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  1. Jan 2026
    1. LONG-TERMPOTENTIATION

      TLDR 1) Glutamate is released and binds to both AMPA and NMDA receptor 2) AMPA receptor opens to allow entry of sodium. NMDA cannot open due to magnesium blockage. 3)Influx of sodium via AMPA receptor causes depolarisation which removes magnesium blockage 4)NMDA channel opens and sodium and calcium can enter 5)Influx of calcium results in activation of kinases that travel to nucleus, leading to upregulation of AMPA receptor in the post synaptic cell or increased glutamate released.

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