837 Matching Annotations
  1. Apr 2023
  2. link.springer.com link.springer.com
    Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells
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    1. scibot 27 Apr 2023
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      DOI: 10.1007/s00432-023-04804-0

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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    1. scibot 21 Apr 2023
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      DOI: 10.1016/j.molcel.2023.03.026

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    sciencedirect.com/science/article/pii/S1097276523002393
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    Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
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    1. scibot 20 Apr 2023
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    sciencedirect.com/science/article/pii/S2211124723003911
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    Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation
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    1. scibot 19 Apr 2023
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    sciencedirect.com/science/article/pii/S1550413123001249
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    FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms
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    1. scibot 13 Apr 2023
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    sciencedirect.com/science/article/pii/S2211124723003923
  7. elifesciences.org elifesciences.org
    NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
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    1. scibot 12 Apr 2023
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      DOI: 10.7554/eLife.81569

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    elifesciences.org/articles/81569
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    1. scibot 12 Apr 2023
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      DOI: 10.1016/j.devcel.2023.03.013

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      DOI: 10.1016/j.devcel.2023.03.013

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    sciencedirect.com/science/article/pii/S1534580723001090
  9. 52.53.155.43 52.53.155.43
    TET1 Catalytic Activity is Required for Reprogramming of Imprinting Control Regions and Patterning of Sperm-Specific Hypomethylated Regions
    1
    1. scibot 12 Apr 2023
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  10. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised cell-to-cell communication
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    1. scibot 06 Apr 2023
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    pubmed.ncbi.nlm.nih.gov/37016051/
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    Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow
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    1. scibot 06 Apr 2023
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    sciencedirect.com/science/article/pii/S1550413123000839
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin
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    1. scibot 04 Apr 2023
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      DOI: 10.1158/2767-9764.CRC-22-0423

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    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
    1
    1. scibot 01 Apr 2023
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      DOI: 10.1186/s12985-023-02021-2

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    link.springer.com/article/10.1186/s12985-023-02021-2
  14. Mar 2023
  15. link.springer.com link.springer.com
    Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations
    1
    1. scibot 29 Mar 2023
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      DOI: 10.1186/s40478-023-01544-7

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    link.springer.com/article/10.1186/s40478-023-01544-7
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drug–gene Interaction Screens Coupled to Tumor Data Analyses Identify the Most Clinically Relevant Cancer Vulnerabilities Driving Sensitivity to PARP Inhibition
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    1. scibot 29 Mar 2023
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      DOI: 10.1158/2767-9764.CRC-22-0119

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035383/
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    Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells
    1
    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.chembiol.2023.03.001

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    sciencedirect.com/science/article/pii/S2451945623000600
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer
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    1. scibot 18 Mar 2023
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      DOI: 10.1158/0008-5472.CAN-22-1444

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    ncbi.nlm.nih.gov/pmc/articles/PMC10015223/
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    A combinatorial approach to uncover an additional Integrator subunit
    1
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112244

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    sciencedirect.com/science/article/pii/S2211124723002553
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    MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes
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    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112249

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    sciencedirect.com/science/article/pii/S2211124723002607
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    Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9
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    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.scr.2023.103069

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    sciencedirect.com/science/article/pii/S1873506123000557
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    Redox proteomics combined with proximity labeling enables monitoring of localized cysteine oxidation in cells
    1
    1. scibot 11 Mar 2023
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      DOI: 10.1016/j.chembiol.2023.02.006

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    sciencedirect.com/science/article/pii/S2451945623000557
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    Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer
    1
    1. scibot 09 Mar 2023
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      DOI: 10.1016/j.ebiom.2023.104500

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    sciencedirect.com/science/article/pii/S2352396423000658
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal trafficking of the glucose transporter GLUT1 requires sequential regulation by TXNIP and ubiquitin
    1
    1. scibot 09 Mar 2023
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      DOI: 10.1016/j.isci.2023.106150

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    ncbi.nlm.nih.gov/pmc/articles/PMC9986520/
  25. www.biorxiv.org www.biorxiv.org
    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
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    1. scibot 08 Mar 2023
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      DOI: 10.1101/2023.01.11.523558

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    biorxiv.org/content/10.1101/2023.01.11.523558v1
  26. www.embopress.org www.embopress.org
    The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse
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    1. scibot 07 Mar 2023
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      DOI: 10.15252/embj.2022111450

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    embopress.org/doi/10.15252/embj.2022111450
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H2-induced transient upregulation of phospholipids with suppression of energy metabolism
    1
    1. scibot 05 Mar 2023
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      DOI: 10.4103/2045-9912.344973

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    ncbi.nlm.nih.gov/pmc/articles/PMC9979205/
  28. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Angiotensin Deficient FVB/N Mice are Normotensive
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    1. scibot 03 Mar 2023
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      DOI: 10.1111/bph.16051

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16051
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuron-restrictive silencer factor/repressor element 1-silencing transcription factor (NRSF/REST) controls spatial K+ buffering in primary cortical astrocytes
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      DOI: 10.1111/jnc.15755

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15755
  30. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
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    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112185

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    sciencedirect.com/science/article/pii/S2211124723001961
  31. Feb 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide
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    1. scibot 23 Feb 2023
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      DOI: 10.3389/fmolb.2023.1096286

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    Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer
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      DOI: 10.1016/j.celrep.2023.112090

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    Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models
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      DOI: 10.1016/j.phrs.2023.106692

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    sciencedirect.com/science/article/pii/S1043661823000488
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    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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      DOI: 10.1016/j.stem.2023.01.007

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    sciencedirect.com/science/article/pii/S1934590923000073
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decorating chromatin for enhanced genome editing using CRISPR-Cas9
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      DOI: 10.1073/pnas.2204259119

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    ncbi.nlm.nih.gov/pmc/articles/PMC9894255/
  38. 52.53.155.43 52.53.155.43
    ajplung.00248.2022-html.html
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    An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
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    sciencedirect.com/science/article/pii/S2451945623000260
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    Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
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      DOI: 10.1016/j.celrep.2022.111940

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    sciencedirect.com/science/article/pii/S2211124722018411
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  42. Jan 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization
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  89. Sep 2022
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    Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses
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    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
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    Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its proinflammatory and neurodegenerative effects
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    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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    Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5
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    Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
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    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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    Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
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    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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    Roflupram attenuates α-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant α-synuclein
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