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    TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
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    SHIP inhibition mediates select TREM2-induced microglial functions
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    Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
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    Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals
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    The Notch-PDGFRβ axis suppresses brown adipocyte progenitor differentiation in early post-natal mice
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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    Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling
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  11. Mar 2024
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    Mild hypothermia promotes neuronal differentiation of human neural stem cells via RBM3-SOX11 signaling pathway
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    Epithelial-derived interleukin-23 promotes oral mucosal immunopathology
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    Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
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    Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA
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    Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
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  20. Feb 2024
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    The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection
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    UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation
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    G-quadruplex DNA structure is a positive regulator of MYC transcription
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    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
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    Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks
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    TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transport
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    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
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    RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
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    Alleviation of monocyte exhaustion by BCG derivative mycolic acid
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    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
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  33. Jan 2024
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    circGlis3 promotes β-cell dysfunction by inhibiting hnRNPF nuclear translocation and encoding Glis3-348aa protein
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    The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression
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    A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity
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    A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS
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    hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50
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    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
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    The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
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    The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
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    Bruton’s Tyrosine Kinase Inhibitors With Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
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    M4-mediated cholinergic transmission is reduced in parkinsonian mice and its restoration alleviates motor deficits and levodopa-induced dyskinesia
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    Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction
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    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    Sphingolipid paracrine signaling impairs keratinocyte adhesion to promote melanoma invasion
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    ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits
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    Nanocurcumin attenuates pyroptosis and inflammation through inhibiting NF-κB/GSDMD signal in high altitude-associated acute liver injury
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    SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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  53. Nov 2023
  54. www.sciencedirect.com www.sciencedirect.com
    In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis
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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease
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    Guanylate Binding Protein 1 (GBP1) modulates proteasomal machinery in ovarian cancer
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
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    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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    Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function
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    Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (−)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice
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  67. Oct 2023
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
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    Modification of Lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression
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    Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice
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    Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency
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    STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
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    Immunoglobulin G inhibits glucocorticoid-induced osteoporosis through occupation of FcγRI
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHOX2 promotes prostate cancer proliferation and metastasis through disruption of the Hippo-YAP pathway
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  87. Aug 2023
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Regulation of mitotic clonal expansion and thermogenic pathway are involved in the antiadipogenic effects of cyanidin-3-O-glucoside
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
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  90. 52.53.155.43 52.53.155.43
    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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  91. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis
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    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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    IL-24 is the key effector of Th9 cell-mediated tumor immunotherapy
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
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  97. 52.53.155.43 52.53.155.43
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  98. 52.53.155.43 52.53.155.43
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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  100. Jul 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Magneto-mechanical stimulation modulates osteocyte fate via the ECM-integrin-CSK axis and wnt pathway
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic combined with transcriptomic analysis of the m6A methylome after spared nerve injury-induced neuropathic pain in mice
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing
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    High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer
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    Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
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    Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis
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  108. 52.53.155.43 52.53.155.43
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  109. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
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  110. www.embopress.org www.embopress.org
    Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization
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    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1
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    Levomilnacipran ameliorates lipopolysaccharide-induced depression-like behaviors and suppressed the TLR4/Ras signaling pathway
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    Selective activation of PPARα maintains thermogenic capacity of beige adipocytes
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  114. Jun 2023
  115. www.sciencedirect.com www.sciencedirect.com
    Glutamine supplementation reverses manganese neurotoxicity by eliciting the mitochondrial unfolded protein response
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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    Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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  121. dx.doi.org dx.doi.org
    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    MAP4K4 is involved in the neuronal development of retinal photoreceptors
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    Human placental LRP5 and Sclerostin are increased in gestational diabetes mellitus pregnancies
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    (A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis
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  126. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  127. www.jneurosci.org www.jneurosci.org
    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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  129. May 2023
  130. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling
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    Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
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    HOTAIR‐Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing
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  138. Apr 2023
  139. www.sciencedirect.com www.sciencedirect.com
    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
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  145. Mar 2023
  146. academic.oup.com academic.oup.com
    Mitoguardin2 is Associated with Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells
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    Celastrol directly binds with VAMP7 and RAB7 to inhibit autophagy and induce apoptosis in preadipocytes
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    Inhibiting tau protein improves the recovery of spinal cord ... : Neural Regeneration Research
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    TRIB2 safeguards naive T cell homeostasis during aging
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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  156. www.sciencedirect.com www.sciencedirect.com
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    Neurotensin Expression, Regulation, and Function during the Ovulatory Period in the Mouse Ovary
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion
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    A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
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    The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant
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    NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer
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  177. Dec 2022
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    Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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  189. academic.oup.com academic.oup.com
    Laminin-α4 negatively regulates adipocyte beiging through the suppression of AMPKα in male mice
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    Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike protein-mediated membrane fusion assay
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    Mitoguardin-2–mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation
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    The family of kallikrein-related peptidases and kinin peptides as modulators of epidermal homeostasis
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    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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