1,867 Matching Annotations
  1. Jun 2021
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    ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia
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    sciencedirect.com/science/article/pii/S1097276521003658
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    SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ
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    pubmed.ncbi.nlm.nih.gov/34077730/
  4. May 2021
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    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    sciencedirect.com/science/article/pii/S2405471221001575
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    SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8106883/
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    A systematic analysis of signaling reactivation and drug resistance
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    sciencedirect.com/science/article/pii/S221112472100499X
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    Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
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    sciencedirect.com/science/article/pii/S1934590921001818
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    Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy
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    link.springer.com/article/10.1007/s00109-021-02091-1
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    Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
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    sciencedirect.com/science/article/pii/S2211124721004964
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    β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles
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    sciencedirect.com/science/article/pii/S2211124721004782
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    The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
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    sciencedirect.com/science/article/pii/S009286742100502X
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    Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway
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    Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria
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    ncbi.nlm.nih.gov/pmc/articles/PMC8102061/
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    Invariant natural killer T cells coordinate removal of senescent cells
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    sciencedirect.com/science/article/pii/S266663402100163X
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    Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity
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    academic.oup.com/endo/article/161/11/bqaa142/5893756
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    The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model
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    journals.physiology.org/doi/abs/10.1152/ajpcell.00299.2020
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    Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis
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    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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    Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes
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    Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model
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    G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD
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    DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells
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    TopBP1 assembles nuclear condensates to switch on ATR signaling
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    Purkinje neurons with loss of STIM1 exhibit age-dependent changes in gene expression and synaptic components
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis
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    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling
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    Oxindole–curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase
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    In-gel proteasome assay to determine the activity, amount, and composition of proteasome complexes from mammalian cells or tissues
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    Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains
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    Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging
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    Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
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    CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
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    Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification
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    LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome
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  39. Apr 2021
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    Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
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    The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
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    High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels
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    acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33567
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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    SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system
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    Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction
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    Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer
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    A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
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    Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form
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    A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
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    LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2
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    Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
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    iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia
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    Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
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    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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    MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
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    A membrane arm of mitochondrial complex I sufficient to promote respirasome formation
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    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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    Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
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    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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    Capturing human trophoblast development with naive pluripotent stem cells in vitro
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    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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    ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  74. Mar 2021
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
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    ncbi.nlm.nih.gov/pmc/articles/PMC8005871/
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    Sarbecovirus ORF6 proteins hamper the induction of interferon signaling
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    On the role of p53 in the cellular response to aneuploidy
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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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    MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells
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    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
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    Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold
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    Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A
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    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer
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    Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics
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    Molecular forms of neurogranin in cerebrospinal fluid
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    BPS Publications
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    Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors
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    nature.com/articles/s41398-021-01266-1
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    LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection
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    Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles
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    An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
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