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    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
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    Trans-omic profiling uncovers molecular controls of early human cerebral organoid formation
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    Hepatoprotective effects of baicalein against liver ischemia-reperfusion injury and partial hepatectomy in a rat model
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    Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice
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    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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  8. May 2024
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    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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    Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging
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    Comprehensive proteogenomic characterization of rare kidney tumors
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    Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice
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    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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  17. Apr 2024
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    BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    Overexpression of α-Klotho isoforms promotes distinct Effects on BDNF-Induced Alterations in Dendritic Morphology
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    Mutant FOXO1 controls an oncogenic network via enhancer accessibility
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    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation
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    Prolactin promotes the recruitment of main olfactory bulb cells and enhances the behavioral exploration toward a socio-sexual stimulus in female mice
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    Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells
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  30. Feb 2024
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    Sphingolipid metabolism controls mammalian heart regeneration
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    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
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    A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin-treated rats
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    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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  36. Jan 2024
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner
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  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice
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  43. Dec 2023
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway
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  52. Oct 2023
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  54. dx.doi.org dx.doi.org
    Adipocyte Subpopulations Mediate Growth Hormone-induced Lipolysis and Glucose Tolerance in Male Mice
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  60. Sep 2023
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    Resistance wheel running improves contractile strength, but not metabolic capacity, in a murine model of volumetric muscle loss injury
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  65. Aug 2023
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    RhoB Promotes Salmonella survival by Regulating Autophagy
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    Allyl isothiocyanate mitigates airway inflammation and constriction in a house dust mite-induced allergic asthma model via upregulation of tight junction proteins and the TRPA1 modulation
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    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    Proteogenomic insights suggest druggable pathways in endometrial carcinoma
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
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    GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
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    Tyrosine Kinase Inhibitors Diminish Renal Neoplasms in a Tuberous Sclerosis Model via induction of Apoptosis
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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    Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
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  85. Jun 2023
  86. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    Endothelial MRs mediate Western diet-induced lipid disorders and skeletal muscle insulin resistance in females
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    Fasting produces antidepressant-like effects via activating mammalian target of rapamycin complex 1 signaling pathway in ovariectomized mice
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    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
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    Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA
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    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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    ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis
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    Dihydroartemisinin inhibited stem cell-like properties and enhanced oxaliplatin sensitivity of colorectal cancer via AKT/mTOR signaling
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
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    Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart: The relationship between mTOR and KATP channel
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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    Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development
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    The TAZ-CAMTA1 Fusion Protein Promotes Tumorigenesis via Connective Tissue Growth Factor and Ras–MAPK Signaling in Epithelioid Hemangioendothelioma
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    Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory
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    Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence
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    Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model
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    MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Liver Endothelium Promotes HER3-mediated Cell Survival in Colorectal Cancer with Wild-type and Mutant KRAS
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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    Active APPL1 sequestration by Plasmodium favors liver-stage development
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    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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  188. Apr 2022
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    Tissue remodeling by an opportunistic pathogen triggers allergic inflammation
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    Cerebroprotein hydrolysate injection is involved in promoting long-term angiogenesis, vessel diameter and density after cerebral ischemia in mice
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    Energetic metabolic reprogramming in Jurkat DFF40-deficient cancer cells
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    Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration
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    Calcineurin/NFATc2 and PI3K/AKT signaling maintains β-cell identity and function during metabolic and inflammatory stress
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  196. Mar 2022
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    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    Proanthocyanidins Inhibit the Transmission of Spinal Pain Information Through a Presynaptic Mechanism in a Mouse Inflammatory Pain Model
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    Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
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    Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity
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    Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
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    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
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  208. Jan 2022
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    Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis
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    Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ2 Attenuates H2O2-Induced IL-6 Expression in Rat Brain Astrocytes
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    PI3K inhibition by BKM120 results in anti-proliferative effects on corticotroph tumor cells
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    Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
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    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth
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    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    The spike protein of SARS-CoV-2 virus induces heme oxygenase-1: Pathophysiologic implications
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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    TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver
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    Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes
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