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  1. Jan 2020
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    A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
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    Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation
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    TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
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    Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
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    The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
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    Paradigms for Precision Medicine in Epichaperome Cancer Therapy
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    Ghrelin-Induced Sodium Reabsorption is Mediated by PKA and Microtubule-Dependent αE Na C Translocation In Female Rats
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    A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
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    Perioperative infusion of glucagon like peptide-1 prevents insulin resistance after surgical trauma in female pigs
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    WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis
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    Hepatic gluconeogenic response to single and long-term SGLT2 inhibition in lean/obese male hepatic G6pc-reporter mice
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    LncRNA MEG3 contributes to adenosine‐induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K‐AKT‐mTOR and beclin‐1 signaling pathway
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    A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
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    Astrocyte truncated tropomyosin receptor kinase B mediates brain‐derived neurotrophic factor anti‐apoptotic effect leading to neuroprotection
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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    Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP+
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    Betulinic acid alleviates endoplasmic reticulum stress‐mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice
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    Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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    Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease
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    Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination
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    Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
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    Insulinlike Growth Factor–Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance
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    Direct Activation of Angiotensin II Type 2 Receptors Enhances Muscle Microvascular Perfusion, Oxygenation, and Insulin Delivery in Male Rats
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    MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
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    JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins
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    Exendin-4, a Glucagonlike Peptide-1 Receptor Agonist, Attenuates Breast Cancer Growth by Inhibiting NF-κB Activation
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    Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1
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    Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival
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    Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling
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    Adipokines and Their Receptors Are Widely Expressed and Distinctly Regulated by the Metabolic Environment in the Prostate of Male Mice: Direct Role Under Normal and Tumoral Conditions
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    Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
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    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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    Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity
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    Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
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    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
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    A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
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    Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis
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    Brief isoflurane anesthesia regulates striatal AKT‐GSK3β signaling and ameliorates motor deficits in a rat model of early‐stage Parkinson′s disease
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    IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis
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    The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior
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    IGF1R Expression in Ovarian Granulosa Cells is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice
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    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
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    MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation
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    Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
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    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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    The Glycoside Oleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells
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    Nitric Oxide–Mediated Regulation of GLUT by T3 and Follicle-Stimulating Hormone in Rat Granulosa Cells
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    Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model
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    Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet–Fed Male Mice
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    Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils
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    Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2
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    Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
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    sciencedirect.com/science/article/pii/S2405471216304082
  164. elifesciences.org elifesciences.org
    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration
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      AB_329827

      Curator: @kaitlinsung

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    elifesciences.org/content/6/e22871
  165. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0092867417304154
  166. www.sciencedirect.com www.sciencedirect.com
    Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
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    1. scibot 08 Nov 2017
      AB_329827

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    sciencedirect.com/science/article/pii/S0092867417302490
  167. www.sciencedirect.com www.sciencedirect.com
    Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S1550413117300943
  168. www.sciencedirect.com www.sciencedirect.com
    Enhancement of brain plasticity and recovery of locomotive function after lumbar spinal cord stimulation in combination with gait training with partial weight support in rats with cerebral ischemia
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @kaitlinsung

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    sciencedirect.com/science/article/pii/S0006899317300793
  169. www.sciencedirect.com www.sciencedirect.com
    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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  170. www.sciencedirect.com www.sciencedirect.com
    Multivalent Small-Molecule Pan-RAS Inhibitors
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @chewbeccax

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  171. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @gabimpine

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  172. www.sciencedirect.com www.sciencedirect.com
    Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @gabimpine

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  173. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5218530/
  174. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of mTORC1 by lysosomal calcium and calmodulin
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    1. scibot 08 Nov 2017
      AB_329827

      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5106211/
  175. www.sciencedirect.com www.sciencedirect.com
    Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
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    1. scibot 08 Nov 2017
      AB_329827

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    sciencedirect.com/science/article/pii/S0092867416314453
  176. elifesciences.org elifesciences.org
    Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery
    1
    1. scibot 08 Nov 2017
      AB_329827

      Curator: @gabimpine

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    elifesciences.org/content/5/e16807
  177. jcs.biologists.org jcs.biologists.org
    PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression
    1
    1. scibot 08 Nov 2017
      AB_329827

      Curator: @gabimpine

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    jcs.biologists.org/content/127/24/5253
  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine
    1
    1. scibot 08 Nov 2017
      AB_329827

      Curator: @jcabotaj

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    ncbi.nlm.nih.gov/pmc/articles/PMC4207903/