837 Matching Annotations
  1. Sep 2020
  2. www.sciencedirect.com www.sciencedirect.com
    Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
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    sciencedirect.com/science/article/pii/S2211124720310020
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
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    Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
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    sciencedirect.com/science/article/pii/S0092867420306863
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    Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
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    Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases
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    Sex‐dependent pronociceptive role of spinal α5‐GABAA receptor and its epigenetic regulation in neuropathic rodents
    1
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      DOI: 10.1111/jnc.15140

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    Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication
    1
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    Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress
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    Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53
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    sciencedirect.com/science/article/pii/S2211124719317218
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    Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress
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    ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin
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    Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge
    1
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    Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function
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      DOI: 10.1002/jcp.29906

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    onlinelibrary.wiley.com/doi/10.1002/jcp.29906
  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Sleep deprivation regulates availability of PrPC and Aβ peptides which can impair interaction between PrPC and laminin and neuronal plasticity
    1
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      DOI: 10.1111/jnc.14960

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    Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway
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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice
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      DOI: 10.7554/eLife.56590

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    ncbi.nlm.nih.gov/pmc/articles/PMC7224700/
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
    1
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    sciencedirect.com/science/article/pii/S2211124720301649
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    Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity
    1
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      DOI: 10.1016/j.neuron.2020.01.020

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    sciencedirect.com/science/article/pii/S0896627320300465
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    E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
    1
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      DOI: 10.1016/j.devcel.2019.12.016

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    sciencedirect.com/science/article/pii/S1534580719310391
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    Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis
    1
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    sciencedirect.com/science/article/pii/S2211124720309839
  23. elifesciences.org elifesciences.org
    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
    1
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      DOI: 10.7554/eLife.59151

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  24. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration
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  25. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle
    1
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      DOI: 10.1096/fj.202001180R

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    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
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      DOI: 10.7554/eLife.50519

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  27. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
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      DOI: 10.1016/j.chembiol.2020.06.013

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  28. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain
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      DOI: 10.1111/jnc.14979

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  29. www.jbc.org www.jbc.org
    The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of alpha-synuclein
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    Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
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    Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition
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    Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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    c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly
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    Idebenone has distinct effects on mitochondrial respiration in cortical astrocytes as compared to cortical neurons due to differential NQO1 activity
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      DOI: 10.1523/JNEUROSCI.1632-17.2020

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    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
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    Cis-activation in the Notch signaling pathway
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      DOI: 10.7554/eLife.37880

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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeted Kruppel-like factor 4 gene knockout in retinal ganglion cells improves visual function in multiple sclerosis mouse model
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      DOI: 10.1523/ENEURO.0320-19.2020

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    Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling
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      GAPDH

      DOI: 10.1210/clinem/dgaa366

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  40. elifesciences.org elifesciences.org
    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
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      DOI: 10.7554/eLife.54993

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  41. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The E3 Ubiquitin-Protein Ligase Cullin 3 Regulates HIV-1 Transcription
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      GAPDH

      DOI: 10.3390/cells9092010

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      DOI: 10.1111/bph.14959

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    Genetic loss of AMPK-glycogen binding destabilizes AMPK and disrupts metabolism
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    Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy
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    Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis
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    Inhibition of the catalytic subunit of DNA‐dependent protein kinase (DNA‐PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism
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    A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
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    RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases
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    The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore
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    Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration
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    Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning
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    The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
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    Biallelic and monoallelic deletion of the RB1 promoter in six isogenic clonal H9 hESC lines
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    Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
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    Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation
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    HSPGs glypican‐1 and glypican‐4 are human neuronal proteins characteristic of different neural phenotypes
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      DOI: 10.1002/jnr.24666

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    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
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      DOI: 10.7554/eLife.35032

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      RRID:AB_561053

      DOI: 10.1111/bph.14918

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    Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis | American Journal of Physiology-Lung Cellular and Molecular Physiology
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      DOI: 10.1152/ajplung.00069.2019

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  64. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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      GAPDH

      DOI: 10.1111/jcmm.15774

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  65. www.nature.com www.nature.com
    Conditional control of fluorescent protein degradation by an auxin-dependent nanobody
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      GAPDH

      DOI: 10.1038/s41467-018-05855-5

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  66. journals.plos.org journals.plos.org
    Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis
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      rabbit anti-GAPDH

      DOI: 10.1371/journal.pone.0234407

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    Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles
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    Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis
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      DOI: 10.1016/j.stem.2019.11.016

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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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  70. Jan 2020
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    m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination
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      DOI: 10.1016/j.neuron.2019.12.013

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  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
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      DOI: 10.1111/jnc.14796

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    SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing
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    Structural Basis for Target-Directed MicroRNA Degradation
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    RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
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    Murine maternal dietary restriction affects neural Humanin expression and cellular profile
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
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      DOI: 10.1111/jnc.14712

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    EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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      DOI: 10.1016/j.chembiol.2019.11.004

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  80. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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    Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli
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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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    N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor
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    Regulation of Phosphoribosyl-Linked Serine Ubiquitination by Deubiquitinases DupA and DupB
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    Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
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    TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine‐induced chemokine production and neutrophil migration
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    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD
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    CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
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    Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes
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    Design on a Rational Basis of High-Affinity Peptides Inhibiting the Histone Chaperone ASF1
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)
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    Histone deacetylase 6 promotes growth of glioblastoma through the MKK7/JNK/c‐Jun signaling pathway
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    The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
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    Hepatic HKDC1 Expression Contributes to Liver Metabolism
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    Hippocampal BDNF regulates a shift from flexible, goal‐directed to habit memory system function following cocaine abstinence
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    Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons
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    Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
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    USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
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    C9-ALS/FTD-linked proline–arginine dipeptide repeat protein associates with paraspeckle components and increases paraspeckle formation
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    Profilin and formin constitute a pacemaker system for robust actin filament growth
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    miR-29a/b1 Inhibits Hair Follicle Stem Cell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling
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    Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice
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    Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis
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    A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
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    PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin
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    MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6
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    Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity
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    Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors
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    ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus
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    AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration
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    Induced pluripotent stem cell line (PEIi003-A) derived from an apparently healthy male individual.
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    Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
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    A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
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    Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
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    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion
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    Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma
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    Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
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    Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia
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    Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice
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    A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome
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    Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice
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    Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells
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      RRID:AB_561053
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    sciencedirect.com/science/article/pii/S1934590917304228
  201. www.sciencedirect.com www.sciencedirect.com
    Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A
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    1. scibot 05 Nov 2018
      RRID:AB_561053

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      (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

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      RRID:AB_561053
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    sciencedirect.com/science/article/pii/S1074761317305265
  202. www.sciencedirect.com www.sciencedirect.com
    Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
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    1. scibot 05 Nov 2018
      RRID:AB_561053

      Curator: @evieth

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      (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      SciCrunch record: RRID:AB_561053

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      RRID:AB_561053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2451945617303549
  203. academic.oup.com academic.oup.com
    Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression
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    1. scibot 05 Nov 2018
      AB_561053

      Curator: @evieth

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      (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

      SciCrunch record: RRID:AB_561053

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      RRID:AB_561053 RRIDCUR:Validated
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    academic.oup.com/endo/article/159/2/883/4706307