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905 Matching Annotations

Oct 2023
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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

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1. scibot 06 Oct 2023
  
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Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

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cell.com/cell-reports/abstract/S2211-1247(23)01082-3
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The geometry of photopolymerized topography influences neurite pathfinding by directing growth cone morphology and migration

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  DOI: 10.1101/2023.08.28.555111
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10491164/
Sep 2023
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The Drosophila ecdysone receptor promotes or suppresses proliferation according to ligand level

1
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A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.stem.2023.07.006
  
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Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

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1. scibot 23 Sep 2023
  
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  DOI: 10.7554/eLife.88143
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10513480/
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Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery

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1. scibot 22 Sep 2023
  
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  DOI: 10.1038/s41596-023-00875-y
  
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nature.com/articles/s41596-023-00875-y
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A subclass of evening cells promotes the switch from arousal to sleep at dusk

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1. scibot 20 Sep 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10491161/
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Orbitofrontal cortex conveys stimulus and task information to the auditory cortex

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1. scibot 19 Sep 2023
  
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  DOI: 10.1016/j.cub.2023.08.059
  
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sciencedirect.com/science/article/abs/pii/S0960982223011399
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Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling

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  DOI: 10.1016/j.molcel.2023.08.005
  
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sciencedirect.com/science/article/pii/S109727652300641X
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Ankyrin B promotes developmental spine regulation in the mouse prefrontal cortex

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1. scibot 08 Sep 2023
  
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  DOI: 10.1093/cercor/bhad311
  
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academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhad311/7252287
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Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits

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  DOI: 10.1016/j.ccell.2023.07.010
  
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sciencedirect.com/science/article/pii/S1535610823002507
Aug 2023
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A comparative analysis of microglial inducible Cre lines

1
1. scibot 30 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113031
  
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sciencedirect.com/science/article/pii/S2211124723010422
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GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

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1. scibot 27 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113030
  
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P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107560
  
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52.53.155.43/5b8bf2feba1d162be73812f5bafbbf3c587c0e7d/PIIS2589004223016371-html.html
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Journal of Neurochemistry - 2023 - Kamte-html.html

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1. scibot 16 Aug 2023
  
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  DOI: 10.1111/jnc.15914
  
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52.53.155.43/8cb485a49ceb78e16481f91948fc91a6dba16017/Journal of Neurochemistry - 2023 - Kamte-html.html
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Lipid nanoparticle-mediated delivery of mRNA into the mouse and human retina and other ocular tissues

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1. scibot 16 Aug 2023
  
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  DOI: 10.1101/2023.07.13.548758
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10369938/
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Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112948
  
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Early clonal extinction in glioblastoma progression revealed by genetic barcoding

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  DOI: 10.1016/j.ccell.2023.07.001
  
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Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte–Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine

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1. scibot 01 Aug 2023
  
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  DOI: 10.3390/cells12141812
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10378353/
Jul 2023
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Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice

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1. scibot 28 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112901
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10552611/
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Anterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.cub.2023.06.070
  
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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium

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1. scibot 22 Jul 2023
  
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  DOI: 10.1038/s41556-023-01187-9
  
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A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

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  DOI: 10.1016/j.neuron.2023.06.023
  
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Combinatorial selective ER-phagy remodels the ER during neurogenesis

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  DOI: 10.1101/2023.06.26.546565
  
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Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice

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1. scibot 14 Jul 2023
  
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  DOI: 10.1038/s41467-023-39805-7
  
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mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons

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  DOI: 10.1016/j.molcel.2023.06.021
  
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A STIM dependent dopamine-neuropeptide axis maintains the larval drive to feed and grow in Drosophila

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1. scibot 12 Jul 2023
  
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  DOI: 10.1371/journal.pgen.1010435
  
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A circuit from the locus coeruleus to the anterior cingulate cortex modulates offspring interactions in mice

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  DOI: 10.1016/j.celrep.2023.112771
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10529180/
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Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.

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  DOI: 10.1101/2023.06.03.543579
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
Jun 2023
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Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation

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1. scibot 24 Jun 2023
  
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  DOI: 10.7554/eLife.85752
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10287160/
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PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems

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  DOI: 10.15252/embr.202256399
  
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  DOI: 10.15252/embr.202256399
  
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Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.05.025
  
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Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body

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1. scibot 22 Jun 2023
  
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  DOI: 10.1016/j.cub.2023.05.064
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10529417/
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Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice

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  DOI: 10.1038/s41596-023-00831-w
  
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Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

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Patterned cPCDH expression regulates the fine organization of the neocortex

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Mating activates neuroendocrine pathways signaling hunger in Drosophila females

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Fiber counts and architecture of the human dorsal penile nerve

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Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

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Medulloblastoma and high-grade glioma organoids for drug screening, lineage tracing, co-culture and in vivo assay

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The phospho-regulated amphiphysin/endophilin interaction is required for synaptic vesicle endocytosis

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Disynaptic inhibition shapes tuning of OFF-motion detectors in Drosophila

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Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure

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Drosophila Tachykininergic Neurons Modulate the Activity of Two Groups of Receptor-Expressing Neurons to Regulate Aggressive Tone

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Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain

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Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice

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A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation

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Neural circuit mechanisms linking courtship and reward in Drosophila males

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Characterization of three cholinergic inputs to the cochlear nucleus

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Regional variation in cholinergic terminal activity determines the non-uniform occurrence of cortical slow waves during REM sleep in mice

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Vascular cells improve functionality of human cardiac organoids

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Nuclear receptor Nr5a2 promotes diverse connective tissue fates in the jaw

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Biphasic expression of thyroid hormone receptor TRβ1 in mammalian retina and anterior ocular tissues

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Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila

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XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors

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Examining the engram encoding specificity hypothesis in mice

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Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

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Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development

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Multiplex translaminar imaging in the spinal cord of behaving mice

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Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila

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Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

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Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

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Dual role of the P2X7 receptor in dendritic outgrowth during physiological and pathological brain development

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Bat pluripotent stem cells reveal unusual entanglement between host and viruses

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Inhomogeneous mechanotransduction defines the spatial pattern of apoptosis-induced compensatory proliferation

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Caldendrin represses neurite regeneration and growth in dorsal root ganglion neurons

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3D human induced pluripotent stem cell–derived bioengineered skeletal muscles for tissue, disease and therapy modeling

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Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits

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The cellular basis of mechanosensation in mammalian tongue

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Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity

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Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

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CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia

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The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism

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A multidimensional atlas of human glioblastoma organoids reveals highly coordinated molecular networks and effective drugs

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Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

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A dopaminergic reward prediction error signal shapes maternal behavior in mice

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Behavioral state-dependent modulation of insulin-producing cells in Drosophila

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Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes

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The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

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Selective integration of diverse taste inputs within a single taste modality

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Generation of an induced pluripotent stem cell (iPSC) line from a patient with GEFS+ carrying a STX1B (p.Lys45delinsArgMetCysIleGlu and p.Leu46Met) mutation

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Humidity sensors that alert mosquitoes to nearby hosts and egg-laying sites

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Neuronopathic GBA1L444P mutation accelerates Glucosylsphingosine levels and formation of hippocampal alpha-synuclein inclusions

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Protrusion growth driven by myosin-generated force

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Neuronal and astrocytic contributions to Huntington’s disease dissected with zinc finger protein transcriptional repressors

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Electrical signals in the ER are cell type and stimulus specific with extreme spatial compartmentalization in neurons

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A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons

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Foxd1 is Required for 3d Patterning of the Kidney Interstitial Matrix

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Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke

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Connections between sister and non-sister telomeres of segregating chromatids maintain euploidy

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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

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The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses

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Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation

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B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

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Table 1 Antibodies and dyes compatible with mLSR-3D

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Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

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Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation

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Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment

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An anti-inflammatory transcriptional cascade conserved from flies to humans

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CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

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Sleep need-dependent changes in functional connectivity facilitate transmission of homeostatic sleep drive

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Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation

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A neurogenetic mechanism of experience-dependent suppression of aggression

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Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia

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Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors

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Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

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Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice

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Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice

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A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

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Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance

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Spatial and temporal control of expression with light-gated LOV-LexA

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Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells

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osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation

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A neural circuit for wind-guided olfactory navigation

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Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

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In vivo photometry reveals insulin and 2-deoxyglucose maintain prolonged inhibition of VMH Vglut2 neurons in male mice

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Glioblastoma hijacks neuronal mechanisms for brain invasion

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Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning

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IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage

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Neuron-specific translational control shift ensures proteostatic resilience during ER stress

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Functional convergence of on-off direction-selective ganglion cells in the visual thalamus

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Cd59 and inflammation regulate Schwann cell development

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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability

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Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

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Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms

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Drosophila gustatory projections are segregated by taste modality and connectivity

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Genetic deletion of the glucocorticoid receptor in Cx3cr1+ myeloid cells is neuroprotective and improves motor recovery after spinal cord injury

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All-viral tracing of monosynaptic inputs to single birthdate-defined neurons in the intact brain

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Stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsins yields opposite behavioral outcomes

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Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment

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An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling

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Recurrent circadian circuitry regulates central brain activity to maintain sleep

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Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes

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Nasally-delivered interferon-λ protects mice against infection by SARS-CoV-2 variants including Omicron

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CCN2/CTGF—A Modulator of the Optic Nerve Head Astrocyte

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Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae

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Drosulfakinin signaling modulates female sexual receptivity in Drosophila

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NanoDam identifies Homeobrain (ARX) and Scarecrow (NKX2.1) as conserved temporal factors in the Drosophila central brain and visual system

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Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the Drosophila testis niche

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Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons

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Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse

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Transformation of an early-established motor circuit during maturation in zebrafish

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Tonic GABAergic inhibition, via GABAA receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons

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Diurnal rhythms in cholinergic modulation of rapid dopamine signals and associative learning in the striatum

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Hemisynapse Formation Between Target Astrocytes and Cortical Neuron Axons in vitro

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NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury

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Large-scale two-photon calcium imaging in freely moving mice

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Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation

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A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

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Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx)

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Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons

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LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function

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The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonates

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Descending neurons coordinate anterior grooming behavior in Drosophila

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Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

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A cell atlas of microbe-responsive processes in the zebrafish intestine

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The lateral posterior clock neurons (LPN) of Drosophila melanogaster express three neuropeptides and have multiple connections within the circadian clock network and beyond

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Serotonergic neurons translate taste detection into internal nutrient regulation

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Trigeminal ganglion and sensory nerves suggest tactile specialization of elephants

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A role for actomyosin contractility in Notch signaling

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Off-Target Expression of Cre-Dependent Adeno-Associated Viruses in Wild-Type C57BL/6J Mice

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Identification and characterization of rostral ventromedial medulla (RVM) neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis

1
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Experimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study

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ACE2 and SCARF expression in human DRG nociceptors: implications for SARS-CoV-2 virus neurological effects

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Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity

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Sep 2021
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Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy

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Brain adiponectin signaling controls peripheral insulin response in Drosophila

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Classification and genetic targeting of cell types in the primary taste and premotor center of the adult Drosophila brain

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Cerebellar spreading depolarization mediates paroxysmal movement disorder

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Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity

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Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions

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Aug 2021
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Dual role for CXCL12 signaling in semilunar valve development

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Establishment of a GFP::LMNB1 knockin cell line (CSUi002-A-1) from a dystonia patient-specific iPSC by CRISPR/Cas9 editing

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The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons

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Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas

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  DOI: 10.1016/j.stem.2021.07.004
  
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Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila

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  DOI: 10.1016/j.devcel.2021.07.002
  
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Small Interference RNA Targeting Connexin-43 Improves Motor Function and Limits Astrogliosis After Juvenile Traumatic Brain Injury - Aleksandra Ichkova, Andrew M. Fukuda, Nina Nishiyama, Germaine Paris, Andre Obenaus, Jerome Badaut, 2019

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Alcohol Consumption during Adolescence in a Mouse Model of Binge Drinking Alters the Intrinsic Excitability and Function of the Prefrontal Cortex through a Reduction in the Hyperpolarization-Activated Cation Current

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  DOI: 10.1016/j.neuron.2017.07.038
  
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  DOI: 10.1016/j.stem.2017.02.012
  
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Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety

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1. scibot 11 Aug 2021
  
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Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons

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  DOI: 10.1016/j.cub.2018.11.070
  
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Modeling Patient-Derived Glioblastoma with Cerebral Organoids

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A neuronal mechanism controlling the choice between feeding and sexual behaviors in Drosophila

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Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination

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Inhibitory Connectivity Dominates the Fan Cell Network in Layer II of Lateral Entorhinal Cortex

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Overlapping morphological and functional properties between M4 and M5 intrinsically photosensitive retinal ganglion cells

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Fast Serotonin Voltammetry as a Versatile Tool for Mapping Dynamic Tissue Architecture: I. Responses at Carbon Fibers Describe Local Tissue Physiology

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1. scibot 31 Jul 2021
  
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Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety

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1. scibot 31 Jul 2021
  
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High-potency ligands for DREADD imaging and activation in rodents and monkeys

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1. scibot 30 Jul 2021
  
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A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in brain neurons

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1. scibot 30 Jul 2021
  
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