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A Novel Allosteric Inhibitor Targeting IMPDH at Y233 Overcomes Resistance to Tyrosine Kinase Inhibitors in Lymphoma

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1. scibot 01 Nov 2025
  
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  AB_2127351
  
  DOI: 10.3390/cancers17203389
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12563536/
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Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

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1. scibot 29 Oct 2025
  
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  RRID:AB_2127351
  
  DOI: 10.1016/j.molcel.2025.10.002
  
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sciencedirect.com/science/article/pii/S1097276525008196
Jan 2025
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Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer

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1. scibot 10 Jan 2025
  
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  RRID:AB_2127351
  
  DOI: 10.1038/s41598-024-85094-5
  
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nature.com/articles/s41598-024-85094-5
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IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth

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1. scibot 03 Jan 2025
  
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  RRID:AB_2127351
  
  DOI: 10.1016/j.celrep.2024.115116
  
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sciencedirect.com/science/article/pii/S2211124724014670
Jun 2024
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De novo and salvage purine synthesis pathways across tissues and tumors

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1. scibot 04 Jun 2024
  
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  RRID:AB_2127351
  
  DOI: 10.1016/j.cell.2024.05.011
  
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sciencedirect.com/science/article/pii/S0092867424005208
Jan 2024
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Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

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1. scibot 11 Jan 2024
  
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  AB_2127351
  
  DOI: 10.1016/j.celrep.2023.113629
  
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sciencedirect.com/science/article/pii/S2211124723016406
May 2021
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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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1. scibot 07 May 2021
  
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  RRID:AB_2127351
  
  DOI: 10.1016/j.molcel.2020.05.001
  
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sciencedirect.com/science/article/pii/S1097276520303026