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    Single-cell and spatial transcriptomics reveal intratumor heterogeneity and immune evasion in natural killer/T cell lymphoma
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    sciencedirect.com/science/article/pii/S2589004225018875
  3. Oct 2025
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    Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer
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    Interindividual Genetic Differences Drive Discordance Between Serum Calcidiol and Calcitriol Concentrations in Females
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    dx.doi.org/10.1210/endocr/bqaf138
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    Capsaicin attenuates sepsis-associated encephalopathy by inhibiting neuroinflammation and apoptosis whilst activating mitophagy through the BNIP3/NIX pathway
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    Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state
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    FLT3L-based drug conjugate effectively targets chemoresistant leukemia stem cells in acute myeloid leukemia
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    Spirodelae Herba ethanol extract attenuates neurotoxicity in hippocampal cells and improves scopolamine-induced cognitive impairment in mice
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    PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis
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    ZBP1 pathway promotes tumor immunogenicity in the combination of anti-HER2 therapy and epigenetic therapy
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    PKN2 is a dependency of the mesenchymal-like cancer cell state
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    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    Cholangiocytes’ Primary Cilia Regulate DNA Damage Response and Repair
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  21. Aug 2025
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    The Function of Transforming Growth Factor 2 in Facilitating Inflammasome Activation to Enhance the Development of Myopia via Complement System
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    Selective Alanine Transporter Utilization is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer
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    Norepinephrine inhibits cell cycle re‐entry of neonatal rat ventricular cardiomyocytes characterized by the absence of de novo nestin expression
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  32. Jul 2025
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    RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma
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    STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20–Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models
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    Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells
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  44. Jun 2025
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    Holothurian Glycosaminoglycan (hGAG) Promoted Bim-Induced Apoptosis in Human Lung Adenocarcinoma A549 Cell Line Through Inhibition of Akt-Mediated FOXO3a Translocation
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    Holothurian Glycosaminoglycan (hGAG) Promoted Bim-Induced Apoptosis in Human Lung Adenocarcinoma A549 Cell Line Through Inhibition of Akt-Mediated FOXO3a Translocation
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  60. May 2025
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    Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
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    Different populations of mouse egg cortical vesicles are responsible for post-fertilization zinc sparks and proteolysis of the zona pellucida
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    Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets
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    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms
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    Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors
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    A Novel Compound DBZ Alleviates Chronic Inflammatory Pain and Anxiety-Like Behaviors by Targeting the JAK2-STAT3 Signaling Pathway
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  72. Apr 2025
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    Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma
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    EFTUD2 is a promising diagnostic and prognostic indicator involved in the tumor immune microenvironment and glycolysis of lung adenocarcinoma
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    Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction
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    The FBXO45–GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis
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    Pyroptosis of pulmonary fibroblasts and macrophages through NLRC4 inflammasome leads to acute respiratory failure
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  80. Mar 2025
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    ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma
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    Mechanical Loading Induces NRF2 Nuclear Translocation to Epigenetically Remodel Oxidative Stress Defense in Osteocytes
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    A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness
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    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    Pathway-instructed therapeutic selection of ruxolitinib reduces neuroinflammation in fungal postinfectious inflammatory syndrome
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    Dual targeting of CXCR4 and EZH2 in endometriosis
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety
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    Increased seizure susceptibility in the collagen-induced arthritis mouse model depends on neuronal IL-1R1
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    Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells
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  94. Feb 2025
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  190. Apr 2024
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