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  1. Apr 2022
    1. And then you begin to see how authoritarian or totalitarian regimes unfold. A common thread from my read of political thought leaders in this space like @anneapplebaum @ruthbenghiat is how authoritarianism relies in part on intellectual cover and Stanford Harvard others delivered
    2. Many thanks @Finneganporter while i predicted some of this, a part that caught me off guard in the pandemic was the rise of contrarian intellectuals from conservative think tanks or even Harvard Stanford so desperate for relevance they aligned themselves with far right extremists
    1. 47/ And finally, GBD, Tucker from AIER/Brownstone, Clare Craig from HART etc are operating in Uganda to increase vax hesitancy and build the antivax movement In how many other countries are they doing the same? Heinous
    1. 45/ And of course this can easily be debunked, Davis surely must have seen the corrections fill his TL, yet its still up and being quoted by others Doesn't help those falling for conspiracy theories to have MPs spreading this crap
    1. 35/ We see groups of politicians, media, astroturf, academics, the far right all coming into alignment and cooperation to undermine the pandemic effort with disinformation and political pressure on a weakened Prime Minister who only cares about his job
    1. 23/ Just look how Sunetra Gupta was silenced last week by writing an article in the Telegraph that reached a large audience. She now says herd immunity means constant reinfection, thats how we protect the vulnerable
    1. 21/ The CRG and the APPG sponsored by the GBDs Collateral Global fill the media with disinformation on a daily basis The APPGs recent attempts to halt vaccination of under 16s shows how far they've embraced the ideology
    1. 19/ More time and effort has been spent on gaslighting to keep measures out of schools than any other aspect of the pandemic It is after all the key part of a pro-infection herd immunity strategy Great read here on Bhattacharya
    1. 17/ What we are dealing with is not just a difference of opinion between experts, its deliberately muddying the waters and there seems to be concern that its the antivaxxers and conspiracy theorists who are lapping this up
    1. 10/ As a full time school worker the idea we can get back to normal in the short term is a joke The "toolkit" they've produced is another example of the weaponisation of mental health to support pro infection policies
    1. 6/ Having minimised covid harms, they find themselves playing down the benefits of vaccination For example in the US, Vinay Prasad has ended with messaging likely to increase hesitancy and embolden antivaxxers A look at an example of this
    1. 5/ There is a reoccurring theme of dividing children into "healthy" and "comordity" then dismissing concerns an individualistic approach to measures leaves vulnerable children greater risk Same vulnerable children they claim to champion when convenient
    1. 4/ These academics provide a statistical shield for policy makers to justify not taking transmission in schools seriously Their minimising of risks is also used by antivaxxers to reinforce their beliefs An example from US is Emily Oster
    1. 3/ Those minimising the impact on schools and children are an important part of the disinformation ecosystem Each country has a small group of over publicised academics fighting against all measures backed up by astroturf campaign groups
    1. 2/ As always theres been a focus in gaslighting around schools and children In the UK education is facing serious disruption due to a lack of measures so adults can pretend everythings back to normal while politicians still chase the herd immunity unicorn
    1. VACCINES Speaking of boosters, it’s not great news I’m afraid. Updated vaccine effectiveness analysis shows mRNA boosters beginning to wane from one month (week 5-9) for Omicron, and as low as 30-50% effective from 10 weeks post-booster. This effect is not seen with Delta.
    1. The health care crisis is of governments making over three decades. Closing half general and acute beds, closing acute hospitals and community services,eviscerating public health, no service planning. Plus unevidenced policies on testing and self isolation of contacts. @dthroat
    1. I am a full-time GP with 2 children of primary school age, one who is clinically vulnerable Unless the situation with schools changes to provide a safe place for education, I am considering a career break to home school my children @nadhimzahawi @sajidjavid @NHSEngland
    1. We compared Omicron to an antibody resistant spike (PMS20) that we previously designed. Omicron distribution of changes and neutralization properties are similar to PMS20. Suggests that antibody evolutionary pressure drove Omicron emergence
    2. Not the first, but a quite comprehensive analyses of Omicron neutralization resistance with @theodora_nyc, @NussenzweigL Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups
    1. And this messaging couldn't possibly put young adults off having the jab? So why were adults with underlying health conditions prioritised around the world, and have they suffered from vaccine complications?
    1. What psychology can contribute to pandemic response - free symposium 15th March https://us06web.zoom.us/webinar/register/WN_24BAGla3R4Kqaqe5YN1qEA… New with endorsement by the @BPSOfficial Crisis, disaster and trauma psych section Please share.
    1. Nathan Grubaugh@NathanGrubaugh·Sep 24, 2021So, yeah, @Newsweek and others, lets put the brakes on the R.1 stories. There will likely be new real threats to sound the alarms about in the future, but this ain't one of them 1650
    2. The meat of the @Newsweek stories is that "Scientists fear the variant's mutations could lead to increased resistance to protective antibodies". I'm not buying that either. In our analysis, R.1 has only a moderate effect on antibodies. (3/4) https://medrxiv.org/content/10.1101/2021.07.14.21260307v1
    3. Data from GISAID and displayed on @DiseaseOutbreak shows that in the US R.1 peaked at ~1% in March-April, and there hasn't been a blip since since June. **It was last detected in the US on July 16th** So not much of a current threat. (2/4) https://outbreak.info/situation-reports?pango=R.1
    4. Hi @Newsweek . I understand that #variant news has been slow recently with the near-complete dominance of Delta, but do you really need to go and make things up? Lineage R.1 is not a concern. Let me briefly explain why. (1/4)
    1. UKHSA tech report out - TL;DR: -BA.2 now represents >80% of omicron in England -Growth rate 80% greater relative to BA.1 per wk - regional growth seems to correlate with BA.2 frequency -?lab reports indicating that BA.1 infection may lead to lower neutralisation against BA.2
    1. 1. A thread on the CDC’s recommendation to de-isolate five days after the onset of symptoms or positive test. First, a disclosure: I was paid as a consultant for this work, done in collaboration with @Color Health, which provides COVID testing services and vaccination logistics.
    1. 1. #ACIP is meeting this afternoon to discuss the recently @US_FDA authorization of Covid boosters for youths aged 12 to 15. I'll be live tweeting. The agenda is here https://cdc.gov/vaccines/acip/meetings/downloads/agenda-archive/agenda-2022-01-05-508.pdf… and the meeting can be monitored here:
    1. Deaths by Grizzly bears each year: ~1.6 Deaths from COVID each year: ~400K. Adjust for age, all you want, his fear of Grizzly bears is irrational. His condescension and complacency about Covid, also irrational.
    1. Canada gave us kindness, tolerance, poutine and hockey, and in turn we exported this awful fake health freedom movement linked to far right extremism that caused so much senseless loss of life in America , and now might do the same there. Our apologies
    1. reports of Covid "parties" and resultant deaths from Austria. This presumably is a potential reason for why policy might chose to not treat recovery as equivalent to vaccination where restrictions based on status are in place (e.g., 2G,3G in Germany and Austria)
    1. ONS Covid survey. 2% of the population +ve. "The percentage of people testing positive for COVID-19 increased for all age groups, except for those in school Year 12 to those aged 34 years, where the trend was uncertain in the week ending 22 October 2021"
    1. 9.1% of secondary school aged children positive in week ending 22nd October. That is bloody awful. 1 in 11 So is 4.1% in Age 2 and primary age . About 1 in 24. That’s doubled in a couple of weeks. And parents age group Least affected are the recent vaxxed ages
    1. Statistics Canada has been asking kids about mental health during the pandemic. Initially, after the first 5 months (with school shutdowns, summer break, lots of restrictions), more kids said they were better than worse, most reported no change. 86% "No change or better"
    1. WAY too soon to be sure (especially w/ potential spread over holidays), but we are seeing a plateau @UCSFHospitals in hospitalizations (Fig L) & test positivity (both symptomatic & asymptomatic; R). Next few days will be key. Until we see sharp downturn, I'm in uber-careful mode.
    1. CDC reports another study that fails to control for vaccination rate differences between mask-wearers (higher vax rate) and non-mask wearers (lower). Vaccines were highly protective vs infection (pre-Omicron), so of course the mask group has lower rates. The vaccines work.
    1. A new @CDCMMWR study shows that people who reported always wearing masks or respirators in indoor public settings in California were less likely to test positive for #COVID19 compared with those who reported not wearing a face covering.
    1. At this point, focus of genomic surveillance should be to identify sub-lineages of Delta bearing mutations that contribute to further transmissibility or to antigenic drift. So far, there is little signal here, but I expect such sub-lineages to emerge in the coming months. 9/9
    2. A couple broader thoughts here: 1. I still expect Delta to sweep through the global virus population. 2. Mu's estimated transmission advantage suggests that it would have spread widely had Delta not interfered 8/9
    3. Model results by @ftzo et al (https://medrxiv.org/content/10.1101/2021.09.07.21263228v1…) show a similar pattern with Mu viruses assigned a higher fitness than non-Delta variants (https://nextstrain.org/ncov/gisaid/global?branches=hide&l=scatter&scatterX=mutational_fitness&scatterY=clade_membership…). 7/9
    4. However, Rt of Delta is substantially greater than that of Mu and if we estimate variant-specific transmission advantage relative to ancestral non-variant viruses we see that Delta > Mu > other variant viruses. 5/9
    5. A more rigorous analysis of variant-specific Rt by @marlinfiggins that partitions @CDCgov case counts across states in the US by sequencing data from @GISAID shows that Mu was maintaining Rt > 1 in most states in July 2021 when Alpha, Beta and Gamma had dropped below 1. 4/9
    6. In neighboring Ecuador, we see a heterogeneous mix of Alpha, Gamma, Iota, Lambda and Mu by June 2021. Delta has been successfully displacing most of this diversity since July 2021, while Mu has remained relatively stable (https://nextstrain.org/ncov/gisaid/south-america?f_country=Ecuador&r=division…). 3/9
    7. If we look within Colombia, we see Mu becoming predominant around May 2021, outcompeting other endogenous South American variants Gamma and Lambda. However, recent sequencing suggests that Delta is successfully invading on this Mu background (https://nextstrain.org/ncov/gisaid/south-america?f_country=Colombia&r=division…). 2/9
    8. I realize this is rather late to the party, but I wanted to provide a look at the prospects of Mu variant virus. I believe we can conclude that Mu appears more transmissible than all circulating variants except for Delta, but Delta is substantially fitter than Mu. 1/9
    1. Tegnell, May '20 to Brazil (absolutely not the only time Sweden claimed Swedish children hadn't caught covid): 200 cases under 20. Tegnell, Jan '21, Sweden: In spring, we didn't test any children. Swedish Public Health Agency, Oct '21: 40% of Swedish children have had covid.
    2. Tegnell states there have been very few cases among children and no spread in schools, but he leaves out they weren't testing children. They were only testing people admitted to hospital for covid. https://youtu.be/TmuoHEtJmYA?t=808…
    3. Tegnell (10:27): 'Healthcare services have kept on functioning at a very good level. There has always been empty beds. Nobody has ever been denied treatment in any way. Everybody has received the same level of treatment they would normally do.' Not true.
    4. 7 May 2020, Brazil. Tegnell marketing Sweden's approach in his second Brazil webinar: No one has been denied care, no sick children, no re-infections, better situation than in Copenhagen & NYC that have lockdowns, no need for masks or quarantines.
    5. Swedish ambassador Johanna Brismar Skoog explains why Sweden doesn't close schools: - Based on the scientific evidence the Swedish authorities look at, children are not big contributors to the spread. They hardly get it at all themselves and they're not spreading it on.
    6. (24:07) Anders Tegnell claims 20-30% of people in Stockholm are now (in April) immune. Next month, a study showed that 7.3% of Stockholmers had antibodies at the end of April. Tegnell commented that now in May it's above 20%. https://theguardian.com/world/2020/may/21/just-7-per-cent-of-stockholm-had-covid-19-antibodies-by-end-of-april-study-sweden-coronavirus…
    7. Tegnell (10:12): We believe in Sweden that this disease is here to stay. ... That's very much the background to what we're doing in Sweden. We're not really thinking that we ever can get rid of it in Sweden. We need to find a way to live together with it.
    8. 22 April 2020, Brazil. Experience Exchange Brazil-Sweden with Anders Tegnell and the Swedish ambassador. Their message: We have to learn to live with the virus. Sweden is doing well. Stockholm has 20-30% immunity. Children don't spread it. https://youtube.com/watch?v=TanU45Pdpwk… (in English)
    9. (04:05): - How are your figures compared to your neighbours? Giesecke: - Higher. But one very important thing: I think we should wait a year in comparing deaths in different countries. [...] In the end, they will be about the same in each country. The situation now:
    1. The first episode of the @thejabgab http://thejabgab.com is LIVE!! Join me and the fabulous comedians @nazeem_hussain and @calbo as they chat about the Delta variant, vaccines …. and cows? with experts @DrKGregorevic and @BedouiSammy! Search your fav platform or...
    1. mRNA is unbelievably fragile. The enzymes that degrade it are literally everywhere. That’s why they had to develop specialized lipid nanoparticles to deliver it. It would last two seconds in a sewer system. Also, it gets separated from the delivery system after it’s injected.
    1. this is how the failure to understand what efficacy means and how it relates to outcomes will be seized on over and over again. Cookie cutter fallacies require cookie cutter clarification by machine tools to be combatted effectively (at least at current levels of moderation) https://twitter.com/TheTwatRises/status/1417160609972604937
    1. 2/2) - here's the link to online published PDF. Vaccine hesitancy is a big deal. And the ED may offer opportunities to reach vulnerable unvaccinated populations. @UPennEM @PennMedEVDCSO @CDCDirector @PennMedNews https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.14376…
    2. hot off the press: our report on vaccine hesitancy in emergency department (ED) patients - first deep dive into hesitancy among this population ED is key opportunity for outreach, education ... and vaccination (1/2 - link to paper in 2nd tweet) #vaccines #vaccinehesitancy
  2. Mar 2022
    1. as someone who has been trying to adapt social media for meaningful scientific exchange (see http://SciBeh.org), I will leave this by pointing out that neither attributing positions out of thin air nor calling your interlocutors views "insanely stupid" enable good dialogue
    2. To clarify: you posted arguments against introducing vaccine passports. One was that there is a survey suggesting passports might decrease vaccine intention. I suggested that one needs to set against that the finding that vaccine uptake increased (often dramatically) 1/n
    3. so, observational data has weaknesses- so does survey data, but it's there and we should look at it. On your second point, yes, that is important, we should study that, if we have no data we can't factor it into decision. Third is separate issue/factor to weigh.
    1. And perish the thought that people who turn up to bellow like water buffalo with an infected haemorrhoid don't manage to differentiate themselves between the... probably one to two hundred Σ(DMs, emails, private messages across four platforms, tweets). There's so much.
    2. You either scream irrelevancies, suddenly demand a year of my time 'to check everything else', or just abuse me. You haven't actually read what I've written, or more importantly what anyone else has written. You just want to argue about something out of reflex.
    3. Perish the thought I would be as peremptory as @GidMK. No, I'm going to hector, mock, or annoy those replies, THEN ask for money, THEN block you when I get bored. See, these aren't rebuttals. No-one's said anything *about the actual work*. Nothing. Not a sausage.
    1. Here's a look at the frequency of BA.2 (Omicron) samples with an unusual mutation: ORF1a:M85del (NSP1:M85del). It was first noticed growing significantly in samples from Denmark. However, it is also growing in other countries - notably Sweden and the UK.
    1. ust over two years ago, we released the http://whichfaceisreal.com game. This is why. It was clear from the start that AI-generated faces would be used for nefarious purposes including the creation of propaganda.
    1. Quick thread: I want you all to meet Vladimir Bondarenko. He’s a blogger from Kiev who really hates the Ukrainian government. He also doesn’t exist, according to Facebook. He’s an invention of a Russian troll farm targeting Ukraine. His face was made by AI.
    1. 2/2 it's like comparing how wet you got in a down pour with and without umbrella... the biggest surprise to me in this pandemic hasn't been the 'overreaction' it's been the constant failure with respect to basic counter-factual reasoning
    1. HEPA air cleaners in hospital...lets compare cost to ECMO. ECMO course in the US costs around $93,000 CDN; US cost:charge ratio is around 0.2, so let's say that's $20,000 CDN. That's the cost of 50 high end hepa air cleaners! Or you could do 250 CR boxes at around $80 a pop.
    1. Vaccines might wane after boosting, how much and how quickly isn't known. The authors could have waited a couple of months and then seen. Instead they decided to be "first", vaccine confidence and truth be damned. 11/12
    2. Any expert who quotes this study as proof of vaccine "waning" should be struck from your internal register of experts. Either they haven't read the study before commenting, or they want to undermine vaccines. 10/12
    3. Every person involved, every author, every funder, every peer reviewer, the managing editor needs to recognise the harm of this, and search their souls for whether they should continue in research. This is knowingly, falsely, undermining vaccination. 9/12
    4. "How well do vaccines work against covid" is the most important medical research question today, bar none. Publishing an "answer" you know is wrong, and you know makes vaccines look worse than they are is reprehensible. 8/12
    5. We know the authors knew this is what they were doing. They acknowledge the mix in the caption of table 2 and the limitations section, but decided to publish anyway. It was a floor that could ONLY make vaccines appear worse than they are. 7/12
    6. This study compared immunocompromised people DIDN'T have boosters, with people with healthy immune systems who HAD boosters. Then from this concluded that vaccines rapidly stop working. Awful awful stuff. So why is this morally and not just technically repugnant? 6/12
    7. Those with 4 or more months follow up had to be vaccinated by mid September at the latest, before the first booster shot was approved. Those with less than 2 months follow up on the other hand would be expected to be dominated by immunocompetent patients getting boosters. 5/12
    8. The study finished on 22 January. The authors recorded that: - those vaccinated less than 2 months ago had 91% protection - those vaccinated 4 or more months ago had 78% protection. Therefore "waning" was observed. Do you see why this is wrong? 4/12
    9. There are two different situations people have a third dose: - immunocompromised people who need it to get the same protection most get from two doses - boosters, EXTRA protection for people with healthy immune systems. The first began on August 12 the second on November 29 3/
    10. These authors set out to determine if protection from vaccines wanes after a booster dose. They didn't have the right data to do this their options were: - give up - wait a couple of months for right data - publish data they knew was wrong anyway They picked the last one. 2/12
    11. This is probably the worst covid research I have read, and I helped expose a fraudulent study that was just the same patient copied-and pasted over and over again, and another which enrolled dead people. This is far more damaging to public health. 1/12
    12. Meanwhile mitigations are key to maintain in schools and in the community to protect children from long COVID and other impacts of infection. And vital to maintain suppression of the virus to prevent new variants evolving - omicron has been a game changer for vaccine efficacy.
    13. Effectiveness against hospitalisations also declined from 100% early on to ~48% 6 wks later, which is a significant decline. Suggests we need dose adjustments/vaccine updates against omicron/boosting to ensure a good response in this age group.
    14. Vaccine dose is the same as adult in 12-17 yr olds but much lower in 5-11 yr olds. There is a clear dose-response, with response greatest in 12 yr olds (greatest dose/wt) & graded lowering for other age gps. For 5-11 yr we see rapid decline in effectiveness against infection.
    15. New study out yesterday suggesting that vaccine efficacy with current dose for 5-11 yr olds likely wanes quickly. Especially against infection, but also against hospitalisation, although protection against severe disease is higher. Seems to be closely linked to vaccine dose
    1. History shows most pandemics last 2-3 years. Covid-19 has been a wily foe #NewYear2022 should see the pandemic’s end in highly vaccinated nations. Strive mightily to access vaccines everywhere But Covid-19 will remain endemic everywhere. The new normal means living with the virus
    1. A reminder that sometimes "living with it" means taking some mitigations, forever, e.g. how in order to live with cholera we make sure our water doesn't have shit in it by building infrastructure to make sure our water doesn't have shit in it.
    1. Full story from me on today’s approval of homegrown, plant-based Medicago #COVID19 vaccine. Approved for adults 18 to 64 Preliminary data shows shot produces neutralizing antibodies against Omicron Canada signed deal to buy 20 million doses
    2. BREAKING: Made-in-Canada #COVID19 vaccine from Medicago approved by Health Canada today. Shot dubbed 'Covifenz,' and uses virus-like particles. Background on the high efficacy against infection seen during Phase 3 clinical trials:
    1. Thanks to everyone who took part in our Workshop on #SciComm as Collective Intelligence It was amazing! materials will be uploaded to http://SciBeh.org website 1/2 @kakape @DrTomori @SpiekermannKai @GeoffreySupran @ArendJK @STWorg @dgurdasani1 @suneman @philipplenz6
    1. 10. Summary: 1. We're starting to see generalised community transmission (as opposed to just cluster outbreaks) 2. Tomorrow @who will assign a Greek name to B.1.1.529 3. We don't yet know for sure, but it looks like B.1.1.529 might be more transmissible and escape immunity.
    2. 8. Scientists = trying to figure out the impact of B.1.1.529's mutations. What could it potentially do (we don't know yet)? * Be more transmissible * Reduce the protection that vaccines and natural immunity offer * Cause milder or more severe disease
    3. 4. Here's how variants have spread in SA: 1. Light gray: lots of different types of virus (1st wave) 2. Green: 2nd wave (Beta) 3. Red: Delta, 3rd wave 4. Yellow: C.1.2 (still detected at low levels, but not increasing) 5. Blue: B.1.1.529 (increasing fast)
    4. [Thread] What is the potential impact of the new B.1.1.529 #COVID19 variant? @rjlessells: 1. It's relatively simple to detect some B.1.1.529 cases, as it's possible to use PCR tests to do this in some cases 2. B.1.1.529 = has many mutations across different parts of the virus
    1. Pandemics don’t end with a parade or armistice. They end when the disease fades into the background & other pressing daily problems take priority. This will happen (& is already happening) in various countries based on the national context.
    1. https://hackmd.io/@scibehC19vax/home… Short update to the @jitsuvax and @SciBeh COVID-19 Communication Handbook. Using the Fact-Sandwich #Debunking2020 to correct some additional myths about COVID-19: Fact Myth Explanation Fact.
    1. https://twitter.com/evebmd/status/1446813833293705222?s=21… We published papers @sweetchinchilla and along with our interns, we presented at conferences across the country @SUInfodemic @NLM_NIH @SocietyGIM
    1. What is the Governments vision of "endemic"? #r4todayQuote TweetSir Karam Bales @karamballes · 8 JanAs other countries are ramping up use of LFTs while UK gov want to go the other way Going to guess this comes alongside end of mandatory isolation if you have covid, as current release policy won't work without them UK Gov thinks its got an "Endgame" plan... twitter.com/0bj3ctivity/st…Show this thread
    1. it seems just yesterday that Twitter was ablaze with "nobody has died of omicron"Quote Tweet(((Howard Forman)))@thehowie · 4 JanWith the large addition of deaths today (139; highest since September), South Africa moving average for this wave is now ~20% and highest since October. It will be hard to translate this into other nations or states, but those who downplay deaths are doing a disservice. twitter.com/nicd_sa/status…
    1. this really is now a disinformation account. I retweeted posts earlier in the pandemic as part of a balanced spread of opinion. But this will be the last one...Quote TweetAllyson Pollock@AllysonPollock · 4 JanLFTs were designed for clinical use in people with symptoms. Government @MHRAgovuk gave repeat emergency authorisation for testing of healthy people with no symptoms and is spending billions. LFTs Have not been shown to reduce transmission or infection or disease. Time to STOPShow this thread