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Jan 2024
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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells

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Dec 2023
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FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects

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Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation

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Heterogeneity and transcriptional drivers of triple-negative breast cancer

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BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development

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Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding

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  DOI: 10.1038/s41467-023-43931-7
  
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Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch

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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

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ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
Nov 2023
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AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms

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Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders

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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice

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1. scibot 26 Nov 2023
  
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Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration

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High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour

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  DOI: 10.1111/jne.13350
  
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onlinelibrary.wiley.com/doi/10.1111/jne.13350
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A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression

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Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins

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can-22-3965-html.html

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Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway

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Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer

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Oct 2023
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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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1. scibot 31 Oct 2023
  
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In vitro generation of mouse morula-like cells

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Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

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Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer

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Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

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Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

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STAT3 modulates CD4+ T mitochondrial dynamics and function in aging

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  DOI: 10.1111/acel.13996
  
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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

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Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

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CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signalling pathway

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can-22-3965-html.html

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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

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Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice

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Sep 2023
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Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms

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In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities

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Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network

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Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells

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A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis

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An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver

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Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

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IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

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The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation

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PIIS2589004223016838-html.html

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British J Pharmacology - 2023 - Han-html.html

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Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice

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The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin

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Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma

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Hedgehog receptors exert immune-surveillance roles in the epidermis across species

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Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3

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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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Lactate modulates iron metabolism by binding soluble adenylyl cyclase

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Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

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Leptin, but not Estradiol, Signaling in PACAP Neurons Modulates Puberty Onset

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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway

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STAT3 regulates antiviral immunity by suppressing excessive interferon signaling

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Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH

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Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

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Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways

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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

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Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice

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Overcoming MET-mediated resistance in oncogene-driven NSCLC

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Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

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New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation

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Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through a ROS-dependent mechanism

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Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma

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Bufalin suppresses esophageal squamous cell carcinoma progression by activating the PIAS3/STAT3 signaling pathway

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cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway

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FEBS Press

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Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion

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DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β

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Bovine blastocyst-like structures derived from stem cell cultures

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KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells

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Exercise-derived peptide protects against pathological cardiac remodeling

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Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies

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LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration

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Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells

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Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages

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Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

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Casein kinase 1α is required to maintain murine hypothalamic POMC expression

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Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers

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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

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A tissue injury sensing and repair pathway distinct from host pathogen defense

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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

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CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue

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IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

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STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

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Transneuronal Delivery of Cytokines to Stimulate Mammalian Spinal Cord Regeneration

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IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

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Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis

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SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

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FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants

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Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells

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943-html.html

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Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer

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Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity

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Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux

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Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling

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Reversal of malignant ADAR1 splice isoform switching with Rebecsinib

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bcd-22-0082-html.html

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Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

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Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice

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Remodeling Chondroitin-6-Sulfate–Mediated Immune Exclusion Enhances Anti–PD-1 Response in Colorectal Cancer with Microsatellite Stability

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CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

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Immunoediting instructs tumor metabolic reprogramming to support immune evasion

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ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis

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Allicin ameliorates IMQ-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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Microglial depletion impairs glial scar formation and... : Neural Regeneration Research

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

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STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.

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Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis

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Niraparib-induced STAT3 inhibition increases its antitumor effects

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Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice

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The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice

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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin

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Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

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1960-html.html

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Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma

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Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation

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British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html

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Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells

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A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

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Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

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EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

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Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells

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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas

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Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts

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Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes

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Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling

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Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway

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BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice

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Ligand-mediated PAI-1 inhibition in a mouse model of peritoneal carcinomatosis

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Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function

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Deletion of PTP 1B from Brain Neurons Partly Protects Mice from Diet-Induced Obesity and Minimally Improves Fertility

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PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

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Olfactory receptor 5B21 drives breast cancer metastasis

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The role of epithelial progesterone receptor isoforms in embryo implantation

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Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain

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Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer

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TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment

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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

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BPS Publications

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A reduction in voluntary physical activity in early pregnancy in mice is mediated by prolactin

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Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

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Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes - John D. Nowery, Rylee N. Cisney, Jacob W. Feldmann, Gordon P. Meares, 2021

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IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2

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ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis

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Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung

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STAT3 activation in hippocampal neural stem cells and cognitive deficits in mice following short-term cuprizone exposure

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Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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The cJUN NH 2 -terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution

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Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

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The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

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Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system

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CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines

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Establishment, maintenance, and recall of inflammatory memory

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Interleukin 35 ameliorates myocardial ischemia‐reperfusion injury by activating the gp130‐STAT3 axis

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Suppression of Leptin Transport Into the Brain Contributes to Leptin Resistance During Pregnancy in the Mouse

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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

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CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota

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Treatment of type 2 diabetes with the designer cytokine IC7Fc

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Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway

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Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

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Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons

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