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May 2021
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MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases

1
1. scibot 09 May 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.str.2020.06.007
  
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sciencedirect.com/science/article/pii/S0969212620302100
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Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension

1
1. scibot 09 May 2021
  
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  DOI: 10.1016/j.stem.2020.11.002
  
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sciencedirect.com/science/article/pii/S1934590920305403
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

1
1. scibot 08 May 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.molcel.2020.10.021
  
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sciencedirect.com/science/article/pii/S1097276520307280
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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

1
1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.09.020
  
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sciencedirect.com/science/article/pii/S109727652030650X
www.cell.com www.cell.com

Evolving cryo-EM structural approaches for GPCR drug discovery

1
1. scibot 06 May 2021
  
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  DOI: 10.1016/j.str.2021.04.008
  
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cell.com/structure/fulltext/S0969-2126(21)00124-6
Apr 2021
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Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

1
1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.07.009
  
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sciencedirect.com/science/article/pii/S1550413120303673
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Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11

1
1. scibot 27 Apr 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.chembiol.2020.08.008
  
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sciencedirect.com/science/article/pii/S2451945620303056
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Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190

1
1. scibot 27 Apr 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.chembiol.2020.08.007
  
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sciencedirect.com/science/article/pii/S2451945620303044
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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.ccell.2020.08.015
  
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sciencedirect.com/science/article/pii/S1535610820304268
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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

1
1. scibot 19 Apr 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.molcel.2021.02.012
  
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sciencedirect.com/science/article/pii/S1097276521000988
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The dystonia gene THAP1 controls DNA double-strand break repair choice

1
1. scibot 15 Apr 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.molcel.2021.03.034
  
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sciencedirect.com/science/article/pii/S109727652100229X
Mar 2021
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Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

1
1. scibot 17 Mar 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.celrep.2021.108857
  
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sciencedirect.com/science/article/pii/S2211124721001716
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TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

1
1. scibot 17 Mar 2021
  
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  RRID:AB_2651127
  
  DOI: 10.7554/eLife.64456
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7946431/
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Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon

1
1. scibot 02 Mar 2021
  
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  RRID:AB_2651127
  
  DOI: 10.3389/fimmu.2021.600056
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7897682/
Feb 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

1
1. scibot 25 Feb 2021
  
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  IRDye 800CW‐conjugated anti‐rabbit
  
  DOI: 10.1111/jnc.15305
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15305
journals.physiology.org journals.physiology.org

Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3

1
1. scibot 24 Feb 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1152/ajpcell.00061.2019
  
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journals.physiology.org/doi/abs/10.1152/ajpcell.00061.2019
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Knockout of the CEP290 gene in human induced pluripotent stem cells

1
1. scibot 12 Feb 2021
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.scr.2021.102243
  
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sciencedirect.com/science/article/pii/S1873506121000891
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

1
1. scibot 13 Jan 2021
  
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  RRID:AB_2651127
  
  DOI: 10.7554/eLife.62518
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7790496/
Dec 2020
www.cell.com www.cell.com

APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival

1
1. scibot 19 Dec 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.neuron.2020.08.011
  
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cell.com/neuron/abstract/S0896-6273(20)30642-5
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Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3

1
1. scibot 07 Dec 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1152/ajpcell.00061.2019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6962522/
Oct 2020
onlinelibrary.wiley.com onlinelibrary.wiley.com

Heparan sulfate proteoglycan‐mediated dynamin‐dependent transport of neural stem cell exosomes in an in vitro blood‐brain barrier model

1
1. scibot 22 Oct 2020
  
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  rabbit
  
  DOI: 10.1111/ejn.14974
  
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onlinelibrary.wiley.com/doi/10.1111/ejn.14974
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Activation of the CARD8 Inflammasome Requires a Disordered Region

1
1. scibot 20 Oct 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.celrep.2020.108264
  
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pubmed.ncbi.nlm.nih.gov/33053349/
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Re-establishment of the epigenetic state and rescue of kinome deregulation in Ts65Dn mice upon treatment with green tea extract and environmental enrichment

1
1. scibot 17 Oct 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1038/s41598-020-72625-z
  
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nature.com/articles/s41598-020-72625-z
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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

1
1. scibot 01 Oct 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.cell.2020.09.032
  
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cell.com/cell/fulltext/S0092-8674(20)31229-0
Sep 2020
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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

1
1. scibot 25 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.immuni.2020.03.009
  
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sciencedirect.com/science/article/pii/S1074761320301229
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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.celrep.2020.107780
  
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sciencedirect.com/science/article/pii/S2211124720307609
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Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.chembiol.2020.04.002
  
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sciencedirect.com/science/article/pii/S2451945620301161
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Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

1
1. scibot 17 Sep 2020
  
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  AB_2651127
  
  DOI: 10.1016/j.molcel.2020.03.004
  
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sciencedirect.com/science/article/pii/S1097276520301520
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Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.devcel.2020.01.011
  
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sciencedirect.com/science/article/pii/S1534580720300125
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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

1
1. scibot 17 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.chembiol.2020.02.003
  
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sciencedirect.com/science/article/pii/S2451945620300672
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A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

1
1. scibot 16 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1038/s41467-020-16747-y
  
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nature.com/articles/s41467-020-16747-y
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Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

1
1. scibot 15 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.celrep.2020.108087
  
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sciencedirect.com/science/article/pii/S2211124720310767
www.cell.com www.cell.com

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

1
1. scibot 14 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.celrep.2018.12.023
  
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cell.com/cell-reports/abstract/S2211-1247(18)31953-3
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Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

1
1. scibot 13 Sep 2020
  
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  RRID:AB_2651127
  
  DOI: 10.1016/j.stem.2019.12.015
  
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Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

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Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice

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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

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Transcriptomic and proteomic profiling of glial versus neuronal Dube3a overexpression reveals common molecular changes in gliopathic epilepsies

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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

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Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3 | American Journal of Physiology-Cell Physiology

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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Dopamine Signaling in the Suprachiasmatic Nucleus Enables Weight Gain Associated with Hedonic Feeding

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Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α

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Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters

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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

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53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer

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DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns

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Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke

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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting

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The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development

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Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks

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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

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ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells

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Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

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Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

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Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential

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[18F]FMPEP-d2 PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer’s disease

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Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family

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The Rheumatoid Arthritis-Associated Citrullinome

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Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

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Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice

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Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division

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Epithelial Cell Adhesion Molecule Fragments and Signaling in Primary Human Liver Cells

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Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

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Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013–2016 Epidemic

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EGFR Dynamics Change during Activation in Native Membranes as Revealed by NMR

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Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment

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IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance

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