387 Matching Annotations
  1. Apr 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
  3. Mar 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    23ME-01473, an Fc Effector–Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell–Mediated Antitumor Immunity through NKG2D and FcγRIIIa Activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11927390/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11913393/
  6. www.sciencedirect.com www.sciencedirect.com
    Antibody-DNA nanostructure conjugate enables targeted delivery of gemcitabine to tumor and improves the anti-tumor efficacy
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    sciencedirect.com/science/article/pii/S0168365925002305
  7. aacrjournals.org aacrjournals.org
    Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy
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    aacrjournals.org/cancerimmunolres/article/13/3/400/752015/Blocking-WNT7A-Enhances-MHC-I-Antigen-Presentation
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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    sciencedirect.com/science/article/pii/S107476132500072X
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dynamic Tracking of Tumor Microenvironment Modulation Using Kaede Photoconvertible Transgenic Mice Unveils New Biological Properties of Viral Immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831061/
  10. Feb 2025
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics
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    pmc.ncbi.nlm.nih.gov/articles/PMC11842356/
  12. www.sciencedirect.com www.sciencedirect.com
    Potentiating anti-tumor immunity by re-engaging immune synapse molecules
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    sciencedirect.com/science/article/pii/S2666379125000485
  13. aacrjournals.org aacrjournals.org
    The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling
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    aacrjournals.org/cancerimmunolres/article/12/10/1438/748724/The-E3-Ubiquitin-Ligase-FBXO38-Maintains-the
  14. pubs.acs.org pubs.acs.org
    Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells
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    pubs.acs.org/doi/full/10.1021/acs.bioconjchem.4c00534
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    A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy
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    sciencedirect.com/science/article/pii/S2211124725000725
  16. 52.53.155.43 52.53.155.43
    can-24-1875-html.html
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  17. aacrjournals.org aacrjournals.org
    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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    aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
  18. Dec 2024
  19. www.cell.com www.cell.com
    Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity
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    cell.com/cancer-cell/abstract/S1535-6108(24)00476-8
  20. www.sciencedirect.com www.sciencedirect.com
    Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
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    sciencedirect.com/science/article/pii/S1074761324005417
  21. www.sciencedirect.com www.sciencedirect.com
    Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes
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    sciencedirect.com/science/article/pii/S0092867424013473
  22. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13763
  23. www.sciencedirect.com www.sciencedirect.com
    Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1535610824004021
  24. Nov 2024
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antagonistic roles of cGAS/STING signaling in colorectal cancer chemotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11513249/
  26. Oct 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC11452177/
  28. www.biorxiv.org www.biorxiv.org
    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
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    biorxiv.org/content/10.1101/2024.09.09.612140v1
  29. Sep 2024
  30. www.sciencedirect.com www.sciencedirect.com
    A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
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    sciencedirect.com/science/article/pii/S2666379124004774
  31. onlinelibrary.wiley.com onlinelibrary.wiley.com
    S100a8/a9 regulated by LPS/TLR4 axis plays an important role in Salmonella-based tumor therapy and host defense
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35128
  32. www.sciencedirect.com www.sciencedirect.com
    Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
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    sciencedirect.com/science/article/pii/S1535610824003180
  33. www.sciencedirect.com www.sciencedirect.com
    IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth
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    sciencedirect.com/science/article/pii/S0753332224012976
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Association of appendectomy with prognosis and tumor-associated macrophages in patients with colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11367569/
  35. www.sciencedirect.com www.sciencedirect.com
    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124724010416
  36. Aug 2024
  37. www.sciencedirect.com www.sciencedirect.com
    CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
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    sciencedirect.com/science/article/pii/S153561082400271X
  38. www.science.org www.science.org
    cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation
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    science.org/doi/10.1126/sciimmunol.adk2612
  39. www.sciencedirect.com www.sciencedirect.com
    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
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    sciencedirect.com/science/article/pii/S1931312824002713
  40. Jul 2024
  41. www.cell.com www.cell.com
    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
  42. www.sciencedirect.com www.sciencedirect.com
    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
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    sciencedirect.com/science/article/pii/S266637912400363X
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol to study the immune profile of syngeneic mouse tumor models
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    pmc.ncbi.nlm.nih.gov/articles/PMC11234017/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Tumor Microbiome Reacts to Hypoxia and Can Influence Response to Radiation Treatment in Colorectal Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11234499/
  45. Jun 2024
  46. www.sciencedirect.com www.sciencedirect.com
    Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1074761324002759
  47. www.sciencedirect.com www.sciencedirect.com
    De novo and salvage purine synthesis pathways across tissues and tumors
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    sciencedirect.com/science/article/pii/S0092867424005208
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  49. May 2024
  50. www.sciencedirect.com www.sciencedirect.com
    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    sciencedirect.com/science/article/pii/S1074761324002590
  51. www.sciencedirect.com www.sciencedirect.com
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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    sciencedirect.com/science/article/pii/S1074761324002309
  52. www.sciencedirect.com www.sciencedirect.com
    One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade
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    sciencedirect.com/science/article/pii/S2451945624001697
  53. www.sciencedirect.com www.sciencedirect.com
    IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy
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    sciencedirect.com/science/article/pii/S2666379124002593
  54. www.sciencedirect.com www.sciencedirect.com
    Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy
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    sciencedirect.com/science/article/pii/S0092867424004100
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC11067828/
  56. link.springer.com link.springer.com
    Fatty acid binding protein 5 suppression attenuates obesity-induced hepatocellular carcinoma by promoting ferroptosis and intratumoral immune rewiring
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    link.springer.com/article/10.1038/s42255-024-01019-6
  57. Apr 2024
  58. aacrjournals.org aacrjournals.org
    The immune suppressor IGSF1 as a potential target for cancer immunotherapy
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    aacrjournals.org/cancerimmunolres/article/12/4/491/741941/The-Immune-Suppressor-IGSF1-as-a-Potential-Target
  59. www.sciencedirect.com www.sciencedirect.com
    Extracellular vesicles derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer
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    sciencedirect.com/science/article/pii/S2589004224008344
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993987/
  61. Mar 2024
  62. www.nature.com www.nature.com
    The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer
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    nature.com/articles/s41598-024-57941-y
  63. www.sciencedirect.com www.sciencedirect.com
    Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming
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    sciencedirect.com/science/article/pii/S0304383524002179
  64. www.sciencedirect.com www.sciencedirect.com
    Phototruncation cell tracking with near-infrared photoimmunotherapy using heptamethine cyanine dye to visualise migratory dynamics of immune cells
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    sciencedirect.com/science/article/pii/S2352396424000859
  65. www.cell.com www.cell.com
    Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer
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    cell.com/cell/fulltext/S0092-8674(24)00224-1
  66. www.sciencedirect.com www.sciencedirect.com
    HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, −10 and −11
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    sciencedirect.com/science/article/pii/S0753332224003111
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neutralizing antibodies impair the oncolytic efficacy of reovirus but permit effective combination with T cell-based immunotherapies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10911706/
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FcγRIIB is an immune checkpoint limiting the activity of Treg-targeting antibodies in the tumor microenvironment
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    ncbi.nlm.nih.gov/pmc/articles/PMC10911703/
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851928/
  70. Feb 2024
  71. www.sciencedirect.com www.sciencedirect.com
    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124724001591
  72. www.sciencedirect.com www.sciencedirect.com
    Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells
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    sciencedirect.com/science/article/pii/S1074761324000451
  73. www.sciencedirect.com www.sciencedirect.com
    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    sciencedirect.com/science/article/pii/S2211124724001256
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10760207/
  75. Jan 2024
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased response to immune checkpoint inhibitors with dietary methionine restriction
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    ncbi.nlm.nih.gov/pmc/articles/PMC10104076/
  77. www.nature.com www.nature.com
    Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
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    nature.com/articles/s41420-023-01770-x
  78. www.sciencedirect.com www.sciencedirect.com
    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    sciencedirect.com/science/article/pii/S2211124724000160
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leukocyte-associated immunoglobulin-like receptor-1 blockade in combination with programmed death-ligand 1 targeting therapy mediates increased tumour control in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10796629/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541144/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10526448/
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Non-IL-2-blocking anti-CD25 antibody inhibits tumor growth by depleting Tregs and has synergistic effects with anti-CTLA-4 therapy
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34823
  83. www.sciencedirect.com www.sciencedirect.com
    Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
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    sciencedirect.com/science/article/pii/S1535610823004415
  84. www.sciencedirect.com www.sciencedirect.com
    Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy
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    sciencedirect.com/science/article/pii/S2666379123005724
  85. Dec 2023
  86. www.sciencedirect.com www.sciencedirect.com
    De novo NAD+ synthesis contributes to CD8+ T cell metabolic fitness and antitumor function
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    sciencedirect.com/science/article/pii/S2211124723015309
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC10772324/
  88. Nov 2023
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
  90. www.sciencedirect.com www.sciencedirect.com
    The antitumor activities of anti-CD47 antibodies require Fc-FcγR interactions
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    sciencedirect.com/science/article/pii/S153561082300363X
  91. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    sciencedirect.com/science/article/pii/S2451945623003719
  92. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fasting-mimicking diet drives antitumor immunity against colorectal cancer by reducing IgA-producing cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618736/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618741/
  95. Oct 2023
  96. www.sciencedirect.com www.sciencedirect.com
    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    sciencedirect.com/science/article/pii/S1550413123003674
  97. 52.53.155.43 52.53.155.43
    can-23-0025-html.html
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  98. 52.53.155.43 52.53.155.43
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  99. www.sciencedirect.com www.sciencedirect.com
    Immunological Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors
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    sciencedirect.com/science/article/pii/S2666364323001169
  100. Sep 2023
  101. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tumor cell-expressed lipolysis-stimulated lipoprotein receptor negatively regulates T-cell function
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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.34738
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10513502/
  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Loss of cancer cell-derived ADAM15 alters the tumor microenvironment in colorectal tumors
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  123. May 2023
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  182. Nov 2021
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  197. Jul 2021
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  201. May 2021
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  206. Apr 2021
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  209. Mar 2021
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  213. Feb 2021
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  215. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Regulation of immune cell metabolism by cancer cell oncogenic mutations
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    onlinelibrary.wiley.com/doi/10.1002/ijc.32888
  216. www.sciencedirect.com www.sciencedirect.com
    Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT)
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    sciencedirect.com/science/article/pii/S2352396421000335
  217. Dec 2020
  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells
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  219. Oct 2020
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    Myeloid TNF and HO‐1 regulate the progression of colorectal liver metastases during hepatic ischemia‐reperfusion
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33334
  221. Sep 2020
  222. www.cell.com www.cell.com
    Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade
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    cell.com/immunity/abstract/S1074-7613(19)30029-9
  223. Aug 2020
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    Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade
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  225. Jan 2020
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    Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
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  228. Nov 2017
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    Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
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