527 Matching Annotations
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    Differential Chromatin Accessibility, Gene Expression, and mRNA Splicing Between Developing Cochlear Inner and Outer Hair Cells
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    link.springer.com/article/10.1007/s10162-025-01005-z
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396674/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial colocalization and molecular crosstalk of myofibroblastic CAFs and tumor cells shape lymph node metastasis in oral squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12410789/
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    HA-1–targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11406181/
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    Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER– breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12406732/
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    PIN1 prolyl isomerase promotes initiation and progression of bladder cancer through the SREBP2-mediated cholesterol biosynthesis pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875963/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ursolic Acid as a Protective Agent Against UVB-Induced Metabolic and Epigenetic Alterations in Human Skin Keratinocytes: An Omics-Based Study
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    pmc.ncbi.nlm.nih.gov/articles/PMC11875927/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical evaluation of an anchored immunotherapy strategy with aluminum hydroxide-tethered interleukin-12 in dogs with advanced malignant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11879767/
  10. Sep 2025
  11. www.nature.com www.nature.com
    Elevated hexosylceramides in Parkinson’s disease cause gene upregulations in neurons mimicking responses to pathogens
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    nature.com/articles/s41531-025-01114-9
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    DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis
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    nature.com/articles/s41419-025-07977-3
  13. Aug 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12363560/
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    AI-driven multimodal algorithm predicts immunotherapy and targeted therapy outcomes in clear cell renal cell carcinoma
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    sciencedirect.com/science/article/pii/S2666379125003726
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    BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer
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  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Glucose transporter 1 is essential to maintain brain endothelial cell homeostasis under hyperglycemia condition | American Journal of Physiology-Cell Physiology | American Physiological Society
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    pmc.ncbi.nlm.nih.gov/articles/PMC12341840/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of ferroptosis as a biomarker to predict treatment outcomes of cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12326525/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11802306/
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    The urokinase receptor/uPAR is a major effector of p53 gain-of-function mutations in gemcitabine-treated pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S0021925825024123
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    Allelic bias contributes to heterogeneous phenotypes of NK cell deficiency
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    sciencedirect.com/science/article/pii/S2211124725008733
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TBK1 Targeting is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment
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  24. Jul 2025
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PLT012, a humanized CD36-blocking antibody, is effective for unleashing anti-tumor immunity against liver cancer and liver metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC7617665/
  26. www.biorxiv.org www.biorxiv.org
    RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma
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    biorxiv.org/content/10.1101/2025.07.21.665972v1
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    TREM2‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302306/
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    Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
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    Dual Regulation of FZD1/7 by IGF2BP3 Enhances Stem-like Properties and Carboplatin Resistance in Triple-Negative Breast Cancer
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    MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281688/
  32. 52.53.155.43 52.53.155.43
    MyoD is Essential in Rhabdomyosarcoma by Promoting Survival Through Differentiation and CYLD
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    Identification of a Novel Gene ARNT2 for Osteogenic Differentiation of Mesenchymal Stem Cells
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    link.springer.com/article/10.1007/s00223-025-01407-4
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    Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729495/
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    Intratumoral heterogeneity in microsatellite instability status at single cell resolution
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    biorxiv.org/content/10.1101/2025.06.11.658021v1
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    HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine
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  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation
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    Lysozyme 1 Inflamed CCR2+ Macrophages Promote Obesity-Induced Cardiac Dysfunction | Circulation Research
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    ahajournals.org/doi/full/10.1161/CIRCRESAHA.124.324106
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    Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein
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    ahajournals.org/doi/10.1161/ATVBAHA.122.318158
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    SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
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    Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model
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    Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
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    elifesciences.org/articles/101369
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    Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma
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  44. Jun 2025
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition
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    Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12154588/
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    POLQ mediated end-joining promotes DNA damage tolerance in neuroblastoma
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Deficiency of Fibroblast Growth Factor 2 Promotes Contractile Phenotype of Pericytes in Ascending Thoracic Aortic Aneurysm
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer
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    Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma
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    First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers
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    Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator
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    RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis
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  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
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  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy
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    Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy
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    Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
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    Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids
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  62. May 2025
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    Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fba.2025-00007
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    Enhancing plasmacytoid dendritic cell functionality with all-trans retinoic acid for improved multiple myeloma therapy
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    An integrated analysis of scRNA-seq and RNA-seq data revealed metastasis-related regulators as prognostic indicators in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12090110/
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    Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex
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    Five Cellular Genes as Candidates for Cervical Adenocarcinoma Molecular Markers
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    Antitumor CD4+ T Helper 1 Cells Target and Control the Outgrowth of Disseminated Cancer Cells
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  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial
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    pmc.ncbi.nlm.nih.gov/articles/PMC12010967/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic Screen in a Pre-Clinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12079103/
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    MCRS1 sensitizes T cell–dependent immunotherapy by augmenting MHC-I expression in solid tumors
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  76. www.nature.com www.nature.com
    Superior survival in diffuse large B cell lymphoma of the bone with immune rich tumor microenvironment
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    Protrusion force and cell-cell adhesion-induced polarity alignment govern collective migration modes
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    sciencedirect.com/science/article/pii/S0006349525002371
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Analysis and Identification of Therapeutic Targets for Neuronal Regeneration After Ischemic Stroke
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050405/
  79. Apr 2025
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  81. aacrjournals.org aacrjournals.org
    The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite Stable Metastatic Colorectal Cancer: A Phase 1b/2a Trial
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  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution
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  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of a TNIK-CDK9 Axis as a Targetable Strategy for Platinum-Resistant Ovarian Cancer
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  85. Mar 2025
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation
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  88. www.biorxiv.org www.biorxiv.org
    The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis
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    biorxiv.org/content/10.1101/2025.03.18.644053v1
  89. academic.oup.com academic.oup.com
    Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining
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  97. Feb 2025
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  166. Aug 2024
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The BET PROTAC inhibitor GNE-987 displays anti-tumor effects by targeting super-enhancers regulated gene in osteosarcoma
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-EGFR Antibody–Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p300 KAT Regulates SOX10 Stability and Function in Human Melanoma
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  180. Jul 2024
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CAR T-cells targeting FGFR4 and CD276 simultaneously show potent antitumor effect against childhood rhabdomyosarcoma
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  184. www.sciencedirect.com www.sciencedirect.com
    Predictive Biomarkers for Response to TGF- β Inhibition in Resensitizing Chemo(radiated) Esophageal Adenocarcinoma
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila model to study Retinitis pigmentosa pathology associated with mutations in the core splicing factor Prp8
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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  187. www.mdpi.com www.mdpi.com
    Immunological Signatures for Early Detection of Human Head and Neck Squamous Cell Carcinoma through RNA Transcriptome Analysis of Blood Platelets
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  188. Jun 2024
  189. aacrjournals.org aacrjournals.org
    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early Changes in Tumor-Naive Cell-Free Methylomes and Fragmentomes Predict Outcomes in Pembrolizumab-Treated Solid Tumors
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  191. May 2024
  192. aacrjournals.org aacrjournals.org
    Preclinical evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
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  193. aacrjournals.org aacrjournals.org
    Development of chromosome 1q+ specific treatment for highest risk pediatric posterior fossa ependymoma
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    aacrjournals.org/clincancerres/article/30/8/1544/742119/Development-of-Chromosome-1q-Specific-Treatment
  194. 52.53.155.43 52.53.155.43
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  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacologic Targeting of Histone H3K27 Acetylation/BRD4-dependent Induction of ALDH1A3 for Early-phase Drug Tolerance of Gastric Cancer
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  196. www.nature.com www.nature.com
    The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans
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  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling Myeloma Dissemination In Vitro with hMSC-interacting Subpopulations of INA-6 Cells and Their Aggregation/Detachment Dynamics
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  200. Apr 2024
  201. aacrjournals.org aacrjournals.org
    Single-cell transcriptomics reveals pre-existing COVID-19 vulnerability factors in lung cancer patients
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  202. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERBB3 overexpression is enriched in diverse patient populations with castration-sensitive prostate cancer and is associated with a unique AR activity signature
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  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia
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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells
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  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT1 sustains de novo fatty acid synthesis by methylating PHGDH to drive chemoresistance in triple-negative breast cancer
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  206. Mar 2024
  207. www.nature.com www.nature.com
    Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer
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  208. www.sciencedirect.com www.sciencedirect.com
    Identification of a DNA-methylome-based signature for prognosis prediction in driver gene-negative lung adenocarcinoma
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  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Xrp1 governs the stress response program to spliceosome dysfunction
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N6-methyladenosine-associated genetic variants in NECTIN2 and HPCAL1 are risk factors for abdominal aortic aneurysm
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