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268 Matching Annotations

Jan 2023
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Nucleosome dyad determines the H1 C-terminus collapse on distinct DNA arms

1
1. scibot 07 Jan 2023
  
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  DOI: 10.1016/j.str.2022.12.005
  
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sciencedirect.com/science/article/pii/S0969212622004919
Dec 2022
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Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

1
1. scibot 13 Dec 2022
  
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  DOI: 10.1016/j.str.2022.11.008
  
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sciencedirect.com/science/article/pii/S0969212622004579
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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

1
1. scibot 13 Dec 2022
  
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  DOI: 10.1038/s41594-022-00863-y
  
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nature.com/articles/s41594-022-00863-y
Nov 2022
www.cell.com www.cell.com

Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes

1
1. scibot 22 Nov 2022
  
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  DOI: 10.1016/j.cell.2022.10.030
  
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cell.com/cell/fulltext/S0092-8674(22)01376-9
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Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

1
1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.10.019
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9606073/
Oct 2022
elifesciences.org elifesciences.org

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

1
1. scibot 19 Oct 2022
  
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  DOI: 10.7554/eLife.79771
  
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elifesciences.org/articles/79771
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In situ structural analysis reveals membrane shape transitions during autophagosome formation

1
1. scibot 01 Oct 2022
  
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  DOI: 10.1073/pnas.2209823119
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9522377/
Sep 2022
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Aminomethanesulfonic acid illuminates the boundary between full and partial agonists of the pentameric glycine receptor

1
1. scibot 21 Sep 2022
  
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  DOI: 10.7554/eLife.79148
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9462852/
Aug 2022
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Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC

1
1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.cell.2022.07.010
  
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sciencedirect.com/science/article/pii/S0092867422009138
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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns

1
1. scibot 05 Aug 2022
  
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  DOI: 10.1016/j.chom.2022.07.002
  
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sciencedirect.com/science/article/pii/S1931312822003183
Jul 2022
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In situ architecture of the lipid transport protein VPS13C at ER–lysosome membrane contacts

1
1. scibot 27 Jul 2022
  
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  DOI: 10.1073/pnas.2203769119
  
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pnas.org/doi/10.1073/pnas.2203769119
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The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

1
1. scibot 06 Jul 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.isci.2022.104646
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9213009/
Jun 2022
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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex

1
1. scibot 10 Jun 2022
  
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  DOI: 10.1016/j.cell.2022.04.016
  
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sciencedirect.com/science/article/pii/S0092867422004639
Apr 2022
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RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex

1
1. scibot 27 Apr 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.celrep.2022.110732
  
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sciencedirect.com/science/article/pii/S2211124722004934
Mar 2022
www.cell.com www.cell.com

Facile discovery of surrogate cytokine agonists

1
1. scibot 31 Mar 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.cell.2022.02.025
  
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cell.com/cell/fulltext/S0092-8674(22)00247-1
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Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB

1
1. scibot 06 Mar 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.str.2022.02.007
  
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sciencedirect.com/science/article/pii/S0969212622000430
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Structure and ion-release mechanism of PIB-4-type ATPases

1
1. scibot 04 Mar 2022
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.73124
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8880997/
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Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance

1
1. scibot 04 Mar 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.molcel.2022.01.028
  
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sciencedirect.com/science/article/pii/S1097276522001046
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Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel

1
1. scibot 04 Mar 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.str.2022.02.005
  
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sciencedirect.com/science/article/pii/S0969212622000417
Feb 2022
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Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

1
1. scibot 16 Feb 2022
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.74437
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8830886/
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Naegleria’s mitotic spindles are built from unique tubulins and highlight core spindle features

2
1. scibot 11 Feb 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.cub.2022.01.034
  
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2. scibot 09 Feb 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.cub.2022.01.034
  
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sciencedirect.com/science/article/pii/S0960982222000458
elifesciences.org elifesciences.org

Structural basis of Plasmodium vivax inhibition by antibodies binding to the circumsporozoite protein repeats

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1. scibot 08 Feb 2022
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.72908
  
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elifesciences.org/articles/72908
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Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family

1
1. scibot 04 Feb 2022
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.74589
  
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elifesciences.org/articles/74589
Jan 2022
elifesciences.org elifesciences.org

Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

1
1. scibot 28 Jan 2022
  
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  RRID:SCR_015872v1
  
  DOI: 10.7554/eLife.72629
  
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elifesciences.org/articles/72629
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Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

1
1. scibot 26 Jan 2022
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.74512
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8776254/
link.springer.com link.springer.com

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

1
1. scibot 08 Jan 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1186/s12915-021-01220-z
  
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link.springer.com/article/10.1186/s12915-021-01220-z
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

1
1. scibot 05 Jan 2022
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.celrep.2021.110210
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8673750/
Oct 2021
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Structural characterization of NrnC identifies unifying features of dinucleotidases

1
1. scibot 08 Oct 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.70146
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8492067/
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TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

1
1. scibot 02 Oct 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.71474
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8480983/
Sep 2021
elifesciences.org elifesciences.org

Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

1
1. scibot 30 Sep 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.71420
  
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elifesciences.org/articles/71420
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Regulation of human mTOR complexes by DEPTOR

1
1. scibot 18 Sep 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.70871
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8439649/
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

1
1. scibot 18 Sep 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.68799
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8439657/
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Clathrin packets move in slow axonal transport and deliver functional payloads to synapses

1
1. scibot 18 Sep 2021
  
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  DOI: 10.1016/j.neuron.2021.08.016
  
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sciencedirect.com/science/article/pii/S0896627321006139
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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes

1
1. scibot 08 Sep 2021
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.str.2021.08.002
  
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sciencedirect.com/science/article/pii/S0969212621002975
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High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor

1
1. scibot 01 Sep 2021
  
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  RRID:SCR_015872
  
  DOI: 10.1016/j.str.2021.08.001
  
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sciencedirect.com/science/article/pii/S0969212621002963
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

1
1. scibot 17 Aug 2021
  
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  RRID:SCR_015872
  
  DOI: 10.7554/eLife.68710
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8357420/
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Structure and analysis of nanobody binding to the human ASIC1a ion channel

1
1. scibot 05 Aug 2021
  
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  DOI: 10.7554/eLife.67115
  
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Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

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Jun 2021
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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

1
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  DOI: 10.1016/j.molcel.2021.06.005
  
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Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

1
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Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex

1
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The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design

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Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

1
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  DOI: 10.7554/eLife.66097
  
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elifesciences.org/articles/66097
Feb 2021
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A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

1
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Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

1
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  DOI: 10.1016/j.molcel.2020.11.001
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30779-6
Jan 2021
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Atomic structures of respiratory complex III 2, complex IV, and supercomplex III 2-IV from vascular plants

1
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  DOI: 10.7554/eLife.62047
  
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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

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ncbi.nlm.nih.gov/pmc/articles/PMC7785296/
Dec 2020
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Structure of the human core transcription-export complex reveals a hub for multivalent interactions

1
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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism

1
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  DOI: 10.1016/j.celrep.2020.108476
  
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The structures of secretory and dimeric immunoglobulin A

1
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  DOI: 10.7554/eLife.56098
  
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Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

1
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  DOI: 10.7554/eLife.59018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7704109/
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A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide

1
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  DOI: 10.1016/j.celrep.2020.108428
  
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cell.com/cell-reports/fulltext/S2211-1247(20)31417-0
Nov 2020
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Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

1
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  DOI: 10.7554/eLife.61496
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7652416/
Oct 2020
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Molecular mechanism for direct actin force-sensing by α-catenin

1
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ncbi.nlm.nih.gov/pmc/articles/PMC7588232/
Sep 2020
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HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

1
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  DOI: 10.1016/j.celrep.2020.107583
  
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Structural basis of substrate recognition by a polypeptide processing and secretion transporter

1
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ncbi.nlm.nih.gov/pmc/articles/PMC6959990/
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Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism

1
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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

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  DOI: 10.7554/eLife.59038
  
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The architecture of EMC reveals a path for membrane protein insertion

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Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

1
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ncbi.nlm.nih.gov/pmc/articles/PMC7112951/
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Structure and activation mechanism of the BBSome membrane protein trafficking complex

1
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  DOI: 10.7554/eLife.53322
  
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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

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ncbi.nlm.nih.gov/pmc/articles/PMC7308080/
Jan 2020
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Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6298777/
Nov 2018
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Untitled document

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Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole

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sciencedirect.com/science/article/pii/S1931312818303159
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Development of a Prototype System for Archiving Integrative/Hybrid Structure Models of Biological Macromolecules

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sciencedirect.com/science/article/pii/S0969212618300923