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  1. Jul 2021
  2. www.sciencedirect.com www.sciencedirect.com
    The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease
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    1. scibot 16 Jul 2021
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    sciencedirect.com/science/article/pii/S1550413121002849
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
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    1. scibot 14 Jul 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8328392/
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    Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival
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    link.springer.com/article/10.1007/s00432-021-03713-4
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    sciencedirect.com/science/article/pii/S1097276521004962
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    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy
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    1. scibot 08 Jul 2021
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      DOI: 10.7554/eLife.66582

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    ncbi.nlm.nih.gov/pmc/articles/PMC8245133/
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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    sciencedirect.com/science/article/pii/S1097276521004500
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    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
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    1. scibot 03 Jul 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8225385/
  9. Jun 2021
  10. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
    1
    1. scibot 29 Jun 2021
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      DOI: 10.1158/2159-8290.CD-20-0797

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    cancerdiscovery.aacrjournals.org/content/11/6/1411
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    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    clincancerres.aacrjournals.org/content/27/12/3432
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    Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC8209278/
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    SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B
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    ncbi.nlm.nih.gov/pmc/articles/PMC8216717/
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    Subcellular localization of neuronal nuclei (NeuN) antigen in size and calcitonin gene-related peptide (CGRP) populations of dorsal root ganglion (DRG) neurons during acute peripheral inflammation
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    sciencedirect.com/science/article/pii/S0304394021003529
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    Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch
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    1. scibot 23 Jun 2021
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    sciencedirect.com/science/article/pii/S2211124721006471
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
    1
    1. scibot 16 Jun 2021
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      DOI: 10.3390/cancers13112840

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    ncbi.nlm.nih.gov/pmc/articles/PMC8201054/
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    Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.cell.2021.05.015

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    sciencedirect.com/science/article/pii/S0092867421006322
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    The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation
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    1. scibot 16 Jun 2021
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    sciencedirect.com/science/article/pii/S2211124721006173
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    Identification and validation of selective deubiquitinase inhibitors
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    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.chembiol.2021.05.012

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    sciencedirect.com/science/article/pii/S2451945621002579
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
    1
    1. scibot 09 Jun 2021
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      DOI: 10.1016/j.celrep.2021.109217

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    sciencedirect.com/science/article/pii/S2211124721005684
  21. www.nature.com www.nature.com
    Muscle regeneration controlled by a designated DNA dioxygenase
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    nature.com/articles/s41419-021-03817-2
  22. May 2021
  23. www.sciencedirect.com www.sciencedirect.com
    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    1. scibot 29 May 2021
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      DOI: 10.1016/j.cels.2021.05.002

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    sciencedirect.com/science/article/pii/S2405471221001575
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    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
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    1. scibot 28 May 2021
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    sciencedirect.com/science/article/pii/S0092867421005729
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
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    1. scibot 21 May 2021
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      DOI: 10.7554/eLife.66519

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    ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
  26. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15340

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15340
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation
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      DOI: 10.7554/eLife.61769

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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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  29. www.sciencedirect.com www.sciencedirect.com
    Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing
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    1. scibot 13 May 2021
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    sciencedirect.com/science/article/pii/S1934590921001600
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    The f subunit of human ATP synthase is essential for normal mitochondrial morphology and permeability transition
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    sciencedirect.com/science/article/pii/S2211124721004459
  31. journals.physiology.org journals.physiology.org
    Altered calcium handling in cardiomyocytes from arginine:glycine amidinotransferase knockout mice is rescued by creatine
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      DOI: 10.1152/ajpheart.00300.2020

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    journals.physiology.org/doi/abs/10.1152/ajpheart.00300.2020
  32. www.sciencedirect.com www.sciencedirect.com
    METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
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    sciencedirect.com/science/article/pii/S2211124721004253
  33. academic.oup.com academic.oup.com
    Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder
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      DOI: 10.1210/endocr/bqaa211

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    academic.oup.com/endo/article/162/1/bqaa211/5988952
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    Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis
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    sciencedirect.com/science/article/pii/S1525001621000666
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    Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells
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    Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
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      DOI: 10.1016/j.neuron.2021.02.023

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    Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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      DOI: 10.1016/j.neuron.2020.07.023

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    The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling
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      DOI: 10.1523/JNEUROSCI.2386-20.2021

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    jneurosci.org/content/41/8/1650
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    Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells
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      DOI: 10.1016/j.molcel.2020.07.010

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    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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    SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts
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    sciencedirect.com/science/article/pii/S1097276520303129
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    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice
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  88. www.sciencedirect.com www.sciencedirect.com
    AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
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  89. www.sciencedirect.com www.sciencedirect.com
    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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  90. www.sciencedirect.com www.sciencedirect.com
    ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy
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      GAPDH

      DOI: 10.1016/j.celrep.2021.108731

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  91. elifesciences.org elifesciences.org
    Diverse viral proteases activate the NLRP1 inflammasome
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  92. Jan 2021
  93. www.sciencedirect.com www.sciencedirect.com
    Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
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    NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
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  95. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  96. www.sciencedirect.com www.sciencedirect.com
    ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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      DOI: 10.1016/j.celrep.2020.108569

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  98. Dec 2020
  99. academic.oup.com academic.oup.com
    A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
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      anti-GAPDH

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  100. www.sciencedirect.com www.sciencedirect.com
    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms
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    A Hemidesmosome-to-Cytoplasm Translocation of Small Heat Shock Proteins Provides Immediate Protection against Heat Stress
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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  105. Nov 2020
  106. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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      DOI: 10.7554/eLife.55994

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    De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment
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    1. scibot 20 Nov 2020
      rabbit polyclonal anti-GAPDH

      DOI: 10.1016/j.ajhg.2020.10.012

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  109. www.frontiersin.org www.frontiersin.org
    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
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      DOI: 10.3389/fendo.2020.579161

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  110. www.cell.com www.cell.com
    A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration
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      DOI: 10.1016/j.cub.2020.09.043

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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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  112. Oct 2020
  113. www.sciencedirect.com www.sciencedirect.com
    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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      DOI: 10.1016/j.chembiol.2020.10.001

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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain
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      RRID:AB_1031003

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    Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry
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      DOI: 10.1016/j.celrep.2020.108292

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  116. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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    Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
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      RRID:AB_561053

      DOI: 10.1016/j.cellsig.2020.109735

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  119. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Activation of the CARD8 Inflammasome Requires a Disordered Region
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      DOI: 10.1016/j.celrep.2020.108264

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  120. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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      glyceraldehyde‐3‐phosphate dehydrogenase

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  121. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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      DOI: 10.1016/j.jss.2020.08.071

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    Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner
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      RRID:AB_561053

      DOI: 10.1016/j.redox.2020.101742

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    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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  125. Sep 2020
  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activity
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      DOI: 10.1016/j.ebiom.2020.102996

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    Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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      DOI: 10.1016/j.molcel.2019.12.022

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    FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
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    Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
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      DOI: 10.1016/j.celrep.2020.108017

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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53
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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
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    E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
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    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
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    Targeted Kruppel-like factor 4 gene knockout in retinal ganglion cells improves visual function in multiple sclerosis mouse model
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    Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling
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    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
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    The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription
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    Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
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    Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
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    Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation
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    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
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      DOI: 10.1111/bph.14918

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    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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    Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis
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    Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles
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    Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
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    Structural Basis for Target-Directed MicroRNA Degradation
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    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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    Murine maternal dietary restriction affects neural Humanin expression and cellular profile
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
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    EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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      DOI: 10.1038/s41467-019-13086-5

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    Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli
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    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.1016/j.cub.2019.08.051

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_561053

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      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0960982219311017
  210. www.sciencedirect.com www.sciencedirect.com
    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
    1
    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.1016/j.celrep.2019.11.079

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_561053

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      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719315700
  211. www.mdpi.com www.mdpi.com
    N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor
    1
    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.3390/cancers11101456

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      Curator: @Naa003

      SciCrunch record: RRID:AB_561053

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      RRID:AB_561053 RRIDCUR:Validated
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    mdpi.com/2072-6694/11/10/1456
  212. www.sciencedirect.com www.sciencedirect.com
    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
    1
    1. scibot 13 Jan 2020
      RRID:AB_561053

      DOI: 10.1016/j.molcel.2019.10.019

      Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_561053

      What is this?

      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S109727651930797X