
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  2. 54.241.53.176 54.241.53.176
    can-25-2892-html.html
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  3. aacrjournals.org aacrjournals.org
    An Optimized Platform Overcomes Excessive Tumor Immune Rejection Induced by the CRISPR/Cas9 Lentiviral System
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    aacrjournals.org/cancerres/article/85/22/4315/767078/An-Optimized-Platform-Overcomes-Excessive-Tumor
  4. aacrjournals.org aacrjournals.org
    ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes
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    aacrjournals.org/cancerres/article/86/1/116/771155/ZNF296-Drives-Immune-Evasion-in-Epithelial-Cancers
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    Combining PD-L1 blockade with a second-generation HSP110 inhibitor enhances antitumor immunity in colorectal cancer
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    54.241.53.176/7fba9f32795d3fd188709e6b4cbf7163473ee228/s41419-026-08826-7_reference-html.html
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    Gut Microbiota-Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment
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    aacrjournals.org/cancerres/article/85/21/4081/766747/Gut-Microbiota-Mediated-Bile-Acid-Metabolism
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    Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
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    sciencedirect.com/science/article/pii/S1074761326002578
  8. Jul 2026
  9. www.nature.com www.nature.com
    S100A14 promotes colorectal cancer progression and anti-PD-1 resistance via UPF1-mediated activation of the non-canonical NF-κB signaling
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    nature.com/articles/s41419-026-09032-1
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    Genetically Programmed Engineered Nanodevices Trigger Cascade Reinforcement between AMPK and cGAS-STING Activation for Colon Cancer Sonoimmunotherapy
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    sciencedirect.com/science/article/pii/S0142961226004370
  11. Jun 2026
  12. www.sciencedirect.com www.sciencedirect.com
    Chlorogenic acid promotes macrophage phagocytosis through the METTL3–SIRPA axis in an m6A-dependent manner for colon cancer therapy
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    sciencedirect.com/science/article/pii/S000629522600537X
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrin CD11b/CD18 reprograms macrophage polarization by suppressing ERK/STAT3 signaling to enhance antitumor immunity in colitis-associated colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13289415/
  14. aacrjournals.org aacrjournals.org
    Targeted TNF Potentiates the Activity of Bispecific T-cell Engagers in Solid Tumors by Turning Cold Tumors Hot
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    aacrjournals.org/cancerimmunolres/article/14/6/919/785412/Targeted-TNF-Potentiates-the-Activity-of
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    CD4 + cell depletion accelerates dendritic cell migration and enhances resident dendritic cell proliferation in tumor-draining lymph nodes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13271325/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DGAT1 Inhibition Induces Ferroptosis and Enhances Cancer Immunotherapy Efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13266341/
  17. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70283
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    CD4 + cell depletion accelerates dendritic cell migration and enhances resident dendritic cell proliferation in tumor-draining lymph nodes
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    tandfonline.com/doi/abs/10.1080/2162402X.2026.2682054
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing Immunotherapeutic Response in Colorectal Cancer with a Neuropilin-1-Targeting Tumor-Penetrating Peptide
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    pmc.ncbi.nlm.nih.gov/articles/PMC13250810/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13131504/
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    CXCL14 Inhibits Colon Cancer Progression by Modulating Tumor Cell Invasion and Immune Microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC13204761/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DDR1 Promotes Immune Evasion in Colorectal Cancer by Orchestrating IL33-Mediated M2-like Polarization of Tumor-Associated Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC13227095/
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    Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid
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    sciencedirect.com/science/article/pii/S1931312826001782
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    Characterization of a transmembrane-activating STING agonist using genetically humanized mice
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    sciencedirect.com/science/article/pii/S221112472600553X
  25. May 2026
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CDK6/4 inactivates BAP1 deubiquitinase destabilizing VHL to promote metastatic colonization in liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC13202817/
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    Uncovering spatially resolved functional genomics with CRISPR screen sequencing
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    sciencedirect.com/science/article/pii/S0092867426005167
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial Multiomics Analyses Reveal That Diabetes Promotes Pancreatic Cancer Progression by Stimulating Cholesterol-Induced Neutrophil Extracellular Trap Formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13176823/
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    GBP2 enhances anti–PD-L1 response in colorectal cancer via GSDMD-mediated YAP nuclear translocation by non-pyroptotic
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  30. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Enhancing CAR-T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF-Mediated Angiogenesis
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202521975
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13130659/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SAICAR Drives T Regulatory Cell Differentiation and FOXP3 Maintenance to Promote Immunotherapy Resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC13136876/
  33. aacrjournals.org aacrjournals.org
    IL-1R2 Deficiency Unleashes Neutrophil-Mediated Antitumor Potential in Sarcoma
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    aacrjournals.org/cancerimmunolres/article/14/5/751/784456/IL1R2-Deficiency-Unleashes-Neutrophil-Mediated
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    Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer
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  35. Apr 2026
  36. aacrjournals.org aacrjournals.org
    Removal of Interstitial Hyaluronan Facilitates Subcutaneous Administration and Lymphatic Delivery of Anti-CTLA4 and Improves Antitumor Efficacy
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    Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13101128/
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    Neferine-enhanced Shenling Baizhu Tang potentiates anti-PD-1 therapy in colorectal cancer liver metastasis via CYP2E1–PPARα–mediated lipid reprogramming
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    sciencedirect.com/science/article/pii/S0944711326004708
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    Activation of T cell-intrinsic p53 by acetylation elicits antitumor immunity to boost cancer immunotherapy
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    aacrjournals.org/cancerdiscovery/article/16/1/155/771238/Activation-of-T-Cell-Intrinsic-p53-by-Acetylation
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    Conditionally Active CD28xVISTA Bispecific Antibodies Promote Myeloid-Driven T-Cell Activation
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    Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages
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    FcRγ-dependent NK cell licensing through CD244 promotes antitumour immunity
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    Radiation-induced MYB reduction unleashes TIM-3 expression in NK cells to attenuate antitumor immunity in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13088527/
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    Macrophage-Specific Loss of Stearoyl-CoA Desaturase 1 Promotes Colon Cancer by Enhancing M2 TAM Polarization
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    onlinelibrary.wiley.com/doi/10.1111/cas.70393
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    Targeted Delivery of a Potent STING Agonist Payload via an Antibody–Drug Conjugate Drives Robust Antitumor Activity in Preclinical Models
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    A novel colchicine-binding site inhibitor suppresses triple-negative breast cancer growth and metastasis and synergizes with anti-PD-L1 immunotherapy in an immunogenic cancer model
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    sciencedirect.com/science/article/pii/S0753332226003860
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting PAR-2 with a negative allosteric modulator increases tumor antigen presentation and potentiates anti-PD-1 immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC13052617/
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    Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment
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    sciencedirect.com/science/article/pii/S1074761326001226
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    Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP-Mediated Invasion Activates Ras Signaling and Destabilizes p53
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517245
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    SHR-2005, an FcγR-Dependent CD40 Agonistic Antibody with Potent Antitumor Activities and Favorable Safety Profile
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    aacrjournals.org/mct/article/24/11/1671/766867/SHR-2005-an-Fc-R-Dependent-CD40-Agonistic-Antibody
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    All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery
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    pmc.ncbi.nlm.nih.gov/articles/PMC13042870/
  52. pubs.acs.org pubs.acs.org
    Dual-Targeting mRNA Cancer Vaccines for Simultaneous Antigen Presentation in Dendritic and Tumor Cells
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    pubs.acs.org/doi/10.1021/acsnano.5c20535
  53. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202522826
  54. Mar 2026
  55. www.sciencedirect.com www.sciencedirect.com
    Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion
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    sciencedirect.com/science/article/pii/S2666379126001217
  56. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment
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    Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity
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    sciencedirect.com/science/article/pii/S153561082600111X
  59. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520055
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    Ultrasmall Au10–12 Nanoclusters: A Novel Platform for 223Ra-Targeted Tumor α-Therapy
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    onlinelibrary.wiley.com/doi/full/10.1002/exp2.70144
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evexomostat (SDX-7320), a methionine aminopeptidase type 2 inhibitor, stimulates weight loss and inhibits obesity-accelerated tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12958372/
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    The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
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    sciencedirect.com/science/article/pii/S1550413126000483
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    TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer
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    sciencedirect.com/science/article/pii/S030438352600159X
  65. Feb 2026
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulating the tumor immune phenotypes by radiotherapy: formulating and validating the combination therapy of radiation, PD-L1, and TIM-3 blockade in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12933762/
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    pH-neutralization strategy to suppress GPCR68 spatiotemporally activates T cells and enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2452199X26001003
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    Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction
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    sciencedirect.com/science/article/pii/S1097276526000973
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    Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection
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    sciencedirect.com/science/article/pii/S1074761326000270
  71. pubs.acs.org pubs.acs.org
    A Folate Receptor β-Targeted TLR7 Agonist Significantly Augments Checkpoint Inhibitor Potencies by Reprogramming Tumor-Associated Macrophages and Myeloid-Derived Suppressor Cells
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    pubs.acs.org/doi/full/10.1021/acs.jmedchem.5c03277
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    Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726000902
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    Engineering Escherichia coli Nissle 1917 to scavenge lactate enhances anti-tumor immunity
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    sciencedirect.com/science/article/pii/S0168365926001409
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EREG promotes colorectal cancer progression and immune suppressive microenvironment formation through IL-17A/NF-κB pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12905030/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12894849/
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    Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases
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    sciencedirect.com/science/article/pii/S1535610826000498
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell
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    pmc.ncbi.nlm.nih.gov/articles/PMC12870062/
  78. www.nature.com www.nature.com
    Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1
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    nature.com/articles/s41416-025-03319-4
  79. www.biorxiv.org www.biorxiv.org
    Evexomostat (SDX-7320), a Methionine Aminopeptidase Type 2 (METAP2) Inhibitor, Stimulates Weight Loss and Inhibits Obesity-Accelerated Tumor Growth
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    biorxiv.org/content/10.64898/2026.01.28.702362v1
  80. Jan 2026
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Three-Dimensional Tumor Spheroids Reveal B7-H3 CAR T Cell Infiltration Dynamics and Microenvironment-Induced Functional Reprogramming in Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12839577/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Thimerosal Inhibits Tumor Malignant Progression through Direct Action and Enhancing the Efficacy of PD-1-Based Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848756/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12849977/
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    Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12810954/
  85. chemistry-europe.onlinelibrary.wiley.com chemistry-europe.onlinelibrary.wiley.com
    Design and Characterization of Prodrugged Anti-CTLA-4 Antibodies
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    chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202500304
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    The dysadherin/carbonic anhydrase 9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression
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  184. Mar 2025
  185. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  191. Feb 2025
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  199. Dec 2024
  200. www.cell.com www.cell.com
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  205. Nov 2024
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  207. Oct 2024
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  210. Sep 2024
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  217. Aug 2024
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  221. Jul 2024
  222. www.cell.com www.cell.com
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