935 Matching Annotations
  1. Aug 2022
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    The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis
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    sciencedirect.com/science/article/pii/S1550413122003102
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    Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance
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    sciencedirect.com/science/article/pii/S2211124722009901
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    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    jneurosci.org/content/42/31/6090
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    Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth
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    sciencedirect.com/science/article/pii/S2589004222010240
  6. Jul 2022
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuregulin-1 signaling regulates cytokines and chemokines expression and secretion in granulosa cell
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    ncbi.nlm.nih.gov/pmc/articles/PMC9316729/
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    Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging
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    sciencedirect.com/science/article/pii/S2211124722009378
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    JNEUROSCI.1989-21.2022.full-html.html
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    52.53.155.43/ff46bc3d23e518f0db8966b4d429d2ce1bef32f5/JNEUROSCI.1989-21.2022.full-html.html
  10. aacrjournals.org aacrjournals.org
    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    sciencedirect.com/science/article/pii/S1550413122003023
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    sciencedirect.com/science/article/pii/S2666379122002221
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    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9205595/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neoadjuvant chemotherapy induces genomic and transcriptomic changes in ovarian cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC8936832/
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    FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity
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    sciencedirect.com/science/article/pii/S1550413122002273
  16. Jun 2022
  17. 52.53.155.43 52.53.155.43
    mcr-21-0994-html.html
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    mct-21-0848-html.html
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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  20. journals.lww.com journals.lww.com
    Icariin ameliorates memory deficits through regulating... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/01000/Icariin_ameliorates_memory_deficits_through.39.aspx
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC9205497/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC9152158/
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    Time-resolved proximity labeling of protein networks associated with ligand-activated EGFR
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    sciencedirect.com/science/article/pii/S221112472200732X
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    sciencedirect.com/science/article/pii/S2589004222007301
  25. aacrjournals.org aacrjournals.org
    Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS
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    aacrjournals.org/mcr/article/20/6/996/699064/Liver-Endothelium-Promotes-HER3-Mediated-Cell
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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    sciencedirect.com/science/article/pii/S0960982222008508
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    IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
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    sciencedirect.com/science/article/pii/S1534580722003707
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    Active APPL1 sequestration by Plasmodium favors liver-stage development
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    sciencedirect.com/science/article/pii/S2211124722006611
  29. May 2022
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    sciencedirect.com/science/article/pii/S1097276522004348
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    Irreversible FLT3 Inhibitor FF-10101 Is Active Against a Diversity of FLT3 Inhibitor Resistance Mechanisms
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    aacrjournals.org/mct/article/21/5/844/694774/The-Irreversible-FLT3-Inhibitor-FF-10101-Is-Active
  33. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
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    Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling
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    sciencedirect.com/science/article/pii/S2211124722005691
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    Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
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    Patient-derived models of brain metastases recapitulate human disseminated disease
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    sciencedirect.com/science/article/pii/S2666379122001409
  37. Apr 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Cerebroprotein hydrolysate injection is involved in promoting long-term angiogenesis, vessel diameter and density after cerebral ischemia in mice
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    sciencedirect.com/science/article/pii/S0024320522002685
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15849
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    sciencedirect.com/science/article/pii/S2589004222004813
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
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    ncbi.nlm.nih.gov/pmc/articles/PMC8530936/
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    The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression
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    sciencedirect.com/science/article/pii/S2211124722004260
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
  44. aacrjournals.org aacrjournals.org
    δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice
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    aacrjournals.org/cancerpreventionresearch/article/15/4/233/682296/Tocotrienol-is-the-Most-Potent-Vitamin-E-Form-in
  45. Mar 2022
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    onlinelibrary.wiley.com/doi/10.1002/glia.23583
  47. asbmr.onlinelibrary.wiley.com asbmr.onlinelibrary.wiley.com
    Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice
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    asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.3731
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8714968/
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC8850919/
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8820717/
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    Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma
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    sciencedirect.com/science/article/pii/S1097276522001058
  52. link.springer.com link.springer.com
    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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    link.springer.com/article/10.1007/s00418-022-02091-3
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    Creatine transport and creatine kinase activity is required for CD8+ T cell immunity
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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  55. Feb 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
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    sciencedirect.com/science/article/pii/S2211124722001334
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    Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling
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    sciencedirect.com/science/article/pii/S2589004222001407
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pigment Epithelium Derived Factor Is Involved in the Late Phase of Osteosarcoma Metastasis by Increasing Extravasation and Cell-Cell Adhesion
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    ncbi.nlm.nih.gov/pmc/articles/PMC8842676/
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    sciencedirect.com/science/article/pii/S2211124722001139
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    BCL-XL inhibition induces an FGFR4-mediated rescue response in colorectal cancer
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    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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    sciencedirect.com/science/article/pii/S0303720722000454
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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    sciencedirect.com/science/article/pii/S2589004222001298
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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  64. www.sciencedirect.com www.sciencedirect.com
    The early reduction of left ventricular mass after sleeve gastrectomy depends on the fall of branched-chain amino acid circulating levels
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    sciencedirect.com/science/article/pii/S2352396422000482
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC8797319/
  66. link.springer.com link.springer.com
    Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
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    link.springer.com/article/10.1007/s10456-022-09831-y
  67. Jan 2022
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ACE2 pathway regulates thermogenesis and energy metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC8776250/
  69. www.sciencedirect.com www.sciencedirect.com
    Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2
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    sciencedirect.com/science/article/pii/S2211124721017654
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
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    ncbi.nlm.nih.gov/pmc/articles/PMC8762293/
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    The portrait of liver cancer is shaped by mitochondrial genetics
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    sciencedirect.com/science/article/pii/S2211124721017666
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
  73. Dec 2021
  74. www.sciencedirect.com www.sciencedirect.com
    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    sciencedirect.com/science/article/pii/S1534580721009941
  75. link.springer.com link.springer.com
    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    link.springer.com/article/10.1007/s10863-018-9750-3
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    Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes
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    sciencedirect.com/science/article/pii/S001429992100707X
  77. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    nature.com/articles/s42003-021-02842-3
  78. journals.sagepub.com journals.sagepub.com
    Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains
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    journals.sagepub.com/doi/full/10.1177/17590914211055064
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8172524/
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC8605346/
  81. Nov 2021
  82. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24984
  83. 52.53.155.43 52.53.155.43
    japplphysiol.00295.2021-html.html
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    CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8551082/
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    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
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    sciencedirect.com/science/article/pii/S2589004221012803
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload
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    ncbi.nlm.nih.gov/pmc/articles/PMC8547954/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states
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    ncbi.nlm.nih.gov/pmc/articles/PMC8555985/
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
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    sciencedirect.com/science/article/pii/S2666634021003421
  91. Oct 2021
  92. www.sciencedirect.com www.sciencedirect.com
    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    sciencedirect.com/science/article/pii/S2589004221011457
  93. www.sciencedirect.com www.sciencedirect.com
    Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
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    sciencedirect.com/science/article/pii/S2451945621004402
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction
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    ncbi.nlm.nih.gov/pmc/articles/PMC8526089/
  95. www.sciencedirect.com www.sciencedirect.com
    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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