466 Matching Annotations
  1. Dec 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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    1. scibot 02 Dec 2022
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    sciencedirect.com/science/article/pii/S1535610822005529
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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    ncbi.nlm.nih.gov/pmc/articles/PMC9708799/
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    Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation
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    sciencedirect.com/science/article/pii/S2211124722016199
  5. Nov 2022
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    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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    1. scibot 16 Nov 2022
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      DOI: 10.1016/j.neuron.2022.10.028

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    sciencedirect.com/science/article/pii/S0896627322009618
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    sciencedirect.com/science/article/pii/S2352345X22001989
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    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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    sciencedirect.com/science/article/pii/S2352396422004947
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Niraparib-induced STAT3 inhibition increases its antitumor effects
    1
    1. scibot 04 Nov 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9618811/
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
    1
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    onlinelibrary.wiley.com/doi/10.1002/glia.24292
  11. Oct 2022
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    The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice
    2
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    sciencedirect.com/science/article/pii/S1550413122004090
  13. Sep 2022
  14. www.sciencedirect.com www.sciencedirect.com
    Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin
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    1. scibot 21 Sep 2022
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    sciencedirect.com/science/article/pii/S221112472201227X
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    Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury
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    1. scibot 20 Sep 2022
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      DOI: 10.14814/phy2.15468

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    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
    1
    1. scibot 13 Sep 2022
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    sciencedirect.com/science/article/pii/S2666379122002932
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic remodeling by vitamin C potentiates plasma cell differentiation
    1
    1. scibot 09 Sep 2022
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      DOI: 10.7554/eLife.73754

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    ncbi.nlm.nih.gov/pmc/articles/PMC9451539/
  18. Aug 2022
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    1. scibot 31 Aug 2022
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    sciencedirect.com/science/article/pii/S2211124722010865
  20. 52.53.155.43 52.53.155.43
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    52.53.155.43/c4d56db1e6e5c8b1ff3e886498341985c378d3ad/1960-html.html
  21. aacrjournals.org aacrjournals.org
    Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
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    1. scibot 27 Aug 2022
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    aacrjournals.org/cancerdiscovery/article/12/8/1960/707258/IL27-Signaling-Serves-as-an-Immunologic-Checkpoint
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
    1
    1. scibot 26 Aug 2022
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      DOI: 10.1016/j.stem.2022.08.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC9438971/
  23. Jul 2022
  24. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
    1
    1. scibot 29 Jul 2022
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    52.53.155.43/eeb521b7ce9ed18aede2526ed77220c5d9e406f5/British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
    1
    1. scibot 12 Jul 2022
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      DOI: 10.3390/cancers14133152

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    ncbi.nlm.nih.gov/pmc/articles/PMC9264918/
  26. Jun 2022
  27. www.sciencedirect.com www.sciencedirect.com
    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
    1
    1. scibot 25 Jun 2022
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      DOI: 10.1016/j.molcel.2022.06.005

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    sciencedirect.com/science/article/pii/S109727652200541X
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    IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
    1
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    sciencedirect.com/science/article/pii/S1534580722003707
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
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    ncbi.nlm.nih.gov/pmc/articles/PMC8716669/
  30. academic.oup.com academic.oup.com
    Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility
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      DOI: 10.1210/endocr/bqac047

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    academic.oup.com/endo/article-abstract/163/5/bqac047/6565906
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  32. Apr 2022
  33. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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    1. scibot 20 Apr 2022
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      DOI: 10.1016/j.immuni.2022.03.018

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    sciencedirect.com/science/article/pii/S1074761322001418
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    EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
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    1. scibot 15 Apr 2022
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      DOI: 10.1016/j.isci.2022.104193

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    sciencedirect.com/science/article/pii/S2589004222004631
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
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    ncbi.nlm.nih.gov/pmc/articles/PMC8990213/
  36. aacrjournals.org aacrjournals.org
    Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
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      DOI: 10.1158/1541-7786.MCR-21-0366

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    aacrjournals.org/mcr/article/20/3/456/681666/Chk1-Inhibition-Potently-Blocks-STAT3-Tyrosine705
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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    sciencedirect.com/science/article/pii/S1074761322001315
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas
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      DOI: 10.3389/fimmu.2022.824586

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    ncbi.nlm.nih.gov/pmc/articles/PMC8966496/
  39. Mar 2022
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    Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
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    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    sciencedirect.com/science/article/pii/S1097276522002076
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    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    sciencedirect.com/science/article/pii/S2211124722002066
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    A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
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    sciencedirect.com/science/article/pii/S1074761322000838
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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      DOI: 10.1007/s00418-022-02091-3

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    link.springer.com/article/10.1007/s00418-022-02091-3
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    Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling
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      DOI: 10.1016/j.isci.2022.103833

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    sciencedirect.com/science/article/pii/S2589004222001031
  46. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway
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      DOI: 10.1111/bph.15806

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15806
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
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      DOI: 10.1002/jnr.25036

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  48. Feb 2022
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    Ligand-mediated PAI-1 inhibition in a mouse model of peritoneal carcinomatosis
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    Deletion of PTP 1B from Brain Neurons Partly Protects Mice from Diet-Induced Obesity and Minimally Improves Fertility
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    PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD
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    Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain
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    Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring
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  66. Oct 2021
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    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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    Suppression of Leptin Transport Into the Brain Contributes to Leptin Resistance During Pregnancy in the Mouse
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    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
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    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway
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  97. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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      DOI: 10.1016/j.neuron.2018.10.031

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  98. www.sciencedirect.com www.sciencedirect.com
    Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons
    1
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  99. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
    2
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      DOI: 10.1002/stem.2744

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  100. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways
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  101. www.sciencedirect.com www.sciencedirect.com
    Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
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  102. academic.oup.com academic.oup.com
    Dopamine Neuron–Restricted Leptin Receptor Signaling Reduces Some Aspects of Food Reward but Exacerbates the Obesity of Leptin Receptor–Deficient Male Mice
    2
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      DOI: 10.1210/en.2017-00513

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      DOI: 10.1210/en.2017-00513

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  103. www.sciencedirect.com www.sciencedirect.com
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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide
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  105. academic.oup.com academic.oup.com
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  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin regulates POMC neuronal plasticity to control glucose metabolism
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      RRID:AB_10694804

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  107. jlb.onlinelibrary.wiley.com jlb.onlinelibrary.wiley.com
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  108. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
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      RRID:AB_561305

      DOI: 10.1016/j.expneurol.2018.02.012

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  109. academic.oup.com academic.oup.com
    Perinatal Exposure to Low-Dose Bisphenol-A Disrupts the Structural and Functional Development of the Hypothalamic Feeding Circuitry
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      AB_10140371

      DOI: 10.1210/en.2016-1718

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  110. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
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  111. www.sciencedirect.com www.sciencedirect.com
    Coupling of GPR30 mediated neurogenesis and protection with astroglial Aromatase-STAT3 signaling in rat hippocampus after global cerebral ischemia
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  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: interactions and redundancies with TNF and IL-6
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  113. Jun 2021
  114. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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  115. www.nature.com www.nature.com
    Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing
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  116. www.frontiersin.org www.frontiersin.org
    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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  119. May 2021
  120. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate
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      9145

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  121. www.nature.com www.nature.com
    Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure
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      DOI: 10.1038/s41398-021-01421-8

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  122. www.sciencedirect.com www.sciencedirect.com
    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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  123. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  124. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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  126. www.sciencedirect.com www.sciencedirect.com
    Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
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  127. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Binge‐Like Ethanol Drinking Activates ALK Signaling and Increases the Expression of STAT3 Target Genes in the Mouse Hippocampus and Prefrontal Cortex
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  128. www.sciencedirect.com www.sciencedirect.com
    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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  129. www.sciencedirect.com www.sciencedirect.com
    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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    Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
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    Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine
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  132. www.sciencedirect.com www.sciencedirect.com
    Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway
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    Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
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  134. Apr 2021
  135. www.sciencedirect.com www.sciencedirect.com
    Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma
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    Nanog is a promising chemo‐resistant stemness marker and therapeutic target by iron chelators for esophageal cancer
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  138. Mar 2021
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  140. Feb 2021
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    Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
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  142. www.nature.com www.nature.com
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA
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    Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity
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    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types
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    Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism
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    MyD88 in myofibroblasts enhances colitis-associated tumorigenesis via promoting macrophage M2 polarization
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  159. Jan 2021
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    Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
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    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network
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  162. Dec 2020
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    CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance
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    Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats
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  165. Nov 2020
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      anti-phospho-STAT3

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    Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling
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  168. Oct 2020
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    Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
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  174. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    Regional Variation in Epidermal Susceptibility to UV-Induced Carcinogenesis Reflects Proliferative Activity of Epidermal Progenitors
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    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization
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    Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation
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    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
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    Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease
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    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.cmet.2019.09.012

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2491009

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      RRID:AB_2491009 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413119305157
  221. www.sciencedirect.com www.sciencedirect.com
    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
    1
    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.ccell.2019.10.002

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2491009

      What is this?

      RRID:AB_2491009 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610819304763
  222. www.sciencedirect.com www.sciencedirect.com
    A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
    1
    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.devcel.2019.07.022

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2491009

      What is this?

      RRID:AB_2491009 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1534580719306288