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1,263 Matching Annotations

Dec 2020
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Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

1
1. scibot 07 Dec 2020
  
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  Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
  
  DOI: 10.1007/s10495-020-01645-x
  
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link.springer.com/article/10.1007/s10495-020-01645-x
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Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice

1
1. scibot 07 Dec 2020
  
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  P‐p44/42 MAPK
  
  DOI: 10.1111/jnc.15151
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15151
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BPS Publications

1
1. scibot 07 Dec 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1111/bph.15169
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15169
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Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling

1
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  DOI: 10.1016/j.celrep.2020.108427
  
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sciencedirect.com/science/article/pii/S2211124720314169
Nov 2020
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Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait

1
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  RRID:AB_2315112
  
  DOI: 10.1016/j.cub.2020.09.071
  
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cell.com/current-biology/abstract/S0960-9822(20)31441-X
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FEBS Press

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  RRID:AB_2315112
  
  DOI: 10.1002/1878-0261.12820
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.12820
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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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  DOI: 10.1096/fj.201900991R
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6894087/
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Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

1
1. scibot 03 Nov 2020
  
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  DOI: 10.1002/glia.23930
  
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onlinelibrary.wiley.com/doi/full/10.1002/glia.23930
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Polyunsaturated Fatty Acids Influence LPS-Induced Inflammation of Fish Macrophages Through Differential Modulation of Pathogen Recognition and p38 MAPK/NF-κB Signaling

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  AB_2315112
  
  DOI: 10.3389/fimmu.2020.559332
  
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frontiersin.org/article/10.3389/fimmu.2020.559332/full
Oct 2020
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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

1
1. scibot 31 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1016/j.cels.2020.10.002
  
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sciencedirect.com/science/article/pii/S2405471220303707
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Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts

1
1. scibot 29 Oct 2020
  
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  AB_2315112
  
  DOI: 10.3389/fimmu.2020.579266
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7576893/
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Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

1
1. scibot 24 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.7554/eLife.57395
  
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elifesciences.org/articles/57395
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Activation of Neuronal Ras‐Related C3 Botulinum Toxin Substrate 1 (Rac1) Improves Post‐Stroke Recovery and Axonal Plasticity in Mice

1
1. scibot 22 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1111/jnc.15195
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15195
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Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling

1
1. scibot 22 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1172/jci.insight.141514
  
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pubmed.ncbi.nlm.nih.gov/32960816/
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Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish

1
1. scibot 17 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1016/j.cub.2020.09.002
  
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cell.com/current-biology/abstract/S0960-9822(20)31333-6
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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

1
1. scibot 15 Oct 2020
  
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  RRID: AB_2315112
  
  DOI: 10.1016/j.devcel.2020.05.031
  
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cell.com/developmental-cell/abstract/S1534-5807(20)30420-2
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Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

1
1. scibot 13 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.7554/eLife.59442
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7541088/
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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

1
1. scibot 08 Oct 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1016/j.celrep.2020.108221
  
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pubmed.ncbi.nlm.nih.gov/33027668/
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AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

1
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  RRID:AB_2315112
  
  DOI: 10.1016/j.devcel.2018.11.033
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7523188/
www.cell.com www.cell.com

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

1
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  RRID:AB_2315112
  
  DOI: 10.1016/j.cell.2020.09.002
  
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cell.com/cell/fulltext/S0092-8674(20)31143-0
Sep 2020
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Roles of Pyk2 in signal transduction after gonadotropin‐releasing hormone receptor stimulation

1
1. scibot 29 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1002/jcp.30077
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.30077
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ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling

1
1. scibot 26 Sep 2020
  
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  phospho ERK1/2
  
  DOI: 10.1002/path.5517
  
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onlinelibrary.wiley.com/doi/10.1002/path.5517
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SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells

1
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  DOI: 10.1016/j.celrep.2020.108184
  
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sciencedirect.com/science/article/pii/S2211124720311736
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Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

1
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  DOI: 10.1016/j.celrep.2020.02.117
  
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sciencedirect.com/science/article/pii/S2211124720302989
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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

1
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  DOI: 10.1126/sciadv.aaz6699
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7299619/
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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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  AB_2315112
  
  DOI: 10.1016/j.celrep.2020.107571
  
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sciencedirect.com/science/article/pii/S2211124720305209
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Angiotensin‐(1‐7) Mitigated Angiotensin II‐induced Abdominal Aortic Aneurysms in Apolipoprotein E Knockout Mice

1
1. scibot 26 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1111/bph.14906
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14906
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Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

1
1. scibot 25 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.7554/eLife.47542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7299341/
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Disruption of EGF Feedback by Intestinal Tumors and Neighboring Cells in Drosophila

1
1. scibot 25 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1016/j.cub.2020.01.082
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7409949/
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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

1
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  RRID:AB_2315112
  
  DOI: 10.1016/j.ccell.2020.02.006
  
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sciencedirect.com/science/article/pii/S1535610820300957
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Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

1
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  DOI: 10.1016/j.celrep.2020.108087
  
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sciencedirect.com/science/article/pii/S2211124720310767
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Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.7554/eLife.51595
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6996930/
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Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis

1
1. scibot 23 Sep 2020
  
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  RRID:AB_2315112
  
  DOI: 10.1016/j.phrs.2020.104751
  
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Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras

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Nutrient-Driven O-GlcNAcylation Controls DNA Damage Repair Signaling and Stem/Progenitor Cell Homeostasis

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Sleep is bi-directionally modified by amyloid beta oligomers

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Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease

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The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

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Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation

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Cdk4 and Cdk6 Couple the Cell-Cycle Machinery to Cell Growth via mTORC1

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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

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A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control

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Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway

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Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture

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FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c‐Jun axis

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EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis

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Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis

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BPS Publications

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Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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The Natural Compound Notopterol Binds and Targets JAK2/3 to Ameliorate Inflammation and Arthritis

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Fyn Kinase Controls Tau Aggregation In Vivo

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

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Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells

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Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling

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Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling

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Prolactin enhances the proliferation of proliferative endometrial glandular cells and endometrial cancer cells

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The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level

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Kinetic Heterogeneity of Cancer Cell Fractional Killing

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GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route

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Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

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An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of Protein Kinase A and EPAC to chronic inflammatory pain

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Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

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Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging

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Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain

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Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

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Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson’s Disease

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Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice

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Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina

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Early effect of laser irradiation in signaling pathways of diabetic rat submandibular salivary glands

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BPS Publications

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HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

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Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling

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Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

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Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation

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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies

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Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis

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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells

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Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer

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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

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Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

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Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation

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Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors

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Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors

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Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation

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CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

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A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling

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The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis

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BPS Publications

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  DOI: 10.1111/bph.14714
  
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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury

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Tanycyte-like cells derived from mouse embryonic stem culture show hypothalamic neural stem/progenitor cell functions

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Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

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Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands

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CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

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The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation

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BPS Publications

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Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway

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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

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EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection

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Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

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The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

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A Simple DMSO-Based Method for Cryopreservation of Primary Hippocampal and Cortical Neurons

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Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation

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Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors

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Systemic Root-Shoot Signaling Drives Jasmonate-Based Root Defense against Nematodes

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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

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Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice

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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

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N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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A bidirectional network for appetite control in larval zebrafish

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Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

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Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

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CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury

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Exploring Targeted Degradation Strategy for Oncogenic KRASG12C

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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

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YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression

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Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition

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The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity

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ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly

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FGF signaling directs the cell fate switch from neurons to astrocytes in the developing mouse cerebral cortex

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Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3

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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content

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3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival

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FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling

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Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells

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O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

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Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity

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KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

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GM1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA

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Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2

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Low expression of CRISP3 predicts a favorable prognosis in patients with mammary carcinoma

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Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions

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Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism

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FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis

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The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism

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Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor

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js.2018-00170.pdf

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Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response

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Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus

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IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

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A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network

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Chromosomal Instability Induces Cellular Invasion in Epithelial Tissues

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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

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The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

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Timing Mechanisms Underlying Gate Control by Feedforward Inhibition

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Luminance Changes Drive Directional Startle through a Thalamic Pathway

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Adaptive Fibrogenic Reprogramming of Osteosarcoma Stem Cells Promotes Metastatic Growth

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SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

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Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation

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Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

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Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy

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Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation

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Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases

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