5,430 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment
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    sciencedirect.com/science/article/pii/S2211124724013111
  3. Nov 2024
  4. pubs.acs.org pubs.acs.org
    Identification of Small-Molecule Antagonists Targeting the Growth Hormone Releasing Hormone Receptor (GHRHR)
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    pubs.acs.org/doi/10.1021/acs.jcim.4c00577
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    TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment
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    sciencedirect.com/science/article/pii/S2211124724013111
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    Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors
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    biorxiv.org/content/10.1101/2024.11.23.624963v1
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    Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis
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    nature.com/articles/s41467-024-54486-6
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    RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity
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    sciencedirect.com/science/article/pii/S0960982224014490
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    A peptide encoded by LINC00944 suppresses the growth of melanoma cells by diminishing EP400-MYC interaction
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    sciencedirect.com/science/article/pii/S000629522400652X
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocols for rapid identification of small-molecule metabolite ligands interacting with proteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11585684/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11579030/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11584840/
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    Berbamine prevents SARS-CoV-2 entry and transmission
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    ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
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    sciencedirect.com/science/article/pii/S155041312400411X
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    Solid tumor immunotherapy using NKG2D-based adaptor CAR T cells
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    sciencedirect.com/science/article/pii/S2666379124005986
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    Identification of a non-canonical planar cell polarity pathway triggered by light in the developing mouse retina
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    Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
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    sciencedirect.com/science/article/pii/S2211124724013366
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    CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2
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    C19MC Drives Nucleolar Invasion of Mitochondria and Meiotic Nuclear Division in Human Cancers
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    Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma
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    Engineered IscB-ωRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
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    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532780/
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    Autophagy-dependent splicing control directs translation toward inflammation during senescence
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    Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress
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    Structure of the TXNL1-bound proteasome
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    Plausible, robust biological oscillations through allelic buffering
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    Acute multi-level response to defective de novo chromatin assembly in S-phase
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    A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
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    Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
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    Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment
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  32. 52.53.155.43 52.53.155.43
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  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes
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    pmc.ncbi.nlm.nih.gov/articles/PMC11549480/
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    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    embopress.org/doi/10.1038/s44318-024-00290-3
  36. 52.53.155.43 52.53.155.43
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    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
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    Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma
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    Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis
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    ZDHHC3-mediated SCAP S-acylation promotes cholesterol biosynthesis and tumor immune escape in hepatocellular carcinoma
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    Rab11-Rab8 cascade dynamics in primary cilia and membrane tubules
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    Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice
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    Longitudinal effects of SARS-CoV-2 breakthrough infection on imprinting of neutralizing antibody responses
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  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of estrogen-related receptor γ by calcium and cadmium
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    pmc.ncbi.nlm.nih.gov/articles/PMC11537906/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539583/
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    A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539462/
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    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539641/
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    Protocol for mapping differential protein-protein interaction networks using affinity purification-mass spectrometry
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    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
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    ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin
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    pmc.ncbi.nlm.nih.gov/articles/PMC11076809/
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    Requirement of Nek2a and cyclin A2 for Wapl-dependent removal of cohesin from prophase chromatin
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    Protocol to identify E3 ligases amenable to biodegraders using a cell-based screening
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Upregulation of circ0000381 attenuates microglial/macrophage pyroptosis after spinal cord injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC11467933/
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    Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Linkage-specific ubiquitin binding interfaces modulate the activity of the chlamydial deubiquitinase Cdu1 towards poly-ubiquitin substrates
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  60. www.nature.com www.nature.com
    Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
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  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Robust SARS-CoV-2-neutralizing antibodies sustained through 6 months post XBB.1.5 mRNA vaccine booster
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    Single-chain A35R-M1R-B6R trivalent mRNA vaccines protect mice against both mpox virus and vaccinia virus
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  63. Oct 2024
  64. www.sciencedirect.com www.sciencedirect.com
    Type I IFN drives unconventional IL-1β secretion in lupus monocytes
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    Targeting RSV-neutralizing B cell receptors with anti-idiotypic antibodies
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    Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11452177/
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    Antitumor effects of intracranial injection of B7-H3-targeted Car-T and Car-Nk cells in a patient-derived glioblastoma xenograft model
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    link.springer.com/article/10.1007/s00262-024-03808-0
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    Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway
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    SIAH3 is frequently epigenetically silenced in cancer and regulates mitochondrial metabolism
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35202
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High specificity of engineered T cells with third generation CAR (CD28-4-1BB-CD3-ζ) based on biotin-bound monomeric streptavidin for potential tumor immunotherapy
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    Sirtuin 1/sirtuin 3 are robust lysine delactylases and sirtuin 1-mediated delactylation regulates glycolysis
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    The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels
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    Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8+ T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis
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  79. www.nature.com www.nature.com
    Use of synthetic circular RNA spike-ins (SynCRS) for normalization of circular RNA sequencing data
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    nature.com/articles/s41596-024-01053-4
  80. aacrjournals.org aacrjournals.org
    Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
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    aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
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    A novel HER2-specific sensor based on DARPin_9–29 and albumin binding domain for real-time fluorescence-guided tumor detection in animal model of cancer
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    Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish
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    ncbi.nlm.nih.gov/pmc/articles/PMC11441976/
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    Monocytic Differentiation and AHR Signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia
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    aacrjournals.org/bloodcancerdiscov/article/2/5/518/665838/Monocytic-Differentiation-and-AHR-Signaling-as
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    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
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    Protocol for the efficient and inducible generation of CRISPR-Cas9-edited human cortical neurons from the iCas9-iNgn2 hPSCs
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    Pervasive mislocalization of pathogenic coding variants underlying human disorders
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