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May 2021
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The USP7-TRIM27 axis mediates non-canonical PRC1.1 function and is a druggable target in leukemia

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1. scibot 06 May 2021
  
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  DOI: 10.1016/j.isci.2021.102435
  
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cell.com/iscience/abstract/S2589-0042(21)00403-X
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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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sciencedirect.com/science/article/pii/S1097276521003178
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Regulation of ARGONAUTE10 Expression Enables Temporal and Spatial Precision in Axillary Meristem Initiation in Arabidopsis

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1. scibot 05 May 2021
  
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sciencedirect.com/science/article/pii/S153458072030839X
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Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

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1. scibot 05 May 2021
  
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sciencedirect.com/science/article/pii/S1534580720305426
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Prestin amplifies cardiac motor functions

1
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  DOI: 10.1016/j.celrep.2021.109097
  
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sciencedirect.com/science/article/pii/S2211124721004319
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Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

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  DOI: 10.1016/j.cmet.2021.01.018
  
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sciencedirect.com/science/article/pii/S1550413121000565
Apr 2021
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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

1
1. scibot 29 Apr 2021
  
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sciencedirect.com/science/article/pii/S1550413120305386
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Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

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1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.05.002
  
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sciencedirect.com/science/article/pii/S1550413120302412
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Plant roots employ cell-layer-specific programs to respond to pathogenic and beneficial microbes

1
1. scibot 28 Apr 2021
  
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  DOI: 10.1016/j.chom.2020.11.014
  
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sciencedirect.com/science/article/pii/S1931312820306363
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Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

1
1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.06.031
  
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sciencedirect.com/science/article/pii/S0092867420308084
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Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening

1
1. scibot 23 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.05.013
  
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sciencedirect.com/science/article/pii/S0092867420305754
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Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: the polyG diseases

1
1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.neuron.2021.03.038
  
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sciencedirect.com/science/article/pii/S0896627321002269
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Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation

1
1. scibot 21 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.109001
  
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sciencedirect.com/science/article/pii/S2211124721003156
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Protocol for electron microscopy ultrastructural localization of the fusogenic lipid phosphatidic acid on plasma membrane sheets from chromaffin cells

1
1. scibot 13 Apr 2021
  
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  DOI: 10.1016/j.xpro.2021.100464
  
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sciencedirect.com/science/article/pii/S2666166721001714
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Friendly mediates membrane depolarization-induced mitophagy in Arabidopsis

1
1. scibot 08 Apr 2021
  
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  DOI: 10.1016/j.cub.2021.02.034
  
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cell.com/current-biology/abstract/S0960-9822(21)00275-X
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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

1
1. scibot 08 Apr 2021
  
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  DOI: 10.1016/j.cub.2021.01.081
  
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cell.com/current-biology/abstract/S0960-9822(21)00146-9
www.jneurosci.org www.jneurosci.org

Neuronal Nitric Oxide Synthase in Nucleus Accumbens Specifically Mediates Susceptibility to Social Defeat Stress through Cyclin-Dependent Kinase 5

1
1. scibot 08 Apr 2021
  
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  DOI: 10.1523/JNEUROSCI.0422-20.2021
  
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jneurosci.org/content/41/11/2523
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SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation

1
1. scibot 01 Apr 2021
  
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  GFP
  
  DOI: 10.1016/j.celrep.2021.108921
  
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sciencedirect.com/science/article/pii/S2211124721002357
Mar 2021
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An early cell shape transition drives evolutionary expansion of the human forebrain

1
1. scibot 26 Mar 2021
  
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  DOI: 10.1016/j.cell.2021.02.050
  
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sciencedirect.com/science/article/pii/S0092867421002397
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Paradoxical activation of c-Src as a drug-resistant mechanism

1
1. scibot 24 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108876
  
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sciencedirect.com/science/article/pii/S221112472100190X
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Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

1
1. scibot 19 Mar 2021
  
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  DOI: 10.1016/j.cell.2021.02.045
  
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sciencedirect.com/science/article/pii/S0092867421002348
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DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1

1
1. scibot 17 Mar 2021
  
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  AB_303395
  
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sciencedirect.com/science/article/pii/S2211124721001546
www.frontiersin.org www.frontiersin.org

Monosynaptic Retrograde Tracing From Prelimbic Neuron Subpopulations Projecting to Either Nucleus Accumbens Core or Rostromedial Tegmental Nucleus

1
1. scibot 03 Mar 2021
  
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  DOI: 10.3389/fncir.2021.639733
  
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frontiersin.org/article/10.3389/fncir.2021.639733/full
Feb 2021
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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

1
1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.celrep.2020.108608
  
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sciencedirect.com/science/article/pii/S2211124720315977
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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

1
1. scibot 26 Feb 2021
  
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  DOI: 10.1016/j.celrep.2018.12.023
  
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cell.com/cell-reports/abstract/S2211-1247(18)31953-3
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

1
1. scibot 25 Feb 2021
  
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  DOI: 10.1111/bph.15084
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15084
www.physiology.org www.physiology.org

The PVN Enhances Cardiorespiratory Responses to Acute Hypoxia via Input to the nTS

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1. scibot 24 Feb 2021
  
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  DOI: 10.1152/ajpregu.00135.2019
  
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physiology.org/doi/abs/10.1152/ajpregu.00135.2019
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An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output during C. elegans Development

1
1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.cub.2020.11.060
  
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cell.com/current-biology/abstract/S0960-9822(20)31773-5
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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

1
1. scibot 24 Feb 2021
  
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  AB_303395
  
  DOI: 10.1016/j.cell.2021.01.034
  
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sciencedirect.com/science/article/pii/S0092867421000775
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Olig3 regulates early cerebellar development

1
1. scibot 24 Feb 2021
  
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  DOI: 10.7554/eLife.64684
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7886330/
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Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers

1
1. scibot 12 Feb 2021
  
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  DOI: 10.1016/j.devcel.2021.01.010
  
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sciencedirect.com/science/article/pii/S153458072100068X
Jan 2021
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Inhibition of p38 Mitogen–Activated Protein Kinase Ameliorates HAP40 Depletion–Induced Toxicity and Proteasomal Defect in Huntington’s Disease Model

1
1. scibot 28 Jan 2021
  
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  anti-GFP
  
  DOI: 10.1007/s12035-020-02280-y
  
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link.springer.com/article/10.1007/s12035-020-02280-y
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Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells

1
1. scibot 27 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108663
  
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sciencedirect.com/science/article/pii/S2211124720316521
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Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

1
1. scibot 26 Jan 2021
  
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  DOI: 10.7554/eLife.62876
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7817182/
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Variability of an Early Developmental Cell Population Underlies Stochastic Laterality Defects

1
1. scibot 22 Jan 2021
  
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  DOI: 10.1016/j.celrep.2020.108606
  
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sciencedirect.com/science/article/pii/S2211124720315953
Dec 2020
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The mechanism of kinesin inhibition by kinesin-binding protein

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RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

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Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

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The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

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A Systematic Protein Turnover Map for Decoding Protein Degradation

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The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina

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Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells

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Protocol for Proximity-Dependent Proteomic Profiling in Yeast Cells by APEX and Alk-Ph Probe

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The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo

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Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

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Combinatorial Action of Temporally Segregated Transcription Factors

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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

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Mapping Cortical Integration of Sensory and Affective Pain Pathways

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HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

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The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

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LET-502/ROCK Regulates Endocytic Recycling by Promoting Activation of RAB-5 in a Distinct Subpopulation of Sorting Endosomes

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Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

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Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons

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Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age- and combination-specific phenotypic profiles in Drosophila

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A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast

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Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

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Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model

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GRAF2, WDR44, and MICAL1 mediate Rab8/10/11–dependent export of E-cadherin, MMP14, and CFTR ΔF508

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Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation

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Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras

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Cycling Stem Cells Are Radioresistant and Regenerate the Intestine

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UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

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Regulation of Expression of Autophagy Genes by Atg8a-Interacting Partners Sequoia, YL-1, and Sir2 in Drosophila

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Engineering DNA nanostructures for siRNA delivery in plants

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Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

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Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells

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Generation of Lungs by Blastocyst Complementation in Apneumic Fgf10-Deficient Mice

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Targeted Kruppel-like factor 4 gene knockout in retinal ganglion cells improves visual function in multiple sclerosis mouse model

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Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27

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A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana

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Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

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A Kinesin adapter directly mediates dendritic mRNA localization during neural development in mice

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AT-Hook Transcription Factors Restrict Petiole Growth by Antagonizing PIFs

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Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis

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Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

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Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion

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DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation

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BMP Signaling Gradient Scaling in the Zebrafish Pectoral Fin

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Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis

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AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering

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ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

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The role of the diencephalon in the guidance of thalamocortical axons in mice

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H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

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SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation

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Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism

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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

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  DOI: 10.1016/j.chom.2019.05.002
  
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Plasma Membrane Domain Patterning and Self-Reinforcing Polarity in Arabidopsis

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Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

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Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer

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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

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TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation

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Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans

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A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses

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Dynamic REM Sleep Modulation by Ambient Temperature and the Critical Role of the Melanin-Concentrating Hormone System

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Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

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Absolute quantification of cohesin, CTCF and their regulators in human cells

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Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules

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Pericentrin-mediated SAS-6 recruitment promotes centriole assembly

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Su(var)2-10 and the SUMO Pathway Link piRNA-Guided Target Recognition to Chromatin Silencing

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Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance

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Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance

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Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

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Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

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CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing

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Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation

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LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

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Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers

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Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

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Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation

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R-Loops Promote Antisense Transcription across the Mammalian Genome

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Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain

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Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

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Neutralization of the Positive Charges on Histone Tails by RNA Promotes an Open Chromatin Structure

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Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

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Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

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Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism

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RRM Transcription Factors Interact with NLRs and Regulate Broad-Spectrum Blast Resistance in Rice

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A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety

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Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity

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mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

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Myelinogenic plasticity of oligodendrocyte precursor cells following spinal cord contusion injury.

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Hippocampal nuclear factor kappa B accounts for stress‐induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)‐carboxy‐terminal PDZ ligand of nNOS‐Dexras1 coupling

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Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs

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Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

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mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease

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A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

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Midgut Laterality Is Driven by Hyaluronan on the Right

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Germ Cell–Specific Retinoic Acid Receptor α Functions in Germ Cell Organization, Meiotic Integrity, and Spermatogonia

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Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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Decoupling Yeast Cell Division and Stress Defense Implicates mRNA Repression in Translational Reallocation during Stress

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APC2 controls dendrite development by promoting microtubule dynamics

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Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors

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The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer

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A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

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Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex

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Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity

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Excitatory and Inhibitory Neurons Utilize Different Ca2+ Sensors and Sources to Regulate Spontaneous Release

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Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

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MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata

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Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl

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Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development

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Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

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Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

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Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability

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Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways

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α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

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Color Processing in the Early Visual System of Drosophila

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Widespread optogenetic expression in macaque cortex obtained with MR-guided, convection enhanced delivery (CED) of AAV vector to the thalamus

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11β-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation

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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.

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Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

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Nov 2017
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis

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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation

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Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels

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Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking

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The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions

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Drosophila CRY Entrains Clocks in Body Tissues to Light and Maintains Passive Membrane Properties in a Non-clock Body Tissue Independent of Light

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Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement

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Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement

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Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

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IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning

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Learning shapes the aversion and reward responses of lateral habenula neurons

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SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

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Electrostatic anchoring precedes stable membrane attachment of SNAP25/SNAP23 to the plasma membrane

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Translation of CircRNAs

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SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication

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Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin

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A Sexually Dimorphic Area of the Dorsal Hypothalamus in Mice and Common Marmosets: Endocrinology: Vol 157, No 12

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An Interaction Landscape of Ubiquitin Signaling

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Untitled document

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RNA Binding to CBP Stimulates Histone Acetylation and Transcription

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Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies

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Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

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Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

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