1,146 Matching Annotations
  1. Oct 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
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    Brain Registration and Evaluation for Zebrafish (BREEZE)-mapping: A pipeline for whole-brain structural and activity analyses
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    sciencedirect.com/science/article/pii/S2666166723006147
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    sciencedirect.com/science/article/pii/S2666379123004214
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    sciencedirect.com/science/article/pii/S1934590923003594
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    sciencedirect.com/science/article/pii/S221112472301210X
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    MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10575927/
  8. www.science.org www.science.org
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    science.org/doi/10.1126/sciadv.adi1328
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex
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    onlinelibrary.wiley.com/doi/10.1002/cne.25546
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    sciencedirect.com/science/article/abs/pii/S245194562300332X
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    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC10556724/
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    Mechanochemical coupling of MGF mediates periodontal regeneration
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    aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
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    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
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    cell.com/iscience/abstract/S2589-0042(23)02017-5
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    sciencedirect.com/science/article/pii/S0896627323006232
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    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    cell.com/cell-reports/abstract/S2211-1247(23)01014-8
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    sciencedirect.com/science/article/pii/S2211124723012147
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinome reprogramming is a targetable vulnerability in ESR1 fusion-driven breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10543968/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activates noncanonical EGFR endocytosis and signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10530101/
  21. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15963
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    sciencedirect.com/science/article/pii/S2589004223019454
  23. Sep 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10483053/
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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    sciencedirect.com/science/article/pii/S2589004223018370
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10479865/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    ncbi.nlm.nih.gov/pmc/articles/PMC10361449/
  28. Aug 2023
  29. www.biorxiv.org www.biorxiv.org
    Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target
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    biorxiv.org/content/10.1101/2023.08.14.553180v1
  30. www.sciencedirect.com www.sciencedirect.com
    LysM-mediated signaling in Marchantia polymorpha highlights the conservation of pattern-triggered immunity in land plants
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    sciencedirect.com/science/article/pii/S0960982223010400
  31. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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    52.53.155.43/5c44b570825d260ed49e3beddaa9d47779a57883/PIIS2211124723009488-html.html
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process
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    ncbi.nlm.nih.gov/pmc/articles/PMC10413268/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411973/
  35. 52.53.155.43 52.53.155.43
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    sciencedirect.com/science/article/pii/S2589004223015547
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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    sciencedirect.com/science/article/pii/S1535610823002453
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical features associated with outcomes and biomarker analysis of dabrafenib plus trametinib treatment in patients with BRAF-mutant melanoma brain metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC9898142/
  41. Jul 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC10368912/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10354042/
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    sciencedirect.com/science/article/pii/S2211124723008057
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    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition
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    sciencedirect.com/science/article/abs/pii/S2405471223001588
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC9938728/
  48. 52.53.155.43 52.53.155.43
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    sciencedirect.com/science/article/pii/S2589004223012786
  50. 52.53.155.43 52.53.155.43
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  51. Jun 2023
  52. 52.53.155.43 52.53.155.43
    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    52.53.155.43/9a5455060dac46a2102bae7baf607274e71beaee/1-s2.0-S2589004223012622-main-html.html
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    ncbi.nlm.nih.gov/pmc/articles/PMC10304905/
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    sciencedirect.com/science/article/pii/S1074761323002376
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Validation of miRNAs as diagnostic and prognostic biomarkers, and possible therapeutic targets in medullary thyroid cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285659/
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    Mechanism underlying follicular hyperproliferation and oncogenesis in hidradenitis suppurativa
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    sciencedirect.com/science/article/pii/S2589004223009732
  57. www.mdpi.com www.mdpi.com
    Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice
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    mdpi.com/2076-3921/12/6/1303
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823001836
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    sciencedirect.com/science/article/pii/S1074761323002315
  60. elifesciences.org elifesciences.org
    Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
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    elifesciences.org/content/5/e18414
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    sciencedirect.com/science/article/pii/S2211124723006587
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    sciencedirect.com/science/article/pii/S1550413123002097
  63. 52.53.155.43 52.53.155.43
    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    52.53.155.43/26aa5ba62138ec506c6f952066d20d6f92d1221c/acs.jmedchem.3c00150-html.html
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    52.53.155.43/a7694b32aeeb75586321cd0d6d28b4685219f279/British J Pharmacology - 2023 - Chen - Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via-html.html
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate
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    ncbi.nlm.nih.gov/pmc/articles/PMC10256685/
  66. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10239700/
  69. www.microbiologyresearch.org www.microbiologyresearch.org
    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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    microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001858
  70. dx.doi.org dx.doi.org
    LZTR1 mutation mediates oncogenesis through stabilization of EGFR and AXL
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    dx.doi.org/10.1158/2159-8290.CD-22-0376
  71. www.sciencedirect.com www.sciencedirect.com
    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    pmc.ncbi.nlm.nih.gov/articles/PMC10244369/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
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    The Scap-SREBP1-S1P/S2P lipogenesis signal orchestrates the homeostasis and spatiotemporal activation of NF-κB
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  75. academic.oup.com academic.oup.com
    Casein kinase 1α regulates testosterone synthesis and testis development in adult mice
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    academic.oup.com/endo/article/164/5/bqad042/7079750
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    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
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    academic.oup.com/endo/article/164/6/bqad045/7079002
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
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  79. 52.53.155.43 52.53.155.43
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  80. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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  81. May 2023
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth
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    ncbi.nlm.nih.gov/pmc/articles/PMC10212997/
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    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
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    sciencedirect.com/science/article/pii/S1097276523003350
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    sciencedirect.com/science/article/pii/S2211124723005818
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Injury-induced activation of the endocannabinoid system promotes axon regeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC10205787/
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10208528/
  88. www.nature.com www.nature.com
    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
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    nature.com/articles/s41467-023-38605-3
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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