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May 2021
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TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs

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1. scibot 09 May 2021
  
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  DOI: 10.1016/j.molcel.2021.03.039
  
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sciencedirect.com/science/article/pii/S1097276521002343
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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

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1. scibot 05 May 2021
  
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  DOI: 10.1016/j.celrep.2021.109088
  
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sciencedirect.com/science/article/pii/S2211124721004216
Apr 2021
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Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-β Signaling

2
1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.11.010
  
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2. scibot 08 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.11.010
  
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sciencedirect.com/science/article/pii/S2451945620304736
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Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11

1
1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.008
  
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sciencedirect.com/science/article/pii/S2451945620303056
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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

1
1. scibot 23 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.04.047
  
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sciencedirect.com/science/article/pii/S0092867420305535
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

1
1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2021.02.016
  
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sciencedirect.com/science/article/pii/S1535610821001185
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MLL3 suppresses tumorigenesis through regulating TNS3 enhancer activity

1
1. scibot 13 Apr 2021
  
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  DOI: 10.1038/s41419-021-03647-2
  
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nature.com/articles/s41419-021-03647-2
aasldpubs.onlinelibrary.wiley.com aasldpubs.onlinelibrary.wiley.com

Deficiency of histone methyltransferase SETD2 in liver leads to abnormal lipid metabolism and hepatocarcinoma

1
1. scibot 09 Apr 2021
  
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  RRID:AB_823586
  
  DOI: 10.1002/hep.31594
  
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aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31594
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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

1
1. scibot 07 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108944
  
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sciencedirect.com/science/article/pii/S2211124721002588
Mar 2021
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On the role of p53 in the cellular response to aneuploidy

1
1. scibot 24 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108892
  
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sciencedirect.com/science/article/pii/S2211124721002060
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Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line

1
1. scibot 02 Mar 2021
  
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  p21 Waf1/Cip1
  
  DOI: 10.1016/j.jbc.2021.100475
  
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sciencedirect.com/science/article/pii/S0021925821002490
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MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage

1
1. scibot 01 Mar 2021
  
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  DOI: 10.1016/j.ccell.2020.12.010
  
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sciencedirect.com/science/article/pii/S1535610820306589
Feb 2021
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Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site

1
1. scibot 27 Feb 2021
  
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  DOI: 10.1016/j.ccell.2020.11.013
  
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sciencedirect.com/science/article/pii/S153561082030605X
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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

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1. scibot 25 Feb 2021
  
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  DOI: 10.1016/j.stem.2021.01.016
  
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sciencedirect.com/science/article/pii/S1934590921000163
Nov 2020
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 10 Nov 2020
  
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  RRID:AB_823586
  
  DOI: 10.1002/1878-0261.12820
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12820
Oct 2020
www.cell.com www.cell.com

Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

1
1. scibot 24 Oct 2020
  
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  AB_823586
  
  DOI: 10.1016/j.celrep.2020.108286
  
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cell.com/cell-reports/abstract/S2211-1247(20)31275-4
Sep 2020
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Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

1
1. scibot 30 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1038/s41598-020-71550-5
  
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nature.com/articles/s41598-020-71550-5
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RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

1
1. scibot 17 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.stem.2020.04.009
  
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sciencedirect.com/science/article/pii/S193459092030148X
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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

1
1. scibot 17 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1084/jem.20191340
  
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rupress.org/jem/article/217/5/e20191340/151561/Glioma-stem-like-cells-evade-interferon
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Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

1
1. scibot 17 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.celrep.2020.107533
  
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sciencedirect.com/science/article/pii/S2211124720304332
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

1
1. scibot 15 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.ccell.2020.01.011
  
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sciencedirect.com/science/article/pii/S1535610820300507
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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

1
1. scibot 14 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.ccell.2019.12.006
  
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sciencedirect.com/science/article/pii/S1535610819305768
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Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling

1
1. scibot 13 Sep 2020
  
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  p21
  
  DOI: 10.1210/clinem/dgaa366
  
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academic.oup.com/jcem/article/105/10/dgaa366/5859150
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Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

1
1. scibot 11 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.celrep.2020.108077
  
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sciencedirect.com/science/article/pii/S2211124720310627
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Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients

1
1. scibot 10 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1038/s12276-020-0413-1
  
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nature.com/articles/s12276-020-0413-1
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 09 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1111/bph.14981
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14981
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A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107897
  
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sciencedirect.com/science/article/pii/S2211124720308780
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Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics

1
1. scibot 06 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.1016/j.celrep.2020.107830
  
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sciencedirect.com/science/article/pii/S2211124720308111
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle

1
1. scibot 05 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.7554/eLife.51107
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7000218/
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Head and neck squamous cancer progression is marked by CLIC4 attenuation in tumor epithelium and reciprocal stromal upregulation of miR-142-3p, a novel post-transcriptional regulator of CLIC4

1
1. scibot 05 Sep 2020
  
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  DOI: 10.18632/oncotarget.27387
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6944452/
mcb.asm.org mcb.asm.org

Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity

1
1. scibot 03 Sep 2020
  
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  2947
  
  DOI: 10.1128/MCB.00122-20
  
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  Curator comments: p21 Waf1/Cip1 (12D1) Rabbit monoclonal antibody Cell Signaling Technology Cat# 2947
  
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mcb.asm.org/content/40/18/e00122-20
mcr.aacrjournals.org mcr.aacrjournals.org

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

1
1. scibot 03 Sep 2020
  
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  p21
  
  DOI: 10.1158/1541-7786.MCR-20-0024
  
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mcr.aacrjournals.org/content/18/8/1142
elifesciences.org elifesciences.org

Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

1
1. scibot 03 Sep 2020
  
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  RRID:AB_823586
  
  DOI: 10.7554/eLife.53367
  
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elifesciences.org/articles/53367
Jan 2020
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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.ebiom.2019.06.049
  
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Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

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Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma

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Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis

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Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

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The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21

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Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells

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PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells

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Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

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β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

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Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization

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Intrinsic Immunity Shapes Viral Resistance of Stem Cells

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Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug

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Metabolic Adaptation Establishes Disease Tolerance to Sepsis

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TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence

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Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

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Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a

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Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

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Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation

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