664 Matching Annotations
  1. Oct 2023
  2. 52.53.155.43 52.53.155.43
    ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
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    52.53.155.43/3932de370933c2759897a986a0751f177eee572e/2023.06.15.545148v1.full-html.html
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    sciencedirect.com/science/article/pii/S1535610823003185
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    sciencedirect.com/science/article/pii/S2211124723012147
  5. Sep 2023
  6. 52.53.155.43 52.53.155.43
    Neuronal AR regulates glucose homeostasis and energy expenditure in lean female mice with androgen excess
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    52.53.155.43/3879cee9653b10d45813ef8c7ed9945ed72f559d/bqad141-html.html
  7. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overfit deep neural network for predicting drug–target interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10480310/
  9. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    sciencedirect.com/science/article/pii/S2211124723010811
  10. Aug 2023
  11. www.sciencedirect.com www.sciencedirect.com
    RhoB Promotes Salmonella survival by Regulating Autophagy
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    sciencedirect.com/science/article/pii/S0171933523000730
  12. www.sciencedirect.com www.sciencedirect.com
    Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation
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    sciencedirect.com/science/article/pii/S0753332223011253
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    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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    biorxiv.org/content/10.1101/2023.08.21.554116v1
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC10433125/
  15. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    52.53.155.43/5c44b570825d260ed49e3beddaa9d47779a57883/PIIS2211124723009488-html.html
  16. 52.53.155.43 52.53.155.43
    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    52.53.155.43/1bbe45cf5b4e78c7829bbc8558904ff45b580eb3/PIIS2211124723009956-html.html
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    Proteogenomic insights suggest druggable pathways in endometrial carcinoma
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    sciencedirect.com/science/article/pii/S1535610823002477
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004223015547
  20. Jul 2023
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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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    sciencedirect.com/science/article/pii/S2589004223013883
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
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    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
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    sciencedirect.com/science/article/abs/pii/S1550413123002267
  24. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
  25. dx.doi.org dx.doi.org
    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    dx.doi.org/10.1158/1535-7163.MCT-22-0224
  26. 52.53.155.43 52.53.155.43
    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    52.53.155.43/bc4680180070caa480cb7798e020596a841eb63c/ajpendo.00329.2022-html.html
  27. journals.physiology.org journals.physiology.org
    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    journals.physiology.org/doi/10.1152/ajpendo.00329.2022
  28. 52.53.155.43 52.53.155.43
    mct-22-0224 (1)-html.html
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  29. 52.53.155.43 52.53.155.43
    cd-22-0411-html.html
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    52.53.155.43/453457acda6208aed297e8061921a5c2d2ddddf2/cd-22-0411-html.html
  30. Jun 2023
  31. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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    nature.com/articles/s41467-023-39241-7
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
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    ncbi.nlm.nih.gov/pmc/articles/PMC10276015/
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    sciencedirect.com/science/article/pii/S1550413123002097
  34. 52.53.155.43 52.53.155.43
    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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    52.53.155.43/505020cd5ddad21196b5171a72c7e74f4f7d8201/bqad091-html.html
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10233788/
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    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124723005922
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    Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA
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    sciencedirect.com/science/article/pii/S0197018623000785
  38. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  39. May 2023
  40. www.sciencedirect.com www.sciencedirect.com
    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    sciencedirect.com/science/article/pii/S2211124723005739
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    sciencedirect.com/science/article/pii/S2211124723005818
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    Impacts of High Fructose Diet and Chronic Exercise on Nitric Oxide Synthase and Oxidative Stress in Rat Kidney
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    mdpi.com/2072-6643/15/10/2322
  43. www.sciencedirect.com www.sciencedirect.com
    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    sciencedirect.com/science/article/pii/S2211124723005478
  44. 52.53.155.43 52.53.155.43
    PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis
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    52.53.155.43/bdf89ee8b17f684d89776b136763c0415969fc5a/RRID9-html.html
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10185814/
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Dihydroartemisinin inhibited stem cell-like properties and enhanced oxaliplatin sensitivity of colorectal cancer via AKT/mTOR signaling
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    onlinelibrary.wiley.com/doi/10.1002/ddr.22067
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  48. link.springer.com link.springer.com
    Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis
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    link.springer.com/article/10.1186/s12974-023-02784-z
  49. Apr 2023
  50. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    sciencedirect.com/science/article/pii/S2211124723004473
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    Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit
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    sciencedirect.com/science/article/pii/S2589004223007381
  52. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
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    sciencedirect.com/science/article/pii/S0896627323002635
  53. www.sciencedirect.com www.sciencedirect.com
    Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes
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    sciencedirect.com/science/article/pii/S2211124723004448
  54. www.sciencedirect.com www.sciencedirect.com
    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    sciencedirect.com/science/article/pii/S1550413123001262
  55. www.biorxiv.org www.biorxiv.org
    RhoB promotes Salmonella survival by regulating autophagy
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    biorxiv.org/content/10.1101/2023.04.05.535690v1
  56. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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    nature.com/articles/s41416-023-02264-4
  57. link.springer.com link.springer.com
    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
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    link.springer.com/article/10.1186/s12935-023-02884-z
  58. www.sciencedirect.com www.sciencedirect.com
    AKT activity orchestrates marginal zone B cell development in mice and humans
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    sciencedirect.com/science/article/pii/S2211124723003893
  59. www.sciencedirect.com www.sciencedirect.com
    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    sciencedirect.com/science/article/pii/S2589004223006181
  60. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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    iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2722
  61. www.sciencedirect.com www.sciencedirect.com
    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    sciencedirect.com/science/article/pii/S2211124723003522
  62. Mar 2023
  63. www.sciencedirect.com www.sciencedirect.com
    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    sciencedirect.com/science/article/pii/S2211124723003078
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise-acclimated microbiota improves skeletal muscle metabolism via circulating bile acid deconjugation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10005909/
  66. Feb 2023
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRF3 activates mTORC1 arginine-dependently for cancer cell viability
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    ncbi.nlm.nih.gov/pmc/articles/PMC9932127/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  69. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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    sciencedirect.com/science/article/pii/S1535610823000077
  70. www.sciencedirect.com www.sciencedirect.com
    Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle
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    sciencedirect.com/science/article/pii/S0016648023000369
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    ncbi.nlm.nih.gov/pmc/articles/PMC9887205/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  73. Jan 2023
  74. www.sciencedirect.com www.sciencedirect.com
    Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development
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    sciencedirect.com/science/article/pii/S1074761322006033
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect
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    ncbi.nlm.nih.gov/pmc/articles/PMC9838174/
  76. www.sciencedirect.com www.sciencedirect.com
    Glutamine and leucine administration attenuates muscle atrophy in sepsis
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    sciencedirect.com/science/article/pii/S002432052201027X
  77. www.sciencedirect.com www.sciencedirect.com
    SLC7A14 imports GABA to lysosomes and impairs hepatic insulin sensitivity via inhibiting mTORC2
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    sciencedirect.com/science/article/pii/S2211124722018885
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9306355/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine
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    ncbi.nlm.nih.gov/pmc/articles/PMC9414303/
  80. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP283959
  81. Dec 2022
  82. www.mdpi.com www.mdpi.com
    Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory
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    mdpi.com/1422-0067/24/1/508
  83. academic.oup.com academic.oup.com
    Membrane Estrogen Receptor Beta is Sufficient to Mitigate Cardiac Cell Pathology
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    academic.oup.com/endo/article/164/2/bqac200/6867852
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    sciencedirect.com/science/article/pii/S2211124722017132
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    The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
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    sciencedirect.com/science/article/pii/S2211124722016916
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    Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis
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    sciencedirect.com/science/article/pii/S2211124722016205
  87. Nov 2022
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Downregulation of protein kinase C gamma reduces epithelial property and enhances malignant phenotypes in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9672935/
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    Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling
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    sciencedirect.com/science/article/pii/S1534580722007638
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    Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier
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    sciencedirect.com/science/article/pii/S2667237522002351
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    CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway
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    academic.oup.com/endo/article-abstract/163/12/bqac171/6761323
  92. academic.oup.com academic.oup.com
    Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac595/6761325
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    sciencedirect.com/science/article/pii/S2352345X22001989
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    sciencedirect.com/science/article/pii/S2589004222014560
  95. www.nature.com www.nature.com
    DHODH inhibition impedes glioma stem cell proliferation, induces DNA damage, and prolongs survival in orthotopic glioblastoma xenografts
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    nature.com/articles/s41388-022-02517-1
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    Disruption of mTORC1 rescues neuronal overgrowth and synapse function dysregulated by Pten loss
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