239 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor–Node–Metastasis Stages
    1
    1. scibot 21 Dec 2024
      RRID:AB_10949053

      DOI: 10.1158/2767-9764.CRC-24-0270

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    pmc.ncbi.nlm.nih.gov/articles/PMC11589669/
  3. Dec 2024
  4. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 13 Dec 2024
      RRID:AB_10949053

      DOI: 10.1111/bph.17404

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17404
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    N-terminal acetylation of transcription factor LIP induces immune therapy resistance via suppression of PD-L1 expression in non-small cell lung cancer
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    1. scibot 11 Dec 2024
      AB_10949053

      DOI: 10.1136/jitc-2024-009905

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    pmc.ncbi.nlm.nih.gov/articles/PMC11624798/
  6. www.sciencedirect.com www.sciencedirect.com
    Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells
    1
    1. scibot 02 Dec 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2024.115023

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    sciencedirect.com/science/article/pii/S2211124724013743
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    Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma
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    1. scibot 02 Dec 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2024.115015

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    sciencedirect.com/science/article/pii/S2211124724013664
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    Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
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    1. scibot 02 Dec 2024
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      DOI: 10.1016/j.ccell.2024.10.014

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    sciencedirect.com/science/article/pii/S1535610824004021
  9. Nov 2024
  10. www.sciencedirect.com www.sciencedirect.com
    ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion
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    1. scibot 24 Nov 2024
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      DOI: 10.1016/j.cmet.2024.10.015

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    sciencedirect.com/science/article/pii/S155041312400411X
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    Synergistic anti-tumor effects of oncolytic virus and anti-programmed cell death protein 1 antibody combination therapy: For suppression of lymph node and distant metastasis in a murine melanoma model
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    1. scibot 24 Nov 2024
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      DOI: 10.1016/j.bbrc.2024.151011

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    sciencedirect.com/science/article/pii/S0006291X2401547X
  12. www.sciencedirect.com www.sciencedirect.com
    Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response
    1
    1. scibot 17 Nov 2024
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      DOI: 10.1016/j.medj.2024.10.007

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    sciencedirect.com/science/article/pii/S2666634024004057
  13. 52.53.155.43 52.53.155.43
    can-24-0880-html.html
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    1. scibot 14 Nov 2024
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      DOI: 10.1158/0008-5472.can-24-0880

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  14. www.sciencedirect.com www.sciencedirect.com
    DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer
    1
    1. scibot 11 Nov 2024
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      DOI: 10.1016/j.medj.2024.10.012

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    sciencedirect.com/science/article/pii/S2666634024004100
  15. www.sciencedirect.com www.sciencedirect.com
    Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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    1. scibot 11 Nov 2024
      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2024.10.008

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    sciencedirect.com/science/article/pii/S1535610824003969
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
    1
    1. scibot 08 Nov 2024
      RRID:AB_10949053

      DOI: 10.1158/0008-5472.CAN-24-0134

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
  17. 52.53.155.43 52.53.155.43
    crc-24-0270-html.html
    1
    1. scibot 07 Nov 2024
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      DOI: 10.1158/2767-9764.crc-24-0270

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    52.53.155.43/6812950de7f1da66ce36837432902250c74146ab/crc-24-0270-html.html
  18. Oct 2024
  19. www.biorxiv.org www.biorxiv.org
    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
    1
    1. scibot 02 Oct 2024
      RRID:AB_10949053

      DOI: 10.1101/2024.09.09.612140

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    biorxiv.org/content/10.1101/2024.09.09.612140v1
  20. aacrjournals.org aacrjournals.org
    Targeting of CD40 and PD-L1 pathways inhibit progression of oral premalignant lesions in a carcinogen-induced model of oral squamous cell carcinoma
    1
    1. scibot 02 Oct 2024
      RRID:AB_10949053

      DOI: 10.1158/1940-6207.CAPR-20-0418

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    aacrjournals.org/cancerpreventionresearch/article/14/3/313/47829/Targeting-of-CD40-and-PD-L1-Pathways-Inhibits
  21. Sep 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
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    1. scibot 25 Sep 2024
      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2024.08.019

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    sciencedirect.com/science/article/pii/S1535610824003180
  23. www.sciencedirect.com www.sciencedirect.com
    Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models
    1
    1. scibot 17 Sep 2024
      AB_10949053

      DOI: 10.1016/j.isci.2024.110854

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    sciencedirect.com/science/article/pii/S2589004224020790
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
    1
    1. scibot 05 Sep 2024
      RRID:AB_10949053

      DOI: 10.1158/2326-6066.CIR-23-0289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11369622/
  25. www.sciencedirect.com www.sciencedirect.com
    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    1
    1. scibot 04 Sep 2024
      AB_10949053

      DOI: 10.1016/j.celrep.2024.114686

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    sciencedirect.com/science/article/pii/S2211124724010374
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type I interferon signaling regulates myeloid and T cell crosstalk in the glioblastoma tumor microenvironment
    1
    1. scibot 04 Sep 2024
      AB_10949053

      DOI: 10.1016/j.isci.2024.110810

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    pmc.ncbi.nlm.nih.gov/articles/PMC11404196/
  27. Aug 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
    1
    1. scibot 28 Aug 2024
      AB_10949053

      DOI: 10.1016/j.devcel.2024.08.003

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    sciencedirect.com/science/article/pii/S1534580724004866
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of novel allogeneic cancer cells vaccine to treat colorectal cancer
    1
    1. scibot 21 Aug 2024
      RRID:AB_10949053

      DOI: 10.3389/fonc.2024.1427428

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    ncbi.nlm.nih.gov/pmc/articles/PMC11303197/
  30. Jul 2024
  31. www.cell.com www.cell.com
    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
    1
    1. scibot 30 Jul 2024
      RRID:AB_10949053

      DOI: 10.1016/j.chom.2024.06.010

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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
    1
    1. scibot 27 Jul 2024
      RRID:AB_10949053

      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
  33. www.sciencedirect.com www.sciencedirect.com
    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
    1
    1. scibot 19 Jul 2024
      AB_10949053

      DOI: 10.1016/j.medj.2024.06.002

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    sciencedirect.com/science/article/pii/S2666634024002484
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis
    1
    1. scibot 18 Jul 2024
      RRID:AB_10949053

      DOI: 10.1158/1078-0432.CCR-23-0433

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    ncbi.nlm.nih.gov/pmc/articles/PMC10872577/
  35. www.sciencedirect.com www.sciencedirect.com
    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
    1
    1. scibot 17 Jul 2024
      AB_10949053

      DOI: 10.1016/j.xcrm.2024.101649

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    sciencedirect.com/science/article/pii/S266637912400363X
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
    1
    1. scibot 16 Jul 2024
      RRID:AB_10949053

      DOI: 10.1016/j.xcrm.2024.101640

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293343/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy
    1
    1. scibot 14 Jul 2024
      RRID:AB_10949053

      DOI: 10.1016/j.isci.2024.110189

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233966/
  38. Jun 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
    1
    1. scibot 04 Jun 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2024.114300

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    sciencedirect.com/science/article/pii/S2211124724006284
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2024.114289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  41. May 2024
  42. www.sciencedirect.com www.sciencedirect.com
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
    1
    1. scibot 24 May 2024
      RRID:AB_10949053

      DOI: 10.1016/j.immuni.2024.04.025

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    sciencedirect.com/science/article/pii/S1074761324002309
  43. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
    1
    1. scibot 21 May 2024
      RRID:AB_10949053

      DOI: 10.1016/j.immuni.2024.04.024

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    sciencedirect.com/science/article/pii/S1074761324002292
  44. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
    1
    1. scibot 10 May 2024
      RRID:AB_10949053

      DOI: 10.1016/j.isci.2024.109800

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    cell.com/iscience/abstract/S2589-0042(24)01022-8
  45. Apr 2024
  46. www.sciencedirect.com www.sciencedirect.com
    LKB1 prevents ILC2 exhaustion to enhance antitumor immunity
    1
    1. scibot 26 Apr 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2023.113579

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    sciencedirect.com/science/article/pii/S2211124723015917
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 24 Apr 2024
      RRID:AB_10949053

      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
  48. www.sciencedirect.com www.sciencedirect.com
    QDPR deficiency drives immune suppression in pancreatic cancer
    1
    1. scibot 23 Apr 2024
      RRID:AB_10949053

      DOI: 10.1016/j.cmet.2024.03.015

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    sciencedirect.com/science/article/pii/S1550413124001190
  49. www.sciencedirect.com www.sciencedirect.com
    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
    1
    1. scibot 12 Apr 2024
      RRID:AB_10949053

      DOI: 10.1016/j.xcrm.2024.101479

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    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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  52. Mar 2024
  53. www.sciencedirect.com www.sciencedirect.com
    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
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    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
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    A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
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    Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers
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    Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
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  58. Feb 2024
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
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      DOI: 10.1158/2767-9764.CRC-23-0399

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    The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model
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    Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  63. Jan 2024
  64. www.sciencedirect.com www.sciencedirect.com
    Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
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    DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities
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    Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
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    A novel translational PET imaging approach to quantifying abscopal immune activation following targeted radiotherapy and checkpoint blockade.
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    Interferon-stimulated neutrophils as a predictor of immunotherapy response
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    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
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  70. Dec 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preventive Treatment with PD-1 Antibody Increases Tissue-Resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis
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      DOI: 10.1158/1940-6207.CAPR-23-0196

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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity
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    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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      DOI: 10.1126/sciimmunol.adj5097

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  75. 52.53.155.43 52.53.155.43
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  76. Nov 2023
  77. link.springer.com link.springer.com
    Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity
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      DOI: 10.1038/s41586-023-06749-3

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    E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC
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    An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
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    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
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  81. Oct 2023
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response
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    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
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    Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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    Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation
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    Glioblastoma vascular plasticity limits effector T-cell infiltration and is blocked by cAMP activation
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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
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  91. Sep 2023
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
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    Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
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  94. Aug 2023
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
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  96. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
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  97. 52.53.155.43 52.53.155.43
    PIIS2211124723009622-html.html
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      DOI: 10.1016/j.celrep.2023.112951

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  98. www.sciencedirect.com www.sciencedirect.com
    A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells
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      DOI: 10.1016/j.xcrm.2023.101154

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  99. www.sciencedirect.com www.sciencedirect.com
    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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  100. 52.53.155.43 52.53.155.43
    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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  101. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OncoLoop: A network-based precision cancer medicine framework
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  103. Jul 2023
  104. www.sciencedirect.com www.sciencedirect.com
    SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
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      DOI: 10.1016/j.celrep.2023.112823

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  105. www.sciencedirect.com www.sciencedirect.com
    A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
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  106. www.sciencedirect.com www.sciencedirect.com
    TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
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  107. Jun 2023
  108. www.sciencedirect.com www.sciencedirect.com
    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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  109. www.sciencedirect.com www.sciencedirect.com
    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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  111. www.sciencedirect.com www.sciencedirect.com
    IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy
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  112. www.sciencedirect.com www.sciencedirect.com
    Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion
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  113. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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  114. May 2023
  115. www.sciencedirect.com www.sciencedirect.com
    CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer
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      DOI: 10.1016/j.medj.2023.04.008

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  116. www.nature.com www.nature.com
    Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
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      DOI: 10.1038/s41467-023-38271-5

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  117. www.sciencedirect.com www.sciencedirect.com
    Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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  118. www.sciencedirect.com www.sciencedirect.com
    Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal
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      DOI: 10.1016/j.stem.2023.04.005

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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition
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      DOI: 10.1158/1078-0432.CCR-21-2394

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  120. www.sciencedirect.com www.sciencedirect.com
    Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer
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    sciencedirect.com/science/article/abs/pii/S1931312823001610
  121. Apr 2023
  122. aacrjournals.org aacrjournals.org
    Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors
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      DOI: 10.1158/1541-7786.MCR-22-0684

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    aacrjournals.org/mcr/article/21/4/332/718954/Targeting-ULK1-Decreases-IFN-Mediated-Resistance
  123. insight.jci.org insight.jci.org
    Lenvatinib or anti-VEGF in combination with anti-PD-1 differentially augments anti-tumor activity in melanoma
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      DOI: 10.1172/jci.insight.157347

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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy
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      DOI: 10.1158/0008-5472.CAN-21-4025

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  125. www.sciencedirect.com www.sciencedirect.com
    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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  126. www.sciencedirect.com www.sciencedirect.com
    Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade
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  127. www.sciencedirect.com www.sciencedirect.com
    An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
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      DOI: 10.1158/1535-7163.MCT-22-0475

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  129. www.sciencedirect.com www.sciencedirect.com
    Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects
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  130. www.sciencedirect.com www.sciencedirect.com
    Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolites
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  131. www.sciencedirect.com www.sciencedirect.com
    T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
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  132. Mar 2023
  133. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
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  134. www.sciencedirect.com www.sciencedirect.com
    Adhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy
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  135. Feb 2023
  136. www.sciencedirect.com www.sciencedirect.com
    Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
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  137. www.embopress.org www.embopress.org
    Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer
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      DOI: 10.15252/embr.202256524

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  138. Jan 2023
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy
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      DOI: 10.3389/fimmu.2022.1011943

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  140. www.sciencedirect.com www.sciencedirect.com
    S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas
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      DOI: 10.1016/j.neo.2022.100874

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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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      DOI: 10.1158/2159-8290.CD-21-0003

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  143. Dec 2022
  144. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  145. www.sciencedirect.com www.sciencedirect.com
    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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      DOI: 10.1016/j.ccell.2022.11.014

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    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CIt protocol: a blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells.
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
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  149. Nov 2022
  150. aacrjournals.org aacrjournals.org
    A novel selective inhibitor JBI-589 targets PAD4-mediated neutrophil migration to suppress tumor progression
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      DOI: 10.1158/0008-5472.CAN-21-4045

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  151. aacrjournals.org aacrjournals.org
    Phototherapy with cancer-specific nanoporphyrin potentiates immunotherapy in bladder cancer
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      DOI: 10.1158/1078-0432.CCR-22-1362

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  152. www.sciencedirect.com www.sciencedirect.com
    Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis
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  153. www.sciencedirect.com www.sciencedirect.com
    Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
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  154. jitc.bmj.com jitc.bmj.com
    Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
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  155. Oct 2022
  156. 52.53.155.43 52.53.155.43
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  157. www.sciencedirect.com www.sciencedirect.com
    Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
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  158. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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      DOI: 10.1016/j.cmet.2022.09.021

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  159. www.sciencedirect.com www.sciencedirect.com
    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
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      DOI: 10.1016/j.cell.2022.09.020

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  160. Sep 2022
  161. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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  162. www.sciencedirect.com www.sciencedirect.com
    Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
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  163. www.sciencedirect.com www.sciencedirect.com
    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
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      DOI: 10.1158/2159-8290.CD-21-0694

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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
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  166. Aug 2022
  167. www.sciencedirect.com www.sciencedirect.com
    Tumor targeted 4-1BB agonist antibody-albumin fusions with high-affinity to FcRn induce anti-tumor immunity without toxicity
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  168. www.sciencedirect.com www.sciencedirect.com
    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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  169. www.sciencedirect.com www.sciencedirect.com
    Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
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  170. www.sciencedirect.com www.sciencedirect.com
    Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
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  171. Jul 2022
  172. www.sciencedirect.com www.sciencedirect.com
    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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  173. Jun 2022
  174. 52.53.155.43 52.53.155.43
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  175. www.sciencedirect.com www.sciencedirect.com
    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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  176. www.sciencedirect.com www.sciencedirect.com
    Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models
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  177. www.sciencedirect.com www.sciencedirect.com
    PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
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  178. www.sciencedirect.com www.sciencedirect.com
    Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
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  179. May 2022
  180. www.sciencedirect.com www.sciencedirect.com
    Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
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  181. www.cell.com www.cell.com
    Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer
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  182. Apr 2022
  183. www.sciencedirect.com www.sciencedirect.com
    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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  184. Mar 2022
  185. www.sciencedirect.com www.sciencedirect.com
    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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  186. www.sciencedirect.com www.sciencedirect.com
    AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
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      DOI: 10.1016/j.xcrm.2022.100554

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  187. www.sciencedirect.com www.sciencedirect.com
    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
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      DOI: 10.7150/thno.69198

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    Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity
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  190. Feb 2022
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    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  192. Jan 2022
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    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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  195. Dec 2021
  196. www.nature.com www.nature.com
    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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  197. www.sciencedirect.com www.sciencedirect.com
    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
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  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
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  199. Nov 2021
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    Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
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  202. Oct 2021
  203. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
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  204. Sep 2021
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    Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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    Effects of exercise and anti-PD-1 on the tumour microenvironment
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  208. Aug 2021
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    Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer
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    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
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    NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
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    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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  215. Jul 2021
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    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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  217. www.ebiomedicine.com www.ebiomedicine.com
    Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma
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    Lipopolysaccharide-mediated chronic inflammation promotes tobacco carcinogen-induced lung cancer and determines the efficacy of immunotherapy
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  221. Jun 2021
  222. www.sciencedirect.com www.sciencedirect.com
    Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
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    Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer
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    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
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    Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response
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    Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
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  227. May 2021
  228. aacrjournals.org aacrjournals.org
    A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma
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      DOI: 10.1158/0008-5472.CAN-20-3510

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    aacrjournals.org/cancerres/article/81/9/2358/670580/A-MyD88-IL1R-Axis-Regulates-PD-1-Expression-on
  229. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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  234. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
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  235. Apr 2021
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    Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets
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    Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells
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      DOI: 10.1016/j.cmet.2020.07.008

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    sciencedirect.com/science/article/pii/S1550413120303661
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    CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
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    1. scibot 26 Apr 2021
      RRID:AB_10949053

      DOI: 10.1016/j.cmet.2021.02.015

      Resource: (Bio X Cell Cat# BE0146, RRID:AB_10949053)

      Curator: @scibot

      SciCrunch record: RRID:AB_10949053

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      RRID:AB_10949053
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    sciencedirect.com/science/article/pii/S1550413121000711