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Jan 2023
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Interleukin 11 confers resistance to dextran sulfate sodium-induced colitis in mice

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A Genome-wide screen identifies PDPK1 as a target to enhance the efficacy of MEK1/2 inhibitors in NRAS mutant melanoma

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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

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A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

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Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect

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Oxygen-carrying sequential preservation mitigates liver grafts ischemia-reperfusion injury

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Characterizing treatment resistance in muscle invasive bladder cancer using the chicken egg chorioallantoic membrane patient-derived xenograft model

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ER-001259851-000, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs

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A single RET mutation in Hirschsprung disease induces intestinal aganglionosis via a dominant-negative mechanism

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Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

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Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin

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Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition

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Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis

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Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation

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Early alveolar epithelial cell necrosis is a potential driver of COVID-19-induced acute respiratory distress syndrome

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DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma

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Dec 2022
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TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development

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1. scibot 31 Dec 2022
  
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  DOI: 10.7554/eLife.80405
  
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Glycolytic flux-signaling controls mouse embryo mesoderm development

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Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality

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ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

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Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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Neural precursor cells tune striatal connectivity through the release of IGFBPL1

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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

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miR-17∼92 exerts stage-specific effects in adult V-SVZ neural stem cell lineages

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Microglial depletion impairs glial scar formation and... : Neural Regeneration Research

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Adaptable toolbox to characterize Alzheimer’s disease pathology in mouse models

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BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis

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Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions

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A druggable UHRF1/DNMT1/GLI complex regulates Sonic hedgehog dependent tumor growth

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Autophagy promotes cell survival by maintaining NAD levels

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Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

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Biofabrication of synthetic human liver tissue with advanced programmable functions

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LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

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  DOI: 10.7554/eLife.81559
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9674348/
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Bone marrow-derived extracellular vesicles modulate the abundance of infiltrating immune cells in the brain and exert an antiviral effect against the Japanese Encephalitis virus

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Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression

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Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells

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F1000Research Article: Tumour cell suppression by spiroleucettadine through dual regulation of cell cycle and apoptosis.

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Effect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex

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Intracellular TMEM16A is necessary for myogenesis of skeletal muscle

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Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

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ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response

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Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis

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Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

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Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair

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Sex differences and risk factors for bleeding in Alagille syndrome

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A systemic cell stress signal confers neuronal resilience toward oxidative stress in a Hedgehog-dependent manner

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Anti-ischemic effect of <i>Tamarindus indica </i>L. seed extract against myocardial hypoxic injury

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Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy

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Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome

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CDON contributes to Hedgehog-dependent patterning and growth of the developing limb

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Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis

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C9orf72 functions in the nucleus to regulate DNA damage repair

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Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation

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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells

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ER stress transforms random olfactory receptor choice into axon targeting precision

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Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors

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Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs

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BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer

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A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice

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NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration

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Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis

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Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster

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Na+/H+-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells

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Gut microbial DL-endopeptidase alleviates Crohn’s disease via the NOD2 pathway

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Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors

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SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression

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can-22-0631-html.html

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can-21-3822-html.html

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Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro

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Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

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Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach

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Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

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A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity

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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway

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Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

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Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6‐dependent pathway

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Accurate and stable chronic in vivo voltammetry enabled by a replaceable subcutaneous reference electrode

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HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance

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Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

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Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression

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GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

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T cells mediate kidney tubular injury via impaired PDHA1 and Autophagy in type 1 diabetes

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Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning

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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

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Melatonin attenuates manganese-induced mitochondrial fragmentation by suppressing the Mst1/JNK signaling pathway in primary mouse neurons

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LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

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Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex

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Jun 2022
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cd-21-1514-html.html

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cd-21-1022-html.html

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cd-21-0680-html.html

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Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

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Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes Grm8a and Grm8b Display Distinct Behavioral Phenotypes in Zebrafish Larvae (Danio rerio)

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MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

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Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation

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Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase 2 Function in Mice

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Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex

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NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs

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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

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The V2 receptor antagonist tolvaptan counteracts proliferation and invasivity in human cancer cells

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Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

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Efficiently suppress of ferroptosis using deferoxamine nanoparticles as a new method for retinal ganglion cell protection after traumatic optic neuropathy

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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

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Targeted ablation of Lgr5-expressing intestinal stem cells in diphtheria toxin receptor-based mouse and organoid models

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Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination

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Posttranslational modification of microtubules by the MATCAP detyrosinase

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Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer

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p53 directs leader cell behavior, migration, and clearance during epithelial repair

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Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization

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ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve.

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Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets

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Brown adipose tissue involution associated with progressive restriction in progenitor competence

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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

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Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis

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Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors

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Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis

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CHD8 haploinsufficiency links autism to transient alterations in excitatory and inhibitory trajectories

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Acetaminophen (APAP, paracetamol) interferes with the first trimester human fetal ovary development in an ex vivo model

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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain

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Asthmatic bronchial smooth muscle increases rhinovirus replication within the bronchial epithelium

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Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models

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Coactivator-associated arginine methyltransferase 1 controls oligodendrocyte differentiation in the corpus callosum during early brain development

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TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury

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Alexa Fluor 488-conjugated cholera toxin subunit B... : Neural Regeneration Research

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OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death

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Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

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Evaluation of the protective effect of Clitoria ternatea L. against propionic acid induced autistic spectrum disorders in rat model

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Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity

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Force-generating apoptotic cells orchestrate avian neural tube bending

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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

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Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting

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Mouse tail skin wholemount staining and intravital calcium imaging

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Biotin controls intestinal stem cell mitosis and host-microbiome interactions

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Activation of the unfolded protein response by Connexin47 mutations associated with Pelizaeus-Merzbacher-like disease

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Central dopaminergic control of cell proliferation in the colonic epithelium

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MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop

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Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system

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Partial p53 reactivation is sufficient to induce cancer regression

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Bacteriocyte development is sexually differentiated in Bemesia tabaci

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Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter

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Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells

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Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer

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Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth

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Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development

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CRAF dimerization with ARAF regulates KRAS-driven tumor growth

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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

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Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

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Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

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Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death

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Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.

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Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development

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Vortioxetine ameliorates motor and cognitive impairments in the rotenone-induced Parkinson's disease via targeting TLR-2 mediated neuroinflammation

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Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs

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Embryonic pericytes promote microglial homeostasis and their effects on neural progenitors in the developing cerebral cortex

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The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression

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faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

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Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy

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MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1

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  DOI: 10.1158/1541-7786.MCR-20-0913
  
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Dec 2021
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Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

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Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo

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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

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  DOI: 10.1038/s41467-021-27452-9
  
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TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits

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Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

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Generation of mixed murine organoids to model cellular interactions

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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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Structure-Activity Relationship of Hydroxycinnamic Acid Derivatives for Cooperating with Carnosic Acid and Calcitriol in Acute Myeloid Leukemia Cells

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Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

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A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

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The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

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Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

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Resident macrophage-dependent immune cell scaffolds drive anti-bacterial defense in the peritoneal cavity

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ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells

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