345 Matching Annotations
  1. Apr 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation
    1
    1. scibot 07 Apr 2022
      RRID:AB_1107769

      DOI: 10.1016/j.immuni.2022.03.005

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    sciencedirect.com/science/article/pii/S1074761322001285
  3. aacrjournals.org aacrjournals.org
    mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
    1
    1. scibot 07 Apr 2022
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      DOI: 10.1158/1541-7786.MCR-20-0799

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    aacrjournals.org/mcr/article/19/4/717/672854/mDKN-01-a-Novel-Anti-DKK1-mAb-Enhances-Innate
  4. Mar 2022
  5. www.sciencedirect.com www.sciencedirect.com
    Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites
    1
    1. scibot 31 Mar 2022
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      DOI: 10.1016/j.immuni.2022.03.003

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    sciencedirect.com/science/article/pii/S1074761322001261
  6. www.sciencedirect.com www.sciencedirect.com
    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
    1
    1. scibot 15 Mar 2022
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      DOI: 10.1016/j.cmet.2022.02.010

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    sciencedirect.com/science/article/pii/S1550413122000547
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
    1
    1. scibot 11 Mar 2022
      RRID:AB_2894744

      DOI: 10.7150/thno.69198

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    ncbi.nlm.nih.gov/pmc/articles/PMC8899568/
  8. elifesciences.org elifesciences.org
    A non-bactericidal cathelicidin provides prophylactic efficacy against bacterial infection by driving phagocyte influx
    1
    1. scibot 03 Mar 2022
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      DOI: 10.7554/eLife.72849

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    elifesciences.org/articles/72849
  9. www.sciencedirect.com www.sciencedirect.com
    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
    1
    1. scibot 02 Mar 2022
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      DOI: 10.1016/j.ccell.2022.02.003

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    sciencedirect.com/science/article/pii/S1535610822000368
  10. Feb 2022
  11. www.sciencedirect.com www.sciencedirect.com
    An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
    2
    1. scibot 11 Feb 2022
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      DOI: 10.1016/j.cell.2022.01.009

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    2. scibot 11 Feb 2022
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      DOI: 10.1016/j.cell.2022.01.009

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    sciencedirect.com/science/article/pii/S0092867422000678
  12. www.sciencedirect.com www.sciencedirect.com
    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
    1
    1. scibot 04 Feb 2022
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      DOI: 10.1016/j.ccell.2022.01.002

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    sciencedirect.com/science/article/pii/S1535610822000046
  13. www.jneurosci.org www.jneurosci.org
    Embryonic pericytes promote microglial homeostasis and their effects on neural progenitors in the developing cerebral cortex
    1
    1. scibot 01 Feb 2022
      RRID:AB_1107769

      DOI: 10.1523/JNEUROSCI.1201-21.2021

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    jneurosci.org/content/42/3/362
  14. Jan 2022
  15. www.sciencedirect.com www.sciencedirect.com
    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
    1
    1. scibot 26 Jan 2022
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      DOI: 10.1016/j.cell.2021.12.039

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    sciencedirect.com/science/article/pii/S0092867421015610
  16. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
    1
    1. scibot 26 Jan 2022
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      DOI: 10.1016/j.ccell.2021.12.009

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    sciencedirect.com/science/article/pii/S1535610821006620
  17. www.nature.com www.nature.com
    Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
    1
    1. scibot 15 Jan 2022
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      DOI: 10.1038/s42003-021-02972-8

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    nature.com/articles/s42003-021-02972-8
  18. www.sciencedirect.com www.sciencedirect.com
    Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion
    1
    1. scibot 12 Jan 2022
      RRID:AB_1107769

      DOI: 10.1016/j.celrep.2021.110215

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    sciencedirect.com/science/article/pii/S2211124721017198
  19. Dec 2021
  20. www.sciencedirect.com www.sciencedirect.com
    Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis
    1
    1. scibot 24 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.chom.2021.12.001

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    sciencedirect.com/science/article/pii/S1931312821005667
  21. www.sciencedirect.com www.sciencedirect.com
    Resolving the immune landscape of human prostate at a single-cell level in health and cancer
    1
    1. scibot 22 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.celrep.2021.110132

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    sciencedirect.com/science/article/pii/S2211124721016284
  22. www.sciencedirect.com www.sciencedirect.com
    Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells
    1
    1. scibot 21 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.immuni.2021.11.017

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    sciencedirect.com/science/article/pii/S1074761321005094
  23. www.nature.com www.nature.com
    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
    1
    1. scibot 11 Dec 2021
      RRID:AB_1107769

      DOI: 10.1038/s41467-021-27349-7

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    nature.com/articles/s41467-021-27349-7
  24. www.sciencedirect.com www.sciencedirect.com
    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
    1
    1. scibot 09 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.xcrm.2021.100464

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    sciencedirect.com/science/article/pii/S2666379121003360
  25. www.sciencedirect.com www.sciencedirect.com
    SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects
    1
    1. scibot 08 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.celrep.2021.110085

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    sciencedirect.com/science/article/pii/S221112472101576X
  26. www.sciencedirect.com www.sciencedirect.com
    Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load
    1
    1. scibot 02 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.stem.2021.11.003

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    sciencedirect.com/science/article/pii/S1934590921004513
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
    1
    1. scibot 01 Dec 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103392

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    ncbi.nlm.nih.gov/pmc/articles/PMC8605339/
  28. Nov 2021
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
    1
    1. scibot 24 Nov 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8593563/
  30. Oct 2021
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RSV infection-elicited high MMP-12–producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration
    1
    1. scibot 28 Oct 2021
      RRID:AB_1107769

      DOI: 10.1016/j.isci.2021.103201

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    ncbi.nlm.nih.gov/pmc/articles/PMC8524145/
  32. pubs.acs.org pubs.acs.org
    Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity
    1
    1. scibot 18 Oct 2021
      RRID:AB_1107769

      DOI: 10.1021/acs.jmedchem.1c00828

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    pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00828
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
    1
    1. scibot 08 Oct 2021
      RRID:AB_1107769

      DOI: 10.1016/j.cell.2021.09.019

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    ncbi.nlm.nih.gov/pmc/articles/PMC8650838/
  34. www.sciencedirect.com www.sciencedirect.com
    Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza
    1
    1. scibot 06 Oct 2021
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      DOI: 10.1016/j.isci.2021.103131

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    sciencedirect.com/science/article/pii/S2589004221010993
  35. Sep 2021
  36. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
    1
    1. scibot 28 Sep 2021
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      DOI: 10.1016/j.cell.2021.09.006

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    sciencedirect.com/science/article/pii/S0092867421010539
  37. link.springer.com link.springer.com
    The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides
    1
    1. scibot 21 Sep 2021
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      DOI: 10.1007/s00262-021-03051-x

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    link.springer.com/article/10.1007/s00262-021-03051-x
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
    1
    1. scibot 18 Sep 2021
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      DOI: 10.1136/jitc-2021-003100

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    ncbi.nlm.nih.gov/pmc/articles/PMC8407215/
  39. www.sciencedirect.com www.sciencedirect.com
    Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors
    1
    1. scibot 18 Sep 2021
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      DOI: 10.1016/j.cell.2021.08.020

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    sciencedirect.com/science/article/pii/S0092867421009946
  40. www.sciencedirect.com www.sciencedirect.com
    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
    1
    1. scibot 15 Sep 2021
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      DOI: 10.1016/j.xcrm.2021.100399

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    sciencedirect.com/science/article/pii/S2666379121002573
  41. www.sciencedirect.com www.sciencedirect.com
    Effects of exercise and anti-PD-1 on the tumour microenvironment
    1
    1. scibot 08 Sep 2021
      RRID:AB_1

      DOI: 10.1016/j.imlet.2021.08.005

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    sciencedirect.com/science/article/abs/pii/S0165247821001401
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer
    1
    1. scibot 04 Sep 2021
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      DOI: 10.2147/OTT.S326178

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    ncbi.nlm.nih.gov/pmc/articles/PMC8403083/
  43. Aug 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors
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    1. scibot 28 Aug 2021
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      DOI: 10.1016/j.chom.2021.08.001

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    sciencedirect.com/science/article/pii/S1931312821003772
  45. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy
    1
    1. scibot 25 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109578

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    sciencedirect.com/science/article/pii/S2211124721010123
  46. www.sciencedirect.com www.sciencedirect.com
    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.celrep.2021.109516

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    sciencedirect.com/science/article/pii/S2211124721009463
  47. www.sciencedirect.com www.sciencedirect.com
    The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.ccell.2021.07.007

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    sciencedirect.com/science/article/pii/S1535610821003846
  48. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.celrep.2018.11.047

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    GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis
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    Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance
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    The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes
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    Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
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    Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
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  95. www.sciencedirect.com www.sciencedirect.com
    Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
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  96. Feb 2021
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    Transcriptional Diversity and Niche-Specific Distribution of Leukocyte Populations during Staphylococcus aureus Craniotomy-Associated Biofilm Infection
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  98. insight.jci.org insight.jci.org
    Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration
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    IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus
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  100. www.cell.com www.cell.com
    Legionella-Infected Macrophages Engage the Alveolar Epithelium to Metabolically Reprogram Myeloid Cells and Promote Antibacterial Inflammation
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  101. Dec 2020
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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  103. Oct 2020
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    PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
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    Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury
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  106. Sep 2020
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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
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    TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes
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    FOXD3 Regulates VISTA Expression in Melanoma
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  111. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis
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    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
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    Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy
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    Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration
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    An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses
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      DOI: 10.1016/j.xcrm.2020.100035

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    Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells
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      DOI: 10.1016/j.cell.2020.04.022

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    Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity
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      DOI: 10.1016/j.cell.2020.02.015

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    Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps
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      DOI: 10.1016/j.chom.2020.01.011

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    The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection
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      DOI: 10.1016/j.celrep.2020.107827

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    Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection
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      Isotype (rat IgG2a isotype)

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  121. Jan 2020
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    Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors
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      DOI: 10.1016/j.cell.2019.05.047

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    T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation
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    UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
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    B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer
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    Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ
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    Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer
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    Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis
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    Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy
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    Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization
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    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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    Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice
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    Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
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    Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
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      DOI: 10.1016/j.cell.2018.12.022

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      DOI: 10.1016/j.immuni.2019.04.010

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      DOI: 10.7554/eLife.45501

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    Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation
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      DOI: 10.1016/j.ccell.2019.04.003

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  143. Nov 2018
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    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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    LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis
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    Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
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    IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy
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    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
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    RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
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    Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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    Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
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    TIM-3 Regulates CD103+ Dendritic Cell Function and Response to Chemotherapy in Breast Cancer
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    Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation
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    Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
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  159. Nov 2017
  160. www.sciencedirect.com www.sciencedirect.com
    Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
    1
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    Dietary Manganese Promotes Staphylococcal Infection of the Heart
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    Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever
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  163. www.sciencedirect.com www.sciencedirect.com
    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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      BioXCellCat#BE0089

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