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  1. Jul 2021
  2. elifesciences.org elifesciences.org
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    1. scibot 30 Jul 2021
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      DOI: 10.7554/eLife.16807

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  3. academic.oup.com academic.oup.com
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      DOI: 10.1210/en.2018-00531

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    DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters
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    1. scibot 29 Jul 2021
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    sciencedirect.com/science/article/pii/S221112471931527X
  5. bmcendocrdisord.biomedcentral.com bmcendocrdisord.biomedcentral.com
    Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner
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    1. scibot 29 Jul 2021
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      DOI: 10.1186/s12902-018-0266-y

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  6. academic.oup.com academic.oup.com
    Selective androgen receptor modulator S42 suppresses prostate cancer cell proliferation
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    1. scibot 29 Jul 2021
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    2. scibot 27 Jul 2021
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  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Norepinephrine protects against apoptosis of mesenchymal stem cells induced by high glucose
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    1. scibot 28 Jul 2021
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      DOI: 10.1002/jcp.28686

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  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase
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    1. scibot 28 Jul 2021
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      DOI: 10.3389/fphys.2018.00789

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    Contrasting Effects of IGF Binding Protein-3 Expression in Mammary Tumor Cells and the Tumor Microenvironment
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    1. scibot 28 Jul 2021
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      DOI: 10.1016/j.yexcr.2018.11.006

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    sciencedirect.com/science/article/pii/S0014482718308218
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      DOI: 10.1016/j.immuni.2018.09.018

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    sciencedirect.com/science/article/pii/S1074761318304333
  11. academic.oup.com academic.oup.com
    Lack of Lrp5 Signaling in Osteoblasts Sensitizes Male Mice to Diet-Induced Disturbances in Glucose Metabolism
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    1. scibot 28 Jul 2021
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      DOI: 10.1210/en.2017-00657

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    academic.oup.com/endo/article/158/11/3805/4117224
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    1. scibot 27 Jul 2021
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  13. press.endocrine.org press.endocrine.org
    Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development: Endocrinology: Vol 157, No 11
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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      DOI: 10.1002/glia.23472

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      DOI: 10.1111/jnc.14311

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  17. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S2211124718317340
  18. www.heliyon.com www.heliyon.com
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  19. academic.oup.com academic.oup.com
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  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 27 Jul 2021
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  22. www.sciencedirect.com www.sciencedirect.com
    Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis
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      DOI: 10.1016/j.mce.2018.04.005

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  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intramuscular Injection of miR-1 Reduces Insulin Resistance in Obese Mice
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    1. scibot 23 Jul 2021
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      DOI: 10.3389/fphys.2021.676265

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    Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
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  25. Jun 2021
  26. journals.physiology.org journals.physiology.org
    Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity | American Journal of Physiology-Cell Physiology
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      DOI: 10.1152/ajpcell.00595.2020

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  27. academic.oup.com academic.oup.com
    Endothelial insulin receptors promote VEGF-A signaling via ERK1/2 and sprouting angiogenesis
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      DOI: 10.1210/endocr/bqab104

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    CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice
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      DOI: 10.1210/endocr/bqab064

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  29. journals.physiology.org journals.physiology.org
    Pancreatic fat cells of humans with type 2 diabetes display reduced adipogenic and lipolytic activity
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  30. www.sciencedirect.com www.sciencedirect.com
    The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
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    sciencedirect.com/science/article/pii/S1535610821002865
  31. www.frontiersin.org www.frontiersin.org
    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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      DOI: 10.7554/eLife.67315

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  33. cmbl.biomedcentral.com cmbl.biomedcentral.com
    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
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  34. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Palmitic acid induces insulin resistance by a mechanism associated with energy metabolism and calcium entry in neuronal cells
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      DOI: 10.1096/fj.202100243R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100243R
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
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    The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia
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  38. May 2021
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
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      DOI: 10.1038/s41467-021-23271-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC8134423/
  40. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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      anti–Akt

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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin
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      DOI: 10.7554/eLife.64944

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  42. rupress.org rupress.org
    Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
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  43. academic.oup.com academic.oup.com
    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice
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    The selective lipoprotein-associated phospholipase A2 inhibitor darapladib triggers irreversible actions on glioma cell apoptosis and mitochondrial dysfunction
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    Alternative signaling pathways from IGF1 or Insulin to Akt activation and Foxo1 nuclear efflux in adult skeletal muscle fibers
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
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  88. journals.sagepub.com journals.sagepub.com
    ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation - Limin Wu, Mohammad R Islam, Janice Lee, Hajime Takase, Shuzhen Guo, Allison M Andrews, Tetyana P Buzhdygan, Justin Mathew, Wenlu Li, Ken Arai, Eng H Lo, Servio H Ramirez, Josephine Lok, 2021
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  89. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  90. www.cell.com www.cell.com
    Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53
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    cell.com/molecular-cell/abstract/S1097-2765(20)30900-X
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    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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  94. onlinelibrary.wiley.com onlinelibrary.wiley.com
    LncRNA RP6‐65G23.1 accelerates proliferation and inhibits apoptosis via p‐ERK1/2/p‐AKT signaling pathway on keratinocytes
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab
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  97. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Reduced Na+K+‐ATPase activity may reduce amino acid uptake in IUGR fetal sheep muscle despite unchanged ex vivo amino acid transporter activity
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    IGFBP-1 in cardiometabolic pathophysiology – insights from loss-of-function and gain-of-function studies in male mice
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  99. www.fasebj.org www.fasebj.org
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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    ARHGEF3 regulates skeletal muscle regeneration and strength through autophagy
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      Akt

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  102. Jan 2021
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    Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
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    The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway
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  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
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    Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3
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    ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy
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  108. elifesciences.org elifesciences.org
    Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
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      DOI: 10.7554/eLife.63835

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  109. Dec 2020
  110. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
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  112. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling
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  113. www.sciencedirect.com www.sciencedirect.com
    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
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    sciencedirect.com/science/article/pii/S221112472031425X
  114. Nov 2020
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
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  116. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
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      AKT

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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
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  118. Oct 2020
  119. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy
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  120. www.jneurosci.org www.jneurosci.org
    Phosphorylation of eIF2α promotes Schwann cell differentiation and myelination in CMT1B mice with activated UPR
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  121. academic.oup.com academic.oup.com
    Mechanisms by which membrane and nuclear ER alpha inhibit adipogenesis in cells isolated from female mice
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  122. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice
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  123. www.cell.com www.cell.com
    Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  125. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development
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  126. www.sciencedirect.com www.sciencedirect.com
    MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Upregulation of C Terminus of Hsc70-Interacting Protein Attenuates Apoptosis and Procoagulant Activity and Facilitates Brain Repair After Traumatic Brain Injury
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  128. Sep 2020
  129. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
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  168. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Impaired AMPA receptor trafficking by a double knockout of zebrafish olfactomedin1a/b
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531
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  170. mct.aacrjournals.org mct.aacrjournals.org
    Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
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  171. www.sciencedirect.com www.sciencedirect.com
    Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation
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  172. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  173. www.sciencedirect.com www.sciencedirect.com
    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1
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  175. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
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      Rabbit anti-Akt

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  177. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      Akt

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  178. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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  179. www.mdpi.com www.mdpi.com
    Toxicity of Carlina Oxide—A Natural Polyacetylene from the Carlina acaulis Roots—In Vitro and In Vivo Study
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      AKT

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  180. www.mdpi.com www.mdpi.com
    Statin Drugs Plus Th1 Cytokines Potentiate Apoptosis and Ras Delocalization in Human Breast Cancer Lines and Combine with Dendritic Cell-Based Immunotherapy to Suppress Tumor Growth in a Mouse Model of HER-2pos Disease
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      total AKT

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  181. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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  182. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Diet Intake Control Is Indispensable for the Gluconeogenic Response to Sodium‐Glucose Cotransporter 2 Inhibition in Male Mice
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      anti‐Akt

      DOI: 10.1111/jdi.13319

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  183. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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      Akt

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  184. Jan 2020
  185. elifesciences.org elifesciences.org
    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
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      DOI: 10.7554/eLife.49882

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  186. www.sciencedirect.com www.sciencedirect.com
    Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation
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      DOI: 10.1016/j.neuron.2019.07.011

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  187. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A novel 2‐aminobenzimidazole‐based compound Jzu 17 exhibits anti‐ angiogenesis effects via targeting VEGFR‐2 signaling
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      DOI: 10.1111/bph.14813

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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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      AB_329827

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  189. www.sciencedirect.com www.sciencedirect.com
    Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
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      DOI: 10.1016/j.celrep.2019.05.017

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  190. elifesciences.org elifesciences.org
    Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA
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      DOI: 10.7554/eLife.49175

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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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  192. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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      DOI: 10.1038/s41467-019-13086-5

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  193. www.sciencedirect.com www.sciencedirect.com
    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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    Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis
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    Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
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      DOI: 10.1016/j.molcel.2019.07.023

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    CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
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    Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity
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  198. academic.oup.com academic.oup.com
    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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      DOI: 10.1210/en.2019-00410

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  199. www.embopress.org www.embopress.org
    Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2
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      DOI: 10.15252/embr.201947845

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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
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    Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome
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  203. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring
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      DOI: 10.1113/JP277936

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  204. www.sciencedirect.com www.sciencedirect.com
    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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    Lipocalin-2 Regulates Epidermal Growth Factor Receptor Intracellular Trafficking
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    CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
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      DOI: 10.1016/j.celrep.2019.09.037

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      Curator: @ethanbadger

      SciCrunch record: RRID:AB_329827

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      RRID:AB_329827 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719312252
  207. www.sciencedirect.com www.sciencedirect.com
    Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking
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    1. scibot 13 Jan 2020
      RRID:AB_329827

      DOI: 10.1016/j.celrep.2019.08.079

      Resource: (Cell Signaling Technology Cat# 9272, RRID:AB_329827)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_329827

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      RRID:AB_329827 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719311349
  208. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
    1
    1. scibot 13 Jan 2020
      RRID:AB_329827

      DOI: 10.1111/jnc.14874

      Resource: (Cell Signaling Technology Cat# 9272, RRID:AB_329827)

      Curator: @Naa003

      SciCrunch record: RRID:AB_329827

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      RRID:AB_329827 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14874