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246 Matching Annotations

May 2021
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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

1
1. scibot 01 May 2021
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2021.02.001
  
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sciencedirect.com/science/article/pii/S1550413121000577
Apr 2021
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Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation

1
1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.109031
  
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sciencedirect.com/science/article/pii/S2211124721003454
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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

1
1. scibot 24 Apr 2021
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cell.2020.10.016
  
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sciencedirect.com/science/article/pii/S0092867420313222
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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2021.03.025
  
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sciencedirect.com/science/article/pii/S1550413121001662
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

1
1. scibot 06 Apr 2021
  
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  RRID:AB_2616025
  
  DOI: 10.7554/eLife.63326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

1
1. scibot 02 Apr 2021
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.molcel.2021.03.009
  
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sciencedirect.com/science/article/pii/S1097276521001775
Mar 2021
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Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

1
1. scibot 18 Mar 2021
  
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  RRID:AB_2616025
  
  DOI: 10.1007/s00204-021-03011-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7961173/
Dec 2020
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CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

1
1. scibot 16 Dec 2020
  
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  RRID:AB_2616025
  
  DOI: 10.7554/eLife.60771
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7728447/
Sep 2020
www.nature.com www.nature.com

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1038/s41467-020-16747-y
  
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nature.com/articles/s41467-020-16747-y
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A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2020.01.011
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7214782/
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1158/1078-0432.CCR-19-1900
  
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clincancerres.aacrjournals.org/content/26/13/3371
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The integrated stress response induces R-loops and hinders replication fork progression

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1038/s41419-020-2727-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7366693/
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Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.molcel.2020.06.005
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276520303907
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Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.celrep.2020.03.070
  
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sciencedirect.com/science/article/pii/S221112472030396X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity

1
1. scibot 09 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.neuron.2020.01.020
  
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  RRID:AB_2616025 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7272217/
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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase

1
1. scibot 07 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2020.03.008
  
  Resource: (Cell Signaling Technology Cat# 11815, RRID:AB_2616025)
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413120301236
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ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin

1
1. scibot 06 Sep 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.celrep.2020.107993
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720309785
Jan 2020
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.celrep.2019.07.086
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719310022
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Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2019.08.021
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413119304954
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Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.molcel.2019.11.008
  
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  RRID:AB_2616025 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519308378
www.embopress.org www.embopress.org

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.15252/emmm.201809423
  
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  RRID:AB_2616025 RRIDCUR:Validated
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embopress.org/doi/full/10.15252/emmm.201809423
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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2019.09.009
  
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sciencedirect.com/science/article/pii/S1550413119305121
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Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.molcel.2019.10.014
  
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sciencedirect.com/science/article/pii/S1097276519307920
onlinelibrary.wiley.com onlinelibrary.wiley.com

No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1111/jnc.14856
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14856
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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.ebiom.2019.08.033
  
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sciencedirect.com/science/article/pii/S2352396419305584
onlinelibrary.wiley.com onlinelibrary.wiley.com

Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1111/jnc.14887
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14887
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Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

1
1. scibot 13 Jan 2020
  
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  AB_2616025
  
  DOI: 10.1016/j.cellsig.2016.08.012
  
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sciencedirect.com/science/article/pii/S0898656816302108
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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.ccell.2019.01.018
  
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sciencedirect.com/science/article/pii/S1535610819300522
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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.ccell.2019.01.006
  
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sciencedirect.com/science/article/pii/S1535610819300406
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Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

1
1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.cmet.2019.01.020
  
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sciencedirect.com/science/article/pii/S1550413119300208
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.7554/eLife.42940
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6326728/
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.celrep.2019.02.037
  
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sciencedirect.com/science/article/pii/S2211124719302086
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_2616025
  
  DOI: 10.1016/j.celrep.2019.04.013
  
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sciencedirect.com/science/article/pii/S2211124719304681
Nov 2018
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Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia

1
1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S2211124718315973
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Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures

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sciencedirect.com/science/article/pii/S2451945618303301
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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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sciencedirect.com/science/article/pii/S1097276518305136
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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sciencedirect.com/science/article/pii/S0092867418305865
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GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death

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sciencedirect.com/science/article/pii/S2451945617304233
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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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Chemical hypoxia‐induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (NRF2)

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onlinelibrary.wiley.com/doi/10.1111/jnc.14270/full
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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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sciencedirect.com/science/article/pii/S153561081730555X
Nov 2017
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Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response

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academic.oup.com/endo/article/158/10/3162/4083504/Angiotensin-II-Causes-Cell-Dysfunction-Through-an
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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

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A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms

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sciencedirect.com/science/article/pii/S1550413117302905
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

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1. scibot 08 Nov 2017
  
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elifesciences.org/content/6/e20725
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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

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1. scibot 08 Nov 2017
  
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elifesciences.org/articles/23063