Hypothesis

329 Matching Annotations

Nov 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response

6
1. scibot 12 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
2. scibot 11 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
3. scibot 10 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
4. scibot 09 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
5. scibot 08 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
6. scibot 07 Nov 2024
  
  in Public
  
  Addgene_21915
  
  Traceback (most recent call last): File "create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers
  
  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11466874/
Oct 2024
aacrjournals.org aacrjournals.org

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

1
1. scibot 02 Oct 2024
  
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  plasmid_21915
  
  DOI: 10.1158/1541-7786.MCR-20-1022
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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aacrjournals.org/mcr/article/19/6/1063/672883/RAF-Mutant-Melanomas-Differentially-Depend-on-ERK2
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells

1
1. scibot 29 Sep 2024
  
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  21915
  
  DOI: 10.1016/j.redox.2024.103301
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11362800/
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

FEBS Press

1
1. scibot 27 Sep 2024
  
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  Plasmid_21915
  
  DOI: 10.1002/1878-0261.13714
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13714
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

1
1. scibot 18 Aug 2024
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1038/s41467-024-50882-0
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11289143/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of leukemia maintenance

1
1. scibot 13 Aug 2024
  
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  21915
  
  DOI: 10.1038/s41375-024-02322-7
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11286530/
www.nature.com www.nature.com

Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer

1
1. scibot 01 Aug 2024
  
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  RRID:Addgene_21915
  
  DOI: 10.1038/s41420-024-02111-2
  
  Resource: Addgene_21915
  
  Curator: @scibot
  
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nature.com/articles/s41420-024-02111-2
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MUC1-C Dependence for the Progression of Pancreatic Neuroendocrine Tumors Identifies a Druggable Target for the Treatment of This Rare Cancer

1
1. scibot 31 Jul 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.3390/biomedicines12071509
  
  Resource: Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11274714/
www.cell.com www.cell.com

DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1

1
1. scibot 18 Jul 2024
  
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  RRID:Addgene_21915
  
  DOI: 10.1016/j.celrep.2024.114368
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00696-X
www.tandfonline.com www.tandfonline.com

Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense

1
1. scibot 16 Jul 2024
  
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  RRID:Addgene_21915
  
  DOI: 10.1080/15548627.2024.2374692
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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tandfonline.com/doi/abs/10.1080/15548627.2024.2374692
www.cell.com www.cell.com

Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis

1
1. scibot 12 Jul 2024
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.celrep.2024.114431
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00760-5
Jun 2024
www.sciencedirect.com www.sciencedirect.com

Hypoxia-induced CTCF promotes EMT in breast cancer

1
1. scibot 21 Jun 2024
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1016/j.celrep.2024.114367
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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  RRID:Addgene_21915
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sciencedirect.com/science/article/pii/S2211124724006958
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth

1
1. scibot 21 Jun 2024
  
  in Public
  
  plasmid_21915
  
  DOI: 10.1038/s42003-024-06290-7
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11101626/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells

1
1. scibot 20 Jun 2024
  
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  21915
  
  DOI: 10.1038/s41467-024-49298-7
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11180199/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma

1
1. scibot 20 Jun 2024
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1038/s44321-024-00077-3
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11178789/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Highlights from MBoC Selection: SARS-CoV-2 Orf6 is positioned in the nuclear pore complex by Rae1 to inhibit nucleocytoplasmic transport

1
1. scibot 20 Jun 2024
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1091/mbc.E23-10-0386
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11151100/
May 2024
aacrjournals.org aacrjournals.org

Bile acid metabolism mediates cholesterol homeostasis and promotes tumorigenesis in clear cell renal cell carcinoma

2
1. scibot 23 May 2024
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1158/0008-5472.CAN-23-0821
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
2. scibot 23 May 2024
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1158/0008-5472.CAN-23-0821
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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aacrjournals.org/cancerres/article/84/10/1570/745316/Bile-Acid-Metabolism-Mediates-Cholesterol
www.sciencedirect.com www.sciencedirect.com

Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis

1
1. scibot 21 May 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.1016/j.cmet.2024.04.018
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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sciencedirect.com/science/article/pii/S1550413124001384
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis

2
1. scibot 19 May 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.1038/s41467-024-48330-0
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
2. scibot 19 May 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.1038/s41467-024-48330-0
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11096184/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

1
1. scibot 17 May 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.1038/s41419-024-06684-9
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11091074/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell Carcinomas

1
1. scibot 17 May 2024
  
  in Public
  
  Plasmid_21915
  
  DOI: 10.1158/2767-9764.CRC-24-0011
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11092937/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

1
1. scibot 17 May 2024
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1038/s41467-024-48386-y
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC11094136/
link.springer.com link.springer.com

Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium

1
1. scibot 15 May 2024
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1007/s10456-024-09927-7
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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  RRID:Addgene_21915
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link.springer.com/article/10.1007/s10456-024-09927-7
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The Janus kinase 1 is critical for pancreatic cancer initiation and progression

2
1. scibot 14 May 2024
  
  in Public
  
  Addgene, #21915
  
  DOI: 10.1016/j.celrep.2024.114202
  
  Resource: RRID:Addgene_21915
  
  Curator: @abever99
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
2. scibot 14 May 2024
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1016/j.celrep.2024.114202
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11194014/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RRP8, associated with immune infiltration, is a prospective therapeutic target in hepatocellular carcinoma

1
1. scibot 12 May 2024
  
  in Public
  
  Addgene_21
  
  DOI: 10.1007/s00432-024-05756-9
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Unresolved RRIDCUR:Incorrect
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ncbi.nlm.nih.gov/pmc/articles/PMC11082032/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors

1
1. scibot 05 May 2024
  
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  21915
  
  DOI: 10.1101/2024.04.15.589533
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042251/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2

1
1. scibot 05 May 2024
  
  in Public
  
  21,915
  
  DOI: 10.1186/s13287-024-03724-1
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11062916/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

1
1. scibot 05 May 2024
  
  in Public
  
  plasmid_21915
  
  DOI: 10.21203/rs.3.rs-4021568/v1
  
  Resource: RRID:Addgene_21915
  
  Curator: @scibot
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11042440/
www.biorxiv.org www.biorxiv.org

Glutaredoxin 3 (GLRX3) confers a fusion oncogene-dependent vulnerability to Ewing sarcoma

1
1. scibot 02 May 2024
  
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  plasmid_21915
  
  DOI: 10.1101/2024.04.24.590877
  
  Resource: RRID:Addgene_21915
  
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biorxiv.org/content/10.1101/2024.04.24.590877v1
Apr 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation

1
1. scibot 30 Apr 2024
  
  in Public
  
  plasmid_21
  
  DOI: 10.1186/s12943-024-01991-3
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRIDCUR:Incorrect RRID:Addgene_21915 RRIDCUR:Unresolved
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ncbi.nlm.nih.gov/pmc/articles/PMC11031964/
www.sciencedirect.com www.sciencedirect.com

RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

1
1. scibot 19 Apr 2024
  
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  AddgeneCat#21915
  
  DOI: 10.1016/j.celrep.2024.114116
  
  Resource: RRID:Addgene_21915
  
  Curator: @abever99
  
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sciencedirect.com/science/article/pii/S2211124724004443
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer

1
1. scibot 15 Apr 2024
  
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  21915
  
  DOI: 10.1038/s41467-024-46785-9
  
  Resource: RRID:Addgene_21915
  
  Curator: @olekpark
  
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  RRID:Addgene_21915
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ncbi.nlm.nih.gov/pmc/articles/PMC10954759/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

1
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Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells

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MUC1-C IS NECESSARY FOR SHP2 ACTIVATION AND BRAF INHIBITOR RESISTANCE IN BRAF(V600E) MUTANT COLORECTAL CANCER

1
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Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer

1
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Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature

1
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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

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PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

1
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The dePARylase NUDT16 promotes radiation resistance of cancer cells by blocking SETD3 for degradation via reversing its ADP-ribosylation

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SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells

3
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NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma

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SOX2 Expression Does Not Guarantee Cancer Stem Cell-like Characteristics in Lung Adenocarcinoma

1
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Heat shock factor 1 directly regulates transsulfuration pathway to promote prostate cancer proliferation and survival

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Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC

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MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells

1
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The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control

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A Novel Druggable Dual-Specificity tYrosine-Regulated Kinase3/Calmodulin Kinase-like Vesicle-Associated Signaling Module with Therapeutic Implications in Neuroblastoma

1
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Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a Myosin Vb Splice Variant and Rab10

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ncbi.nlm.nih.gov/pmc/articles/PMC10814003/
Dec 2023
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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

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A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment

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MUC1-C INTEGRATES AEROBIC GLYCOLYSIS WITH SUPPRESSION OF OXIDATIVE PHOSPHORYLATION IN TRIPLE-NEGATIVE BREAST CANCER STEM CELLS

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Oct 2023
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Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis

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52.53.155.43/dfd537dd38159a379f0051e34a95d721924018c7/Intl Journal of Cancer - 2023 - Yu - Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73-html.html
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TERRA R-loops connect and protect sister telomeres in mitosis

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Sep 2023
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Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

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RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells

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52.53.155.43 52.53.155.43

vdad120-html.html

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52.53.155.43/6d7222f39ce6ff806d6be40a37ce30f7488ce63a/vdad120-html.html
Aug 2023
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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

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Jul 2023
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Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

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52.53.155.43 52.53.155.43

cd-22-0411-html.html

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Jun 2023
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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

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Mar 2023
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Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers

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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad172/7079642
Feb 2023
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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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Nov 2022
52.53.155.43 52.53.155.43

Nuclear envelope protein LBR protects the genome from chromosomal instability and tumorigenesis

1
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Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

1
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ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance

1
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Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids

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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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Mar 2022
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A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

2
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IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth

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ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy

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RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia

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BRD9 is a critical regulator of androgen receptor signaling and prostate cancer progression

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Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance

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Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

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Untitled document

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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

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The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability

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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

1
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cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer

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Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

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cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
academic.oup.com academic.oup.com

Downregulation of ARID1B, a tumor-suppressor in the WNT subgroup medulloblastoma, activates multiple oncogenic signaling pathways

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academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab134/6265029
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Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth

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nature.com/articles/s42003-021-02075-4
Jun 2021
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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir

1
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Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

1
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ncbi.nlm.nih.gov/pmc/articles/PMC8192123/
May 2021
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NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4

1
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  DOI: 10.1126/sciadv.abf7114
  
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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

1
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SEED-MEDIATED RNA INTERFERENCE OF ANDROGEN SIGNALING AND SURVIVAL NETWORKS INDUCES CELL DEATH IN PROSTATE CANCER CELLS

1
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Mar 2021
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Calcium Wave Promotes Cell Extrusion

1
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Feb 2021
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Calcium Wave Promotes Cell Extrusion

1
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MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities

1
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  DOI: 10.1016/j.celrep.2020.02.041
  
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Sep 2020
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Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer

1
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Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma

1
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  DOI: 10.3390/cancers12092541
  
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Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

1
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  RRID:Addgene_21915
  
  DOI: 10.1186/s40170-019-0202-2
  
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journals.plos.org journals.plos.org

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration

1
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journals.plos.org/plospathogens/article
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
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The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

1
1. scibot 05 Sep 2020
  
  in Public
  
  Tet-pLKO-puro
  
  DOI: 10.1016/j.celrep.2020.107917
  
  Resource: RRID:Addgene_21915
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_21915
  
  Curator comments: Tet-pLKO-puro
  
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  RRID:Addgene_21915 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S2211124720308986
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Gli2 mediates the development of castration‑resistant prostate cancer

1
1. scibot 05 Sep 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.3892/ijo.2020.5044
  
  Resource: RRID:Addgene_21915
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7252461/
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Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

1
1. scibot 03 Sep 2020
  
  in Public
  
  pLKO-Tet-On vector
  
  DOI: 10.1016/j.cmet.2020.06.002
  
  Resource: RRID:Addgene_21915
  
  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_21915
  
  Curator comments: Tet-pLKO-puro
  
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  RRID:Addgene_21915 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S155041312030303X
Aug 2020
link.springer.com link.springer.com

Autophagy inhibition impairs the invasion potential of medulloblastoma cells

1
1. scibot 26 Aug 2020
  
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  RRID: Addgene_21915
  
  DOI: 10.1007/s11033-020-05603-3
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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link.springer.com/article/10.1007/s11033-020-05603-3
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

1
1. scibot 20 Aug 2020
  
  in Public
  
  Addgene ID: 21915
  
  DOI: 10.1016/j.cell.2020.05.053
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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sciencedirect.com/science/article/pii/S0092867420306863
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 15 Aug 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.ccell.2019.12.007
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915
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sciencedirect.com/science/article/pii/S153561081930577X
Jan 2020
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A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.celrep.2019.11.018
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124719314895
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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.celrep.2019.07.070
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112471930974X
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Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance

1
1. scibot 13 Jan 2020
  
  in Public
  
  plasmid_21915
  
  DOI: 10.1016/j.ebiom.2019.102612
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: plasmid_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2352396419308278
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Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.celrep.2018.12.043
  
  Resource: RRID:Addgene_21915
  
  Curator: @evieth
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718319739
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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

1
1. scibot 13 Jan 2020
  
  in Public
  
  plasmid_21915
  
  DOI: 10.1016/j.cmet.2018.12.020
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: plasmid_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1550413118307575
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Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1016/j.celrep.2018.12.013
  
  Resource: RRID:Addgene_21915
  
  Curator: @evieth
  
  SciCrunch record: Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124718319247
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Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer

1
1. scibot 13 Jan 2020
  
  in Public
  
  Addgene_21915
  
  DOI: 10.1016/j.devcel.2017.10.027
  
  Resource: RRID:Addgene_21915
  
  Curator: @Jmenke
  
  SciCrunch record: Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1534580717308717
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Untitled document

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:Addgene_21915
  
  DOI: 10.1016/j.ebiom.2019.01.064
  
  Resource: RRID:Addgene_21915
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:Addgene_21915
  
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  RRID:Addgene_21915 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2352396419300702

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