537 Matching Annotations
  1. Jan 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Multi-CUT&Tag to simultaneously profile multiple chromatin factors
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    1. scibot 21 Jan 2022
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      DOI: 10.1016/j.xpro.2021.101100

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    sciencedirect.com/science/article/pii/S2666166721008066
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    Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos
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      DOI: 10.1016/j.xgen.2021.100083

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    sciencedirect.com/science/article/pii/S2666979X2100104X
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    Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome
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      DOI: 10.1186/s13072-021-00433-4

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    link.springer.com/article/10.1186/s13072-021-00433-4
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    YAP1 and PRDM14 converge to promote cell survival and tumorigenesis
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      DOI: 10.1016/j.devcel.2021.12.006

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    sciencedirect.com/science/article/pii/S1534580721009953
  6. Dec 2021
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    SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity
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      DOI: 10.1016/j.molcel.2021.11.011

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    sciencedirect.com/science/article/pii/S1097276521009904
  8. Nov 2021
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    Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling
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      DOI: 10.1016/j.celrep.2021.110036

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    sciencedirect.com/science/article/pii/S2211124721015187
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    Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine
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      DOI: 10.1016/j.celrep.2021.110044

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    sciencedirect.com/science/article/pii/S2211124721015308
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    An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8591992/
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    Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers
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      DOI: 10.1038/s41467-021-26600-5

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    nature.com/articles/s41467-021-26600-5
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    1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
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    1. scibot 11 Nov 2021
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      DOI: 10.1016/j.devcel.2021.10.018

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    sciencedirect.com/science/article/pii/S1534580721008492
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    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
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    sciencedirect.com/science/article/pii/S2211124721014327
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    Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage
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      DOI: 10.1016/j.celrep.2021.109938

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    sciencedirect.com/science/article/pii/S221112472101411X
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    Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription
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    1. scibot 03 Nov 2021
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      DOI: 10.1016/j.celrep.2021.109943

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    sciencedirect.com/science/article/pii/S2211124721014169
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    An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
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      DOI: 10.1016/j.neuron.2021.10.014

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    sciencedirect.com/science/article/pii/S0896627321007820
  18. Oct 2021
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    Reprogramming CBX8-PRC1 function with a positive allosteric modulator
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    1. scibot 29 Oct 2021
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      DOI: 10.1016/j.chembiol.2021.10.003

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    sciencedirect.com/science/article/pii/S2451945621004372
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    A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
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    1. scibot 28 Oct 2021
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      DOI: 10.1016/j.devcel.2021.10.004

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    sciencedirect.com/science/article/pii/S1534580721008054
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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      DOI: 10.1016/j.molcel.2021.10.005

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    sciencedirect.com/science/article/pii/S1097276521008340
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    The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
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    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109864

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    sciencedirect.com/science/article/pii/S2211124721013310
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    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
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      DOI: 10.1016/j.molcel.2021.09.020

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    sciencedirect.com/science/article/pii/S1097276521007541
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    Simultaneous profiling of multiple chromatin proteins in the same cells
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    1. scibot 12 Oct 2021
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      DOI: 10.1016/j.molcel.2021.09.019

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    sciencedirect.com/science/article/pii/S109727652100753X
  25. Sep 2021
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    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
    1
    1. scibot 22 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109725

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    sciencedirect.com/science/article/pii/S2211124721011748
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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      DOI: 10.1016/j.celrep.2021.109706

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    sciencedirect.com/science/article/pii/S2211124721011530
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Environment tunes propagation of cell-to-cell variation in the human macrophage gene network
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      DOI: 10.1016/j.cels.2017.03.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC8392141/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
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    1. scibot 04 Sep 2021
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      DOI: 10.3390/ijms22168792

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    ncbi.nlm.nih.gov/pmc/articles/PMC8395720/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer
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      DOI: 10.1016/j.isci.2021.102953

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    ncbi.nlm.nih.gov/pmc/articles/PMC8384902/
  31. www.sciencedirect.com www.sciencedirect.com
    Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions
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      DOI: 10.1016/j.neuron.2021.08.005

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    sciencedirect.com/science/article/pii/S0896627321005808
  32. Aug 2021
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative control of noise in mammalian gene expression by dynamic histone regulation
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      DOI: 10.7554/eLife.65654

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    ncbi.nlm.nih.gov/pmc/articles/PMC8357418/
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    Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
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      DOI: 10.1016/j.molcel.2021.07.024

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    sciencedirect.com/science/article/pii/S1097276521005931
  35. www.nature.com www.nature.com
    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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      DOI: 10.1038/s41467-021-24687-4

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    nature.com/articles/s41467-021-24687-4
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    Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    sciencedirect.com/science/article/pii/S2405471219301152
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      DOI: 10.1016/j.stem.2019.03.012

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      DOI: 10.1016/j.ajhg.2016.11.016

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      DOI: 10.15252/embj.2018100293

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    academic.oup.com/endo/article/158/4/842/2877139
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    cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
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    ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
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    ncbi.nlm.nih.gov/pmc/articles/PMC6344342/
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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      DOI: 10.1016/j.stem.2018.11.014

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    sciencedirect.com/science/article/pii/S1934590918305502
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    sciencedirect.com/science/article/pii/S1934590918304983
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
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    A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets
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    Induction of OCT2 contributes to regulate the gene expression program in human neutrophils activated via TLR8
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    Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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    Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage
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    Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases
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    Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells
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    Genome‐Wide Estrogen Receptor β Chromatin Binding in Human Colon Cancer Cells Reveals its Tumor Suppressor Activity
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    Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates
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    H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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    STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
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    Principles of signaling pathway modulation for enhancing human naive pluripotency induction
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    B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
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    Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
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    A compendium and comparative epigenomics analysis of cis -regulatory elements in the pig genome
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    Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
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    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
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    TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
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    MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity
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    Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory
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    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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    A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
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    A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    Definition of a small core transcriptional circuit regulated by AML1-ETO
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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    Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4
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    The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist
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    DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders
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  140. Nov 2020
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    Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
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    Characterization of Organoid Cultures to Study the Effects of Pregnancy Hormones on the Epigenome and Transcriptional Output of Mammary Epithelial Cells
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  143. Oct 2020
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    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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    The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression
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    H3K4me1 Distribution Predicts Transcription State and Poising at Promoters
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    Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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    Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
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    Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism
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    Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells
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    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18
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    REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes
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    Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia
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    Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells
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    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
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    Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity
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    Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
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    Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
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    Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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    Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers
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    Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
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    De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads
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    Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma
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    The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
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  177. Aug 2020
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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    Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4
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    CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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    A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
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    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet
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    Nucleome Dynamics during Retinal Development
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses
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    SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring
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      DOI: 10.1016/j.neuron.2019.07.013

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    Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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      DOI: 10.1016/j.immuni.2019.06.005

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    Organization of Chromatin by Intrinsic and Regulated Phase Separation
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      DOI: 10.1016/j.cell.2019.08.037

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    Bone marrow stromal cells transcriptionally repress ESR1 but cannot overcome constitutive ESR1 mutant activity
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      RRID:AB_2118291

      DOI: 10.1210/en.2019-00299

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    Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
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      DOI: 10.1016/j.celrep.2019.11.039

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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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      DOI: 10.1016/j.ccell.2019.09.002

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    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle
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      DOI: 10.7554/eLife.50087

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    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
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      DOI: 10.1016/j.celrep.2019.09.032

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    MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition
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      DOI: 10.1016/j.celrep.2019.06.029

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    PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression
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    Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
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      DOI: 10.1016/j.stem.2019.04.021

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    Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases
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      DOI: 10.1016/j.immuni.2019.09.021

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    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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      DOI: 10.1016/j.cell.2019.10.044

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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
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    Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded
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    Improved CUT&RUN chromatin profiling tools
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    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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    Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities
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    Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction
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    Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
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