519 Matching Annotations
  1. Oct 2021
  2. www.sciencedirect.com www.sciencedirect.com
    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
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    sciencedirect.com/science/article/pii/S1097276521007541
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    Simultaneous profiling of multiple chromatin proteins in the same cells
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    sciencedirect.com/science/article/pii/S109727652100753X
  4. Sep 2021
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    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S2211124721011748
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    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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    sciencedirect.com/science/article/pii/S2211124721011530
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    Environment tunes propagation of cell-to-cell variation in the human macrophage gene network
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    ncbi.nlm.nih.gov/pmc/articles/PMC8392141/
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    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
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      DOI: 10.3390/ijms22168792

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    ncbi.nlm.nih.gov/pmc/articles/PMC8395720/
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    ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8384902/
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    Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions
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    sciencedirect.com/science/article/pii/S0896627321005808
  11. Aug 2021
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative control of noise in mammalian gene expression by dynamic histone regulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8357418/
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    Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
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    sciencedirect.com/science/article/pii/S1097276521005931
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    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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      DOI: 10.1038/s41467-021-24687-4

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    nature.com/articles/s41467-021-24687-4
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    Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
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    sciencedirect.com/science/article/pii/S2211124719306023
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    sciencedirect.com/science/article/pii/S2405471219301152
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    sciencedirect.com/science/article/pii/S1934590919301110
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      DOI: 10.1016/j.ajhg.2016.11.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC5223059/
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      DOI: 10.15252/embj.2018100293

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    onlinelibrary.wiley.com/doi/10.15252/embj.2018100293
  21. academic.oup.com academic.oup.com
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      DOI: 10.1210/en.2016-1854

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    academic.oup.com/endo/article/158/4/842/2877139
  22. www.cell.com www.cell.com
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    cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.10.051

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    ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6344342/
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    Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules
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    1. scibot 10 Aug 2021
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      DOI: 10.1016/j.stem.2018.11.014

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    sciencedirect.com/science/article/pii/S1934590918305502
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    sciencedirect.com/science/article/pii/S1934590918304983
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    sciencedirect.com/science/article/pii/S2211124718316413
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      DOI: 10.1016/j.cell.2018.11.045

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    sciencedirect.com/science/article/pii/S0092867418315708
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    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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      DOI: 10.1016/j.molcel.2021.07.018

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    sciencedirect.com/science/article/pii/S1097276521005876
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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      DOI: 10.1016/j.immuni.2021.07.004

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    sciencedirect.com/science/article/pii/S1074761321002909
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    sciencedirect.com/science/article/pii/S2211124718316401
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    sciencedirect.com/science/article/pii/S1535610818305269
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    sciencedirect.com/science/article/pii/S153561081830480X
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    TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
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    sciencedirect.com/science/article/pii/S1934590921002885
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6306333/
  36. academic.oup.com academic.oup.com
    Gestational Diabetes Epigenetically Reprograms the Cart Promoter in Fetal Ovary, Causing Subfertility in Adult Life
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      DOI: 10.1210/en.2019-00319

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    academic.oup.com/endo/article/160/7/1684/5506444
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    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
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    sciencedirect.com/science/article/pii/S2211124719312203
  38. Jul 2021
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6286384/
  40. elifesciences.org elifesciences.org
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    elifesciences.org/articles/39380
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    The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
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      Anti-Histone H3 (acetyl K27) antibody

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    sciencedirect.com/science/article/pii/S1074761319303644
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    academic.oup.com/endo/article/159/12/3965/5104455
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    SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States
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    sciencedirect.com/science/article/pii/S193459091830482X
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    Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia
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    sciencedirect.com/science/article/pii/S1535610818304835
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus
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    ncbi.nlm.nih.gov/pmc/articles/PMC6287930/
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    Thyroid Hormone Receptor β Suppression of RUNX2 is Mediated by Brahma Related Gene 1 Dependent Chromatin Remodeling
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    Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
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    AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance
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    Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Robust Hi-C Maps of Enhancer-Promoter Interactions Reveal the Function of Non-coding Genome in Neural Development and Diseases
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    Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells
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    Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates
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    Folding Keratin Gene Clusters during Skin Regional Specification
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    H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization
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    The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
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  89. Apr 2021
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    STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma
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    Principles of signaling pathway modulation for enhancing human naive pluripotency induction
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    B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
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    Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease
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    A compendium and comparative epigenomics analysis of cis -regulatory elements in the pig genome
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    Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
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    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
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    TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation
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    MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity
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    Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma
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  101. Mar 2021
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    Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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    Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory
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  104. Feb 2021
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    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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    A Genome-wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
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    A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation
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    The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages
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    Definition of a small core transcriptional circuit regulated by AML1-ETO
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers
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  114. Jan 2021
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    Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4
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    The Hox Transcription Factor Ubx Ensures Somatic Myogenesis by Suppressing the Mesodermal Master Regulator Twist
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  117. Dec 2020
  118. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders
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  119. Nov 2020
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    Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
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    Characterization of Organoid Cultures to Study the Effects of Pregnancy Hormones on the Epigenome and Transcriptional Output of Mammary Epithelial Cells
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  122. Oct 2020
  123. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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    Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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  127. Sep 2020
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    The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators
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    Large domains of heterochromatin direct the formation of short mitotic chromosome loops
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    Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue
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    The Number of Transcription Factors at an Enhancer Determines Switch-like Gene Expression
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    H3K4me1 Distribution Predicts Transcription State and Poising at Promoters
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    Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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    Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells
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    Genome-wide Profiling Identifies DNA Methylation Signatures of Aging in Rod Photoreceptors Associated with Alterations in Energy Metabolism
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    Super-Enhancer Redistribution as a Mechanism of Broad Gene Dysregulation in Repeatedly Drug-Treated Cancer Cells
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    Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18
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    GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
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    REST Inhibits Direct Reprogramming of Pancreatic Exocrine to Endocrine Cells by Preventing PDX1-Mediated Activation of Endocrine Genes
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    Gata3-controlled nucleosome eviction drives Myc enhancer activity in T-cell development and leukemia
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    Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells
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    Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
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    Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity
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    Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
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    The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
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    Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
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    Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming
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    KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
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    KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage
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    Oct4-Mediated Inhibition of Lsd1 Activity Promotes the Active and Primed State of Pluripotency Enhancers
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    Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
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  153. academic.oup.com academic.oup.com
    De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads
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      DOI: 10.1093/gigascience/gix085

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    Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma
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      Histone H3 (acetyl K27) rabbit pAb (ChIP grade)

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    The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
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  156. Aug 2020
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    The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway
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  158. Jan 2020
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    Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4
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    CoBATCH for High-Throughput Single-Cell Epigenomic Profiling
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      DOI: 10.1016/j.molcel.2019.07.015

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    A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling
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      DOI: 10.1016/j.stem.2019.06.008

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    A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers
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      DOI: 10.1016/j.cell.2019.07.011

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    Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
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    Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury
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      DOI: 10.1016/j.immuni.2019.11.013

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    An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer
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    Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet
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    Nucleome Dynamics during Retinal Development
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    The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
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    H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation
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    The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma
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    Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses
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    SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring
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      DOI: 10.1016/j.neuron.2019.07.013

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    Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
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    The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
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    Organization of Chromatin by Intrinsic and Regulated Phase Separation
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    Bone marrow stromal cells transcriptionally repress ESR1 but cannot overcome constitutive ESR1 mutant activity
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    Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle
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    The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer
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    MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition
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    PRC2-Associated Chromatin Contacts in the Developing Limb Reveal a Possible Mechanism for the Atypical Role of PRC2 in HoxA Gene Expression
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    Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
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    Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases
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    Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes
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    Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded
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    Improved CUT&RUN chromatin profiling tools
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    Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
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    Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities
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    Identification and Massively Parallel Characterization of Regulatory Elements Driving Neural Induction
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    Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors
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    Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
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    MeCP2 Represses Enhancers through Chromosome Topology-Associated DNA Methylation
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    Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function
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    Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons
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    Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition
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    Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
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    Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs
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    Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3
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    Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation
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    Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4
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    The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
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    Reconstruction of the Global Neural Crest Gene Regulatory Network In Vivo
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    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
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