1,102 Matching Annotations
  1. Apr 2021
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    sciencedirect.com/science/article/pii/S2451945620302348
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    Personalized Genome-Scale Metabolic Models Identify Targets of Redox Metabolism in Radiation-Resistant Tumors
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    sciencedirect.com/science/article/pii/S2405471220305020
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    Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
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    sciencedirect.com/science/article/pii/S0092867420307455
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    Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation
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    sciencedirect.com/science/article/pii/S1097276521002331
  6. academic.oup.com academic.oup.com
    Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation
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    academic.oup.com/jes/article/5/5/bvab035/6159317
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15428
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC8042115/
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    Dietary spermidine improves cognitive function
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    sciencedirect.com/science/article/pii/S2211124721002990
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    Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
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    sciencedirect.com/science/article/pii/S2211124721003089
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    The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
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    sciencedirect.com/science/article/pii/S1074761321001205
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    Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras
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    sciencedirect.com/science/article/pii/S2451945621001501
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    Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
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    sciencedirect.com/science/article/pii/S1074761321000868
  14. Mar 2021
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    A short isoform of STIM1 confers frequency-dependent synaptic enhancement
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    sciencedirect.com/science/article/pii/S2211124721001583
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC7920255/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
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    ncbi.nlm.nih.gov/pmc/articles/PMC7891930/
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    Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles
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    sciencedirect.com/science/article/pii/S1534580720310224
  19. Feb 2021
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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    ncbi.nlm.nih.gov/pmc/articles/PMC7909318/
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    Targeted degradation of the enhancer lysine acetyltransferases CBP and p300
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    sciencedirect.com/science/article/pii/S2451945620305134
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    Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency
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    sciencedirect.com/science/article/pii/S109727652030887X
  23. atm.amegroups.com atm.amegroups.com
    Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages
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    atm.amegroups.com/article/view/61325/html
  24. elifesciences.org elifesciences.org
    Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development
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    elifesciences.org/articles/55263
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
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    ncbi.nlm.nih.gov/pmc/articles/PMC7375811/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24
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    ncbi.nlm.nih.gov/pmc/articles/PMC7362799/
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    Depletion of microglia in developing cortical circuits reveals its critical role in glutamatergic synapse development, functional connectivity, and critical period plasticity
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24641
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    Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function
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    ncbi.nlm.nih.gov/pmc/articles/PMC7124252/
  29. academic.oup.com academic.oup.com
    The autophagy gene Atg16L1 is necessary for endometrial decidualization
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    academic.oup.com/endo/article/161/1/bqz039/5686885
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success
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    ncbi.nlm.nih.gov/pmc/articles/PMC7880688/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC7884690/
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    AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
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    sciencedirect.com/science/article/pii/S2211124721000267
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    Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
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    sciencedirect.com/science/article/pii/S1934590920300606
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    ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy
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    sciencedirect.com/science/article/pii/S2211124721000449
  35. elifesciences.org elifesciences.org
    Diverse viral proteases activate the NLRP1 inflammasome
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    elifesciences.org/articles/60609
  36. Jan 2021
  37. www.sciencedirect.com www.sciencedirect.com
    Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
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    sciencedirect.com/science/article/pii/S2211124720316727
  38. www.sciencedirect.com www.sciencedirect.com
    NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
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    sciencedirect.com/science/article/pii/S2211124720316491
  39. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15288
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    ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy
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    sciencedirect.com/science/article/pii/S2211124720315837
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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    sciencedirect.com/science/article/pii/S2211124720315588
  42. Dec 2020
  43. academic.oup.com academic.oup.com
    A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa1224/6042962
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    CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
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    sciencedirect.com/science/article/pii/S2211124720315345
  45. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q
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    sciencedirect.com/science/article/pii/S2211124720314820
  46. www.nature.com www.nature.com
    Weak acids induce PGE 2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms
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    nature.com/articles/s41598-020-77495-z
  47. www.sciencedirect.com www.sciencedirect.com
    A Hemidesmosome-to-Cytoplasm Translocation of Small Heat Shock Proteins Provides Immediate Protection against Heat Stress
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    sciencedirect.com/science/article/pii/S2211124720313991
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7685705/
  49. Nov 2020
  50. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15269
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
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    De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment
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    sciencedirect.com/science/article/pii/S0002929720303700
  53. www.frontiersin.org www.frontiersin.org
    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
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    frontiersin.org/article/10.3389/fendo.2020.579161/full
  54. www.cell.com www.cell.com
    A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration
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    cell.com/current-biology/abstract/S0960-9822(20)31413-5
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC7584921/
  56. Oct 2020
  57. www.sciencedirect.com www.sciencedirect.com
    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    sciencedirect.com/science/article/pii/S2451945620303809
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC7575323/
  59. www.sciencedirect.com www.sciencedirect.com
    Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry
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    sciencedirect.com/science/article/pii/S221112472031281X
  60. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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    elifesciences.org/articles/57395
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC7567700/
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    Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
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    sciencedirect.com/science/article/pii/S0898656820302126
  63. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Activation of the CARD8 Inflammasome Requires a Disordered Region
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    pubmed.ncbi.nlm.nih.gov/33053349/
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
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    onlinelibrary.wiley.com/doi/full/10.1002/cac2.12103
  65. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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    pubmed.ncbi.nlm.nih.gov/33031745/
  66. www.sciencedirect.com www.sciencedirect.com
    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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    sciencedirect.com/science/article/pii/S002248042030634X
  67. www.sciencedirect.com www.sciencedirect.com
    Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner
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    sciencedirect.com/science/article/pii/S2213231720309472
  68. www.cell.com www.cell.com
    Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
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    cell.com/cell/fulltext/S0092-8674(20)31143-0
  69. Sep 2020
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC7501074/
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    Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
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    sciencedirect.com/science/article/pii/S0092867420303457
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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    sciencedirect.com/science/article/pii/S1097276519309529
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    FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
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    sciencedirect.com/science/article/pii/S2211124720302564
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    Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
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    sciencedirect.com/science/article/pii/S2211124720310020
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    sciencedirect.com/science/article/pii/S1934590920300540
  76. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
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    pubmed.ncbi.nlm.nih.gov/32853547/
  77. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    sciencedirect.com/science/article/pii/S0092867420306863
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    Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
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    sciencedirect.com/science/article/pii/S1550413120300061
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    Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
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    sciencedirect.com/science/article/pii/S2211124720311700
  80. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sex‐dependent pronociceptive role of spinal α5‐GABAA receptor and its epigenetic regulation in neuropathic rodents
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15140
  81. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
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    pubmed.ncbi.nlm.nih.gov/32966791/
  82. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress
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    pubmed.ncbi.nlm.nih.gov/32966795/
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    Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53
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    sciencedirect.com/science/article/pii/S2211124719317218
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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    sciencedirect.com/science/article/pii/S2211124720306227
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    ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin
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    sciencedirect.com/science/article/pii/S2211124720309785
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    Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
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    sciencedirect.com/science/article/pii/S0960982220306333
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    Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function
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    onlinelibrary.wiley.com/doi/10.1002/jcp.29906
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    Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14960
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    Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway
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    sciencedirect.com/science/article/pii/S1550413120300590
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC7224700/
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    sciencedirect.com/science/article/pii/S2211124720301649
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
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    ncbi.nlm.nih.gov/pmc/articles/PMC7272217/
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    E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
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    sciencedirect.com/science/article/pii/S1534580719310391
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    Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis
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