264 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
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    1. scibot 20 Jul 2024
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      DOI: 10.1038/s41540-024-00400-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11252164/
  3. www.sciencedirect.com www.sciencedirect.com
    ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
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    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114406

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    sciencedirect.com/science/article/pii/S2211124724007356
  4. Jul 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferases METTL7A and METTL7B confer resistance to thiol-based histone deacetylase inhibitors
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    1. scibot 06 Jul 2024
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      DOI: 10.1158/1535-7163.MCT-23-0144

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    ncbi.nlm.nih.gov/pmc/articles/PMC11223745/
  6. Jun 2024
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The clock gene BHLHE40 and atypical CCNG2 control androgen-induced cellular senescence as a novel tumor suppressive pathway in prostate cancer
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    1. scibot 27 Jun 2024
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      DOI: 10.1186/s13046-024-03097-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11188219/
  8. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific effects of age and sex on human cortical neurons
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    1. scibot 05 Jun 2024
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      DOI: 10.1016/j.neuron.2024.05.013

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    sciencedirect.com/science/article/pii/S089662732400360X
  9. May 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of HDAC2 sensitises antitumour therapy by promoting NLRP3/GSDMD-mediated pyroptosis in colorectal cancer
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    1. scibot 30 May 2024
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      DOI: 10.1002/ctm2.1692

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    ncbi.nlm.nih.gov/pmc/articles/PMC11131357/
  11. aacrjournals.org aacrjournals.org
    Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma
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    1. scibot 23 May 2024
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      DOI: 10.1158/0008-5472.CAN-23-0821

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      DOI: 10.1158/0008-5472.CAN-23-0821

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    aacrjournals.org/cancerres/article/84/10/1570/745316/Bile-Acid-Metabolism-Mediates-Cholesterol
  12. 52.53.155.43 52.53.155.43
    mcr-23-0295-html.html
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    1. scibot 23 May 2024
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    52.53.155.43/d0655220046c67483bcefd25ef239fc58ad80cdd/mcr-23-0295-html.html
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    T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells
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    1. scibot 23 May 2024
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      DOI: 10.1016/j.celrep.2024.114258

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    sciencedirect.com/science/article/pii/S2211124724005862
  14. www.sciencedirect.com www.sciencedirect.com
    Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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    1. scibot 14 May 2024
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      DOI: 10.1016/j.stem.2024.04.015

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    sciencedirect.com/science/article/pii/S1934590924001425
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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    1. scibot 08 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
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    1. scibot 07 May 2024
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      DOI: 10.1016/j.molcel.2024.04.007

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    sciencedirect.com/science/article/pii/S1097276524002855
  17. www.sciencedirect.com www.sciencedirect.com
    Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
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    1. scibot 03 May 2024
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    sciencedirect.com/science/article/pii/S1535610824001314
  18. Apr 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
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    1. scibot 11 Apr 2024
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      DOI: 10.1371/journal.pbio.3002240

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    ncbi.nlm.nih.gov/pmc/articles/PMC11003700/
  20. www.sciencedirect.com www.sciencedirect.com
    A senescence restriction point acting on chromatin integrates oncogenic signals
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    1. scibot 04 Apr 2024
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    sciencedirect.com/science/article/pii/S2211124724003723
  21. Mar 2024
  22. link.springer.com link.springer.com
    From degraded to deciphered: ATAC-seq’s application potential in forensic diagnosis
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    1. scibot 19 Mar 2024
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      DOI: 10.1007/s00414-024-03206-2

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    link.springer.com/article/10.1007/s00414-024-03206-2
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA methylation-environment interactions in the human genome
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    1. scibot 17 Mar 2024
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      DOI: 10.7554/eLife.89371

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942648/
  24. www.sciencedirect.com www.sciencedirect.com
    The transcription factor NF-κB orchestrates nucleosome remodeling during the primary response to Toll-like receptor 4 signaling
    1
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.immuni.2024.02.004

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    sciencedirect.com/science/article/pii/S1074761324000803
  25. Feb 2024
  26. www.cell.com www.cell.com
    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.028

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    cell.com/neuron/fulltext/S0896-6273(24)00054-0
  27. www.biorxiv.org www.biorxiv.org
    A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1101/2023.12.10.570854

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    biorxiv.org/content/10.1101/2023.12.10.570854v1
  28. www.nature.com www.nature.com
    A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
    1
    1. scibot 08 Feb 2024
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      DOI: 10.1038/s41467-024-45067-8

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    nature.com/articles/s41467-024-45067-8
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
    1
    1. scibot 04 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-22-0165

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    ncbi.nlm.nih.gov/pmc/articles/PMC10836196/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses
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    1. scibot 03 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0358

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    ncbi.nlm.nih.gov/pmc/articles/PMC10832605/
  31. Jan 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
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    1. scibot 20 Jan 2024
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      DOI: 10.1158/0008-5472.CAN-23-1148

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    ncbi.nlm.nih.gov/pmc/articles/PMC10790128/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRDM3/16 Regulate Chromatin Accessibility Required for NKX2-1 Mediated Alveolar Epithelial Differentiation and Function
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    1. scibot 20 Jan 2024
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      DOI: 10.1101/2023.12.20.570481

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    ncbi.nlm.nih.gov/pmc/articles/PMC10769259/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    β-catenin-driven differentiation is a tissue-specific epigenetic vulnerability in adrenal cancer
    1
    1. scibot 10 Jan 2024
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      DOI: 10.1158/0008-5472.CAN-22-2712

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    ncbi.nlm.nih.gov/pmc/articles/PMC10330305/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation
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    1. scibot 06 Jan 2024
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      DOI: 10.1016/j.xgen.2023.100471

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    ncbi.nlm.nih.gov/pmc/articles/PMC10794847/
  36. Dec 2023
  37. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis
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    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.032

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    sciencedirect.com/science/article/pii/S1097276523009784
  38. www.sciencedirect.com www.sciencedirect.com
    Pluripotency state transition of embryonic stem cells requires the turnover of histone chaperone FACT on chromatin
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    1. scibot 21 Dec 2023
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      DOI: 10.1016/j.isci.2023.108537

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    sciencedirect.com/science/article/pii/S2589004223026147
  39. www.sciencedirect.com www.sciencedirect.com
    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.ccell.2023.11.010

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    sciencedirect.com/science/article/pii/S1535610823004014
  40. Nov 2023
  41. www.nature.com www.nature.com
    Selective inhibition of CDK9 in triple negative breast cancer
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    1. scibot 25 Nov 2023
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      DOI: 10.1038/s41388-023-02892-3

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    nature.com/articles/s41388-023-02892-3
  42. www.science.org www.science.org
    LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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    1. scibot 17 Nov 2023
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      DOI: 10.1126/sciadv.adh9543

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    science.org/doi/10.1126/sciadv.adh9543
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
    1
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      DOI: 10.1126/sciadv.adh9543

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619931/
  44. Oct 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells
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      DOI: 10.1016/j.xgen.2023.100424

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    sciencedirect.com/science/article/pii/S2666979X23002501
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    nf-core/clipseq - a robust Nextflow pipeline for comprehensive CLIP data analysis
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      RRID:SCR_010881

      DOI: 10.12688/wellcomeopenres.19453.1

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    ncbi.nlm.nih.gov/pmc/articles/PMC10565428/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
    1
    1. scibot 12 Oct 2023
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      DOI: 10.1101/2023.07.11.548643

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    ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
  48. www.nature.com www.nature.com
    TET2 lesions enhance the aggressiveness of CEBPA-mutant acute myeloid leukemia by rebalancing GATA2 expression
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      DOI: 10.1038/s41467-023-41927-x

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    nature.com/articles/s41467-023-41927-x
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.isci.2023.107887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10522999/
  50. Sep 2023
  51. www.sciencedirect.com www.sciencedirect.com
    A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
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    1. scibot 27 Sep 2023
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      DOI: 10.1016/j.cels.2023.07.008

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    sciencedirect.com/science/article/pii/S2405471223002156
  52. Aug 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  54. Jul 2023
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-level repressive histone marks fine-tune gene transcription in neural stem cells
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    1. scibot 15 Jul 2023
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      DOI: 10.7554/eLife.86127

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    Inferring regulators of cell identity in the human adult pancreas
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    Metabolic regulation of CTCF expression and chromatin association dictates starvation response in mice and flies
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  58. Jun 2023
  59. 52.53.155.43 52.53.155.43
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    Comprehensive DNA methylation analysis indicates that pancreatic intraepithelial neoplasia lesions are acinar-derived and epigenetically primed for carcinogenesis
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    aacrjournals.org/cancerres/article/83/11/1905/726442/Comprehensive-DNA-Methylation-Analysis-Indicates
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    HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
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    Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency
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  63. May 2023
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    L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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  65. Apr 2023
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    Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload
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    SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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  69. Mar 2023
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    A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans
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    Epigenetic dosage identifies two major and functionally distinct β cell subtypes
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    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution
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  74. Feb 2023
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    Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling
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  76. Jan 2023
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex differences in molecular rhythms in the human cortex
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  80. Dec 2022
  81. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  82. Nov 2022
  83. www.sciencedirect.com www.sciencedirect.com
    Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation
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    Essential role of MESP1-RING1A complex in cardiac differentiation
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    Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
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  86. Oct 2022
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    Human-specific regulation of neural maturation identified by cross-primate transcriptomics
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    A neurogenetic mechanism of experience-dependent suppression of aggression
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  89. Sep 2022
  90. aacrjournals.org aacrjournals.org
    PU.1-dependent enhancer inhibition separates Tet2-deficient hematopoiesis from malignant transformation
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    aacrjournals.org/bloodcancerdiscov/article/3/5/444/708355/PU-1-Dependent-Enhancer-Inhibition-Separates-Tet2
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAG2 promotes the myelination transcriptional program in oligodendrocytes
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    Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms
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  93. Aug 2022
  94. www.sciencedirect.com www.sciencedirect.com
    Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction
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    The sage genome provides insight into the evolutionary dynamics of diterpene biosynthesis gene cluster in plants
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  98. Jun 2022
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    Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
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  100. www.nature.com www.nature.com
    TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
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  101. elifesciences.org elifesciences.org
    Dnmt3a knockout in excitatory neurons impairs postnatal synapse maturation and increases the repressive histone modification H3K27me3
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    Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
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  103. Apr 2022
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    An optimized 4C-seq protocol based on cistrome and epigenome data in the mouse RAW264.7 macrophage cell line
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    HNF4A modulates glucocorticoid action in the liver
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  106. aacrjournals.org aacrjournals.org
    Targeted Therapy of TERT-Rearranged Neuroblastoma with BET Bromodomain Inhibitor and Proteasome Inhibitor Combination Therapy
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    aacrjournals.org/clincancerres/article/27/5/1438/83571/Targeted-Therapy-of-TERT-Rearranged-Neuroblastoma
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    GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of CDK4/6 promotes CD8 T cell memory formation
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  109. Mar 2022
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    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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    The mTOR chromatin-bound interactome in prostate cancer
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    ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
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  113. Feb 2022
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    EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells
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    An AIB1 isoform alters enhancer access and enables progression of early stage triple-negative breast cancer
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    Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs
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  117. Jan 2022
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    scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells
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    Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos
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  121. Dec 2021
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    Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis
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    Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
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  124. Oct 2021
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    An atlas of gene regulatory elements in adult mouse cerebrum
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    Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis
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  128. Sep 2021
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    SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling
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  130. Aug 2021
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    Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes
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    Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
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    Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding
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    The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
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    Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity
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    CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN
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    Glucocorticoid Receptor–Tethered Mineralocorticoid Receptors Increase Glucocorticoid-Induced Transcriptional Responses
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    Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT
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    Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia
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  142. Jul 2021
  143. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension
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    Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs
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    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons
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      DOI: 10.1016/j.celrep.2019.11.025

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    A scalable platform for the development of cell-type-specific viral drivers
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    α-Ketoglutarate links p53 to cell fate during tumour suppression
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    Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases
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    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells
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    Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors
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  152. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    High‐Resolution Chromatin Profiling Using CUT&RUN
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    Cooperation of PU.1 With IRF8 and NFATc1 Defines Chromatin Landscapes During RANKL‐Induced Osteoclastogenesis
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    Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity
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    Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition
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    Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models
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    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    N6-methyladenine DNA Modification in Glioblastoma
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    A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells
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    Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
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    Deletion of RBMX RGG/RG motif in Shashi-XLID syndrome leads to aberrant p53 activation and neuronal differentiation defects
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  163. Jun 2021
  164. www.cell.com www.cell.com
    Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota
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    Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states
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    H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve.
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    PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR
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  168. May 2021
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity
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    Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
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    Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells
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    Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis
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    Transcription factor chromatin profiling genome-wide using uliCUT&RUN in single cells and individual blastocysts
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  176. Apr 2021
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    5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease
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    Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia
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    Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants
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  180. Mar 2021
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria
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    KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation
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    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells
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    Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
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  186. Feb 2021
  187. www.biorxiv.org www.biorxiv.org
    An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  191. Jan 2021
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    Protocol for assaying chromatin accessibility using ATAC-seq in plants
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    Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
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    QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis
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  195. Dec 2020
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes
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  197. Oct 2020
  198. elifesciences.org elifesciences.org
    Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks
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    Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
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  200. Sep 2020
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18
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    Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes
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    Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
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  204. elifesciences.org elifesciences.org
    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
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    Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
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    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
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    Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy
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    C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor
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    Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells
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    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors
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    Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
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    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation
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    RNA Interactions Are Essential for CTCF-Mediated Genome Organization
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    The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility
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    Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF
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    Endodermal Maternal Transcription Factors Establish Super-Enhancers during Zygotic Genome Activation
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    The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
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    Meta-analysis of Chromatin Programming by Steroid Receptors
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    A Unique Epigenomic Landscape Defines Human Erythropoiesis
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    FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
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    Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques
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    The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma
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