304 Matching Annotations
  1. Aug 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
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      DOI: 10.1016/j.chembiol.2021.07.010

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    sciencedirect.com/science/article/pii/S2451945621003500
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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      DOI: 10.1016/j.molcel.2018.07.034

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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
  4. Jul 2021
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.molcel.2018.07.034

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    ncbi.nlm.nih.gov/pmc/articles/PMC6127031/
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    cell.com/cell-chemical-biology/abstract/S2451-9456(17)30358-6
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    Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2
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    sciencedirect.com/science/article/pii/S0945053X18302841
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    sciencedirect.com/science/article/pii/S2211124721008238
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    Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
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    sciencedirect.com/science/article/pii/S1097276521005074
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    The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity
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    sciencedirect.com/science/article/pii/S2211124721006902
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    Global mapping of Salmonella enterica-host protein-protein interactions during infection
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    sciencedirect.com/science/article/pii/S1931312821002821
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    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
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    1. scibot 03 Jul 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8225385/
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    Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC8188302/
  14. Jun 2021
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    Enhanced C/EBP binding to G·T mismatches facilitates fixation of CpG mutations in cancer and adult stem cells
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    sciencedirect.com/science/article/pii/S2211124721005726
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    High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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    sciencedirect.com/science/article/pii/S2211124721005623
  17. May 2021
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    1. scibot 20 May 2021
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      DOI: 10.1111/bph.15435

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15435
  19. mcr.aacrjournals.org mcr.aacrjournals.org
    Metabolic regulator IAPP (Amylin) is required for BRAF and RAS oncogene-induced senescence
    1
    1. scibot 10 May 2021
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      DOI: 10.1158/1541-7786.MCR-20-0879

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    mcr.aacrjournals.org/content/19/5/874
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
    1
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      DOI: 10.1016/j.stem.2020.06.022

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    sciencedirect.com/science/article/pii/S1934590920302897
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    Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal
    1
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      DOI: 10.1016/j.stem.2020.04.010

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    sciencedirect.com/science/article/pii/S1934590920301491
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
    1
    1. scibot 07 May 2021
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      DOI: 10.1016/j.molcel.2020.09.028

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    ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
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    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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      DOI: 10.1016/j.molcel.2020.10.015

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    sciencedirect.com/science/article/pii/S109727652030722X
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    Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging
    1
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      DOI: 10.1016/j.molcel.2020.06.027

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    sciencedirect.com/science/article/pii/S1097276520304299
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    Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
    1
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      DOI: 10.1016/j.molcel.2020.05.004

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    sciencedirect.com/science/article/pii/S1097276520303051
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    Glutamine Metabolism Controls Chondrocyte Identity and Function
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      DOI: 10.1016/j.devcel.2020.05.001

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    sciencedirect.com/science/article/pii/S1534580720303579
  27. Apr 2021
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
    1
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      DOI: 10.1016/j.cmet.2020.08.007

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    sciencedirect.com/science/article/pii/S1550413120304204
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    YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
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      DOI: 10.1016/j.ccell.2020.10.004

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    sciencedirect.com/science/article/pii/S1535610820304980
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    Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer
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      DOI: 10.1016/j.molcel.2021.03.043

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    sciencedirect.com/science/article/pii/S1097276521002641
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    SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways
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      DOI: 10.1016/j.ccell.2020.05.022

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    sciencedirect.com/science/article/pii/S1535610820302725
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    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
    1
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      DOI: 10.1016/j.celrep.2021.108966

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    sciencedirect.com/science/article/pii/S2211124721002801
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    Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
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      DOI: 10.1016/j.immuni.2021.03.011

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    sciencedirect.com/science/article/pii/S1074761321001230
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    Reducing acetylated tau is neuroprotective in brain injury
    1
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      DOI: 10.1016/j.cell.2021.03.032

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    sciencedirect.com/science/article/pii/S0092867421003639
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    Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation
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    sciencedirect.com/science/article/pii/S0303720721001088
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    sciencedirect.com/science/article/pii/S1097276521001775
  37. Mar 2021
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    IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility
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    sciencedirect.com/science/article/pii/S2211124721002059
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    Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A
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      histone H3

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    sciencedirect.com/science/article/pii/S0753332221002481
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15378
  41. Feb 2021
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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      DOI: 10.1016/j.cmet.2020.12.011

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    sciencedirect.com/science/article/pii/S1550413120306665
  43. www.cell.com www.cell.com
    Ad and AAV8-Mediated ABCA1 Gene Therapy in a Murine Model with Retinal Ischemia/Reperfusion Injuries
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      DOI: 10.1016/j.omtm.2021.01.012

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    cell.com/molecular-therapy-family/methods/abstract/S2329-0501(21)00012-7
  44. www.liebertpub.com www.liebertpub.com
    NF-κB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells
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      DOI: 10.1089/dna.2019.5086

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    liebertpub.com/doi/abs/10.1089/dna.2019.5086
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
    1
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      DOI: 10.1016/j.celrep.2021.108749

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    sciencedirect.com/science/article/pii/S2211124721000620
  46. Jan 2021
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    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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  48. Dec 2020
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    Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5
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      Rabbit monoclonal anti-H3

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    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
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  51. Nov 2020
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    Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17
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    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
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    Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling
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    Critical Role for Cold Shock Protein YB-1 in Cytokinesis
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    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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    Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1
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    Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models
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    Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer
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    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    NF-κB/Cartilage Acidic Protein 1 Promotes Ultraviolet B Irradiation-Induced Apoptosis of Human Lens Epithelial Cells | DNA and Cell Biology
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    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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  77. Jan 2020
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    Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors
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    HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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    Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression
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    Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer
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    Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production
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    LEFKOTHEA Regulates Nuclear and Chloroplast mRNA Splicing in Plants
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    The Toll Signaling Pathway Targets the Insulin-like Peptide Dilp6 to Inhibit Growth in Drosophila
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    Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
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    Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
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    Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
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    CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells
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    Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses
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    Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration
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    Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance
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  99. Nov 2018
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    An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs
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    SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function
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    FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange
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    Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential
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    Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses
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    Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection
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    lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS
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    Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
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    Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
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    A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells
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    Rapid DNA replication origin licensing protects stem cell pluripotency
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    Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
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    Aberrant TGF-β Signaling Drives Castration-Resistant Prostate Cancer in a Male Mouse Model of Prostate Tumorigenesis
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