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May 2021
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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

1
1. scibot 08 May 2021
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.molcel.2021.02.038
  
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sciencedirect.com/science/article/pii/S1097276521001684
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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

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1. scibot 08 May 2021
  
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  DOI: 10.1016/j.molcel.2020.10.021
  
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sciencedirect.com/science/article/pii/S1097276520307280
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TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology

1
1. scibot 07 May 2021
  
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  DOI: 10.1016/j.molcel.2020.10.018
  
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sciencedirect.com/science/article/pii/S1097276520307255
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Decreased Expression of the Host Long-Noncoding RNA-GM Facilitates Viral Escape by Inhibiting the Kinase activity TBK1 via S-glutathionylation

1
1. scibot 07 May 2021
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.immuni.2020.11.010
  
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sciencedirect.com/science/article/pii/S1074761320304970
Apr 2021
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Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

1
1. scibot 15 Apr 2021
  
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  DOI: 10.1016/j.immuni.2021.03.011
  
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sciencedirect.com/science/article/pii/S1074761321001230
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Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

1
1. scibot 07 Apr 2021
  
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  DOI: 10.1016/j.cmet.2021.03.006
  
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sciencedirect.com/science/article/pii/S1550413121001133
Mar 2021
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Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

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1. scibot 19 Mar 2021
  
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  DOI: 10.1016/j.cels.2021.02.004
  
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sciencedirect.com/science/article/pii/S2405471221000788
Feb 2021
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Disruption of DNA polymerase ζ engages an innate immune response

1
1. scibot 25 Feb 2021
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2021.108775
  
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sciencedirect.com/science/article/pii/S2211124721000887
Jan 2021
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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

1
1. scibot 20 Jan 2021
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2020.108631
  
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sciencedirect.com/science/article/pii/S221112472031620X
Dec 2020
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Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

1
1. scibot 12 Dec 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2020.108490
  
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sciencedirect.com/science/article/pii/S2211124720314790
Sep 2020
elifesciences.org elifesciences.org

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

1
1. scibot 26 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.7554/eLife.60637
  
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elifesciences.org/articles/60637
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
1. scibot 26 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2020.03.056
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720303703
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Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity

1
1. scibot 25 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.molcel.2020.06.020
  
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  RRIDCUR:Validated RRID:AB_823547
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sciencedirect.com/science/article/pii/S1097276520304226
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The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

1
1. scibot 23 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.neuron.2020.03.005
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0896627320301914
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Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

1
1. scibot 16 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2020.108053
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112472031038X
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

1
1. scibot 10 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.immuni.2020.03.016
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1074761320301291
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactive oxygen species oxidize STING and suppress interferon production

1
1. scibot 10 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.7554/eLife.57837
  
  Resource: (Cell Signaling Technology Cat# 4947, RRID:AB_823547)
  
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  RRID:AB_823547 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7473769/
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Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1

1
1. scibot 04 Sep 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2020.108044
  
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  RRIDCUR:Validated RRID:AB_823547
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sciencedirect.com/science/article/pii/S2211124720310299
jvi.asm.org jvi.asm.org

Middle East respiratory syndrome coronavirus nucleocapsid protein suppresses type I and type III interferon induction by targeting RIG-I signaling

1
1. scibot 03 Sep 2020
  
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  phospho-IRF3
  
  DOI: 10.1128/JVI.00099-20
  
  Resource: (Cell Signaling Technology Cat# 4947, RRID:AB_823547)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_823547
  
  Curator comments: Phospho-IRF-3 (Ser396) (4D4G) Rabbit mAb antibody Cell Signaling Technology Cat# 4947
  
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  RRIDCUR:Missing RRID:AB_823547
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jvi.asm.org/content/94/13/e00099-20
Jan 2020
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The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.chom.2019.08.010
  
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sciencedirect.com/science/article/pii/S1931312819304196
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.cell.2019.05.035
  
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sciencedirect.com/science/article/pii/S009286741930563X
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MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses

1
1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2019.07.085
  
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sciencedirect.com/science/article/pii/S2211124719310010
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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.ccell.2019.11.003
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610819305239
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.cell.2019.05.003
  
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sciencedirect.com/science/article/pii/S009286741930501X
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Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2019.07.081
  
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sciencedirect.com/science/article/pii/S2211124719309854
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.immuni.2019.11.015
  
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sciencedirect.com/science/article/pii/S1074761319304960
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.immuni.2019.01.014
  
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sciencedirect.com/science/article/pii/S1074761319300378
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Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2019.04.071
  
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sciencedirect.com/science/article/pii/S2211124719305443
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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.immuni.2018.12.013
  
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sciencedirect.com/science/article/pii/S1074761318305612
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Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS

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1. scibot 13 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.cels.2018.10.010
  
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  Curator: @Jmenke
  
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  RRID:AB_823547 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2405471218304356
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chom.2019.02.015
  
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sciencedirect.com/science/article/pii/S1931312819301118
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.celrep.2019.01.029
  
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sciencedirect.com/science/article/pii/S2211124719300385
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Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

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1. scibot 12 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.cell.2019.01.039
  
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sciencedirect.com/science/article/pii/S0092867419301023
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Untitled document

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1. scibot 12 Jan 2020
  
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  RRID:AB_823547
  
  DOI: 10.1016/j.cell.2019.03.046
  
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  Curator: @ethanbadger
  
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Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach

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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

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The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

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An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

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Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

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Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling

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By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation

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Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

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Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

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Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection

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Dampened STING-Dependent Interferon Activation in Bats

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Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

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The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling

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Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

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SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

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Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

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Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses

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Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

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The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

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The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

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