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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PFKFB3-dependent redox homeostasis and DNA repair support cell survival under EGFR-TKIs in non-small cell lung carcinoma
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  3. Dec 2024
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    PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination
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    TCR-Engineered T Cells Directed against Ropporin-1 Constitute a Safe and Effective Treatment for Triple-Negative Breast Cancer
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    The L27 domain of MPP7 enhances TAZ-YY1 cooperation to renew muscle stem cells
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    Dissecting the differential role of C-terminal truncations in the regulation of aSyn pathology formation and the biogenesis of Lewy bodies
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    tp53 R217H and R242H mutant zebrafish exhibit dysfunctional p53 hallmarks and recapitulate Li-Fraumeni syndrome phenotypes
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  9. Nov 2024
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    Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
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    sciencedirect.com/science/article/pii/S2211124724013366
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    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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  12. Oct 2024
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    NAPRT silencing in FH-deficient renal cell carcinoma confers therapeutic vulnerabilities via NAD+ depletion
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    Design of a Cytotoxic Neuroblastoma-Targeting Agent Using an Enzyme Acting on Polysialic Acid Fused to a Toxin
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  15. Sep 2024
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    A Drug Discovery Pipeline for MAPK/ERK Pathway Inhibitors in Caenorhabditis elegans
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    Focal adhesion kinase regulates tendon cell mechanoresponse and physiological tendon development
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    Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups
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    Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response
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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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  21. Aug 2024
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    Prolonged extracellular low sodium concentrations and subsequent their rapid correction modulate nitric oxide production dependent on NFAT5 in microglia
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    RAD51 protects abasic sites to prevent replication fork breakage
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    Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
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    Retinal pigment epithelial integrity is compromised in the developing albino mouse retina
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  26. Jul 2024
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    Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function
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    Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities
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    The primitive endoderm supports lineage plasticity to enable regulative development
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    Protocol for iterative indirect immunofluorescence imaging in cultured cells, tissue sections, and metaphase chromosome spreads
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    Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue
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    A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
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      DOI: 10.1039/d4lc00107a

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  33. Jun 2024
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi
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    Spatiotemporal sphingosine-1-phosphate receptor 3 expression within the cerebral vasculature after ischemic stroke
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  36. www.biorxiv.org www.biorxiv.org
    Neighbouring modifications interfere with the detection of phosphorylated alpha-synuclein at Serine 129: Revisiting the specificity of pS129 antibodies
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  37. May 2024
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    Fatal COVID-19 pulmonary disease involves ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11106344/
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    Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus
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      DOI: 10.1111/ejn.16109

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    intracellular-and-extracellular-mhc-ii-immunostain-dc442yyw-html.html
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      DOI: 10.17504/protocols.io.bp2l62191gqe/v1

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    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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      DOI: 10.1016/j.isci.2024.109708

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  42. 52.53.155.43 52.53.155.43
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease
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      DOI: 10.1101/2024.01.15.575737

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  43. www.biorxiv.org www.biorxiv.org
    Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi
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      DOI: 10.1101/2023.12.28.573590

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    biorxiv.org/content/10.1101/2023.12.28.573590v1
  44. Apr 2024
  45. www.sciencedirect.com www.sciencedirect.com
    ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection
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    sciencedirect.com/science/article/pii/S2211124724004844
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    Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
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    sciencedirect.com/science/article/pii/S0092867424003179
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11014935/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elucidating the role of EPPK1 in lung adenocarcinoma development
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      DOI: 10.1186/s12885-024-12185-x

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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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  50. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
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    Impaired oxysterol-liver X receptor signaling underlies aberrant cortical neurogenesis in a stem cell model of neurodevelopmental disorder
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  54. www.nature.com www.nature.com
    Combinatorial selective ER-phagy remodels the ER during neurogenesis
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    Protocol for localized macrophage stimulation with small-molecule TLR agonist via fluidic force microscopy
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  56. Feb 2024
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    Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
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    An iron rheostat controls hematopoietic stem cell fate
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    A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration
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    Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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    O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evidence of collective influence in innate sensing using fluidic force microscopy
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  65. Jan 2024
  66. www.sciencedirect.com www.sciencedirect.com
    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
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    Protocol for image-based small-molecule screen to identify neuroprotective compounds for dopaminergic neurons in zebrafish
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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  69. www.science.org www.science.org
    Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B
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    Cytoneme signaling provides essential contributions to mammalian tissue patterning
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    Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity
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  74. Dec 2023
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
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      DOI: 10.1158/0008-5472.CAN-22-2948

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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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  77. Nov 2023
  78. www.biorxiv.org www.biorxiv.org
    Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum
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  79. Oct 2023
  80. www.sciencedirect.com www.sciencedirect.com
    Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism
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  81. www.biorxiv.org www.biorxiv.org
    A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
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    Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP
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    Journal Production Guidance for Software and Data Citations
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  85. Sep 2023
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor induced colitis
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    A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish
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    GATA1 deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils
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    Antiviral mechanisms of sorafenib against foot-and-mouth disease virus via c-RAF and AKT/PI3K pathways
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in distribution and identity of aromatase gene expressing cells in the young adult rat brain
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  92. Aug 2023
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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  95. Jul 2023
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    Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
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    Combinatorial selective ER-phagy remodels the ER during neurogenesis
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    Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis
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    Parkinson’s VP535[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
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  101. Jun 2023
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    Claustral neurons projecting to frontal cortex restrict opioid consumption
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    Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO
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    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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    A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids
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    Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke
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  107. May 2023
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    Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease
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    Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus
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  110. Apr 2023
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    High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly
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  112. elifesciences.org elifesciences.org
    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications
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    Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix
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    Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
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    The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling
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  116. Mar 2023
  117. www.biorxiv.org www.biorxiv.org
    Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo
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    A central chaperone-like role for 14-3-3 proteins in human cells
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    O2-sensitive microcavity arrays: A new platform for oxygen measurements in 3D cell cultures
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  121. Feb 2023
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    Injury primes mutation-bearing astrocytes for dedifferentiation in later life
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    MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α
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    Detecting RNA-protein proximity at DNA double-strand breaks using combined fluorescence in situ hybridization with proximity ligation assay
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  125. Jan 2023
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    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  127. Dec 2022
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    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death
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  129. Nov 2022
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    POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps
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    Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
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    Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system
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  133. Oct 2022
  134. www.nature.com www.nature.com
    Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity
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      DOI: 10.1038/s41531-022-00388-7

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    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
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  136. Sep 2022
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression
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      DOI: 10.1136/gutjnl-2021-324994

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  139. Aug 2022
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    Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphoma
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  142. Jul 2022
  143. elifesciences.org elifesciences.org
    Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala
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    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
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  145. Jun 2022
  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
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    Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine
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    The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity
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  149. May 2022
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    The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis
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    An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling
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    H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape
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    A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
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      DOI: 10.1126/sciadv.abn0044

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    Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction
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    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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      DOI: 10.1186/s13024-022-00526-y

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    A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity
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    FILIP1L loss is a driver of aggressive mucinous colorectal adenocarcinoma and mediates cytokinesis defects through PFDN1
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  158. Apr 2022
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    Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes
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    Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors
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    DNA replication is highly resilient and persistent under the challenge of mild replication stress
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    SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo
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  163. Mar 2022
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    Loss of mouse Stmn2 function causes motor neuropathy
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    Epithelial-to-mesenchymal transition proceeds through directional destabilization of multidimensional attractor
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  166. aacrjournals.org aacrjournals.org
    MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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      DOI: 10.1158/2767-9764.CRC-21-0103

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    In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish
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    Isoform- and cell-state-specific lipidation of ApoE in astrocytes
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  169. Feb 2022
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    Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping
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      DOI: 10.3389/fncir.2021.768235

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  171. Jan 2022
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    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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    Multimodal regulatory elements within a hormone-specific super enhancer control a heterogeneous transcriptional response
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    Characterization of a patient-derived variant of GPX4 for precision therapy
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  175. Dec 2021
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    Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds
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    Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic
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    CA1 pyramidal cell diversity is rooted in the time of neurogenesis
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  179. Nov 2021
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    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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    Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction
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    Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
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    Deep learning and pathomics analyses reveal cell nuclei as important features for mutation prediction of BRAF-mutated melanomas
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  184. Oct 2021
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    Retinal ganglion cell distribution and spatial resolution in the Asiatic toad Bufo gargarizans (Günther, 1859)
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  186. Sep 2021
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    Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
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    A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons
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    Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response
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    Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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  192. Aug 2021
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    Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation
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    Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
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    Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition
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    Familial X-Linked Acrogigantism: Postnatal Outcomes and Tumor Pathology in a Prenatally Diagnosed Infant and His Mother
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      DOI: 10.1210/jc.2019-00817

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  200. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Contribute to Neuronal Cell Loss in an Animal Model of Multiple Sclerosis
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  201. Jul 2021
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    The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing
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    Co-Localization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways
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  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dysfunctional RNA‐binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice
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  205. www.embopress.org www.embopress.org
    Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2
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  206. pubs.acs.org pubs.acs.org
    A novel small molecule supports the survival of cultured dopamine neurons and may restore the dopaminergic innervation of the brain in the MPTP mouse model of Parkinson's disease
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  207. www.biorxiv.org www.biorxiv.org
    A lncRNA/Lin28/Mirlet7 axis coupled to DNA methylation fine tunes the dynamics of a cell state transition
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    Cell numbers, distribution, shape, and regional variation throughout the murine hippocampal formation from the adult brain Allen Reference Atlas
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms
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  211. www.jneurosci.org www.jneurosci.org
    Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.
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  212. www.sciencedirect.com www.sciencedirect.com
    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43
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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
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  216. Jun 2021
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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    Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development
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  219. www.nature.com www.nature.com
    Pericentromeric Satellite III transcripts induce etoposide resistance
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  222. May 2021
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  225. Apr 2021
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    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice
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    Immunogenomic Landscape of Hematological Malignancies
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  229. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling
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  230. Mar 2021
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    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
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  233. Feb 2021
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    CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes
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  236. elifesciences.org elifesciences.org
    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
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    Amelioration of elastase‐induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice
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    Unique signatures of stress-induced senescent human astrocytes
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  239. Jan 2021
  240. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ecd promotes U5 snRNP maturation and Prp8 stability
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