961 Matching Annotations
  1. Jul 2021
  2. academic.oup.com academic.oup.com
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    1. scibot 27 Jul 2021
      AB_2315112

      DOI: 10.1210/en.2017-00029

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    academic.oup.com/endo/article/158/10/3281/3885816
  3. pubs.acs.org pubs.acs.org
    Pierced Lasso Topology Controls Function in Leptin
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    1. scibot 27 Jul 2021
      AB_2281741

      DOI: 10.1021/acs.jpcb.6b11506

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    pubs.acs.org/doi/full/10.1021/acs.jpcb.6b11506
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    Behavioral and cellular dopamine D1 and D3 receptor-mediated synergy: Implications for L-DOPA-induced dyskinesia
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      DOI: 10.1016/j.neuropharm.2018.06.024

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    sciencedirect.com/science/article/pii/S0028390818303137
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    Maternal separation stress reduced prenatal-ethanol-induced increase in exploratory behaviour and extracellular signal-regulated kinase activity
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    1. scibot 27 Jul 2021
      RRID:AB_10234795

      DOI: 10.1016/j.bbr.2018.06.004

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    sciencedirect.com/science/article/pii/S0166432818300573
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    Early ethanol exposure and vinpocetine treatment alter learning‐ and memory‐related proteins in the rat hippocampus and prefrontal cortex
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    1. scibot 27 Jul 2021
      AB_10234795

      DOI: 10.1002/jnr.23894

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23894/full
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis
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    1. scibot 27 Jul 2021
      AB_2315112

      DOI: 10.15252/msb.20145877

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    Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner
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    1. scibot 23 Jul 2021
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      DOI: 10.3389/fncir.2021.660199

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    ncbi.nlm.nih.gov/pmc/articles/PMC8291085/
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    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
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    1. scibot 23 Jul 2021
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      DOI: 10.7554/eLife.66596

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    Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior
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    1. scibot 22 Jul 2021
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      DOI: 10.1016/j.celrep.2021.109417

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    sciencedirect.com/science/article/pii/S2211124721008305
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    Treprostinil reduces mitochondrial injury during rat renal ischemia-reperfusion injury
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    1. scibot 16 Jul 2021
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      DOI: 10.1016/j.biopha.2021.111912

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    sciencedirect.com/science/article/pii/S0753332221006946
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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    1. scibot 14 Jul 2021
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      DOI: 10.1016/j.isci.2021.102724

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    Gut-microbiota-targeted diets modulate human immune status
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    cell.com/cell/fulltext/S0092-8674(21)00754-6
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    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
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    1. scibot 09 Jul 2021
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      DOI: 10.1016/j.cub.2021.06.030

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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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    Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
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      AB_2315112

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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  18. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    1. scibot 30 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109291

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    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration
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    1. scibot 26 Jun 2021
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      DOI: 10.7554/eLife.68830

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    Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
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      DOI: 10.1016/j.celrep.2021.109272

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    sciencedirect.com/science/article/pii/S2211124721006392
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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    1. scibot 23 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109280

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    sciencedirect.com/science/article/pii/S2211124721006471
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    1. scibot 23 Jun 2021
      RRID:AB_2315112

      DOI: 10.1016/j.celrep.2021.109281

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    sciencedirect.com/science/article/pii/S2211124721006483
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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      DOI: 10.1016/j.molcel.2021.05.031

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    sciencedirect.com/science/article/pii/S1097276521004445
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    Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage
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      DOI: 10.1016/j.phymed.2021.153630

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    sciencedirect.com/science/article/pii/S0944711321001732
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    Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
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      DOI: 10.1016/j.cmet.2021.05.019

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    sciencedirect.com/science/article/pii/S1550413121002709
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    Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
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      DOI: 10.1016/j.isci.2021.102643

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    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence
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      DOI: 10.7554/eLife.64204

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    ncbi.nlm.nih.gov/pmc/articles/PMC8203294/
  29. www.sciencedirect.com www.sciencedirect.com
    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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      DOI: 10.1016/j.ccell.2021.05.015

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    sciencedirect.com/science/article/pii/S1535610821002816
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    Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening
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    sciencedirect.com/science/article/pii/S2211124721005921
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    NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma
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      DOI: 10.1016/j.celrep.2021.109238

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    sciencedirect.com/science/article/pii/S2211124721005970
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    Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
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    sciencedirect.com/science/article/pii/S221112472100574X
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
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  34. May 2021
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
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    Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
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    The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation
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    sciencedirect.com/science/article/pii/S1074761321001898
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    Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15291
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    Dynamic subcellular localization and transcription activity of the SRF cofactor MKL2 in the striatum are regulated by MAPK
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15303
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    VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway
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    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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      DOI: 10.7554/eLife.68348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8118655/
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    SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells
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    sciencedirect.com/science/article/pii/S1097276521002690
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    LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through MEK/ERK signaling pathway
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    sciencedirect.com/science/article/pii/S2212877821000752
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    PDZ domain protein SYNJ2BP regulates GRK-dependent Sst2A phosphorylation and downstream MAPK signaling
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    Hydroxychloroquine Inhibits Macrophage Activation and Attenuates Renal Fibrosis After Ischemia-Reperfusion Injury
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  59. Apr 2021
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    Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
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      Rabbit anti-Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) Monoclonal antibody

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    Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma
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    TNFα-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation
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    Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
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    CDKN2A Deletion in Melanoma Excludes T Cell Infiltration by Repressing Chemokine Expression in a Cell Cycle-Dependent Manner
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    Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models
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  87. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
    1
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  88. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease
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  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells
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  90. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
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  91. www.sciencedirect.com www.sciencedirect.com
    Inhibition of FGF10-ERK signal activation suppresses intraductal papillary neoplasm of the bile duct and its associated carcinomas
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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  93. link.springer.com link.springer.com
    Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
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  94. www.cell.com www.cell.com
    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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  95. academic.oup.com academic.oup.com
    Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish
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  96. www.fasebj.org www.fasebj.org
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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  99. Jan 2021
  100. www.frontiersin.org www.frontiersin.org
    DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
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  101. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
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  102. www.sciencedirect.com www.sciencedirect.com
    Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
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    Lactate regulates autophagy through ROS-mediated activation of ERK1/2/m-TOR/p-70S6K pathway in skeletal muscle
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  104. Dec 2020
  105. www.cell.com www.cell.com
    Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells
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  106. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
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  107. link.springer.com link.springer.com
    Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death
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      Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

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  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice
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      P‐p44/42 MAPK

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  109. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15169

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    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  111. Nov 2020
  112. www.cell.com www.cell.com
    Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait
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  113. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  115. onlinelibrary.wiley.com onlinelibrary.wiley.com
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  116. www.frontiersin.org www.frontiersin.org
    Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling
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  117. Oct 2020
  118. www.sciencedirect.com www.sciencedirect.com
    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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  120. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    Activation of Neuronal Ras‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice
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  123. www.cell.com www.cell.com
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    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  126. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment
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  128. www.sciencedirect.com www.sciencedirect.com
    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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  129. Sep 2020
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    Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation
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    ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
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    SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells
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    Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Angiotensin‐(1‐7) Mitigated Angiotensin II‐induced Abdominal Aortic Aneurysms in Apolipoprotein E Knockout Mice
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    Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila
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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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    Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress
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    Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis
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    Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis
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    Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease
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    Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation
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      DOI: 10.1016/j.cub.2018.11.007

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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
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    A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control
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    Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture
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    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
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    Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis
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    Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis
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    Fyn Kinase Controls Tau Aggregation In Vivo
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells
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    Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling
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    Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling
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      p-ERK1/2

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    Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells
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    The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level
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  172. dev.biologists.org dev.biologists.org
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis
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    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis
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    A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies
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    Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation
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  203. www.jneurosci.org www.jneurosci.org
    Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation
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    CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
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  205. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    sciencedirect.com/science/article/pii/S1074761319302778
  208. www.sciencedirect.com www.sciencedirect.com
    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1016/j.devcel.2019.05.043

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @ethanbadger

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S153458071930485X
  209. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1111/bph.14714

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2315112

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      RRID:AB_2315112 RRIDCUR:Validated
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14714
  210. www.sciencedirect.com www.sciencedirect.com
    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1016/j.celrep.2019.12.017

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @ethanbadger

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      RRID:AB_2315112 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719316675
  211. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1111/jnc.14827

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @Naa003

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      RRID:AB_2315112 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14827
  212. academic.oup.com academic.oup.com
    Tanycyte-like cells derived from mouse embryonic stem culture show hypothalamic neural stem/progenitor cell functions
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    1. scibot 13 Jan 2020
      RRID:AB_2315112

      DOI: 10.1210/en.2019-00105

      Resource: (Cell Signaling Technology Cat# 4370, RRID:AB_2315112)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2315112

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      RRID:AB_2315112 RRIDCUR:Validated
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    academic.oup.com/endo/article/160/7/1701/5498458