935 Matching Annotations
  1. Feb 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Sphingolipid metabolism controls mammalian heart regeneration
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    sciencedirect.com/science/article/pii/S1550413124000172
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10870818/
  4. content.iospress.com content.iospress.com
    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    content.iospress.com/articles/journal-of-alzheimers-disease/jad221058
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    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10864204/
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    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    52.53.155.43/6951e0010ae4c14df11b3315f954e81c6a9c88a4/bqae015-html.html
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    A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10847737/
  8. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
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    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
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    ncbi.nlm.nih.gov/pmc/articles/PMC10845070/
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin-treated rats
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    onlinelibrary.wiley.com/doi/10.1002/brb3.3398
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
  12. Jan 2024
  13. www.nature.com www.nature.com
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    nature.com/articles/s41388-024-02947-z
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
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    Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival
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    sciencedirect.com/science/article/pii/S2589004224000166
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    Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis
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    link.springer.com/article/10.1038/s41416-023-02556-9
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770728/
  19. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  20. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Simulated altitude is medicine: intermittent exposure to hypobaric hypoxia and cold accelerates injured skeletal muscle recovery
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285398
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    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9799154/
  22. Dec 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    sciencedirect.com/science/article/pii/S2211124723015723
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    MORG1 limits mTORC1 signaling by inhibiting Rag GTPases
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    sciencedirect.com/science/article/pii/S1097276523009681
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amniotic MSC affect CD8 naive polarization toward SLEC/MPEC subsets by down-modulating IL-12Rβ1 and IL-2Rα signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10709131/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
  27. Nov 2023
  28. www.sciencedirect.com www.sciencedirect.com
    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    sciencedirect.com/science/article/pii/S2211124723013864
  29. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
  30. www.sciencedirect.com www.sciencedirect.com
    Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway
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    sciencedirect.com/science/article/pii/S2405844023100089
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    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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  32. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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    embopress.org/doi/full/10.15252/embr.202357339
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  35. Oct 2023
  36. academic.oup.com academic.oup.com
    Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice
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    academic.oup.com/endo/article-abstract/164/11/bqad151/7332055
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    Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    sciencedirect.com/science/article/pii/S1934590923003594
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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    sciencedirect.com/science/article/pii/S002839082300357X
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10585400/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic safety profile of pancreatic cancer‑bearing mice fed a ketogenic diet in combination with gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10561147/
  42. aiche.onlinelibrary.wiley.com aiche.onlinelibrary.wiley.com
    Mechanochemical coupling of MGF mediates periodontal regeneration
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    aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
  43. 52.53.155.43 52.53.155.43
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  44. www.cell.com www.cell.com
    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    cell.com/cell-reports/abstract/S2211-1247(23)01014-8
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  46. Sep 2023
  47. www.sciencedirect.com www.sciencedirect.com
    TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice
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    sciencedirect.com/science/article/pii/S0925443923002624
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos
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    ncbi.nlm.nih.gov/pmc/articles/PMC10509694/
  49. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Horie-html.html
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    British J Pharmacology - 2023 - Yin-html.html
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  51. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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    physoc.onlinelibrary.wiley.com/doi/10.1113/EP091284
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RLY-4008, the first highly selective FGFR2 inhibitor with activity across FGFR2 alterations and resistance mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10481131/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overfit deep neural network for predicting drug–target interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10480310/
  54. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  55. Aug 2023
  56. www.sciencedirect.com www.sciencedirect.com
    RhoB Promotes Salmonella survival by Regulating Autophagy
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    sciencedirect.com/science/article/pii/S0171933523000730
  57. www.science.org www.science.org
    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
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    Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation
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    sciencedirect.com/science/article/pii/S0753332223011253
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC10433125/
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    Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation
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  61. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    Proteogenomic insights suggest druggable pathways in endometrial carcinoma
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    sciencedirect.com/science/article/pii/S1097276523005580
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  70. Jul 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
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    Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development
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    sciencedirect.com/science/article/abs/pii/S1534580723003349
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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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    sciencedirect.com/science/article/pii/S2589004223013883
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
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    ncbi.nlm.nih.gov/pmc/articles/PMC10361714/
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
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    GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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    Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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  85. journals.physiology.org journals.physiology.org
    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    journals.physiology.org/doi/10.1152/ajpendo.00329.2022
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
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  89. Jun 2023
  90. www.sciencedirect.com www.sciencedirect.com
    Identification of XAF1 as an endogenous AKT inhibitor
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  91. bmcendocrdisord.biomedcentral.com bmcendocrdisord.biomedcentral.com
    Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner
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    bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-018-0266-y
  92. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
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