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296 Matching Annotations

May 2021
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Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics

1
1. scibot 12 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.chembiol.2021.04.014
  
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sciencedirect.com/science/article/pii/S2451945621002075
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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

1
1. scibot 10 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.chembiol.2021.04.013
  
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sciencedirect.com/science/article/pii/S2451945621002063
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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

1
1. scibot 10 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.cell.2021.04.016
  
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sciencedirect.com/science/article/pii/S0092867421004955
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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

1
1. scibot 07 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.molcel.2020.09.004
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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sciencedirect.com/science/article/pii/S1097276520306122
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Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

1
1. scibot 07 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.molcel.2020.06.028
  
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sciencedirect.com/science/article/pii/S1097276520304305
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Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

1
1. scibot 05 May 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.devcel.2020.11.012
  
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sciencedirect.com/science/article/pii/S1534580720308881
Apr 2021
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

1
1. scibot 29 Apr 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.stem.2021.03.005
  
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sciencedirect.com/science/article/pii/S1934590921001119
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

1
1. scibot 28 Apr 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2021.109013
  
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sciencedirect.com/science/article/pii/S2211124721003272
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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

1
1. scibot 28 Apr 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.chembiol.2021.04.004
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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sciencedirect.com/science/article/pii/S2451945621001598
Mar 2021
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Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development

1
1. scibot 11 Mar 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.canlet.2021.03.004
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
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  RRID:AB_2160739 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0304383521001087
Feb 2021
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CARM1 regulates replication fork speed and stress response by stimulating PARP1

1
1. scibot 28 Feb 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.molcel.2020.12.010
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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sciencedirect.com/science/article/pii/S1097276520309023
academic.oup.com academic.oup.com

A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-Negative Breast Cancer Anoikis Resistance

1
1. scibot 28 Feb 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1210/endocr/bqaa226
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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academic.oup.com/endo/article/162/2/bqaa226/6027912
www.nature.com www.nature.com

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

1
1. scibot 28 Feb 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1038/s41418-020-00733-4
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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nature.com/articles/s41418-020-00733-4
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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

1
1. scibot 27 Feb 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.cell.2020.11.042
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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sciencedirect.com/science/article/pii/S0092867420316147
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis

1
1. scibot 24 Feb 2021
  
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  RRID:AB_2
  
  DOI: 10.1113/JP279150
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
  Curator comments: PARP Antibody Cell Signaling Technology Cat# 9542
  
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  RRID:AB_2160739 RRIDCUR:Unresolved RRIDCUR:SyntaxError
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP279150
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BRD4-mediated repression of p53 is a target for combination therapy in AML

1
1. scibot 24 Jan 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1038/s41467-020-20378-8
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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ncbi.nlm.nih.gov/pmc/articles/PMC7801601/
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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

1
1. scibot 20 Jan 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.xcrm.2020.100188
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
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  RRIDCUR:Validated RRID:AB_2160739
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sciencedirect.com/science/article/pii/S2666379120302433
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon

1
1. scibot 05 Jan 2021
  
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  RRID:AB_2160739
  
  DOI: 10.1038/s41598-020-79450-4
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7758332/
Dec 2020
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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

1
1. scibot 17 Dec 2020
  
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  RRID:AB_216073
  
  DOI: 10.1016/j.molcel.2020.12.006
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
  Curator comments: PARP Antibody Cell Signaling Technology Cat# 9542
  
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  RRID:AB_2160739 RRIDCUR:Unresolved RRIDCUR:Incorrect
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sciencedirect.com/science/article/pii/S1097276520308984
Nov 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

1
1. scibot 11 Nov 2020
  
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  PARP1
  
  DOI: 10.3390/cancers12113269
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
  Curator comments: PARP Antibody Cell Signaling Technology Cat# 9542
  
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  RRID:AB_2160739 RRIDCUR:Missing
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pubmed.ncbi.nlm.nih.gov/33167355/
Oct 2020
link.springer.com link.springer.com

A uro-protective agent with restorative actions on urethral and striated muscle morphology

1
1. scibot 27 Oct 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1007/s00345-020-03492-6
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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link.springer.com/article/10.1007/s00345-020-03492-6
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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

1
1. scibot 27 Oct 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2020.108284
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
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  RRID:AB_2160739 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720312730
www.cell.com www.cell.com

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

1
1. scibot 24 Oct 2020
  
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  AB_2160739
  
  DOI: 10.1016/j.celrep.2020.108286
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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cell.com/cell-reports/abstract/S2211-1247(20)31275-4
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Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

1
1. scibot 20 Oct 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2020.108261
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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sciencedirect.com/science/article/pii/S221112472031250X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

1
1. scibot 13 Oct 2020
  
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  RRID:AB_2160739
  
  DOI: 10.7554/eLife.59442
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7541088/
Sep 2020
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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer

1
1. scibot 25 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2020.107994
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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sciencedirect.com/science/article/pii/S2211124720309797
link.springer.com link.springer.com

Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1186/s13148-020-00839-z
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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link.springer.com/article/10.1186/s13148-020-00839-z
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.jsbmb.2020.105730
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7482430/
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MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2020.02.041
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720302023
elifesciences.org elifesciences.org

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.7554/eLife.60637
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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elifesciences.org/articles/60637
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer

1
1. scibot 13 Sep 2020
  
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  RRID:AB_2160739
  
  DOI: 10.1016/j.ebiom.2020.102988
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_2160739
  
  Curator comments: PARP Antibody Cell Signaling Technology Cat# 9542
  
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pubmed.ncbi.nlm.nih.gov/32927276/
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 11 Sep 2020
  
  in Public
  
  RRID:AB_2160739
  
  DOI: 10.1111/bph.14981
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14981
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Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30

1
1. scibot 11 Sep 2020
  
  in Public
  
  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2020.03.011
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2160739
  
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  RRIDCUR:Validated RRID:AB_2160739
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sciencedirect.com/science/article/pii/S221112472030317X
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FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

1
1. scibot 10 Sep 2020
  
  in Public
  
  RRID:AB_2160739
  
  DOI: 10.1016/j.celrep.2019.12.032
  
  Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_2160739
  
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  RRID:AB_2160739 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719316821
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Synthesis, biological evaluation and toxicity of novel tetrandrine analogues

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SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP

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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro

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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress

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A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor

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Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Development and Characterization of a Wee1 Kinase Degrader

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The N-Degron Pathway Mediates ER-phagy

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Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

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Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation

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21-benzylidene digoxin decreases proliferation by inhibiting the egfr/erk signaling pathway and induces apoptosis in hela cells

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BPS Publications

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Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses

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Salidroside Protects Dopaminergic Neurons by Regulating the Mitochondrial MEF2D‐ND6 Pathway in the MPTP/MPP+‐Induced Model of Parkinson's Disease

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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss

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NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

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Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression

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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

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Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms

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EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

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Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma

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The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression

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Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib

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SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production

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Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

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Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis

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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

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Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

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Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport

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Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

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Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma

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Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

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Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

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Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

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Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

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The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes

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Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury

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