557 Matching Annotations
  1. Oct 2023
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    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    sciencedirect.com/science/article/pii/S2666379123004159
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    sciencedirect.com/science/article/pii/S2211124723012822
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    sciencedirect.com/science/article/pii/S221112472301330X
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    Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10581688/
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    STAT3 modulates CD4+ T mitochondrial dynamics and function in aging
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    onlinelibrary.wiley.com/doi/10.1111/acel.13996
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    pmc.ncbi.nlm.nih.gov/articles/PMC10591052/
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    Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1
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    sciencedirect.com/science/article/pii/S1550413123003364
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    CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signalling pathway
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    cell.com/iscience/abstract/S2589-0042(23)02147-8
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice
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    sciencedirect.com/science/article/pii/S0006899323003797
  13. Sep 2023
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
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    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975769/
  16. Aug 2023
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
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    ncbi.nlm.nih.gov/pmc/articles/PMC10456850/
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    Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
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    An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
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    nature.com/articles/s41467-023-40688-x
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    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    embopress.org/doi/10.15252/emmm.202217367
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    IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10425906/
  23. 52.53.155.43 52.53.155.43
    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    British J Pharmacology - 2023 - Han-html.html
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    Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10409725/
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    The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin
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    ncbi.nlm.nih.gov/pmc/articles/PMC10400920/
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    Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10393801/
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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    ncbi.nlm.nih.gov/pmc/articles/PMC10392084/
  31. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Lactate modulates iron metabolism by binding soluble adenylyl cyclase
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    Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
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    Leptin, but not Estradiol, Signaling in PACAP Neurons Modulates Puberty Onset
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    ncbi.nlm.nih.gov/pmc/articles/PMC10341598/
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway
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    STAT3 regulates antiviral immunity by suppressing excessive interferon signaling
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation
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    Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
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  42. Jun 2023
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    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
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    Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
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    mdpi.com/2076-3921/12/6/1303
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    Overcoming MET-mediated resistance in oncogene-driven NSCLC
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    Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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  48. May 2023
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    Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through a ROS-dependent mechanism
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    sciencedirect.com/science/article/pii/S0006295223002034
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    Bufalin suppresses esophageal squamous cell carcinoma progression by activating the PIAS3/STAT3 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10183519/
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    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
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    Rewiring the Regenerated Zebrafish Retina: Reemergence of Bipolar Neurons and Cone-Bipolar Circuitry Following an Inner Retinal Lesion
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    DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β
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    Bovine blastocyst-like structures derived from stem cell cultures
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    Exercise-derived peptide protects against pathological cardiac remodeling
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    Premorbid use of selective beta-blockers improves sepsis incidence and course: Human cohort and animal model studies
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    LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration
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    Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
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  62. Apr 2023
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    Inter-organ insulin-leptin signal crosstalk from the liver enhances survival during food shortages
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    Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
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    Casein kinase 1α is required to maintain murine hypothalamic POMC expression
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    Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    A tissue injury sensing and repair pathway distinct from host pathogen defense
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    The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
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    CX3CR1hi macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue
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    IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104468/
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    STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease
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    Transneuronal Delivery of Cytokines to Stimulate Mammalian Spinal Cord Regeneration
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    IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
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    Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis
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  76. Mar 2023
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    SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression
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    FDA-approved Abl/EGFR/PDGFR kinase inhibitors show potent efficacy against pandemic and seasonal influenza A virus infections of human lung explants
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    ncbi.nlm.nih.gov/pmc/articles/PMC10034449/
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    Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells
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    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    Phosphoenolpyruvate regulates the Th17 transcriptional program and inhibits autoimmunity
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  83. Feb 2023
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    Genetic Val66Met BDNF Variant Increases Hyperphagia on Fat-rich Diets in Mice
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux
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    Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling
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    Reversal of malignant ADAR1 splice isoform switching with Rebecsinib
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    Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer
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  91. Jan 2023
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    Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9852934/
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    Remodeling Chondroitin-6-Sulfate–Mediated Immune Exclusion Enhances Anti–PD-1 Response in Colorectal Cancer with Microsatellite Stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC9414301/
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    CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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    ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
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  97. Dec 2022
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