204 Matching Annotations
  1. Dec 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease
    1
    1. scibot 02 Dec 2024
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2024.114982

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    sciencedirect.com/science/article/pii/S2211124724013330
  3. Nov 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model
    1
    1. scibot 14 Nov 2024
      RRID:AB_223647

      DOI: 10.1016/j.stem.2024.10.005

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    sciencedirect.com/science/article/pii/S1934590924003679
  5. www.sciencedirect.com www.sciencedirect.com
    Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
    1
    1. scibot 14 Nov 2024
      RRID:AB_223647

      DOI: 10.1016/j.cell.2024.10.027

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    sciencedirect.com/science/article/pii/S0092867424012091
  6. 52.53.155.43 52.53.155.43
    effects_of_p301l_tau_on_post_translational.25-html.html
    1
    1. scibot 07 Nov 2024
      AB_223647

      DOI: 10.4103/nrr.nrr-d-23-01742

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    52.53.155.43/6f5189698d9c1b8a18d3fb9b9f3d0cf87ff075d6/effects_of_p301l_tau_on_post_translational.25-html.html
  7. www.mdpi.com www.mdpi.com
    A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer’s Disease
    2
    1. scibot 07 Nov 2024
      RRID:AB_223647

      DOI: 10.3390/ijms252011117

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    2. scibot 07 Nov 2024
      RRID:AB_223647

      DOI: 10.3390/ijms252011117

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    mdpi.com/1422-0067/25/20/11117
  8. Oct 2024
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Human Alzheimer's Disease ATN/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI-Based Regional Gray Matter Volume
    1
    1. scibot 03 Oct 2024
      RRID:AB_223647

      DOI: 10.1002/cne.25670

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    onlinelibrary.wiley.com/doi/10.1002/cne.25670
  10. www.sciencedirect.com www.sciencedirect.com
    Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
    1
    1. scibot 02 Oct 2024
      AB_223647

      DOI: 10.1016/j.neuron.2024.09.006

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    sciencedirect.com/science/article/pii/S0896627324006548
  11. Sep 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Failure in a population: Tauopathy disrupts homeostatic set-points in emergent dynamics despite stability in the constituent neurons
    1
    1. scibot 06 Sep 2024
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2024.08.006

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    sciencedirect.com/science/article/pii/S0896627324005786
  13. www.sciencedirect.com www.sciencedirect.com
    Gut-induced alpha-Synuclein and Tau propagation initiate Parkinson’s and Alzheimer’s disease co-pathology and behavior impairments
    1
    1. scibot 06 Sep 2024
      AB_223647

      DOI: 10.1016/j.neuron.2024.08.003

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    sciencedirect.com/science/article/pii/S0896627324005762
  14. Aug 2024
  15. www.cell.com www.cell.com
    Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer’s pathology
    1
    1. scibot 18 Aug 2024
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2024.114574

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    cell.com/cell-reports/fulltext/S2211-1247(24)00903-3
  16. academic.oup.com academic.oup.com
    Neuropathology and morphometry of dentate nucleus neurons in DYT1 brains: Cerebellar abnormalities in isolated dystonia
    1
    1. scibot 13 Aug 2024
      MN1020; Thermo-Fishe

      DOI: 10.1093/jnen/nlad044

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    academic.oup.com/jnen/article-abstract/82/8/695/7205924
  17. Jul 2024
  18. www.sciencedirect.com www.sciencedirect.com
    Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
    1
    1. scibot 27 Jul 2024
      AB_223647

      DOI: 10.1016/j.neuron.2024.06.029

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    sciencedirect.com/science/article/pii/S0896627324004914
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer’s disease
    1
    1. scibot 26 Jul 2024
      RRID:AB_223647

      DOI: 10.1016/j.isci.2023.106152

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    ncbi.nlm.nih.gov/pmc/articles/PMC9984563/
  20. www.biorxiv.org www.biorxiv.org
    Enhancing sleep via rocking ameliorates motor behavior and reduces beta-amyloid levels in a mouse model of Alzheimer’s disease
    1
    1. scibot 23 Jul 2024
      RRID:AB_223647

      DOI: 10.1101/2024.07.15.603512

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    biorxiv.org/content/10.1101/2024.07.15.603512v1
  21. Jun 2024
  22. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cdk5 inhibition in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival
    2
    1. scibot 28 Jun 2024
      RRID:AB_223647

      DOI: 10.1111/jnc.16160

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      RRID:AB_223647

      DOI: 10.1111/jnc.16160

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16160
  23. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 28 Jun 2024
      RRID:AB_223647

      DOI: 10.1111/bph.16441

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16441
  24. www.sciencedirect.com www.sciencedirect.com
    Imaging α-synuclein pathologies in animal models and patients with Parkinson’s and related diseases
    1
    1. scibot 06 Jun 2024
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2024.05.006

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    sciencedirect.com/science/article/pii/S0896627324003325
  25. May 2024
  26. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hyperphosphorylated tau in Alzheimer's disease disseminates along pathways predicted by the Structural Model for Cortico-cortical Connections
    1
    1. scibot 30 May 2024
      RRID:AB_223647

      DOI: 10.1002/cne.25623

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    onlinelibrary.wiley.com/doi/10.1002/cne.25623
  27. www.biorxiv.org www.biorxiv.org
    Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
    1
    1. scibot 10 May 2024
      MN1020; Thermofisher

      DOI: 10.1101/2024.01.25.577280

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    biorxiv.org/content/10.1101/2024.01.25.577280v1
  28. 52.53.155.43 52.53.155.43
    Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy
    1
    1. scibot 03 May 2024
      AB_223647

      DOI: 10.1093/braincomms/fcae136

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    52.53.155.43/88fa296b3636c5d5cfc19001d0db77c2230ebd0a/fcae136-html.html
  29. Apr 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
    1
    1. scibot 16 Apr 2024
      RRID:AB_223647

      DOI: 10.1016/j.stem.2024.03.013

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    sciencedirect.com/science/article/pii/S1934590924000948
  31. www.sciencedirect.com www.sciencedirect.com
    Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
    1
    1. scibot 09 Apr 2024
      RRID:AB_223647

      DOI: 10.1016/j.cell.2024.03.015

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    sciencedirect.com/science/article/pii/S0092867424003064
  32. www.sciencedirect.com www.sciencedirect.com
    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    1
    1. scibot 05 Apr 2024
      RRID:AB_223647

      DOI: 10.1016/j.stem.2024.03.004

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    sciencedirect.com/science/article/pii/S1934590924000857
  33. Mar 2024
  34. www.sciencedirect.com www.sciencedirect.com
    P-tau217 correlates with neurodegeneration in Alzheimer’s disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy
    2
    1. scibot 21 Mar 2024
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2024.02.017

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      RRID:AB_223647

      DOI: 10.1016/j.neuron.2024.02.017

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    sciencedirect.com/science/article/pii/S0896627324001272
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
    1
    1. scibot 06 Mar 2024
      RRID:AB_223647

      DOI: 10.1186/s40035-024-00403-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC10910783/
  36. Feb 2024
  37. www.sciencedirect.com www.sciencedirect.com
    Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer’s disease profile and possible mechanisms of disease protection
    1
    1. scibot 29 Feb 2024
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2024.02.009

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    sciencedirect.com/science/article/pii/S089662732400093X
  38. www.biorxiv.org www.biorxiv.org
    Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
    1
    1. scibot 22 Feb 2024
      AB_223647

      DOI: 10.1101/2024.02.17.580698

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    biorxiv.org/content/10.1101/2024.02.17.580698v1
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease
    1
    1. scibot 06 Feb 2024
      RRID:AB_223647

      DOI: 10.1093/brain/awad388

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834249/
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
    1
    1. scibot 01 Feb 2024
      RRID:AB_223647

      DOI: 10.1016/j.isci.2024.108800

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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  41. Jan 2024
  42. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glioblastoma and its treatment are associated with extensive accelerated brain aging
    1
    1. scibot 23 Jan 2024
      RRID:AB_223647

      DOI: 10.1111/acel.14066

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    onlinelibrary.wiley.com/doi/10.1111/acel.14066
  43. Dec 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo
    1
    1. scibot 29 Dec 2023
      RRID:AB_223647

      DOI: 10.1016/j.xpro.2023.102788

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    sciencedirect.com/science/article/pii/S2666166723007554
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury
    2
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      RRID:AB_223647

      DOI: 10.1186/s40478-023-01709-4

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      RRID:AB_223647

      DOI: 10.1186/s40478-023-01709-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10731794/
  46. www.sciencedirect.com www.sciencedirect.com
    Early Alzheimer’s disease pathology in human cortex involves transient cell states
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      RRID:AB_223647

      DOI: 10.1016/j.cell.2023.08.005

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    sciencedirect.com/science/article/pii/S0092867423008590
  47. alz-journals.onlinelibrary.wiley.com alz-journals.onlinelibrary.wiley.com
    Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients
    1
    1. scibot 08 Dec 2023
      RRID:AB_223647

      DOI: 10.1002/alz.13557

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    alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13557
  48. Nov 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
    1
    1. scibot 17 Nov 2023
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2023.113436

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    sciencedirect.com/science/article/pii/S2211124723014481
  50. www.sciencedirect.com www.sciencedirect.com
    APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
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    1. scibot 02 Nov 2023
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2023.113252

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    sciencedirect.com/science/article/pii/S2211124723012640
  51. www.sciencedirect.com www.sciencedirect.com
    The yeast protein Ure2p triggers Tau pathology in a mouse model of tauopathy
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    1. scibot 02 Nov 2023
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2023.113342

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    sciencedirect.com/science/article/pii/S2211124723013542
  52. Oct 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Cerebral organoids derived from patients with Alzheimer’s disease with PSEN1/2 mutations have defective tissue patterning and altered development
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113310

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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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      DOI: 10.3389/fnagi.2023.1265151

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    ncbi.nlm.nih.gov/pmc/articles/PMC10576558/
  55. www.biorxiv.org www.biorxiv.org
    LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
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    biorxiv.org/content/10.1101/2023.10.06.561190v1
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Determinants of astrocytic pathology in stem cell models of primary tauopathies
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  57. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    A Human Neuron/Astrocyte Co-culture to Model Seeded and Spontaneous Intraneuronal Tau Aggregation
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  58. www.cell.com www.cell.com
    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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    cell.com/cell-reports/abstract/S2211-1247(23)01082-3
  59. Sep 2023
  60. www.sciencedirect.com www.sciencedirect.com
    Early Alzheimer’s disease pathology in human cortex involves transient cell states
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    Assessing individual variability of the entorhinal subfields in health and disease
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  62. Aug 2023
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    Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
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    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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    IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy
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  67. Jul 2023
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    Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
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    Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
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    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
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  71. Jun 2023
  72. www.sciencedirect.com www.sciencedirect.com
    Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation
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  73. www.biorxiv.org www.biorxiv.org
    KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss
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    An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sex specific molecular networks and key drivers of Alzheimer’s disease
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  76. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
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  77. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  78. May 2023
  79. www.sciencedirect.com www.sciencedirect.com
    Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain
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  80. Apr 2023
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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  82. Mar 2023
  83. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of phosphorylated Tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission.
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  84. www.mdpi.com www.mdpi.com
    Anterograde and Retrograde Propagation of Inoculated Human Tau Fibrils and Tau Oligomers in a Non-Transgenic Rat Tauopathy Model
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model
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  86. www.sciencedirect.com www.sciencedirect.com
    Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy
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  87. journals.sagepub.com journals.sagepub.com
    Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies
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  88. Feb 2023
  89. www.sciencedirect.com www.sciencedirect.com
    Cofilin promotes tau pathology in Alzheimer’s disease
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer’s disease
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  91. www.nature.com www.nature.com
    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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  92. Jan 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus)
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    Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration
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  95. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain
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  96. 52.53.155.43 52.53.155.43
    Intraneuronal tau aggregation induces the integrated stress response in astrocytes
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  97. Dec 2022
  98. link.springer.com link.springer.com
    The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
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  99. link.springer.com link.springer.com
    Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease
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  100. Nov 2022
  101. www.sciencedirect.com www.sciencedirect.com
    Spread of pathological human Tau from neurons to oligodendrocytes and loss of high-firing pyramidal neurons in aging mice
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  102. Oct 2022
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered low-frequency brain rhythms precede changes in gamma power during tauopathy
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  104. www.sciencedirect.com www.sciencedirect.com
    SYK coordinates neuroprotective microglial responses in neurodegenerative disease
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    Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis
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  106. Sep 2022
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    Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models
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    A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency
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    A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
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  110. Aug 2022
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    NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer’s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal Loss
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  114. Jul 2022
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    Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease
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    Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
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  118. Jun 2022
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    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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    Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease
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    Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
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  123. May 2022
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  127. Apr 2022
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  129. Mar 2022
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    Familial natural short sleep mutations reduce Alzheimer pathology in mice
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    Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
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    Crry silencing alleviates Alzheimer’s disease injury by regulating neuroinflammatory cytokines and the complement system
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  136. Feb 2022
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    Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion
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  138. Jan 2022
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    Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies
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    Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
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  141. Dec 2021
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    Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including the Stratum lucidum
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  143. Nov 2021
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    The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function
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  145. Oct 2021
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    Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer’s disease in nonhuman primates
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  147. Sep 2021
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    Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
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    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
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  152. Aug 2021
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    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
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    In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy
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    Secretion of Tau via an Unconventional Non-vesicular Mechanism
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  160. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    1
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      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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  161. www.sciencedirect.com www.sciencedirect.com
    Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease
    1
    1. scibot 01 Aug 2021
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2019.11.044

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    sciencedirect.com/science/article/pii/S2211124719315268
  162. Jul 2021
  163. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
    1
    1. scibot 31 Jul 2021
      tau phosphorylated on S202 and T205

      DOI: 10.1093/hmg/ddz255

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    academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddz255/5613690
  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    2
    1. scibot 31 Jul 2021
      AB_223647

      DOI: 10.1523/JNEUROSCI.1550-17.2017

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      AB_223647

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  165. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_223647

      DOI: 10.1002/cne.24610

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      RRID:AB_223647

      DOI: 10.1002/cne.24610

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24610
  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    6
    1. scibot 30 Jul 2021
      AB_223647

      DOI: 10.1371/journal.pone.0132075

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      AB_223647

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      AB_223647

      DOI: 10.1371/journal.pone.0132075

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      AB_223647

      DOI: 10.1371/journal.pone.0132075

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    ncbi.nlm.nih.gov/pmc/articles/PMC4489868/
  167. www.sciencedirect.com www.sciencedirect.com
    Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
    1
    1. scibot 30 Jul 2021
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2018.10.014

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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      RRID:AB_223647

      DOI: 10.1016/j.neuron.2016.12.023

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    ncbi.nlm.nih.gov/pmc/articles/PMC5363269/
  169. www.sciencedirect.com www.sciencedirect.com
    Secretion of Tau via an Unconventional Non-vesicular Mechanism
    1
    1. scibot 28 Jul 2021
      RRID: AB_223647

      DOI: 10.1016/j.celrep.2018.10.078

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    sciencedirect.com/science/article/pii/S2211124718316826
  170. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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      RRID:AB_223647

      DOI: 10.1111/ejn.14212

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    onlinelibrary.wiley.com/doi/full/10.1111/ejn.14212
  171. www.jneurosci.org www.jneurosci.org
    Untitled document
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      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.1353-14.2014

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    jneurosci.org/content/34/41/13629
  172. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    1
    1. scibot 27 Jul 2021
      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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  173. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment
    2
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      AB_223647

      DOI: 10.1002/cne.23877

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      AB_223647

      DOI: 10.1002/cne.23877

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    onlinelibrary.wiley.com/doi/10.1002/cne.23877/full
  174. www.sciencedirect.com www.sciencedirect.com
    Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia
    1
    1. scibot 22 Jul 2021
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2021.109419

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    sciencedirect.com/science/article/pii/S2211124721008329
  175. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature
    1
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      RRID:AB_223647

      DOI: 10.1186/s40478-021-01220-8

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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01220-8
  176. Jun 2021
  177. www.jneurosci.org www.jneurosci.org
    Cereblon regulates the proteotoxicity of tau by tuning the chaperone activity of DNAJA1
    1
    1. scibot 29 Jun 2021
      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.2494-20.2021

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    jneurosci.org/content/41/24/5138
  178. www.sciencedirect.com www.sciencedirect.com
    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
    1
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      MN1020

      DOI: 10.1016/j.neurobiolaging.2021.06.012

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    sciencedirect.com/science/article/pii/S0197458021002062
  179. May 2021
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
    1
    1. scibot 27 May 2021
      RRID:AB_223647

      DOI: 10.7554/eLife.65301

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    ncbi.nlm.nih.gov/pmc/articles/PMC8139826/
  181. www.sciencedirect.com www.sciencedirect.com
    Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
    1
    1. scibot 08 May 2021
      RRID:AB_223647

      DOI: 10.1016/j.neuron.2021.02.010

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    sciencedirect.com/science/article/pii/S0896627321000842
  182. www.sciencedirect.com www.sciencedirect.com
    Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease
    1
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      RRID:AB_223647

      DOI: 10.1016/j.neuron.2020.11.002

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    sciencedirect.com/science/article/pii/S0896627320308618
  183. www.sciencedirect.com www.sciencedirect.com
    Impaired Hippocampal-Cortical Interactions during Sleep in a Mouse Model of Alzheimer’s Disease
    1
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      RRID:AB_223647

      DOI: 10.1016/j.cub.2020.04.087

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    sciencedirect.com/science/article/pii/S0960982220306357
  184. Apr 2021
  185. www.sciencedirect.com www.sciencedirect.com
    Tau seeds are subject to aberrant modifications resulting in distinct signatures
    1
    1. scibot 28 Apr 2021
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2021.109037

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    sciencedirect.com/science/article/pii/S2211124721003533
  186. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
    1
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      RRID:AB_223647

      DOI: 10.1016/j.cell.2020.07.011

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    sciencedirect.com/science/article/pii/S009286742030876X
  187. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
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      RRID:AB_223647

      DOI: 10.1016/j.cell.2021.03.048

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    sciencedirect.com/science/article/pii/S0092867421003792
  188. www.sciencedirect.com www.sciencedirect.com
    Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components
    1
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      RRID:AB_223647

      DOI: 10.1016/j.neuron.2021.03.026

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    sciencedirect.com/science/article/pii/S0896627321001963
  189. Mar 2021
  190. onlinelibrary.wiley.com onlinelibrary.wiley.com
    α‐Synuclein Abnormalities Trigger Focal Tau Pathology, Spreading to Various Brain Areas in Parkinson’s Disease
    1
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      RRID:AB_223647

      DOI: 10.1111/jnc.15257

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15257
  191. Feb 2021
  192. www.nature.com www.nature.com
    MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis
    1
    1. scibot 25 Feb 2021
      RRID:AB_223647

      DOI: 10.1038/s41380-020-0824-3

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    nature.com/articles/s41380-020-0824-3
  193. www.nature.com www.nature.com
    Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway
    1
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      RRID:AB_223647

      DOI: 10.1038/s41538-021-00084-5

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    nature.com/articles/s41538-021-00084-5
  194. Jan 2021
  195. link.springer.com link.springer.com
    GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
    1
    1. scibot 06 Jan 2021
      mouse anti-phospho tau (AT8)

      DOI: 10.1007/s10571-020-01020-z

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  196. Nov 2020
  197. www.sciencedirect.com www.sciencedirect.com
    High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies
    1
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      RRID:AB_223647

      DOI: 10.1016/j.neuron.2020.09.042

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  198. Oct 2020
  199. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Tau phosphorylation by glycogen synthase kinase 3β modulates AChE expression
    1
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      RRID:AB_223647

      DOI: 10.1111/jnc.15189

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15189
  200. link.springer.com link.springer.com
    Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy
    1
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      RRID:AB_223647

      DOI: 10.1007/s10571-020-00972-6

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    link.springer.com/article/10.1007/s10571-020-00972-6
  201. Sep 2020
  202. www.sciencedirect.com www.sciencedirect.com
    Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission
    1
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      RRID:AB_223647

      DOI: 10.1016/j.stem.2019.12.015

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    sciencedirect.com/science/article/pii/S1934590919305739
  203. www.jneurosci.org www.jneurosci.org
    Activated CX3CL1/Smad2 signals prevent neuronal loss and Alzheimer's tau pathology-mediated cognitive dysfunction
    1
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      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.1333-19.2019

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    jneurosci.org/content/40/5/1133
  204. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease
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      AB_223647

      DOI: 10.1111/jnc.14961

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14961
  205. www.sciencedirect.com www.sciencedirect.com
    Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease
    1
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      RRID:AB_223647

      DOI: 10.1016/j.cmet.2020.02.004

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    sciencedirect.com/science/article/pii/S1550413120300632
  206. elifesciences.org elifesciences.org
    Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau
    1
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      RRID:AB_223647

      DOI: 10.7554/eLife.51859

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    elifesciences.org/articles/51859
  207. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ acan mouse model
    1
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      RRID:AB_223647

      DOI: 10.1111/ejn.14923

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    onlinelibrary.wiley.com/doi/10.1111/ejn.14923
  208. insight.jci.org insight.jci.org
    Identification of Alzheimer’s disease–associated rare coding variants in the <i>ECE2</i> gene
    1
    1. scibot 04 Sep 2020
      tau

      DOI: 10.1172/jci.insight.135119

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  209. Jan 2020
  210. link.springer.com link.springer.com
    Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease
    2
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      RRID:AB_223647

      DOI: 10.1186/s40478-019-0836-x

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      DOI: 10.1186/s40478-019-0836-x

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  211. www.sciencedirect.com www.sciencedirect.com
    Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
    1
    1. scibot 13 Jan 2020
      RRID:AB_223647

      DOI: 10.1016/j.celrep.2019.07.060

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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microglia changes associated to Alzheimer’s disease pathology in aged chimpanzees
    1
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      RRID:AB_223647

      DOI: 10.1002/cne.24484

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    ncbi.nlm.nih.gov/pmc/articles/PMC6283685/
  213. onlinelibrary.wiley.com onlinelibrary.wiley.com
    High specificity of widely used phospho‐tau antibodies validated using a quantitative whole‐cell based assay
    1
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      RRID:AB_223647

      DOI: 10.1111/jnc.14830

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14830
  214. www.sciencedirect.com www.sciencedirect.com
    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
    1
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      RRID:AB_223647

      DOI: 10.1016/j.celrep.2019.06.054

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    sciencedirect.com/science/article/pii/S2211124719308277
  215. www.sciencedirect.com www.sciencedirect.com
    The neuritic plaque in Alzheimer's disease: Perivascular degeneration of neuronal processes
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      RRID:AB_223647

      DOI: 10.1016/j.neurobiolaging.2019.06.009

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    sciencedirect.com/science/article/pii/S0197458019301915
  216. onlinelibrary.wiley.com onlinelibrary.wiley.com
    β‐amyloid and Tau Pathology in the Aging Feline Brain
    1
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      RRID:AB_223647

      DOI: 10.1002/cne.24741

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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24741
  217. www.frontiersin.org www.frontiersin.org
    Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade
    1
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      RRID:AB_223647

      DOI: 10.3389/fncel.2019.00399

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    frontiersin.org/article/10.3389/fncel.2019.00399/full
  218. www.jneurosci.org www.jneurosci.org
    Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin
    1
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      RRID:AB_223647

      DOI: 10.1523/JNEUROSCI.3632-16.2017

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    jneurosci.org/content/37/12/3181
  219. www.sciencedirect.com www.sciencedirect.com
    The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
    1
    1. scibot 13 Jan 2020
      RRID:AB_223647

      DOI: 10.1016/j.mcn.2019.103409

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    sciencedirect.com/science/article/pii/S1044743119300661
  220. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_223647

      DOI: 10.1016/j.celrep.2018.12.085

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    sciencedirect.com/science/article/pii/S221112471832045X
  221. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.nbd.2018.12.009

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  222. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_223647

      DOI: 10.1002/cne.24484

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  223. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Untitled document
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      RRID:AB_223647

      DOI: 10.1002/cne.24610

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  224. www.sciencedirect.com www.sciencedirect.com
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      RRID:AB_223647

      DOI: 10.1016/j.celrep.2019.01.023

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  225. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's‐associated pathologies
    1
    1. scibot 12 Jan 2020
      RRID:AB_223647

      DOI: 10.1111/jnc.14647

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  226. Nov 2018
  227. www.sciencedirect.com www.sciencedirect.com
    Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody
    1
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      RRID:AB_223647

      Curator: @Jmenke

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  228. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  229. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0603-4
  230. www.sciencedirect.com www.sciencedirect.com
    APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
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    sciencedirect.com/science/article/pii/S0896627318303805
  231. onlinelibrary.wiley.com onlinelibrary.wiley.com
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      RRID:AB_223647

      Curator: @anp055

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24447
  232. www.sciencedirect.com www.sciencedirect.com
    Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease
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      RRID:AB_223647

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  233. www.sciencedirect.com www.sciencedirect.com
    Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
    1
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      ThermoFisher Scientific#MN1020

      Curator: @bandrow

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    sciencedirect.com/science/article/pii/S2213231717306687
  234. Nov 2017
  235. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Fluorine‐19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice
    1
    1. scibot 08 Nov 2017
      RRID:AB_223647

      Curator: @patriciaelyse_

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    onlinelibrary.wiley.com/doi/10.1002/jnr.24188/full
  236. www.nature.com www.nature.com
    ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury
    1
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      Curator: @kaitlinsung

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    nature.com/articles/s41598-017-11654-7
  237. www.sciencedirect.com www.sciencedirect.com
    Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease
    1
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      RRID:AB_223647

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276517305361
  238. www.sciencedirect.com www.sciencedirect.com
    Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation
    1
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      AB_223647

      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S2352396417302098
  239. www.sciencedirect.com www.sciencedirect.com
    Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
    1
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      AB_223647

      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0896627317300582
  240. www.sciencedirect.com www.sciencedirect.com
    Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
    1
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      AB_223647

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S0896627316309965
  241. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets
    1
    1. scibot 08 Nov 2017
      AB_223647

      Curator: @jcabotaj

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