1,082 Matching Annotations
  1. Dec 2024
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    Proteolethargy is a pathogenic mechanism in chronic disease
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    sciencedirect.com/science/article/pii/S0092867424012741
  3. Nov 2024
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    AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
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    sciencedirect.com/science/article/pii/S2211124724013524
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    ESR1 fusion proteins invoke breast cancer subtype-dependent enrichment of ligand independent pro-oncogenic signatures and phenotypes
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    biorxiv.org/content/10.1101/2023.09.18.558175v1
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2
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    pmc.ncbi.nlm.nih.gov/articles/PMC11534337/
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    Structure of the TXNL1-bound proteasome
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    biorxiv.org/content/10.1101/2024.11.08.622741v1
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Porcine NLRC3 specially binds short dsDNA to regulate cGAS activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11544074/
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    Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer
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    biorxiv.org/content/10.1101/2024.11.06.621982v1
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    SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release
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    pmc.ncbi.nlm.nih.gov/articles/PMC11549447/
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    Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
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    embopress.org/doi/10.1038/s44318-024-00290-3
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    Systematic screens for fertility genes essential for malaria parasite transmission reveal conserved aspects of sex in a divergent eukaryote
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    Constitutive and Conditional Epitope Tagging of Endogenous G-Protein–Coupled Receptors in Drosophila
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    Chemogenetic activation of RFRP neurons reduces LH pulse frequency in female but not male mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11458915/
  16. Oct 2024
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    MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC11425777/
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    CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
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  19. Sep 2024
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    C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17256
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    Highlights from MBoC Selection: Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
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    ncbi.nlm.nih.gov/pmc/articles/PMC11244170/
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    Mechanism of barotaxis in marine zooplankton
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    Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion
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    Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
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    Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit
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    Protein UFMylation regulates early events during ribosomal DNA-damage response
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    ESR1 Fusions Invoke Breast Cancer Subtype-Dependent Enrichment of Ligand-Independent Oncogenic Signatures and Phenotypes
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384147/
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    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
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    E3 ubiquitin ligase ANKIB1 attenuates antiviral immune responses by promoting K48-linked polyubiquitination of MAVS
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  33. Aug 2024
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    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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    Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity
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    An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation
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    Galectin-3 induces pathogenic immunosuppressive macrophages through interaction with TREM2 in lung cancer
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    Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells
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    A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development
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    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
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    The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
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    Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model
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    Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease
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    Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis
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    Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
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    Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases
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  48. 52.53.155.43 52.53.155.43
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    Neuroarchitecture and neuroanatomy of the Drosophila central complex: A GAL4‐based dissection of protocerebral bridge neurons and circuits
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    onlinelibrary.wiley.com/doi/10.1002/cne.23705/full
  50. Jul 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for linking enhanced interferon immunity to virus resistance in gene-knockout zebrafish
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    ncbi.nlm.nih.gov/pmc/articles/PMC11260832/
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    Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
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    Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
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    Piezo1 ion channels are capable of conformational signaling
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    A hominoid-specific signaling axis regulating the tempo of synaptic maturation
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    A two-layer neural circuit controls fast forward locomotion in Drosophila
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    Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors
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    Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
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    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
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    Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma
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    Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis
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    High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila
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    Ultra-large Scale Virtual Screening Identifies a Small Molecule Inhibitor of the Wnt transporter WLS
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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    TSPAN4 influences glioblastoma progression through regulating EGFR stability
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    Discovery of a peptide proteolysis-targeting chimera (PROTAC) drug of p300 for prostate cancer therapy
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    Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome
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    Hippocampal astrocytes induce sex-dimorphic effects on memory
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    Axon targeting of Drosophila medulla projection neurons requires diffusible Netrin and is coordinated with neuroblast temporal patterning
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    ncbi.nlm.nih.gov/pmc/articles/PMC10155933/
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    Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila
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    Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching
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    Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
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    Kainate receptors regulate synaptic integrity and plasticity by forming a complex with synaptic organizers in the cerebellum
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    Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities
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    Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9
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    Protocol for qualitative analysis of lysosome immunoprecipitation from patient-derived glioblastoma stem-like cells
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    Inhibitory circuits coordinate leg movements during Drosophila grooming
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    ROS are required for the germinative cell proliferation and metacestode larval growth of Echinococcus multilocularis
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    Generation and characterization of inducible KRAB-dCas9 iPSCs from primates for cross-species CRISPRi
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  85. Jun 2024
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    KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
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    NLRC5 senses NAD+ depletion, forming a PANoptosome and driving PANoptosis and inflammation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11283362/
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    Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice
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    RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia
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    SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA
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    Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy
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    ATG16L1 induces the formation of phagophore-like membrane cups
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